Viewing affirmative mentions of regulation in T cells

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Zhao et al. (1998)TPOthrombopoietinT lymphocyteThe aim of this study was to evaluate the effect of thrombopoietin (TPO) on T lymphocyte in Balb/c mice delivered hTPO cDNA with plasmid vector.
Mouly et al. (2007)CD4CD4 silencerT-cellsCollectively, our results suggest that beyond its well-characterized function in T-cells, the CD4 silencer also regulates CD4 gene expression in human lymphoid non-T-cells.
Breit et al. (1996)IL-4IL-4T cellThe role of interleukin-4 (IL-4) in the induction of IL-4 in mouse T cells is well established, but conflicting results have been reported with anti-CD3-primed human T cells and T cell clones.
Welte et al. (1984)Tac antigenInterleukin 2T lymphocytesInterleukin 2 regulates the expression of Tac antigen on peripheral blood T lymphocytes.
Xu et al. (2010)IL-17C5aT cellsComplement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis.
Zauli et al. (1995)Bcl-2TatT-cellIn this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T-cell lines and primary peripheral blood mononuclear cells.
Ostrand-Rosenberg et al. (1986)402AX teratocarcinoma MHC class I antigenLytT cells402AX teratocarcinoma MHC class I antigen expression is regulated in vivo by Lyt 1, Lyt 2, and L3T4 expressing splenic T cells.
Gerrard et al. (1988)class II histocompatibility antigensIFN-gammaT cellModulation of class I and class II histocompatibility antigens on human T cell lines by IFN-gamma.
Gerrard et al. (1988)class II histocompatibility AgIFN-gammaT cellThus, although IFN-gamma can bind to human T cell lines and enhance class I histocompatibility Ag on these cells, IFN-gamma alone does not appear to regulate expression of class II histocompatibility Ag on T cell lines.
Satoh et al. (2007)lymphoid enhancer factorNemo-like kinaseT-cellWe previously reported that Nemo-like kinase (NLK) negatively regulates Wnt signaling via the phosphorylation of T-cell factor/lymphoid enhancer factor.
Soos et al. (2001)MHCCIITAT-cellCIITA may be a key target to modulate MHC class II expression, which could augment immunogenicity, Ag presentation, and CD4(+) T-cell activation in MG therapy.
Ekman et al. (1993)CRHphytohemagglutininT-lymphocyteWe studied the effects of phytohemagglutinin (PHA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the biosynthesis of CRH in human T-lymphocyte cell cultures.
Yip-Schneider et al. (1993)c-mycinterleukin-7T cellsCharacterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
Bell et al. (2007)TLR10FOXP3T cellTranscriptional control of TLR10 by FOXP3 was determined through luciferase reporter assays in Jurkat T cell lines.
Sanchez-Merino et al. (2005)CD8T cellMother-to-child transmission of CD8+ T cell escape variants may particularly affect CD8+ T cell recognition of infant HIV-1 epitopes.
Barbi et al. (2008)CXCR3PI3KgammaT cellsLevels of CXCR3 and T-bet mRNA were significantly lower in PI3Kgamma inhibitor-treated T cells, indicating that PI3Kgamma may control CXCR3 expression in part through induction of T-bet.
Modiano et al. (1997)IL-2immunoglobinT-cellPosttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin.
Otomo et al. (2001)CD4RIB 5/2T cellsMonoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating recipient T cells.
Lemasson et al. (1997)p56lckrex genesT cellsTo understand the mechanism of p56lck protein downregulation observed in human T cells infected by human T-cell leukemia virus type 1 (HTLV-1), we have investigated the ability of the 3' end of the HTLV-1 genome as well as that of the tax and rex genes to modulate p56lck protein expression and p56lck mRNA synthesis.
Lemasson et al. (1997)p56lcktaxT cellsTo understand the mechanism of p56lck protein downregulation observed in human T cells infected by human T-cell leukemia virus type 1 (HTLV-1), we have investigated the ability of the 3' end of the HTLV-1 genome as well as that of the tax and rex genes to modulate p56lck protein expression and p56lck mRNA synthesis.
Seckinger et al. (1994)mycInterleukin-7T cellsInterleukin-7 regulates c-myc expression in murine T cells and thymocytes: a role for tyrosine kinase(s) and calcium mobilization.
Metcalfe (2005)LIFaxotrophinT lymphocyteThis approach has revealed unexpected patterns of gene activity in tolerance and most notably that a novel stem cell gene, axotrophin, regulates T lymphocyte responsiveness both in terms of proliferation and in release of leukaemia inhibitory factor (LIF).
Kantarci et al. (2005)CCR5Delta32T cellCCR5*Delta32 has a dose effect on CCR5 expression in the CNS, but is neither necessary for development of MS, nor CD3+ T cell recruitment into the CNS.
