Viewing affirmative mentions of phosphorylation in T cells

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Wykes et al. (2002)CD227T cellsAdditionally, we confirm CD227 expression by activated human T cells and show for the first time that the CD227 cytoplasmic domain is tyrosine-phosphorylated in activated T cells and DC and is associated with other phosphoproteins, indicating a role in signaling.
Brattsand et al. (1989)PKCT-cellIn the present report we describe a fractionation method that allows quantitative analysis of phosphorylation of two distinct PKC substrates using normal human T cells and T-cell tumour lines.
Walker (2001)prolactinT cellUnmodified and phosphorylated prolactin and gamma delta T cell development and function.
Walker (2001)PRLT cellResults demonstrate that the ratio of unmodified to phosphorylated PRL during rat pregnancy is crucial to normal epidermal gamma delta T cell development in the pup thymus.
Walker (2001)PRLT cellElevation of phosphorylated PRL in the dams, by administration of a recombinant molecular mimic of phosphorylated PRL, produces a defect in epidermalgamma delta T cell seeding and subsequent function in the offspring.
Cénit et al. (2010)STAT3T cellsMoreover, increased phosphorylated STAT3 was reported in T cells of patients evolving from clinically isolated syndrome to defined MS and in relapsing patients.
Kung et al. (1989)IL-2T cellThere was no difference in biological activity between non-phosphorylated and phosphorylated IL-2, as determined by a T cell growth assay.
Axelsson and Perlmann (1989)CD43T cellsPersistent superphosphorylation of leukosialin (CD43) in activated T cells and in tumour cell lines.
Axelsson and Perlmann (1989)CD43T cellsInterestingly, the high level of phosphorylation of CD43 was maintained in long-term cultures of T cells activated by various means.
Krämer and Heinzel (2010)STAT1T cellHere, we review these analyses and the finding that a switch from phosphorylated to acetylated STAT1 regulates acetylation-dependent dephosphorylation of STAT1 via the T cell tyrosine phosphatase.
Autero and Gahmberg (1987)CD45T cellsPhorbol diesters increase the phosphorylation of the leukocyte common antigen CD45 in human T cells.
Autero and Gahmberg (1987)CD45T cellsCD45 was weakly phosphorylated in nonactivated T cells, but a treatment of the cells with 10, 60 or 200 nM phorbol 12,13-dibutyrate (PDBu) markedly increased the phosphorylation of the glycoprotein.
Autero and Gahmberg (1987)CD45T cellsThe phosphorylation of CD45 was found to clearly increase after a treatment of T cells with 60 nM PDBu for only 30 s, and the phosphorylation reached its maximum in about 5 min.
Volker et al. (1997)LSFT cellsMitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity.
Crawley et al. (2010)IL-7-mediatedT cellsIn this study, we demonstrated that recombinant and native sources of sCD127 significantly inhibited IL-7-mediated STAT5 and Akt phosphorylation in CD8(+) T cells.
Rodriguez-Mora et al. (2005)CREBT lymphocytesHydrogen peroxide (HP) induced the phosphorylation of cAMP response element binding protein (CREB) on Ser133 in Jurkat T lymphocytes via p38 and MSK1.
Acres et al. (1987)CD8T cellCD8 phosphorylation is induced upon addition of heterologous, Epstein-Barr virus-transformed B cells, which cause proliferation and are target cells for a cytotoxic CD8+CD4+ T cell line and a CD8+CD4- T cell clone.
Kim et al. (2006)ZAP-70T cellWe found that some over-expressed partially agonistic ligands (OPALs) induced T cell responses without tyrosine-phosphorylation and kinase activation of ZAP-70.
Hamasaki et al. (2007)gammaH2AXT lymphocytesIn this study, we established a flow cytometry (FCM) system for measuring radiation-induced phosphorylated histone H2AX (gammaH2AX) in cultured human T lymphocytes to evaluate individual radiation sensitivity in vitro.
Gold et al. (1994)LckT cellsThis Lck "band shift" has been observed previously in activated T cells and correlates with phosphorylation of Lck at serine 59.
Fiorillo et al. (2010)LYPT cellT cell receptor-induced phosphorylation of LYP by Lck on an inhibitory tyrosine residue releases tonic inhibition of signaling by LYP.
Fiorillo et al. (2010)LYPT cellThe R620W variation disrupts the interaction between Lck and LYP, leading to reduced phosphorylation of LYP, which ultimately contributes to gain-of-function inhibition of T cell signaling.
Hunter et al. (2000)FYBT cellsStimulation of T cells via the alpha4beta1 integrin enhances the association of tyrosine phosphorylated SLAP-130/FYB with the SH2 domain of the src tyrosine kinase p59fyn.
