Viewing negative mentions of regulation in T cells

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Ercolani et al. (1985)InsulininsulinT-lymphocytesInsulin receptors were not regulated by insulin before mitogen activation and culture of T-lymphocytes.
Yelo et al. (2008)Dock10IL4T cellsIn contrast, IL4 did not affect the levels of Dock10 expression in normal PB-T cells.
Bonnotte et al. (1996)IL-12CsAT cellsIn contrast, CsA had no effect on IL-12-receptor beta 1 chain (IL-12 R beta 1) expression in T cells induced upon allogeneic activation.
Sillett et al. (2001)CD95TGF-betaT cellsTGF-beta had no effect on mitogen-induced up-regulation of Fas (CD95) or Fas ligand and did not enhance killing of the Fas-sensitive Jurkat cell line by activated T cells.
Scheurich et al. (1985)TacIL1T cellsAs IL1 had no significant effect on Tac expression of T3-stimulated T cells, we conclude from these data that IL1 exerts in addition to its influence on IL2 production an effect, which allows antigen receptor-triggered T cells to enter the cell cycle.
Patrignani et al. (1987)TAC-antigenPAFT-cellsPAF receptor antagonists did not affect the expression of IL-2 receptors (TAC-antigen) on T-cells.
Khan and Poisson (1999)cellprotein kinase CT-cellThe T-cell 5-HT3 receptor-channel is not regulated either by the protein kinase C or by the free intracellular calcium concentrations as the agents known to activate the PKC and to induce increases in intracellular free calcium concentrations failed to influence the free intracellular Na+ concentrations, [Na+]i, in these cells.
Tsudo et al. (1982)Ia-like antigenanti-Tac antibodyT cellsTac antigen was reexpressed on T cells after restimulation when the anti-Tac antibody was removed, whereas Ia-like antigen already expressed on allo-activated T cells was not modulated by anti-Tac antibody.
Gabutti et al. (2005)CD4T-lymphocyteCD4+ T-lymphocyte counts and viraemia levels were not negatively affected by vaccination.
Gulino et al. (1990)IL-2 geneT cellsPhorbol ester and calcium ionophore did not modulate the expression of the transfected IL-2 gene in NIH-3T3 and HeLa cells, while these agents increased its expression in transfected BFS lymphoma T cells.
Choudhry et al. (2000)IL-2T cellsNo significant change in the proliferation and IL-2 production was observed in splenic T cells derived from sham-injured mice regardless of alcohol exposure.
Cunnick et al. (1991)interleukin 2T-cellThere was no difference in the production of interleukin 2 (IL-2) nor was there a difference in the percentage of IL-2 receptor positive T cells or T-cell subsets after culture for 24 hr.
Ware and Haynes (1993)CD7T cellIn previous work, we found that CD7 was upregulated on PB T cells following a non-mitogenic ionomycin-induced transmembrane calcium flux, which induced new T cell CD7 transcription without affecting CD7 mRNA stability.
Crocker et al. (1987)CD4T cellsThis species heterogeneity indicates that T cells and M phi regulate CD4 antigen expression independently and that CD4 may not be essential for M phi function.
Wonigeit et al. (1997)RT6T cellsExpression of the ectoenzyme RT6 is not restricted to resting peripheral T cells and is differently regulated in normal peripheral T cells, intestinal IEL, and NK cells.
Wonigeit et al. (1997)RT6T cellsTaken together, these findings demonstrate that the expression of RT6 is not restricted to T cells and is differently regulated in normal peripheral T cells, intestinal IEL, and NK cells.
Piccotti et al. (1997)IL-2T cellThe decrease in splenic T cell proliferation in response to alloantigens in the thirty minute exposure group did not reflect alterations in calcium influx or IL-2 production.
Del Gobbo et al. (1990)IL-2T cellsIL-2 production was not dependent on (i) a decreased number of T cells or (ii) a primary defect in IL-1 production, but on a T-suppressor cell subpopulation.
Veazey et al. (2000)CD4T cellHowever, since this particular cell type is present in such small numbers in circulation, its loss does not significantly affect total CD4(+) T cell counts.
Gmünder et al. (1990)IL-2 mRNAT cellAs in cultures of splenic T cells, GSH depletion had no substantial effect on the induction of IL-2 mRNA and TCGF production in several mitogenically stimulated T cell clones.
