Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in B cells

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Bruserud and Moen (1984)IL-2B lymphocytesAddition of indomethacin or irradiated EBV-transformed B lymphocytes to the cultures, removal of adherent cells, and 18 h preincubation of the cells before PHA stimulation had an additive enhancing effect on the IL-2 production.
Strauchen (1989)IL-2B-cellIL-2 receptor expression may also play a role in some B-cell non-Hodgkin's lymphomas and histiocytic proliferations.
Mingari et al. (1984)interleukin 2B cellProduction of B cell growth factor and interleukin 2 by T8+ and T4+ cytolytic clones.
Gearing et al. (1985)interleukin 2B cellsThe proliferation of human B cells was studied for response to interleukin 2 (IL-2) produced in Escherichia coli using recombinant DNA technology.
Mayer et al. (1985)IL 2B cellThe addition of IL 2 to the B cell and BCDF cultures resulted in almost 100% expression of the IL 2 receptor, Tac, on the surface of these cells, and the augmented PFC response could be inhibited 70 to 80% by the addition of anti-Tac to the culture.
Emmrich et al. (1985)IL-2B cellsSusceptibility to IL-2 is accompanied with the expression of the IL-2 receptor (Tac antigen) on B cells.
Muraguchi et al. (1985)interleukin 2B cellIn the present study, we examined the expression of interleukin 2 (IL-2) receptors on normal human B cells as well as established B cell lines.
Muraguchi et al. (1985)IL-2B cellThese results suggest that normal B cells may express functional IL-2 receptors or closely related proteins and thus IL-2 may play a significant role in the modulation of B cell function.
Owen et al. (1996)interleukin 2B cellsOur results clearly show that the majority of peripheral blood B cells can be induced to an activated stage (blast transformation) and interleukin 2 (IL-2) receptor expression, following very simple manipulations of the lymphoid population.
Mingari et al. (1984)IL-2B cellsRecently, however, a monoclonal antibody reacting with the IL-2 receptor molecules expressed by activated T cells (anti-Tac) was shown to react also with certain B tumour cells; in addition, murine B cells proliferate in response to pure human IL-2.
Lagoo et al. (1990)Interleukin 2B lymphocytesInterleukin 2 produced by activated B lymphocytes acts as an autocrine proliferation-inducing lymphokine.
Lagoo et al. (1990)IL 2B cellsComparison of IL 2 production by decreasing numbers of purified T cells and purified B cells also indicated that the B cells were the source of IL 2 activity.
Panayotides et al. (1986)IL-2B-cellsRecently it has been shown that activated murine and human B-cells also express IL-2 receptors and respond to IL-2 with an increase of DNA synthesis.
Panayotides et al. (1986)IL-2B-cellHere, in five of 11 B-cell leukemia/lymphoma cases, we identified cells which not only express the IL-2 receptor, but also respond to IL-2 stimulation, as shown by a marked increase of 3H-thymidine incorporation and by differentiation of lymphoma cells.
Strauchen and Breakstone (1987)IL-2B-cellIL-2 receptor expression is not confined to T-cell neoplasia, but is also a feature of neoplastic and nonneoplastic histiocytic proliferations, Hodgkin's disease, and some intermediate and high-grade B-cell lymphomas.
Chatenoud et al. (1986)IL-2B-cellInterleukin 2 (IL-2) and B-cell growth factors I and II (BCGF I and BCGF II) are lymphokines produced by T cells that play a major role in T- and B-cell cooperation.
Lagoo et al. (1990)IL-2B cellsWe have shown earlier that rabbit B cells can be activated to produce IL-2 and express functional IL-2 receptors after treatment with ionomycin and PMA.
Lagoo et al. (1990)IL-2B cellInterestingly, IL-2 production by the PBL cultures was also three to four times higher than in B cell cultures, suggesting an involvement of IL-2 in inducing DNA synthesis in these cells.
Lagoo et al. (1990)IL-2B cellsThe hypothesis that IL-2, which is produced in early G1, acts in late G1 and is required for G1 to S transition in B cells was supported by the following observations: (i) IL-2 production by B cells was detected as early as 6 hr after activation and preceded DNA synthesis by at least 24 hr.