Hunter et al. (2000)SLAP-130T cellsActivation of normal T cells, but not H9 T cells, via alpha4beta1 leads to tyrosine phosphorylation of SLP-76 as well as SLAP-130/FYB.
Tagawa et al. (1991)CD4T cellMurine T cell surface antigens, CD4 and CD8 are phosphorylated in response to phorbol 12-myristate 13-acetate, a protein kinase C activator, but not phosphorylated after concanavalin A, Ca2+ ionophore or dibutyryl-cAMP treatment.
Sancho et al. (1993)CD3-epsilonT cellThe T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif.
Sancho et al. (1993)CD3-epsilonT cellsSince both CD3-epsilon and the zeta chain contain a tyrosine-based signaling motif, we examine phosphorylation of CD3-epsilon in human T cells.
Mukherjee et al. (2005)MUC1T cellUsing the Jurkat T cell lymphoma cell line and normal human T cells, we demonstrate that MUC1 is not only expressed in these cells but is also phosphorylated upon T cell receptor (TCR) ligation and associates with the Src-related T cell tyrosine kinase, p56lck.
Scott et al. (1997)NFATpT-cellT-cell activation results in the activation of the phosphatase calcineurin (CaN), which leads to the dephosphorylation and subsequent nuclear localization of NFATp.
Brown et al. (2003)ERMT lymphocytesChemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization.
Yamaguchi and Hendrickson (1996)LckT-cellActivated Lck phosphorylates T-cell receptor zeta-chains, which then recruit the ZAP70 kinase to promote T-cell activation.
Jurrmann et al. (2005)IRAKT-cellCurcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.
Davies et al. (1992)CD5T-cellCD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex.
Jung et al. (2010)NLKT-cellNemo-like kinase (NLK), which is mediator of Wnt/beta-catenin signaling pathway, phosphorylates T-cell factor/lymphoid enhancer factor (TCF/LEF) factor and inhibits interaction of beta-catenin/TCF complex.
Kobarg et al. (1997)CD6T cellCD6 becomes phosphorylated on tyrosine (Tyr) residues following stimulation through the T cell receptor (TCR) complex.
Izuhara and Harada (1993)IL-4T cellInterleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2.
Lübbert et al. (1989)p53T-cellWe studied expression, kinetics, phosphorylation, DNA methylation and chromatin structure of p53 in resting and proliferating untransformed T-lymphocytes and in human T-cell leukemia virus type I transformed T-lymphocytes from the same individuals. p53 expression is indistinguishable in transformed compared to untransformed proliferating T-lymphocytes by: (1) p53 mRNA levels, (2) rate of synthesis and stability of p53 protein, (3) change in protein stability after exposure to an inhibitor of protein synthesis, (4) presence of phosphorylation of the p53 protein.
Lorenz et al. (1994)SH-PTP1T cellsWe have found that SH-PTP1 is basally phosphorylated on serine in resting T cells.
Lorenz et al. (1994)SH-PTP1T-cellUpon stimulation of CD4 or CD8 either in a T-cell hybridoma cell line or in primary thymocytes, SH-PTP1 becomes tyrosyl phosphorylated.
Harnick et al. (1995)IP3RT cellDuring T cell activation the IP3R was tyrosine phosphorylated.
Mody et al. (2007)CD43T cellsTo investigate whether CD43 phosphorylation regulates its function in T cells, we used tandem mass spectrometry and identified Ser76 in murine CD43 as a previously unidentified site of basal phosphorylation.
Khan et al. (1998)hsp60T cellsBy contrast, PKA-catalyzed phosphorylation of both hsp60 and H2B caused dissociation of H2B from hsp60 and loss of H2B from the plasma membrane of intact T cells.
Khan et al. (1998)hsp60T cellThese results suggest that (i) hsp60 and H2B can localize in the T cell plasma membrane; (ii) hsp60 functions as a molecular chaperone for H2B; and (iii) PKA-catalyzed phosphorylation of both hsp60 and H2B appears to regulate the attachment of H2B to hsp60.
Jin et al. (1999)SHP-1LT cellsIn contrast to SHP-1, tyrosine phosphorylation of SHP-1L is not detected upon stimulation in Jurkat T cells.
Chen et al. (2010)HOX11T-cellPhosphorylation of HOX11 in clinically relevant T-cell lines impacts the mitotic spindle checkpoint
Chen et al. (2010)HOX11T-cellThus the phosphorylation of HOX11 following nocodazole or colchicine treatment was reproducible in clinically relevant T-cell lines and may be applicable to HOX11 disease pathology.
Schraven et al. (1994)LPAPT-lymphocytesSince tyrosine phosphorylation of LPAP is undetectable in T-lymphocytes expressing enzymatically active CD45, these data suggest that LPAP likely represents a novel substrate for CD45.