Stoll et al. (1997)IL-18T cellsIL-18 signals were not affected by depletion with anti-CD3 (T cells) or anti-MHC class II mAb-coupled beads identifying KC as a major source of IL-18.
Gros et al. (1983)Bcg geneT lymphocytesA kinetic study of BCG infection in congenitally athymic mice that carried the "nude" mutation on Bcgr (AKR/J) or Bcgs (BALB/c) background showed that the functional absence of T lymphocytes did not influence the expression of the Bcg gene.
Shimizu et al. (1988)interleukin-2T cellsIn contrast, surfactant had no effect on pokeweed-mitogen (PWM, T cell-dependent B lymphocyte mitogen)-induced DNA synthesis or on interleukin-2 (IL-2) receptor expression on T cells activated with PHA, Con A or PWM.
Sørensen et al. (2008)DGAT1T cellsIn the studies with MAC-T cells, there were no significant effects of CLA isomers or other FA on DGAT1 expression, whereas all FA tested showed enhanced DGAT2 expression (P < 0.05 to P < 0.001), with alpha-linolenic acid (alpha-18:3) having the greatest effect.
Creemers et al. (1986)IL-2T cellsWe conclude that a defect in IL-2 production is associated with human T-cell lymphotropic virus III infection, but that the expression of the IL-2 receptor on T cells is not greatly affected.
Lacabaratz-Porret et al. (2003)CD8T cellFinally, whether HAART was initiated before or after seroconversion had little effect on HIV-specific CD4(+) and CD8(+) T cell responses.
Chao et al. (2007)CD25 mRNAT cellsHowever, there was no change in the amount of CD25 mRNA in T cells after coculture.
Teutsch et al. (1995)CD5T cellsMoreover, in both B and T cells, the same immunosuppressive drugs did not affect constitutive CD5 expression but only blocked de novo induction.
Varga et al. (2001)CD4T cellThese data indicate that the CD4(+) and CD8(+) memory T cell pools are regulated independently and that the loss in CD8(+) T cell memory following heterologous virus infections is not a consequence of a parallel loss in the memory CD4(+) T cell population.
Kucharska et al. (2009)CTLA-4T cellsWe therefore conclude that decreased expression of CTLA-4 on T cells in children with Hashimoto's thyroiditis is not dependent on polymorphic changes at position +49 of CTLA-4 gene.
Shin et al. (2005)STAT4T cellsSTAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism.
Shifera et al. (2010)NF-kappaBT cellsVitamin D does not modulate NF-kappaB activity in Jurkat T cells.
Liu and Zheng (2001)MHCT cellsIn contrast, both the inductive and the effector phases of MHC class II-restricted T cells are independent of MHC class II expression on tumors.
Yiangou and Hadjipetrou-Kourounakis (1989)IL-2T cellsIL-2 production was not significantly affected, indicating differential sensitivity of T cells to magnesium deficiency.
Pardoux et al. (1997)IL-12RTGF-betaT cellsIn contrast to its effect on IL-12 production, TGF-beta did not alter the expression of IL-12R beta1-chain (IL-12R beta) in T cells induced upon allogeneic activation.
Demas and Nelson (1998)immunoglobulin MT-cellIndividual mice implanted with melatonin underwent reproductive regression and displayed enhanced splenocyte proliferation to the T-cell mitogen concanavalin A; antigen-specific serum immunoglobulin M production was unaffected by melatonin treatment.
Kucharz et al. (1988)IL-2T-cellsLithium did not influence the expression of IL-2 receptors on T-cells.
Chang and Norman (1992)IL2T-cellMechanism of ethanol-mediated immunosuppression in mice: ethanol suppresses T-cell proliferation without affecting IL2 production and IL2 receptor expression.
Chang and Norman (1992)IL2T-cellsHowever, the ability of T-cells from ethanol diet-fed mice to produce IL2 and to express IL2 R or CD4+/CD8+ subset markers was not affected.
Kucharz and Sierakowski (1990)interleukin 2T cellsIsoniazid did not affect the expression of interleukin 2-receptors on the surface of T cells, except a slight decrease in cells exposed to high levels of the drug.
Kristensen et al. (1993)interleukin-8T-cellFurther, no significant effect on either interleukin-8, leukotriene B4 or fMLP-directed T-cell migration was observed.