Chan et al. (1994)cellCD7T cellTogether, our results suggest that CD7 is associated with tyrosine kinase activity and that this tyrosine kinase activity correlates with the ability of CD7 to regulate T cell integrin functional activity.
Merrell et al. (1997)IgTFE3T lymphocytesTo understand the role of TFE3 in Ig expression and lymphoid development, we used embryonic stem (ES) cell-mediated gene targeting and RAG2-/- blastocyst complementation to generate mice which lack TFE3 in their B and T lymphocytes.
Toungouz et al. (1996)IFN-gammaIVIgT cellThe aim of the present work is to investigate the influence of IVIg on IFN-gamma production occurring during MLR and its subsequent impact on T cell proliferation and tumor necrosis factor (TNF)-alpha secretion.
Monticelli and Rao (2002)IL-4NFAT family membersNFATWe have taken a positive approach to the question of whether these two NFAT family members differentially regulate IL-4 gene transcription.
Himes et al. (2000)IL-2high-mobility group I(Y) proteinsT cellThe role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation.
Wang et al. (2007)SKAP-55ADAPT cellsADAP controls SKAP-55 expression such that ADAP(-/-) T cells are also deficient in SKAP-55 expression.
Kayagaki et al. (1999)TRAILTypeT cellsType I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
Kayagaki et al. (1999)TRAILIFNsT cellsType I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
Reem and Yeh (1984)gamma interferonInterleukin 2T lymphocytesInterleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes.
Reem and Yeh (1984)gamma interferonInterleukin 2T lymphocytesInterleukin 2 (IL-2) has an important role in the regulation of the expression of IL-2 receptors and the synthesis of gamma interferon (IFN-gamma) by T lymphocytes.
Ernst et al. (1988)IgAanti-suppressor circuitT cellsA novel mechanism for the selection of isotype-specific antibody responses: the role of intestinal T cells in the regulation of IgA synthesis by the anti-suppressor circuit.
Liang et al. (2003)T-cellJNKNFATA mechanism underlying this effect was suggested by the observation that JNK directly regulated nuclear factor of activated T-cell (NFAT) activation in culture and in transgenic mice containing an NFAT-dependent luciferase reporter.
Morandi et al. (2010)chemokine receptorHLA-GT cellsThe effect of sHLA-G on chemokine receptor expression was lower on resting T cells (not shown).
Kuo and Jan (2009)antigen-specific antibodysilibininT-cellThe effect of silibinin on antigen-specific antibody production and T-cell cytokine expression was investigated.
Sánchez-Valdepeñas et al. (2007)NF-kappaBzetaT cellsDifferential regulation of p65 and c-Rel NF-kappaB transactivating activity by Cot, protein kinase C zeta and NIK protein kinases in CD3/CD28 activated T cells.
Xue et al. (2007)IL-7RalphaEts-familyT cellsGA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor alpha chain (IL-7Ralpha) in T cells, whereas it is dispensable for IL-7Ralpha expression in fetal liver B cells.
Medeiros et al. (2005)integrinsPKCT cellThe functional activity of integrins is dynamically regulated by T cell receptor stimulation and by protein kinase C (PKC).
Medeiros et al. (2005)integrinsprotein kinase CT cellThe functional activity of integrins is dynamically regulated by T cell receptor stimulation and by protein kinase C (PKC).
Fischer et al. (2004)CXCL12ITKT cellsITK regulates the ability of CXCL12/SDF-1alpha to induce T cell migration as overexpression of wild-type ITK-enhanced migration, and T cells lacking ITK exhibit reduced migration as well as adhesion in response to CXCL12/SDF-1alpha.
Pierdominici et al. (2002)beta-chemokinesMIPT-cellThe effect of highly active antiretroviral therapy (HAART) on the expression of CCR5 and CXCR4 HIV coreceptors and the production of the beta-chemokines regulated upon activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta has been investigated in 30 HIV-1-infected individuals during 12-36 months of therapy.
van Oirschot et al. (2001)kip1Protein kinase AT cellProtein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines.
Straube and Herrmann (2001)CD8betarat gammadeltaT cellsDifferential modulation of CD8beta by rat gammadelta and alphabeta T cells after activation.
Brunner et al. (2000)Fas ligandc-MycT cellsExpression of Fas ligand in activated T cells is regulated by c-Myc.
Paulsen et al. (1995)gluten antigensT-cellHere we report studies on the influence of aa substitutions in the DQ beta 1*0201 chain on DQ2-restricted T-cell recognition of gluten antigens.
Dubois et al. (1995)annexin IIannexin VT cellsIn vivo and in vitro phosphorylation of annexin II in T cells: potential regulation by annexin V.