Lyck et al. (2003)ICAM-1T cellsSurprisingly, tyrosine phosphorylation of endothelial ICAM-1 was not necessary for TEM of T cells or for Rho guanosine triphosphatase (RhoGTPase) activation.
Zhang et al. (2009)PHPT1T cellRecently Srivastava et al. (11) described that K+ channel KCa3.1 is dephosphorylated by PHPT1, thereby affecting CD4 T cell function that could have an impact on autoimmunity.
Lazarovits et al. (1994)CD7T cellsIn vitro phosphorylation of CD7, CD3, or CD45 immunoprecipitates prepared from lysates of human T cells showed a similar pattern of multiple phosphorylated polypeptides; in addition, these immunoprecipitates phosphorylated a tyrosine kinase-specific peptide.
Asao et al. (1990)IL-2Rp75T cellsThe present study using TU11 mAb demonstrates the IL-2-induced phosphorylation of IL-2Rp75 on tyrosine residues in IL-2-dependent T cells.
Granum et al. (2006)TSAdT cellsThe TSAd N-terminus modifies phosphorylation of TSAd in Jurkat T cells
Gupta et al. (2007)Chk2T-cellHuman T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2.
Øster et al. (2005)p53T cellsHuman herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells.
Øster et al. (2005)p53T-cellThus, a productive HHV-6B infection suppresses T-cell proliferation concomitant with the phosphorylation and accumulation of p53.
Chae et al. (2010)ZAP-70T cellsExpression of CA-Lck in Jurkat T cells induced the phosphorylation of ZAP-70, CD3?
Veillette and Fournel (1990)LckT-cellContrary to what we have previously reported for an antigen-dependent murine T-cell clone, as well as murine thymocytes, the CD4 induced activation of p56lck observed in fibroblasts does not result in marked changes in Lck tyrosine phosphorylation, suggesting that other lymphoid specific components may be required for these tyrosine phosphorylation changes.
Edmunds et al. (1999)SHIPT cellIn this study, we demonstrate using the murine T cell hybridoma DC27.1, that SHIP is strongly tyrosine phosphorylated after ligation of CD28 by either mAb or the natural ligand B7.1.
Kiani et al. (2004)NFATc2T lymphocytesNFATc2 dephosphorylation/rephosphorylation as well as nuclear/cytoplasmic translocation in CD34+ cells follow the same calcineurin-dependent pattern as in T lymphocytes, suggesting that NFATc2 activation in these cells is equally sensitive to inhibition with CsA.
Hanawa et al. (2002)CD28iT cellsCD28i was found noncovalently associated with CD28 and was tyrosine-phosphorylated/PI3-kinase-complexed following the crosslinking of CD28, and the CD28 costimulatory signal was enhanced in T cells expressing CD28i.
Iguchi-Manaka et al. (2008)DNAM-1T cellsDNAM-1 also associates with LFA-1 in activated T cells, for which the protein kinase C–induced serine phosphorylation in the cytoplasmic domain of DNAM-1 is responsible (8), and is involved in an LFA-1–mediated costimulatory signal for naive T cell differentiation and proliferation (9).
Saarela et al. (2006)PKCT lymphocytesThe golli product expressed in T lymphocytes, BG21, can be phosphorylated by PKC, but the inhibition of the PKC pathway is independent of the phosphorylation.
Qing et al. (2003)FKBP52T-cellIn the present study, we have identified that the tyrosine-phosphorylated form of FKBP52 is a substrate for the cellular T-cell protein tyrosine phosphatase (TC-PTP).
Pognonec et al. (1990)Ets1T cellsWe demonstrate here that T cell receptor (TCR) specific stimulation with monoclonal antibodies of mature CD8+ or CD4+ T cells also results in the rapid phosphorylation of Ets1, reinforcing the hypothesis of a possible role for Ets1 in T cell activation.
Liu and Golan (1999)CD2T cellThese data suggest that T cell activation through the TCR/CD3 complex controls CD2 lateral mobility by a Ca2+/calmodulin-dependent mechanism, and that this mechanism may involve regulated phosphorylation and dephosphorylation of CD2 or a closely associated protein.
Wang et al. (2005)LABT cellsNTAL (non-T-cell activation linker, also called LAB) and LAT (linker for activation of T cells) are evolutionarily related transmembrane adaptor proteins that are phosphorylated upon immunoreceptor engagement.
Ishida et al. (2010)Vav1T cellAlteration of the PKC theta-Vav1 complex and phosphorylation of Vav1 in TCDD-induced apoptosis in the lymphoblastic T cell line, L-MAT.