Rivas et al. (1988)CD4T cellsSimilar treatment of PHA-activated CD4+ T cells with anti-CD3/Ti antibodies also induced CD4 modulation; however, the same antibodies failed to affect CD4 expression on fresh resting T cells.
Bruyns et al. (1999)SHIP1 proteinT lymphocytesSHIP1 protein level was not modulated after activation of T lymphocytes, in contrast to SHIP2, which was increased after long-term stimulation.
de Moraes et al. (2007)CD4T-cellPimecrolimus did not alter CD4(+) and CD8(+) T-cell counts or viral load during the treatment period.
Hillman et al. (1997)IFN-gammaT-cellLymphocyte depletion of either natural killer (NK) cells or CD4+ or CD8+ T-cell subsets or both T-cell subsets did not affect the IFN-gamma effect, whereas depletion of both NK and T cells decreased the antitumor activity of IFN-gamma.
Vakhitova et al. (2004)Fas-receptorT-lymphocytesAt the same time, ladasten virtually did not change the activation-induced expression of Fas-receptor on T-lymphocytes, but reduced the rate of the Fas-induced apoptosis.
Hernández-Caselles et al. (1996)CD49dT cellInterestingly, neither target cells nor NK cells modulated CD49d expression after interaction with T cells of K562, respectively, suggesting that CD49d expression was linked to specific T cell activation.
Cauvi et al. (2007)Daf1T cellsMurine mercury-induced autoimmunity-resistant DBA/2 mice, which fail to accumulate CD44(high) T cells, showed no change in Daf1 expression.
Carvalho et al. (2001)IFN-gammaT cellsAlthough depletion of CD8+ T cells and natural killer cells did not affect IFN-gamma production, depletion of CD4+ T cells significantly decreased IFN-gamma production.
Grillot et al. (1995)Bcl-xLT cellThese studies demonstrate that Bcl-2 and Bcl-xL, two functionally related proteins, are regulated independently during T cell development.
Sloand et al. (1999)FasT cellsIn the presence of ritonavir, CD4(+) T cells from HIV-infected patients showed similar changes in ICE intracellular levels without alteration of Fas expression.
Jacobs et al. (2008)Glut1T cellsConsistent with a role for Akt in Glut1 trafficking, transgenic expression of constitutively active myristoylated Akt increased glucose uptake of resting T cells, but did not alter Glut1 protein levels.
McCracken et al. (2004)NF-kappaBT cellsIn contrast, PMA stimulation had no effect on NF-kappaB activity in T cells from pregnant females, and this was reflected in reduced Th1 cytokine production.
Rossetti et al. (2010)TNFT cellsThe failure of G-DC to induce suppressive T cells does not depend on defective IL-10 production, or on the release of IL-12 and TNF-?
Crooks et al. (2010)integrinT-cell4 integrin so for these cohorts there are no apparent exercise induced changes to this immune parameter; hence, this study suggests that exercise-related physiological stress may not affect integrin expression, although the mechanisms influencing exercise induced T-cell redistribution are still to be determined [26].
Yoo et al. (2010)T-betT cellsNotably, T-bet expression in OT-II T cells was not modulated by incubation with LAPCs.
Randall (2010)CCL21T cellsexpression and has no effect on either CXCL13 or CCL21 expression (GeurtsvanKessel et al., 2009), it seems that DCs are likely involved in the maintenance of iBALT via some other mechanism, such as the presentation of IL-15 to CD8 T cells (McGill et al., 2010).
Burnier et al. (2010)WTT-cellIn addition, lack of Gas6 in antigen-presenting cells did not affect WT or Gas6(-/-) T-cell proliferation.
Enose-Akahata et al. (2009)2 BT cellsCD48 expression on CD4+ T cells did not change over time despite the expression of HTLV-I Tax (Figure 2 B).
Halpin (2008)TNFT cellFor example, although inhibition of PDE7A with BRL 50481 does not itself affect T cell proliferation or TNF-?
Odobasic et al. (2008)T helper type 1/type 2T-cellInhibition of CD86 or both CD80 and CD86 reduced T-cell accumulation in joints without affecting T helper type 1/type 2 (Th1/Th2) differentiation or antibody levels.
