Viewing affirmative mentions of localization in T cells

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Agrawal et al. (1998)MUC1T-cellSecreted cancer-associated MUC1 is immunosuppressive and inhibits human T-cell proliferation.
Dong et al. (2007)high mobility group box IT cellsWe have recently demonstrated that cytolysis of human melanoma cells by immune effectors (both NK and T cells) is associated with release of the nuclear chromatin protein, high mobility group box I (HMGB1).
Grattan et al. (2002)Idd4T-cellIdd4.2 is localized within the D11Mit38/325 interval that mainly influences diabetes incidence and restores T-cell proliferative responsiveness.
Mix et al. (2004)MOGT cellTests for immunoreactivity to MOG (T cell proliferation and interferon-gamma (IFN-gamma) secretion) revealed no stronger immune response in B6 compared to B10 mice supporting the hypothesis of an immunosuppressive effect as a target to prevent EAE in the B10 mice.
Martin et al. (1989)IL-2T cellNone of the generated T cell hybridomas exhibited antigen-specific IL-2 secretion when stimulated with autologous thyrocytes, although 60% of the hybridomas expressed CD3 antigen and the T cell receptor alpha/beta heterodimer.
Porter et al. (2008)CXCL11T cellPolarized localization of epithelial CXCL11 in chronic obstructive pulmonary disease and mechanisms of T cell egression.
Moseley et al. (1991)PTHrPT cellThis finding suggests that PTHrP may be involved in the production of hypercalcaemia in at least some cases of T cell lymphoma - proof of a causal relationship however must await the demonstration of tissue release of PTHrP resulting in raised circulating hormone levels.
Houchins et al. (1993)NKG5T cellsWe reported previously the isolation of a cDNA clone, designated NKG5, encoding a secreted protein that is expressed only in natural killer and T cells and is strongly upregulated upon cell activation.
Kaplan et al. (1988)IL-2T cellSurface IL-2 epitopes were also detected on the Jurkat tumor cell line which secretes IL-2 upon stimulation and on another T cell tumor line MOLT 4.
Kaplan et al. (1988)IL-2T cellsAlthough it is possible that the epitopes seen were present on a distinct molecule independent of secreted IL-2, the distribution on a variety of T cells and regulation via cellular activation suggest that the surface expression of IL-2 epitopes is in some way related to the soluble lymphokine.
Prowse (1982)IL2T lymphocytesThe lymphokine Interleukin 2 (IL2) is secreted by T lymphocytes from mice infected by the murine parasitic nematode Nematospiroides dubius upon in vitro re-stimulation by specific parasite antigens.
Bonini et al. (1999)NGFT cellHuman CD4+ T cell clones (preferentially of activated Th2 type) produce and release NGF, and express high-affinity NGF receptors.
Fontenot et al. (2002)CD4T cellsTarget organ localization of memory CD4(+) T cells in patients with chronic beryllium disease.
Brown et al. (2007)Foxp3T cellsUltra-localization of Foxp3+ T cells within renal allografts shows infiltration of tubules mimicking rejection.
Nakamichi et al. (2007)RANKLT cellsOsteoblasts and activated T cells in culture released a large amount of RANKL in the absence of OPG.
Guo et al. (2000)TPOT cellsThese data suggest that TPO-specific B cells are involved in antigen presentation to sensitized T cells and are supported by the ability of spleen cells from TPO cell-injected (but not control) mice to secrete TPO antibodies spontaneously in culture.
Kinkhabwala et al. (1990)TNF moleculeT cellsCell surface radioiodination studies of stimulated T cells demonstrated the presence of 26-kD transmembrane protein, a size predicted by TNF cDNA and different from that of the 17-kD secreted TNF molecule.
Mori et al. (2004)CCL5T-cellAmong various human T-cell lines, those infected with HTLV-I selectively expressed the CCL5 gene and secreted CCL5.