Vilà et al. (2001)CD5T cellWe propose that T cell activation mediates CD5 tyrosine phosphorylation at residues Y429 and Y463 mainly through the activation of Lck.
Salmerón et al. (1995)TfRT cellWe have found several protein substrates to be tyrosine phosphorylated upon TfR stimulation in the human Jurkat T cell line.
Matsumoto et al. (1993)p50T cellsConcanavalin A (Con A) stimulated the phosphorylation of a protein with a molecular mass of 50 kDa and an approximate pI of 4.7 (p50) in mouse spleen T cells.
Matsumoto et al. (1993)p50T cellsThis phosphorylation of p50 was limited to serine and threonine residues in both Con A- and PMA-stimulated T cells.
Torigoe et al. (2007)LATLATExperiments in which the concentrations of two ligands with different dwell times are adjusted to equalize the level of LAT phosphorylation in rat basophilic leukemia 2H3 cells show that Erk2 phosphorylation, intracellular Ca(2+), and degranulation exhibit kinetic proofreading downstream of LAT phosphorylation.
Shirakawa et al. (2006)DNAM-1T cellsHere, we show that, although the TCR-mediated signal induced the serine phosphorylation of DNAM-1, DNAM-1 did not associate with lipid rafts in CD4+ T cells derived from mice deficient in LFA-1 expression, indicating that lipid raft recruitment of DNAM-1 depends on LFA-1 expression.
Wang et al. (1993)Op18T cellsPhorbol 12-myristate 13-acetate-induced phosphorylation of Op18 in Jurkat T cells.
Di Bartolo et al. (1999)ZAP-70T cellTyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.
Di Bartolo et al. (1999)ZAP-70T cellFollowing T cell antigen receptor (TCR) engagement, the protein tyrosine kinase (PTK) ZAP-70 is rapidly phosphorylated on several tyrosine residues, presumably by two mechanisms: an autophosphorylation and a trans-phosphorylation by the Src-family PTK Lck.
Wang et al. (2004)Stat6T-cellsWe demonstrate in primary human T-cells (>95% CD3+) that IL4 and for the first time IL13 induce Stat6 serine but not threonine phosphorylation that closely paralleled early IL4 receptor alpha-chain activation (10 min).
DeCaprio et al. (1992)RBT lymphocytesWe characterized RB phosphorylation after mitogenic stimulation of primary human T lymphocytes, initially arrested in the G0 state.
DeCaprio et al. (1992)RBT cellsRB is phosphorylated in at least three steps when T cells are driven into the cell cycle.
Hao et al. (2004)H2AXT cellsPhosphorylation of H2AX at short telomeres in T cells and fibroblasts.
Badour et al. (2004)WASpT cellsTCR-induced WASp tyrosine phosphorylation was also disrupted in T cells lacking Fyn, a kinase shown here to bind, colocalize with, and phosphorylate WASp.
Szkanderová et al. (2003)p53T-lymphocyteGamma irradiation results in phosphorylation of p53 at serine-392 in human T-lymphocyte leukaemia cell line MOLT-4.
Zhang et al. (2003)ShcT-cellShc becomes rapidly tyrosine phosphorylated after T-cell receptor (TCR) engagement.
Kim et al. (2007)CREBT-cellConsonant with a fundamental role for CREB phosphorylation in Tax recruitment to the complex, we found that CREB is highly phosphorylated in a panel of HTLV-1-infected human T-cell lines.
Kim et al. (2007)CREBT-cellBecause pCREB has been implicated in leukemogenesis, enhancement of CREB phosphorylation by the virus may play a role in the etiology of adult T-cell leukemia.
le Gouvello et al. (1991)StathminT lymphocyteStathmin phosphorylation patterns discriminate between distinct transduction pathways of human T lymphocyte activation through CD2 triggering.
Jayaraman et al. (1996)IP3RT cellT cell receptor stimulation triggered a physical association between the nonreceptor protein tyrosine kinase Fyn and the IP3R, which induced tyrosine phosphorylation of the IP3R.
Rueda et al. (2007)Bcl10T cellsIn this study, we report that Bcl10 is rapidly phosphorylated upon activation of human T cells by PMA/ionomycin- or anti-CD3 treatment, and identify Ser(138) as a key residue necessary for Bcl10 phosphorylation.
Scott et al. (1997)NFATpT-cellsThe nuclear factor of activated T-cells (NFATp) is a phosphorylated transcription factor that resides in the cytoplasm of unactivated T-cells.
Osborn et al. (2007)FADDT cellCell cycle-specific regulation of FADD phosphorylation plays an important role in FADD proliferative function since mice with a mutant form of FADD mimicking constitutive phosphorylation at serine 191 (FADD-D) exhibit defective T cell proliferation.