Odobasic et al. (2008)Th2T-cellInhibition of CD86 or both CD80 and CD86 reduced T-cell accumulation in joints without affecting T helper type 1/type 2 (Th1/Th2) differentiation or antibody levels.
Sato et al. (2007)T-cell-receptor complexT-cellHere we demonstrate that the T-cell-receptor complex is not a target for the suppression, suggesting that downstream signals mediate the suppression.
Lambert et al. (2007)NFATT cellsAcrolein inhibited induction of NF-kappaB DNA binding activity after mitogenic stimulation of T cells but had no effect on induction of NFAT or AP-1.
Byrne et al. (2005)tumour necrosis factor alphaT cellCD4+CD45RBHi T cell recipients also had a bone marrow inflammatory cell infiltrate expressing tumour necrosis factor alpha which was unaffected by treatment with Fc-OPG.
Laichalk and Thorley-Lawson (2005)major histocompatibility complex class I moleculesT-lymphocyteConsistent with the later conclusion, the cells did not down regulate major histocompatibility complex class I molecules, suggesting that this is not an immune evasion tactic used by EBV and that the cells remain vulnerable to cytotoxic-T-lymphocyte attack.
Einecke et al. (2005)CATT-cellLack of mature B cells had little effect on CAT expression, confirming that CATs reflect T-cell-mediated rejection.
Tewari et al. (2004)CD8T cellInterestingly, in an acute infection, increasing the viral dose caused significant changes in the epitope hierarchy of the LCMV-specific memory CD8 T cell pool, with no effect on the primary CD8 T cell response.
Eynott et al. (2004)tumour necrosis factor-betaT-cellEosinophil and T-cell accumulation in the airways, mRNA expression for interleukin-1beta, tumour necrosis factor-beta, interleukin-3, interleukin-4 and interleukin-5, serum levels of allergen-specific immunoglobulin E and bronchial hyperresponsiveness were not affected by SP600125.
Denton et al. (2004)tumour growth factor-betaT cellsWe describe here that regulatory CD8+ T cells reduce in vitro IFN-gamma production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-beta or tumour necrosis factor-alpha production.
Gao et al. (2003)concanavalin AT cellsSpleen cells, which were stimulated in vitro after being removed from mice which had been administered resveratrol for 2 or 4 weeks, showed no significant change in IL-2 or concanavalin A induced proliferation of T cells or production of IL-2 induced lymphokine activated killer cells.
Nagafuku et al. (2003)sphingomyelinT cellsSurface GM1 expression and the expression of GSLs in rafts were profoundly reduced by D-PDMP treatment, whereas the expression of other lipid and protein constituents, such as cholesterol, sphingomyelin, Lck, and linker for activation of T cells, was not affected.
Bühler et al. (2002)PTCT-cellHere we show that inhibition of mRNA export by two independent approaches does not affect the downregulation of PTC-containing T-cell receptor beta transcripts in the nuclear fraction of mammalian cells, providing strong evidence for intranuclear NMD.
Mori et al. (2001)BaxT-cellExpression of Tax in a human T-cell line, Jurkat, induced the expression of the Bcl-xL gene, but did not significantly affect the expression of the other apoptosis-related genes, Bcl-2 and Bax.
Chiang et al. (2000)mitogen-activated kinasesT cellsThe main TCR signalling pathways, such as tyrosine kinases Zap-70 and Lck, Ras/mitogen-activated kinases, phospholipase Cgamma-1 and Ca2+ mobilization, were not affected in Cbl-b(-/-) T cells.
Hong et al. (2000)immunoglobulin GT cellsThis was not a result of the overall immune suppression, because the numbers of B and T cells and the total immunoglobulin G production were not altered during treatment with H4B4.
Migita et al. (1999)FasT cellsFK506 did not affect the expression of Fas antigen on SEB-activated Vbeta8+ T cells.
Howard et al. (1999)T-cellMutations in the first and second transmembrane domains increase RANTES (regulated on activation normal T-cell expressed) binding affinity but did not affect MIP1beta binding affinity presumably based on differences in ligand-receptor interaction sites.
Choudhry et al. (1999)fynT cellsIn contrast, no change in p59(fyn) autophosphorylation and kinase activity in T cells treated with cAMP analogues was observed.
Matsumoto et al. (1999)STAT3T cellsFurthermore, the IL-2-induced activation of STAT5 was markedly inhibited in T cells in transgenic mice, while leukemia inhibitory factor-induced STAT3 phosphorylation was not affected.