Egerton et al. (1992)ezrinprotein tyrosine phosphatasesT cellWe also observed no increases in ezrin tyrosine phosphorylation in TCR-stimulated Jurkat T cells, unless the cells were pretreated with protein tyrosine phosphatase inhibitors, suggesting that T cell ezrin tyrosine phosphorylation is tightly controlled by protein tyrosine phosphatases.
Ho et al. (1991)cellGATA-3T cellHuman GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.
Hivroz-Burgaud et al. (1991)NF-ATTcRT cellsData are presented that indicate that either the [Ca2+]i or PKC signal generated via the TcR/CD3 complex would not alone induce NF-AT expression, and that the TcR/CD3 complex probably regulates NF-AT expression because of its ability to regulate multiple intracellular signals in T cells, and not via any single biochemical event.
Nakanishi et al. (1988)IgT cell replacing factorT cellBoth B151-T cell replacing factor 1 and IL-5 regulate Ig secretion and IL-2 receptor expression on a cloned B lymphoma line.
Tsudo et al. (1982)Tac antigenanti-Tac monoclonal antibodyT cellsModulation of Tac antigen on activated human T cells by anti-Tac monoclonal antibody.
Palacios (1981)MLRHLA-DR antigensT lymphocytesSince resting T cells cells do not respond to IL-1 or produce IL-2, it is concluded that HLA-DR antigens of the stimulator cells participate in the production of IL-2 in AMLR and MLR by enabling the IL-2 producer T lymphocytes to respond to IL-1.
Shi et al. (2007)CD4beta-arrestin 1T cellCritical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1.
Kashiwakura et al. (1999)interferon gammaTxkT lymphocytesTxk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes.
Broxmeyer and Platzer (1984)I-ALactoferrinT lymphocytesLactoferrin acts on I-A and I-E/C antigen+ subpopulations of mouse peritoneal macrophages in the absence of T lymphocytes and other cell types to inhibit production of granulocyte-macrophage colony stimulatory factors in vitro.
Kogkopoulou et al. (2006)IL-2p38T cellsHere, the role of p38 on interleukin-2 (IL-2) production by human peripheral blood CD4+ T cells was examined.
Okamura et al. (1998)TCRalphaLEF-1T cellRedundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1.
Okamura et al. (1998)TCRalphaLEF-1T cellLymphoid enhancer factor 1 (LEF-1) and T cell factor 1 (TCF-1) are closely related transcription factors that are both expressed during murine T cell differentiation and that regulate the T cell receptor alpha (TCRalpha) enhancer in transfection assays.
Fowlkes and Robey (2002)Notch1Notch1T cellA reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development.
Oestreich et al. (2008)PD-1NFATc1T cellNFATc1 regulates PD-1 expression upon T cell activation.
Wu et al. (2005)GATA-3CpG oligodeoxynucleotideT cellsAIM: To investigate effects of CpG oligodeoxynucleotide (CpG ODN) on the mRNA expression of transcription factors GATA binding protein 3 (GATA-3) and T-box expressed in T cells (T-bet) in asthmatic mice.
Dokter et al. (1992)Interleukin-4IL-4T cellsInterleukin-4 (IL-4) receptor expression on human T cells is affected by different intracellular signaling pathways and by IL-4 at transcriptional and posttranscriptional level.
Kobielak et al. (2001)cellLEF-1T-cellLymphoid enhancer-binding factor-1 (LEF-1), a member of the high mobility group (HMG) family of proteins, regulates expression of T-cell receptor-alpha gene and is one of the key regulatory molecules in the epithelial-mesenchymal interactions during embryonic development.
Rouas et al. (2009)FOXP3miR-31T cellsUsing lentiviral transduction of fresh cord blood T cells, we demonstrated that miR-31 and miR-21 had an effect on FOXP3 expression levels.
Chung and Schlichter (1997)Kv1.3PKCT lymphocytesBecause PKC activation (as well as increased intracellular Ca2+) is required for T-cell proliferation, we have studied the regulation of Kv1.3 current by PKC in normal (nontransformed) human T lymphocytes.
Mittelstadt and Ashwell (1999)FasLEgr-3T cellsThus, Egr-2, in addition to Egr-3, regulates FasL expression in activated normal T cells, and Egr-2 is likely to play a direct role in aberrant fasL up-regulation in lpr/lpr and gld/gld CD4(-)CD8(-) T cells.
Daynes and Araneo (1989)IL4glucocorticoid (GCS) hormonesT cellHere we provide compelling evidence that production of the murine T cell growth factors interleukin (IL) 2 and IL4 are differentially regulated by glucocorticoid (GCS) hormones.
Maruyama et al. (2007)IFNTxkT lymphocytesHowever, how Txk regulates interferon (IFN)-gamma gene transcription in human T lymphocytes was not fully elucidated.