Mori et al. (2004)CCL5T-cellInducible expression of HTLV-I transcriptional activator Tax in a human T-cell line Jurkat, up-regulated CCL5 mRNA and induced CCL5 secretion.
Donlon et al. (1990)RANTEST-cellLocalization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12.
Donlon et al. (1990)RANTEST-cellWe report here the localization of the gene for a human T-cell-specific molecule, designated RANTES, to human chromosome region 17q11.2-q12 by in situ hybridization and analysis of somatic cell hybrids using a cDNA probe to the gene.
Palacios et al. (1983)IFN-gammaT cellStimulation of these cells with concanavalin A, phytohemagglutinin, or the UCHT1 monoclonal anti-human T cell antibody significantly increased the number of IFN-gamma-secreting cells.
Palacios et al. (1983)IFN-gammaT cellsFinally, cyclosporin A, a potent and selective immunosuppressive drug for T cells, strongly inhibited the secretion of IFN-gamma as assayed at the cell level.
Bernton et al. (1992)PRLT-cellSuppression of prolactin (PRL) secretion with the dopamine agonist, bromocriptine, has been shown in rodents to diminish a variety of immunologic responses, including delayed type hypersensitivity, primary antibody response, T-cell dependent macrophage activation, and ex vivo T- and B-lymphocyte proliferation in response to mitogens.
Kawahara et al. (2007)HMGB1T cellsHMGB1 release in co-cultures of porcine endothelial and human T cells.
Kawahara et al. (2007)HMGB1T-cellThe released HMGB1 originated from both cell types, as immunofluorescent microscopy showed that it was present in the cytosol of PAEC in contact with T cells, and had disappeared from the T-cell nuclei.
Meuer et al. (1982)IL 2T cellMitogen stimulation led to secretion of equivalent amounts of IL 2 from both the major T cell subsets; in contrast, after allogeneic activation, IL 2 was produced predominantly from the T4+ subset.
Haagmans et al. (1994)IFN-gammaT lymphocytesThese data suggest that IFN-gamma can play different and even opposite roles in the regulation of RCMV replication in vivo; T lymphocytes may contribute to the progression of RCMV infection by secreting IFN-gamma.
Chun et al. (2004)CTLA-4T cellAfter peripheral T cell activation, we observed that most of CTLA-4 is localized primarily to intracellular compartment rather than to the cell surface.
Guerriero et al. (2003)Myelin basic proteinT cellsMyelin basic protein epitopes secreted by human T cells encounter natural autoantibodies in the serum.
Guerriero et al. (2003)MBPT lymphocytesPeripheral T lymphocytes secreted MBP epitopes, and secretion increased in time after mitogen stimulation.
Karpuzoglu-Sahin et al. (2001)IFN-gammaT cellsCell mixing experiments suggested that the DES-induced increase in IFN-gamma secretion is due to hormonal effects on T cells but not on APC.
Grum-Schwensen et al. (2010)S100A4T cellsWe suggest that release of S100A4 in the primary tumor stimulates infiltration of T cells and activates secretion of cytokines, thus triggering sequential events that fuel tumor cells to metastasize.
Maeda et al. (2004)TARPT cellThe T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria.
Müller et al. (1999)IL-10T cellT cell stimulation upon long-term secretion of viral IL-10.
Müller et al. (1999)vIL-10T cellsHere we show in vivo and in vitro that after long-term secretion vIL-10 has a stimulatory effect on T cells.
Solbach et al. (1982)Il-2T cellIn order to release Il-2, the OKT4 positive T cell requires a stimulus, such as allogeneic cells or the lectin phytohaemagglutinin A (PHA).
Vie and Miller (1986)IL 2T cellsEstimation by limiting dilution analysis of human IL 2-secreting T cells: detection of IL 2 produced by single lymphokine-secreting T cells.
