Viewing affirmative mentions of binding of Tcr (D. melanogaster) in T cells

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Document Target Regulator Anatomy Sentence
Kaufmann (1996)TCRT-cellT lymphocytes recognize specific ligands by clonally distributed T-cell receptors (TCR).
Zheng et al. (2009)TCRT cellFull T cell activation requires TCR engagement (signal 1) in the context of costimulation (signal 2).
Dustin (2005)TCRT cellT cell activation requires interactions of T cell antigen receptors (TCR) and peptides presented by major histocompatibility complex molecules (MHCp) in an adhesive junction between the T cell and antigen-presenting cell.
Bachmann et al. (1998)TCRT cellT cell activation involves specific interactions between the TCR and peptides presented by the MHC.
Bachmann et al. (1998)TCRT cellThus, minimal TCR oligomerization is an essential step for peptide-mediated T cell activation.
Minguet and Schamel (2008)TCRT-lymphocyteLigand binding to the T-cell antigen receptor (TCR) evokes receptor triggering and subsequent T-lymphocyte activation.
Zhu et al. (2005)TCRT cellApplication of the various segments of TCR BV may establish TCR BV spectrotyping that can be used to analyze and recognize the different functional T cell clones, and understand the function and proliferation of various T cell clones in malignancy and autoimmune disease.
Schrum et al. (2003)TCRT cellsAlthough the TCR can undergo vast changes in surface expression, T cells remain capable of sustaining TCR engagement for long periods of time.
Li et al. (2010)TCRT cellsEngagement of the TCR by antigenic peptides presented by the MHC activates specific T cells to control infections.
Komatsu et al. (1996)TCRT cellsThese T cells were induced to display cytolytic activity by ligation of the CD3/TCR-alpha beta complex.
Evavold et al. (1993)TCRT-cellRecent observations of T-cell responses following T-cell receptor (TCR) interaction with altered peptide ligands have highlighted the complexity of this signalling system.
Roncagalli et al. (2010)TCRT cellsIn the absence of LAT, antigen-specific T cells give rise to self-perpetuating pro-inflammatory responses and induce the production of autoantibodies independently of TCR engagement.
Stotz et al. (1999)TCRT cellThis competitive inhibition is effective during the entire commitment period, where sustained TCR engagement is essential for full T cell activation.
Boesteanu et al. (1998)TCRT cellsSuch libraries were used to probe the requirements for TCR recognition by cloned CD8+ T cells directed against Ags presented by H-2Kb class I molecules.
Schrum et al. (2000)TCRT cellFurthermore, engagement of newly expressed TCR on activated T cells re-induces CD69, suggesting participation of these replenishing TCR in continued T cell signaling.
Garcia et al. (1997)TCRT cellCellular immunity is mediated by the interaction of an alphabeta T cell receptor (TCR) with a peptide presented within the context of a major histocompatibility complex (MHC) molecule.
Gatzka and Walsh (2007)TCRT cellsReferred to as negative selection, central tolerance in the thymus serves as the first checkpoint for the developing T cell repertoire and involves the apoptotic elimination of potentially autoreactive T cells clones bearing high affinity T cell receptors (TCR) that recognize autoantigens presented by thymic epithelial cells.
Sebille et al. (2001)TCRT-cellT-cell activation, which is an essential feature of graft rejection, requires a first signal provided by T-cell receptor (TCR) ligation and a second signal provided by engagement of co-stimulatory molecules with their respective ligands on antigen-presenting cells.
Sette et al. (1995)TCRT cellAnalysis of various experimental systems suggests that this effect might be related to engagement of the T cell receptor (TCR) by low-affinity ligands and that the observed inhibition may be mediated by interference with membrane events crucial for signal transduction, such as proper TCR oligomerization.
Jenkins et al. (1990)TCRT cellsThe inefficient stimulation of T cell proliferation by resting B cell APC was dramatically improved by the addition of allogeneic low-density accessory cells incapable of being recognized by the TCR on the responding T cells.