Kraft et al. (1998)BaxT-cellA comparative examination of HVS-transformed T-cell clones and their native parental clones revealed that the expression of Bcl-2, Bcl-X(L), Bax, and members of the tumor necrosis factor receptor (TNF-R) superfamily with a death domain, namely, TNF-RI, CD95, and TRAMP, were not modulated by HVS.
Lederman et al. (1998)cellT lymphocyteDysregulated immune activation was partially corrected by this regimen; however, the perturbed expression of T cell receptor V regions in the CD4 and CD8 T lymphocyte populations was not significantly affected.
Lehmann et al. (1997)CD3 mRNAT cellsThe reverse transcriptase-polymerase chain reaction analyses of long-term renal allografts before and after donor-specific antigen challenge revealed no changes in CD3 mRNA level, but showed up-regulation of CD25, interleukin (IL) 2, interferon (IFN) gamma, IL-4, and IL-10 mRNA in the early phase, suggesting the presence of alloreactive T cells in tolerant rats.
Sayles and Johnson (1996-1997)interferon gammaT cellsDepletion of neutrophils had no effect on interferon gamma production, but had a profound effect on the total numbers of peripheral blood CD4+ and CD8+ T cells.
Delmon-Moingeon et al. (1996)surface receptorsT lymphocyteThe radiolabeling procedure does not alter expression of surface receptors involved in T lymphocyte effector functions, adhesion function, cytolytic activity or proliferative response to IL-2.
Deckert-Schlüter et al. (1996)IgMT cellsIn contrast, activation of T cells, recruitment of immune cells to inflammatory foci, and anti-T. gondii IgM antibody production were unaffected by the mutation of the IFN-gamma R.
Chirmule et al. (1995)protein kinase CT-cellFinally, treatment of T-cell clones with the Tat peptide did not affect the antigen-induced increase in intracellular calcium, hydrolysis of phosphatidyl inositol to inositol trisphosphate, or translocation of protein kinase C from the cytosol to the membrane.
Wang et al. (1995)surface receptorsT cellsAnti-CD4-reactive T cells avoid the exodus into the bloodstream when their TCR is engaged by anti-CD3 or by a superantigen, do not modulate surface receptors and are not deleted.
Chowdhury et al. (1995)env V3 sequence of monocytotropic HIV-1T cellPassage through T cell lines did not affect the tropism or the env V3 sequence of monocytotropic HIV-1 strains.
Kerlin et al. (1994)IgT cellAt this concentration of SSF, Ig secretion induced by a T cell-independent stimulus, lipopolysaccharide (LPS), is not affected.
Li et al. (1993)IFN-gammaT cellsIn contrast, the capacity of CD4+ T cells to produce MAF/IFN-gamma was not affected but was maintained at high levels even late in the tumor-bearing state.
Fischer et al. (1993)immunoglobulin isotypesT cellsAddition of allogeneic T cells was followed by an increase in IgM production but had no effect on the other immunoglobulin isotypes.
Lee et al. (1993)T cellIn addition, the increased binding of AP-1, NF-AT, and NF-kappa B during T cell activation was not significantly affected by cAMP.
Kesari and Geliebter (1993)H-2KbT cellRejuvenated expression of H-2Kb in RMA-S cells does not affect alloreactive T cell- and natural killer cell-mediated lysis.
Kristensen et al. (1993)leukotriene B4T-cellFurther, no significant effect on either interleukin-8, leukotriene B4 or fMLP-directed T-cell migration was observed.
Flanagan et al. (1991)NF-kappa BT cellsA transcription factor, NF-AT, which is essential for early T-cell gene activation, seems to be a specific target of cyclosporin A and FK506 action because transcription directed by this protein is blocked in T cells treated with these drugs, with little or no effect on other transcription factors such as AP-1 and NF-kappa B.
Bowlin et al. (1991)Con AT cellCAST had no effect on Con A, anti-CD3, or alloantigen-induced T cell proliferation.
Pique et al. (1991)HLA-class I antigensT cellIn addition, GT1b ganglioside could also decrease strongly the expression of the T cell antigens CD3, CD2, CD4, CD8 and the alpha/beta T cell receptor antigenic complex whereas it did not affect HLA-class I antigens.