Marafioti et al. (2005)NFATNFATNuclear factor of activated T cells (NFAT) transcription factors, involved in a major Ca2+-dependent signalling pathway, normally reside in the cytoplasm but re-locate to the nucleus when activation of the pathway (e.g. following ligation of antigen receptors) leads to their dephosphorylation.
Ohhara et al. (1987)colony stimulating factorT-lymphocytesFurthermore, colony stimulating factor was released when T-lymphocytes were incubated with forphenicinol.
Stark et al. (1992)IL-2T lymphocytesThe data suggest that IL-2 may potentiate GVHD and alloreactivity induced by an adequate number of irradiated, nondividing but viable allogeneic spleen cells and/or that secretion of IL-2 by alloactivated T lymphocytes, supplied exogenously in the present study, may play a role in the GVHD syndrome.
Batey et al. (1999)tumor necrosis factor-alphaT lymphocyteThe lesion in the T lymphocyte is characterized by reduced baseline secretion of cytokines, including tumor necrosis factor-alpha; although characterized by an exaggerated release of cytokines when stimulated by polyclonal activators such as endotoxin.
Rabinowitz et al. (1982)TCIIT lymphocyteMurine thymus cells of T lymphocyte tumors secreted only small quantities of TCII.
Lacosta et al. (1999)Interleukin-2T cellsInterleukin-2 (IL-2), released from activated T cells, influences central neurochemical functioning, and IL-2 immunotherapy in cancer patients may provoke neuropsychiatric and cognitive disturbances.
DosReis et al. (1986)IL-2T-cellClAdo inhibited both IL-2 secretion and induction of IL-2 responsiveness up to control levels in the same dose range it inhibited T-cell mitogenesis.
DosReis et al. (1986)IL-2T cellsExtracellular administration of dbcAMP to splenic T cells stimulated by Con A mimicked the effects of ClAdo on T-cell activation parameters, as revealed by a dose-dependent blockade of both IL-2 secretion and IL-2 responsiveness induction, without affecting IL-2 receptor expression.
Hu et al. (1997)TNF-alphaT lymphocytesA variety of human tumor cells and T lymphocytes transduced by AdVtTA.TNF-alpha secreted high-titer (5,000-100,000 pg/10(6) cells/24 h) and biologically active TNF-alpha in the absence of Tc.
Pinkston et al. (1987)interleukin 2T lymphocytesCorticosteroid therapy suppresses spontaneous interleukin 2 release and spontaneous proliferation of lung T lymphocytes of patients with active pulmonary sarcoidosis.
Pinkston et al. (1987)IL 2T cellIn contrast, over the same period, the treated group had marked reduction of spontaneous lung T cell release of IL 2 and proliferation (p less than 0.01, all comparisons before therapy).
Duc Dodon and Gazzolo (1987)IL2T cellsThe results also suggest that viral attachment to T cells possibly supplies an accessory function triggering autocrine secretion of IL2 by these cells.
Dautry-Varsat et al. (1988)interleukin-2T-cellThe effect of cyclosporin A (CsA), a potent immunosuppressive agent, on a human T-cell line, IARC 301, which constitutively secretes interleukin-2 (IL-2) and expresses high-affinity IL-2 receptors, was investigated.
Dautry-Varsat et al. (1988)IL-2T-cellCsA also prevents the constitutive secretion of IL-2 in this T-cell line by blocking transcription of the IL-2 gene.
Park et al. (2007)IFN-gammaT cellsIFN-gamma secreting T cells specific for survivin was found after temozolomide (TMZ) treatment in C57BL/6 mice intracranial (i.c.) inoculated with GL26 cells.
Fausch et al. (2002)IL-12T cellsHowever, in contrast to dendritic cells, Langerhans cells are not activated by human papillomavirus virus-like particles, illustrated by the lack of: up-regulating activation markers, secreting IL-12, stimulating T cells in an MLR, inducing human papillomavirus-specific immunity, and migrating from epidermal tissue.