Arudchelvan et al. (2002)TCRT cellR73, a monoclonal antibody that recognizes a rat T cell surface antigen of TCR(alphabeta), was used to identify thymocytes that express major histocompatibility complex-restricted antigen receptors, and to define the spatial relation between these receptor-bearing thymocytes and individual thymic cortical and medullary epithelial subtypes by ultrastructural immunohistochemistry.
Evavold et al. (1995)TCRT cellThe T cell receptor (TCR) can interact with a spectrum of peptides as part of its ligand, including the immunogenic peptide, variants of this peptide,and apparently unrelated peptides.
Vukmanovi? and Santori (2005)TCRT cellDeciphering the mechanism(s) of action of TCR antagonists can yield important information about interactions of the TCR with ligands, T cell development, and TCR signaling.
Lavoie et al. (2005)TCRT cellsOur results suggest that the failure of these TCRVbeta-bearing T cells to reach the activation threshold at sub-optimal ligand concentration is due to the inefficiency of TCR engagement, as measured by TCR internalization, and does not correlate with the relative precursor frequency in the non-immune repertoire.
Lavoie et al. (2005)TCRT cellAltogether, our results indicate that the development of a T cell response to a scarce display of ligand significantly narrows TCR repertoire diversity by mechanisms that involve focusing of the repertoire on the expansion of those T cells with the highest avidity of TCR engagement.
von Greyerz et al. (1999)TCRT cellsOur data demonstrate that, despite the special way of presentation, nonpeptide Ag like drugs appear to interact with the TCR of specific T cells in a similar way as peptide Ags.
Kim et al. (2006)TCRT cellTCR affinity of these two T cell populations appeared different, suggesting avidity selection based on antigen availability.
Pinilla et al. (1999)TCRT cellsThe use of this approach has had four major effects: first, the definition of high affinity ligands both for T cells and antibodies; second, the application of alternative means for identifying immunologically relevant peptides for use as potential preventive and therapeutic vaccines; third, a new appreciation of the requirements for TCR interactions with peptide-MHC complexes in immunogenicity; fourth, the establishment of new principles regarding the level of cross-reactivity in immunological recognition.
Fahmy et al. (2001)TCRT cellThis increased avidity for peptide-MHC depends on TCR reorganization and is sensitive to the cholesterol content of the T cell membrane.
Fahmy et al. (2001)TCRT cellsAnalysis of the binding data indicates the enhanced avidity is due to increases in cross-linking of TCR on activated T cells.
Dustin (2008)TCRT-cellT-cell activation requires interactions of T-cell antigen receptors (TCR) and peptides presented by major histocompatibility complex molecules (MHCp) in an adhesive junction between the T-cell and antigen-presenting cell (APC).
San José et al. (2000)TCRT cellsWe studied transfected and transgenic T cells expressing CD3zeta chimeras to demonstrate that ligand engagement of the TCR or chimeras causes comodulation of nonengaged receptors.
Clements et al. (1999)TCRT cellT lymphocytes also require activation of tyrosine kinases following T cell receptor (TCR) ligation for maximal stimulation.
Maier and Greene (1998)TCRT cellsT cell anergy is a functionally defined state of hyporesponsiveness in which T cells neither proliferate nor produce IL2 following subsequent TCR ligation.
Whittaker (1996)TCRT-cellEach T cell expresses a unique membrane bound T-cell antigen receptor (TCR) which combines with specific antigenic peptides and major histocompatibility complex molecules.
Weber and Cantor (1994)TCRT cellsWe show that TCR ligation by conventional peptide Ag is coupled to a burst of PI synthesis in nontransformed T cells, which may represent a rate-limiting step for downstream PI hydrolysis.
Weber and Cantor (1994)TCRT cellBy contrast, TCR ligation of the same T cell clone by retroviral superantigen leads to similar levels of T cell proliferation without detectable PI synthesis.
Sette et al. (1994)TCRT cellTCR antagonism appears to be associated with engagement of the TCR below a crucial affinity threshold necessary for full T cell activation.
Rocha and von Boehmer (1991)TCRT cellPeripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism.
Rocha and von Boehmer (1991)TCRT cellUnlike thymic selection, peripheral selection required binding of antigen to the TCR, and it induced expansion of T cell clones.
Cai et al. (1998)TCRT cellsAnalysis of these structures has provided some basic rules for how TCR and MHC/peptide interact; however, the critical question of how this interaction transduces Signal 1 to T cells remains unclear.
Sun et al. (1997)TCRT cellIn this study, we demonstrate that sequences of the TCR CDR3 region are excellent clonotypic markers for rat MBP-reactive T cell clones and oligonucleotide probes complementary to the CDR3 region of three T cell clones specifically recognized the TCR from which they were derived, but failed to recognize syngeneic T cells that express a similar TCR beta-chain or T cells that share both V beta and J beta usage.
Du Bois et al. (1992)TCRT-cellsTo differentiate whether the T-cells accumulate in organs nonspecifically (e.g., through chemotaxis or tumorlike proliferation) or more specifically through an antigen-driven ordered immune response, the present study capitalized on the knowledge that specific antigen stimulation of T-cells requires antigen interactions with the T-cell antigen receptor (TCR), resulting in a decrease in the number of surface TCR and a concomitant increase in TCR mRNA levels, i.e., if lung T-cell accumulation in pulmonary sarcoid results from an ordered immune response, lung, but not blood, T-cells should demonstrate evidence of recent triggering of the alpha beta receptor, the most abundant type of TCR.
Gumperz (2004)TCRT cellsThe discovery of subsets of canonical T cells that have structurally homogeneous TCR presents an enigma: What antigens do these T cells recognize, and how does their antigen specificity relate to their functions?
Dietrich et al. (2002)TCRT cellsTCR internalization takes place both in resting T cells as part of constitutive TCR cycling, after PKC activation, and during TCR triggering.
Gakamsky et al. (2007)TCRT cellThermodynamics and kinetics of the interaction between T cell receptor specific for cytomegalovirus peptide (TCR(CMV)) and its specific ligand, pp65-HLA-A*0201 complex, were studied by surface plasmon resonance and stopped-flow methods.
Deng and Mariuzza (2007)TCRT cellT cell receptors (TCR) recognize antigenic peptides displayed by MHC molecules.
Mirshahidi et al. (2004)TCRT cellThe magnitude of TCR engagement is a critical predictor of T cell anergy or activation.
Gumperz (2004)TCRT cellsMounting evidence indicates that alpha-GalCer responsive T cells are heterogeneous in their reactivities to cellular antigens, suggesting that an individual semi-invariant TCR may be capable of recognizing more than one ligand.
Radoja et al. (2006)TCRT-cellT-cell receptor (TCR) engagement by antigen results in proliferation, differentiation and cytokine secretion.
Janes et al. (2000)TCRT cellIn T lymphocytes, key T cell antigen receptor (TCR) signalling molecules associate with rafts, and disrupting raft-association of certain of these abrogates TCR signalling.
Weber et al. (1995)TCRT cellWe show here that this differential response phenotype is apparent at the level of individual T cell clones following TCR ligation with peptide or MTV antigen.
Liu et al. (2000)TCRT cellsWe show that the TCR:CD3 complex is very stable and is rapidly internalized and recycled in resting T cells.
Schodin et al. (1996)TCRT cellCorrelation between the number of T cell receptors required for T cell activation and TCR-ligand affinity.
Matis (1990)TCRT cellsFinally, the identification of T-cell superantigens and their ability to stimulate T cells on the basis of TCR V beta expression alone has defined a new and distinct type of TCR/ligand interaction.
Gakamsky et al. (2004)TCRT cellKinetic parameters of T cell receptor (TCR) interactions with its ligand have been proposed to control T cell activation.
Rubin and Kretz-Rommel (1999)TCRT cellsDevelopment and maturation of antigen-specific T cells take place in the thymus in a process dependent on recognition by the T cell antigen receptor (TCR) of endogenous self-peptides presented by several types of specialized stromal cells.
Siu et al. (1990)TCRT cellProper recognition of antigen and MHC-restriction by the TCR is necessary for the activation of the T cell.
Anderson et al. (2005)TCRT cellWe explored this possibility by investigating the physical interactions among Notch, Numb, and the TCR signaling apparatus and by examining the consequences of a Numb mutation on T cell development.
Davis et al. (1997)TCRT cellThis suggests that the stability of TCR binding to a given ligand is critically important with respect to whether the T cell is stimulated, inhibited or remains indifferent.
Laugel et al. (2005)TCRT cellThe use of recombinant T cell receptors (TCRs) to target therapeutic interventions has been hindered by the naturally low affinity of TCR interactions with peptide major histocompatibility complex ligands.
Berg and Kang (2001)TCR repertoireT cellRecent advances have provided insights into the molecular mechanisms that regulate TCR repertoire formation at the level of alphabeta versus gammadelta T cell fate and CD4(+) versus CD8(+) lineage determination.
Noble (2000)TCRT cellsThis review focuses on more recent developments concerning the choices that peripheral T cells make between first encountering antigen through TCR recognition and death.
Sloan-Lancaster and Allen (1996)TCRT cellThe elucidation of the phenomena of T cell antagonism and partial activation by altered peptide ligands has necessitated a revision in the traditional concepts of TCR recognition of antigen and subsequent signal transduction.
Kalergis and Nathenson (2000)TCRT cellTCR engagement by these altered peptide ligands usually impairs normal T cell function.
Sireci et al. (2001)TCRT cellsHuman T cells expressing Vgamma9Ndelta2-encoded TCR recognize several nonpeptide phosphoantigens in the absence of major histocompatibility complex restriction.
Madrenas et al. (1996)TCRT-cellFull activation of T cells requires signaling through the T-cell antigen receptor (TCR) and additional surface molecules interacting with ligands on the antigen-presenting cell.
Kalra et al. (2002)TCRT cellMoreover, the ability of spleen cells to mobilize intracellular Ca(2+) after ligation of the T cell antigen receptor (TCR) with an anti-alphabeta TCR antibody was significantly less in SA than in control rats.
Mann et al. (1994)TCRT cellSpontaneous proliferation and virus production increased in the presence of antibodies reacting with CD3 and alpha/beta T cell receptors (TCR) while antibodies to HLA class II and viral proteins had no effect.
von Greyerz et al. (1999)TCRT cellsFinally, the number of down-regulated TCRs was a logarithmic function of the ligand concentration, implicating that specific T cells were activated by serial TCR engagement.
Li et al. (1998)TCRT-cellTCR-alpha and the mutant TCR-beta chains assembled with the CD3-epsilon, -gamma, -delta, and -zeta subunits and were efficiently transported to the cell surface; however, the hybrid TCR molecules exhibited a diminished response to T-cell activation by major histocompatibility complex-bound antigen, superantigen, and TCR cross-linking.
Palmer and Naeher (2009)TCRT-cellThe affinity of the T-cell receptor (TCR) for self antigen is the basis for the selection of a useful (MHC-restricted) and safe (self-tolerant) T-cell repertoire.
Carson et al. (1991)TCRT cellsIt has been known for some time that physical associations between the CD3 proteins and the TCR chains are essential for efficient transport of either component to the surface of T cells.
Lin et al. (1990)TCRT cellThe interaction of the T cell receptor for antigen (TCR) with its antigen-major histocompatibility complex ligand is difficult to study because both are cell surface multimers.
Cai et al. (1998)TCRT cellsAt least two signals are required for T-cell activation: Signal 1 results from recognition of MHC/peptide complexes on the APC by cell surface T-cell receptors (TCR), whereas Signal 2 is induced by the interactions of co-stimulatory molecules on APC with their complementary receptors on T cells.
Laugel et al. (2005)TCRT cellNotably, the A6 TCR specific for the immunodominant HLA A2-restricted human T cell leukemia virus type 1 Tax(11-19) epitope bound to HLA A2-HuD(87-95) (K(D) 120 microm by surface plasmon resonance), an epitope implicated as a causal antigen in the paraneoplastic neurological degenerative disorder anti-Hu syndrome.
Balow and Kerase (1996)TCRT cellIsolation of newly expressed surface T cell antigen receptor complexes by serial precipitation with anti-TCR antibodies and immobilized streptavidin.
Cole et al. (2010)TCRT cellModification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
Cole et al. (2010)TCRT cellImproving T cell Ags by altering MHC anchor residues is a common strategy used to enhance peptide vaccines, but there has been little assessment of how such modifications affect TCR binding and T cell recognition.
Bakács et al. (2007)TCRT cellsT cells survey the stability of the self: a testable hypothesis on the homeostatic role of TCR-MHC interactions.
Bandyopadhyay et al. (2007)TCRT cellsIn the absence of costimulation, T cell receptor (TCR) engagement results in unopposed calcium signaling that leads to the activation of a cell-intrinsic program of inactivation, which makes T cells hyporesponsive to subsequent stimulations.
Call et al. (2006)TCRT cellThe T cell receptor (TCR) alphabeta heterodimer communicates ligand binding to the cell interior via noncovalently associated CD3gammaepsilon, CD3deltaepsilon, and zetazeta dimers.
Schade and Levine (2004)TCRT cellsTherefore, we investigated whether varying the strength of TCR engagement in various human T cells would yield different second messenger responses.
Schade and Levine (2004)TCRT cellThe kinetics and duration of extracellular signal-regulated kinase (ERK) activation, central to multiple cellular responses, are distinctly dependent on the T cell activation state (naive vs effector), strength of TCR cross-linking, and input from the phosphatidylinositol-3 kinase pathway, which is regulated by cytokines and growth factors.
Pitcher et al. (2003)TCRT cellsThe dramatic and diverse biological responses of T cells are proposed to be partly regulated by the relative ratios of the 21- vs. 23-kDa phosphorylated forms of TCR zeta that are induced following TCR ligation.
Krogsgaard et al. (2003)TCRT cellEvidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
Krogsgaard et al. (2003)TCRT cellWhile in many cases the half-life of T cell receptor (TCR) binding to a particular ligand is a good predictor of activation potential, numerous exceptions suggest that other physical parameter(s) must also play a role.
Krogsgaard et al. (2003)TCRT cellBy combining the values for heat capacity (DeltaCp) and the half-life of TCR binding (t(1/2)), we find that we can accurately predict the degree of T cell stimulation.
Michielin and Karplus (2002)TCRT-cellRecognition by the T-cell receptor (TCR) of immunogenic peptides presented by class I major histocompatibility complexes (MHCs) is the determining event in the specific cellular immune response against virus-infected cells or tumor cells.
Miceli et al. (2001)TCRT cellT cell receptor (TCR) antigen recognition induces the formation of a specialized 'immunological synapse' at the T cell : antigen presenting cell (APC) junction.
Uherek et al. (2001)TCRT lymphocytesT lymphocytes recognize specific antigens through interaction of the T cell receptor (TCR) with short peptides presented by major histocompatibility complex (MHC) class I or II molecules.
Hemmer et al. (2000)TCRT-cellT-cells recognize by their T-cell receptor (TCR) short peptides presented by major histocompatibility complex (MHC) molecules.
Germain and Stefanová (1999)TCRT cellThe decision of a T cell "to sense and to respond" with proliferation and effector activity rather than "to sense, live on, but not respond" is dependent on TCR interaction with a low number of specific foreign peptide:MHC molecule complexes recognized simultaneously with abundant self peptide-containing complexes.
Hudrisier et al. (1998)TCRT cellIn addition, permanent TCR engagement by TCR-ligand photocross-linking completely abolished sustained intracellular calcium mobilization, which is required for T cell activation.
Lee et al. (1997)TCRT cellThe earliest detectable event in T cell activation, within seconds of TCR ligand recognition, is tyrosine phosphorylation of TCR subunits.
Radvanyi et al. (1996)TCRT cellsWe demonstrate here that primary-activated T cells induced to undergo apoptosis by TCR recrosslinking during the G1 phase of the cell cycle did not arrest in the G1 phase of the cell cycle.
Nishimura et al. (1992)TCRT-cellThe antibody competed with WT31, a monoclonal antibody (MoAb) to T-cell receptor (TCR), in binding to TCR of the T-cell clones.