Vazquez et al. (1987)IL-2B cellsTo determine the respective targets of the 50,000 BCGF and of IL-2, B cells were activated with anti-mu Ab and separated according to the expression of the IL-2 receptor (cluster designation (CD)25 antigen).
Miedema et al. (1985)IL2B cellHelper T cell activity can thus be divided into two distinct activities: IL2 production and the ability to deliver the actual helper signal such as helper factors for B cell differentiation.
Dukovich et al. (1987)IL-2B lymphocytesAlthough activated human T and B lymphocytes express both high-affinity and low-affinity membrane receptors for interleukin-2 (IL-2), the structural features that distinguish these receptors have remained unresolved.
Antonaci et al. (1989)interleukin 2B cellThe suppressive factors are also responsible for a decreased interleukin 2 (IL-2) synthesis since a similar pretreatment of cell suspensions or exogenous human IL-1 and/or IL-2 supplementation of aged cell cultures leads to a recovery of T regulatory effects on B cell differentiation.
Cunningham-Rundles et al. (1995)IL-2B cellsAfter 12 weeks, each patient had enhanced T cell proliferation, normal IL-2 production, boosted BCDF secretion, and B cells responsive to differentiation signals.
Mouzaki et al. (1995)IL-2B cellsHowever, B cells can also synthesize IL-2.
Mouzaki et al. (1995)IL-2B cellsSimilarly, a human immunodeficiency virus promoter, whose activity is controlled through chi B factors, was found to be active in the IL-2 producing EBV-B cells, but inactive in the non-IL-2-producing cells.
Mouzaki et al. (1995)IL-2B cellsThese results demonstrate that the IL-2 NF-chi B site is indispensable for the activity of the IL-2 promoter in EBV-transformed B cells, whereas other transcription factors appear to be less important for IL-2 expression in these cells.
Tao et al. (1991)IL-2B cellsT2 at 0.1-1 micrograms/ml inhibited antigen- and mitogen-stimulated proliferation of T cells and B cells, interleukin-2 (IL-2) production by T cells, and immunoglobulin production by B cells.
Puett and Fuchs (1994)IL-2B cellStudies using supernatants from peripheral T lymphocytes of patients with scleroderma have shown increased levels of IL-2, IL-2 receptor, IL-4 and B cell growth factors, indications of activation of immune mechanisms.
Polke et al. (1986)interleukin 2B cellsPhorbol ester enhances both interleukin 2 receptor expression and immunoglobulin secretion in human Epstein-Barr virus-immortalized B cells.
Polke et al. (1986)IL2B cellThe enhanced expression of interleukin 2 (IL2) receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) on sublines of an Epstein-Barr virus-immortalized human B17 B cell line (M.
Polke et al. (1986)IL2B cellsThe capacity of TPA to induce differentiation in human B cells and the biological significance of IL2 receptor expression by activated B cells are discussed.
Kierszenbaum et al. (1991)interleukin-2B lymphocytesTrypanosoma cruzi induces suppression of DNA synthesis and inhibits expression of interleukin-2 receptors by stimulated human B lymphocytes.
Kierszenbaum et al. (1991)interleukin-2B cellsThis inference was confirmed by the finding that the proportion of PS-stimulated B cells expressing interleukin-2 (IL-2) receptors was significantly reduced when the parasite was present in the culture.
Kierszenbaum et al. (1991)IL-2B-cellThese results demonstrate for the first time that T. cruzi can affect human B-cell responses and that the mechanism involves inhibition of IL-2 receptor expression.
Volkman et al. (1984)IL-2B cellIn addition, some clones were also capable of producing both B cell growth factor and IL-2 following KLH stimulation.
Murakami et al. (1988)IL2B cellsSimilar suppression of IL2 and IgM production was observed in cultures of B cells and T4+ cells.
Oudrhiri et al. (1985)IL 2B cellUsing recombinant IL 2 and anti-Tac monoclonal antibody as a probe for the IL 2 receptor, we demonstrate that the requirement of accessory cells (here an irradiated B cell line) in inducing IL 2 responsiveness relies on their enhancing effect in functional IL 2 receptor expression by the T colony progenitors.
W├Ârmann et al. (1987)interleukin-2B cellWe have studied the expression and function of interleukin-2 (IL-2) receptors on B cell precursor acute lymphoblastic leukemias (ALL).
Drexler et al. (1988)IL-2B cellsOur data suggest that (a) B-CLL cells are able to respond to direct stimulation of the second messenger pathway (through protein kinase C) but not to the physiological stimuli IL-2 or BCDF; (b) the defect in signal transduction appears to be located upstream of protein kinase C (a possible candidate is a G protein); (c) malignant B cells may spontaneously or after treatment with inducers express the IL-2 receptor (Tac antigen) in the absence of a functional differentiating response to IL-2; and (d) signs of proliferation/differentiation in B-CLL samples after incubation with IL-2 or BCDF might be due to contamination of the cell populations with residual normal B cells.
Kabelitz et al. (1985)IL 2B lymphocytesThese findings indicate that certain leukemic B lymphocytes can be induced to express IL 2 receptors and respond to IL 2.
Kindler et al. (1995)IL-2B cellWhile Epstein-Barr virus (EBV)-immortalized B cell lines have been shown to secrete interleukin (IL)-2 after stimulation with either teleocidin or phorbol myristate acetate (PMA) and ionomycin, experimental conditions leading to IL-2 production by normal human B cells have not been reported.
Kindler et al. (1995)IL-2B lymphocytesThe production rate of IL-2 by B lymphocytes reached a maximum after 6 days of priming in such cultures followed by 48 h of stimulation with PMA plus ionomycin, corresponding to 7% or 15% of that of fresh CD4+ T cells activated, respectively, with phytohemagglutinin plus PMA, or with PMA plus ionomycin for 48 h.
Kindler et al. (1995)IL-2B cellsThis IL-2 production could not be attributed to T cell contamination nor to EBV-infected B cells according to flow cytometric and reverse transcriptase-polymerase chain reaction analysis of cultured B cells.
Kindler et al. (1995)IL-2B lymphocytesLower IL-2 expression (detected only as mRNA synthesis) was also induced in the cultured B lymphocytes after incubation with cross-linking anti-IgM antibodies instead of PMA plus ionomycin.
Kindler et al. (1995)IL-2B lymphocytesThese results show that the production of IL-2 by normal B lymphocytes occurs as a late event relative to their activation and proliferation, and is in this respect subject to regulation different to that found in T lymphocytes.
Gaspar et al. (1988)IL-2B-cellWhen in vitro production of interleukin-2 (IL-2) and B-cell growth factor (BCGF) was tested, both activities were found to be diminished in the group of patients (P less than 0.01), while B-cell differentiation factor (BCDF) activity was higher in this group with respect to normal controls (P less than 0.01).
McKay et al. (2000)IL-2B lymphocytesInterleukin-4 (IL-4) regulates the expression of the 55-kDa alpha-subunit (CD25) of the IL-2 receptor complex in human B lymphocytes.
Smiers et al. (1995)IL-2B cellHeterogeneity of proliferative responses of human B cell precursor acute lymphoblastic leukemia (BCP-ALL) cells to interleukin 7 (IL-7): no correlation with immunoglobulin gene status and expression of IL-7 receptor or IL-2/IL-4/IL-7 receptor common gamma chain genes.
Antikainen et al. (1994)IL-2B cellsImmunohistochemistry did not reveal any activated T or B cells, or any expression of IL-1 or IL-2 receptors.
Plate et al. (1993)IL-2B cellsIL-1 beta and IL-2 receptors, on the other hand, were expressed by B cells from both normal and B-CLL patients.
Becker et al. (1988)interleukin 2B lymphocytes[Expression of interleukin 2 receptors in in vivo Epstein-Barr virus transformed B lymphocytes].
Tanaka et al. (1988)interleukin 2B cellExpression of novel interleukin 2 binding molecules and their functional roles in human B cell differentiation.
Kosco et al. (1988)IL 2B cellsIn the next (table; see text) series, it was demonstrated that GC B cells isolated as early as 1 day and for over a week following an antigenic challenge with OVA (i.e. where they obtained antigen from the FDC-derived iccosomes in vivo), were able to stimulate high levels of IL 2 production in the absence of exogenous OVA.
Rugeles et al. (1987)IL-2B-cellThe potentiation of human B-cell responses with autologous RBC can be abrogated by pretreatment of PBMNC with anti-CD2 antibodies and is associated with increased expression of IL-2 receptors and increased production of gamma interferon (IFN-gamma).
Bentaboulet et al. (1987)interleukin-2B cellsCharacterization of interleukin-2 receptors expressed on acute leukemic B cells.
Bentaboulet et al. (1987)interleukin 2B cellMore than 90% of both unfractionated and blast-enriched T cell-depleted mononuclear cells (MNC) from a patient with a morphologically and phenotypically unclassified acute leukemia expressed interleukin 2 receptors (IL2-R), whereas 50% unfractionated MNC displayed monocyte/myeloid- (My7, My9, and OKM1) and B cell-restricted (B4) antigens.
Rimsky et al. (1986)IL 2B cellsIn addition to inducing the proliferation of murine thymocytes in the co-stimulator assay. 3B6-IL 1 is active on both human T and B cells, respectively, in inducing IL 2 synthesis by cells from a subcloned HSB 2 line and promoting the proliferation of anti-IgM-stimulated human peripheral blood B lymphocytes.
Pistoia et al. (1985)IL 2B cellsThe factor released by this LGL subset was not IL 1 or IL 2 mistakenly interpreted as BCGF, because: a) cell supernatants particularly rich in BCGF activity contained very little or no IL 1 or IL 2; b) BCGF-induced B cell proliferation was not inhibitable by anti-Tac antibodies (this in spite of the expression of IL 2 receptor by a proportion of activated B cells); and c) BCGF activity was absorbed by B but not T blasts.
Sinigaglia et al. (1985)IL 2B cellsIn the presence of Ni, they polyclonally activate autologous B cells, and in the presence of Ni and autologous EBV-B cells, they produce IL 2 and very high levels of IFN-gamma.
Waldmann et al. (1984)interleukin 2B cellsExpression of interleukin 2 receptors on activated human B cells.
Steinberger et al. (1997)Interleukin-2B-cellInterleukin-2 (IL-2) receptor alpha, beta and gamma subunit expression as a function of B-cell lineage ontogeny: the use of IL-2-PE66(4Glu) to characterize internalization via IL-2 receptor subunits.
Casseb and Penalva-de-Oliveira (2000)IL-2B cellsThe current hypothesis about the pathogenesis of TSP/HAM is: 1) presence of HTLV-I antigens in the lumbar spinal cord, noted by an increased DNA HTLV-I load; 2) CTL either with their lytic functions or release/production of soluble factors, such as CC-chemokines, cytokines, and adhesion molecules; 3) the presence of Tax gene expression that activates T-cell proliferation or induces an inflammatory process in the spinal cord; 4) the presence of B cells with neutralizing antibody production, or complement activation by an immune complex phenomenon, and 5) lower IL-2 and IFN-gamma production and increased IL-10, indicating drive to a cytokine type 2 pattern in the TSP/HAM subjects and the existence of a genetic background such as some HLA haplotypes.
Tanaka et al. (1988)IL-2B cellsExpressions and functional roles of novel IL-2 binding molecules (p70, 75) in the differentiation of B cells into Ig secreting cells were explored by using human several B cell lines and tonsillar B cells.
Tanaka et al. (1988)IL-2B cellsThese results taken together suggest that B cells may express novel IL-2 binding molecules, associated with B cell differentiation and differentiate into Ig secreting cells by IL-2 through novel IL-2 binding molecules.
Ben-Ari et al. (2000)interleukin-2B-cellThe results show that CF B-cell lines presented a staphylococcal superantigen to the immortalized T-cell line (Jurkat) as effectively as did control B-cell lines as measured by interleukin-2 production.
Takahashi et al. (2001)interleukin 2B cellsAutologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes.
Litjens et al. (2008)IL-2B cellBy depleting for IL-2 producing memory T cells, we demonstrated that these cells are important for B cell differentiation into IgG-producing plasma cells.
Umetsu et al. (1988)interleukin 2B cellsYet in contrast to allogeneic monocytes, allogeneic B cells failed to induce a rise in the intracellular calcium ion concentration and failed to cause interleukin 2 (IL2) receptor expression in Clone A1.
Tomita et al. (1990)IL-2B cellThis factor modulates the function of CD4+ cells suppressing their IL-2 production and suppressing PWM-induced B cell differentiation into Ig producing cells.
Benjamin et al. (1990)IL-2B cellDifferential effects of teleocidin on TNF alpha receptor regulation in human B cell lines: relationship to coexpression of IL-2 and IL-1 receptors and to lymphokine secretion.
Suzuki and Cooper (1985)IL 2B cellsComparison of the expression of IL 2 receptors by human T and B cells: induction by the polyclonal mitogens, phorbol myristate acetate, and anti-mu antibody.
Suzuki and Cooper (1985)IL 2B cellsActivated B cells were also recently found to express IL 2 receptors.
Suzuki and Cooper (1985)IL 2B cellsThe present studies were designed to compare qualitative, quantitative, and functional aspects of IL 2 receptor expression by activated T and B cells.
Suzuki and Cooper (1985)IL 2B cellsPMA induced both T and B cells to express functional IL 2 receptors before cellular proliferation.
Suzuki and Cooper (1985)IL 2B cellsThe m.w. of the IL 2 receptors expressed by activated T and B cells was identical: 54,000 to 59,000.
Suzuki and Cooper (1985)IL 2B cellsSmall B cells from the blood could also be induced by a mitogenic monoclonal anti-IgM antibody to express functional IL 2 receptors.
Suzuki and Cooper (1985)IL 2B cellsRelatively large B cells in fresh blood samples were found to express functional IL 2 receptors and were capable of a modest proliferative response to IL 2.
Suzuki and Cooper (1985)IL 2B cellsThe intensity of the IL 2 receptor expression and the proliferative response by large B cells were enhanced by PMA stimulation.
Hashimoto et al. (1986)IL2B cellsMed. 1984. 160: 1070), it has been shown that B cells which have been activated with lipopolysaccharide (LPS) plus anti-Ig antibodies express interleukin 2 (IL2) receptors and proliferate in response to pure IL2.
Rossi et al. (1985)Interleukin 2B cellInterleukin 2 production in B cell chronic lymphocytic leukemia.
Decker et al. (2000)IL-2B cellsThis resulted in the expression of functional high-affinity IL-2 receptors in B-CLL cells, but fewer numbers of receptors with less affinity were expressed in normal B cells.
Yoshimura et al. (1989)IL-2B cellInhibition of the production of IL-2 and gamma-IFN, but not B cell-stimulating factor 2.
Gosselin et al. (1989)IL-2B cells(d) In contrast, expression of IL-2 receptors after EBV infection was higher on B cells from S-PBL than on B cells from R-PBL.
Biagi et al. (2005)interleukin-2B-cellEXPERIMENTAL DESIGN: We prepared autologous B-cell chronic lymphocytic leukemia cells that expressed both human CD40 ligand (>90% positive) and human interleukin-2 (median secretion, 1,822 pg/mL/10(6) cells; range, 174-3,604 pg).
Kohno et al. (1990)IL-2B cellIL-2 production by PHA-stimulated MOLT 14 cells (a TcR gamma/delta-bearing human leukemic T cell line) and MOLT 16 cells (a TcR alpha/beta-bearing human leukemic T cell line) was markedly augmented by coculturing with BALL-1 cells ( a human leukemic B cell line), or with recombinant human interleukin-1 alpha (rhIL-1 alpha).
Perri and Kay (1987)interleukin 2B cellsMalignant chronic lymphocytic leukemia B cells express interleukin 2 receptors but fail to respond to interleukin 2's proliferative signal.
Katano et al. (1994)Interleukin-2B-cellInterleukin-2 (IL-2) production by human B-cell line.