Wee and Bach (1984)Interleukin-2T cellVarious functionally distinct human T cell clones derived from in vitro mixed leukocyte cultures are found to secrete lymphokines with detectable Interleukin-2 (IL-2)-like activity upon antigenic stimulation.
Weiss et al. (1984)IL 2T cellThese studies demonstrated that antibodies reactive with the T cell-specific T3 antigen were insufficient to result in the activation of Jurkat cells, determined by the secretion of IL 2.
Klinman et al. (1998)IgGT cellsGene gun-mediated DNA vaccination stimulates an immune response characterized by the activation of IgG-secreting B cells and IFN-gamma-secreting T cells.
Ruscetti and Gallo (1981)TCGFT cellsThus, release of TCGF and development of receptors for it appear to be obligatory for the clonal expansion of all activated T cells.
Szeto et al. (2010)CD4T cellsMinocycline treatment resulted in significant changes in activation marker expression and inhibited proliferation and cytokine secretion of CD4+ T cells in response to activation.
Matangkasombut et al. (2009)AHRT cellsA crucial role has been suggested for invariant natural killer T cells (iNKT) in regulating the development of asthma, a complex and heterogeneous disease characterized by airway inflammation and airway hyperreactivity (AHR). iNKT cells constitute a unique subset of T cells responding to endogenous and exogenous lipid antigens, rapidly secreting a large amount of cytokines, which amplify both innate and adaptive immunity.
Cech et al. (2006)IL-2T cellsEchinacea alkylamides suppressed IL-2 secretion by stimulated T cells, and this effect was significantly lessened upon oxidation of the alkylamides to carboxylic acids and hydroxylated metabolites.
Splawski and Lipsky (1987)IgAT cellMitogen-stimulated T cell supernatants increased IgA secretion of the hybridoma cells but did not cause synergistic stimulation of the cells in the presence of PC-Sepharose.
Mori et al. (1992)parathyroid hormone-related proteinT-cell[Urinary excretion of parathyroid hormone-related protein in patients with adult T-cell leukemia and other hematologic disorders].
Huang et al. (2009)IFN-gammaT-cellImmunogenicity studies in mice have shown that antigen-specific antibody titers and T-cell proliferative responses, as well as the secretion of IFN-gamma, were significantly enhanced for ovalbumin after formulation with PEG-b-PLACL-based emulsions.
Frémeaux-Bacchi et al. (1996)CR2T lymphocytesWe report on a soluble (s) form of CD21 (the C3dg/Epstein-Barr virus receptor, CR2) that is spontaneously released by B and T lymphocytes.
Smith et al. (2005)MOGT cellFollowing acute EAE with MOG(-/-) SCH, mice developed T cell responses to recombinant mouse MOG (rmMOG), indicating that MOG released from myelin is antigenic; however, the lack of chronic disease indicates that such responses were not pathogenic.
Geha and Leung (1987)IgET cellsIsotype-specific regulation of the IgE response was mediated in the secretion of IgE-binding factors by T cells suppressing Fc receptors for IgE.
Salvadori and Zier (1996)IL-2T cellsTo test this, we compared the signal-transducing ability of T cells from mice inoculated with parental tumors (PTB) with that of T cells from mice immunized with IL-2-secreting tumor cells (ITB).
Huang et al. (2008)CXCL16T lymphocyteBecause we first found chemokine CXCL16 was highly expressed in and secreted by the first-trimester human trophoblasts previously, in this study we tested the hypothesis of whether the fetal trophoblasts can direct migration of maternal T lymphocyte and monocytes into decidua by secreting CXCL16.
Hunninghake et al. (1983)IL-2T-cellsThese studies suggest that the release of IL-2 by lung T-cells may explain in part the local proliferation of T-cells and hypergammaglobulinemia that are characteristic of pulmonary sarcoidosis.
Manger et al. (1986)interleukin 2T cellDifferent T cell lines, which can be induced to secrete interleukin 2 (IL-2) in vitro, were used to dissect the effect of cyclosporin A (CsA).
Goldstein and Audhya (1985)ThymopoietinT cellThymopoietin is secreted by epithelial cells of the thymus and is pleiotropic in action, affecting neuromuscular transmission, induction of early T cell differentiation and immune regulation.
Johnson et al. (1992)interleukin-2T-cellsConditioned media from interleukin-2 secreting Jurkat T-cells as well as the glucocorticoid-insensitive, but receptor positive clone, CEM-C1, failed to prevent lymphocytolysis; exogenous interleukin-2 also did not provide protection.
Karanikas et al. (2008)Foxp3T cellsIn particular, under the light of recent findings revealing the physical interaction of Foxp3 with the nuclear factor of activated T cells (NFAT), it appears that at least with respect to its nuclear localization, Foxp3 plays a pivotal role in the formation of nuclear complexes that are important to regulate the transcription of several target genes [16], that confer to Tregs their suppressive function [17].
Xu et al. (2010)IL-17T cellsIL-17 was secreted mainly by gammadelta T cells in this model.
Xu et al. (2010)IL-17T cellsImportantly, our data suggest that C5a participates in the regulation of IL-17 secretion by gammadelta T cells.
Westendorp et al. (1994)interleukin-2T cellsHuman immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.
Westendorp et al. (1994)IL-2T cellsIL-2 secretion was increased more than twofold in both Jurkat T cells and primary T cells stimulated by extracellular HIV-1 Tat protein.
Li et al. (2010)IL-2T lymphocytesIn the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin.
Yamaguchi et al. (2005)uPAT lymphocytesIn our previous study, [Deamino-Cys1, D-Arg8]-vasopressin (dDAVP) induced urokinase-type plasminogen activator (uPA) release from human peripheral T lymphocytes via arginine vasopressin (AVP) V2-receptor-mediated reaction enhanced by an AVP V1-receptor antagonist.
Yamaguchi et al. (2005)uPAT lymphocytesTherefore, we examined the level of uPA released from peripheral T lymphocytes by AVP in transplant patients with CAN in comparison with control groups.
Kasempimolporn et al. (1997)IL-2T-cellThere was also a marked suppression of IL-2 secretion in parallel with a decrease of the T-cell proliferative response to mitogen.
Matsumoto et al. (1989)IFN-gammaT-lymphocytesIFN-gamma, also called immune interferon, is regarded as an important immunoregulator secreted by T-lymphocytes.
Yang and Miller (1999)PKCthetaT lymphocytesTo see whether aging affects this PKCtheta; clustering reaction in mouse T lymphocytes, we used immunofluorescence staining and confocal microscopy to observe the localization of PKCtheta; in CD4 and CD8 T lymphocytes activated by coincubation with anti-CD3 hybridoma cells.
Simmons et al. (2007)GM-CSFT cellThese studies revealed that GM-CSF-secreting cancer immunotherapies elicit T cell responses that effectively control growth of related but antigenically distinct tumors.
Franchini et al. (1986)HTLV-III 3' orf proteinT cellsCytoplasmic localization of the HTLV-III 3' orf protein in cultured T cells.
Sileghem et al. (1986)IL-2T-cellFurthermore, lymph node cells derived from infected mice suppressed both secondary T-cell proliferative responses and IL-2 secretion, indicating that the trypanosome-induced suppression is mediated by a suppressive cell which interferes at the level of IL-2 secretion.
Stoll et al. (1993)interferon-gammaT cellLocalization of interferon-gamma and Ia-antigen in T cell line-mediated experimental autoimmune encephalomyelitis.
Stoll et al. (1993)IFN-gammaT cellsThis study reports the cellular localization of interferon-gamma (IFN-gamma) and MHC class II antigen (Ia) in the spinal cord of rats with experimental autoimmune encephalomyelitis induced by adoptive transfer of myelin basic protein-specific T cells.