Hildebrandt et al. (2008)TNFalphaIL-13T cellIn vitro studies further demonstrate that both exogenous and T cell-derived IL-13 can regulate TNFalpha production by macrophages following lipopolysaccharide stimulation.
Sander et al. (2006)NFATc1PPARgammaT cellsPeroxisome proliferator-activated receptor gamma (PPARgamma) inhibits NFATc1 activity in T cells and cardiomyocytes, but it is not known if PPARgamma controls NFATc1 function in endothelial cells.
Prontera et al. (1996)metalloproteaseIL-4T-cellHere we have evaluated the effects of a T-cell cytokine interleukin-4 (IL-4) on the expression and activity of a metalloprotease, stromelysin, and its tissue inhibitor (TIMP-1) in human skin fibroblasts.
Singh et al. (2007)FasTCDDT cellsWe investigated the regulation of Fas or FasL promoter by TCDD in EL4 T cells using luciferase reporter constructs.
Yu et al. (2008)CCR7SOCS1T cellsSOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.
Carmo et al. (1999)CD5CD2T cellsCD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells.
Yu et al. (1998)STAT6IL-13T cellThese findings show that IL-13 and IL-4 have the ability to regulate NK and T cell activation and that IL-13 is a potent regulator of STAT6 and JAK3 in these cell types.
Li et al. (2010)BimInterleukin-7T-cellInterleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.
Möttönen et al. (2000)CD154IL-15T cellsAs interleukin (IL)-15 is a potent activator of synovial T cells we wanted to study whether IL-15 also regulated the expression of CD154 on these T cells.
Hontecillas and Bassaganya-Riera (2007)CD4PPAR-gammaT cellPeroxisome proliferator-activated receptor (PPAR) gamma activation has been implicated in the prevention of immunoinflammatory disorders; however, the mechanisms of regulation of effector and regulatory CD4+ T cell functions by endogenously activated PPAR-gamma remain unclear.
Lu et al. (2009)CD4TSLPT cellThese results demonstrate that IL-7 and TSLP use different mechanisms to regulate human CD4(+) T cell homeostasis.
Marie-Cardine et al. (1999)NF-ATSITT cellHowever, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2.
Thulesen et al. (2001)IL-2interleukin-2T cellsIn the present study, we investigated the effects of interleukin-2 (IL-2) and IL-15 on human thymocytes with respect to development of CD8(+) CD56(+) T cells.
Bordon et al. (2009)IL-17AD6T cellsThus, D6 can contribute to the development of colitis by regulating IL-17A secretion by gammadelta T cells in the inflamed colon.
Tylaska et al. (2002)MCP-1Ccr2T cellCcr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen.
Richard et al. (2005)PTHrPETST-cellOur data demonstrate that transcriptional regulation of PTHrP in ATLL cells can be controlled by T-cell receptor signaling and the ETS and MAPK ERK pathway in a Tax-independent manner.
Fujino et al. (2000)IL-2muscarinic receptorsT cellPossible intracellular signal pathways of muscarinic receptors to regulate IL-2 production were examined in human T cell line Jurkat cells.
Gerber et al. (1989)interleukin-2T lymphocytesThe influence of interleukin-2, feeder cells, and timing of irradiation on the radiosensitivity of human T lymphocytes assessed by the colony-forming assay.
Steen et al. (1993)hypoxanthine phosphoribosyltransferaseT-cellThe phenotypic effects of mutation in the hypoxanthine phosphoribosyltransferase (hprt) gene on hprt enzyme activity and hprt mRNA levels were studied in 6-thioguanine (TG) resistant human T-cell clones with various types of hprt mutation.
Motoya et al. (1997)ICAM-1T-cellIn order to investigate the factors that influence the induction of ICAM-1 molecules, Northern blot analysis to measure the expression level of ICAM-1 mRNAs and Southern blot hybridization to analyze the integration of human T-cell-leukemia virus type 1 (HTLV-1) provirus were done.
Inouye et al. (1980)TCGFT cellIn an effort to increase the potency of T cell growth factor (TCGF), several variables were examined for their effects on the production of TCGF.
Yoshizawa et al. (1998)MBPT-cellStudies of the MBP-directed response of these mice suggest that endogenous MBP expression is directly responsible for EAE resistance in BALB/c mice, by quantitatively affecting expression of the T-cell repertoire.
Boschelli (2009)PKCThetaT cellPKCTheta, first identified in 1992, is a key enzyme in the regulation of T cell activation and survival.
Lechner et al. (1996)CD95T cellsRegulation of CD95 (APO-1) expression and the induction of apoptosis in human T cells: changes in old age.
Clerici (1995)CD4T lymphocytesThus, HIV infection is characterised by quantitative and qualitative defects affecting CD4 T lymphocytes.
Kalish et al. (2000)CD4T cellSeveral studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels.