Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in B cells

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Lagoo et al. (1990)IL-2B cellsWe have shown earlier that rabbit B cells can be activated to produce IL-2 and express functional IL-2 receptors after treatment with ionomycin and PMA.
Polke et al. (1986)interleukin 2B cellsPhorbol ester enhances both interleukin 2 receptor expression and immunoglobulin secretion in human Epstein-Barr virus-immortalized B cells.
Polke et al. (1986)IL2B cellThe enhanced expression of interleukin 2 (IL2) receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) on sublines of an Epstein-Barr virus-immortalized human B17 B cell line (M.
Wiebke et al. (1988)IL-2B-lymphocytesFlow cytometry revealed marked increases in T-lymphocyte numbers after IL-2 alone (973 +/- 252 to 3,436 +/- 754 cells/mL; P less than .01) and IL-2 receptor-bearing cells (105 +/- 28 to 983 +/- 215; P less than .01), but not in numbers of B-lymphocytes or monocytes.
Kindler et al. (1995)IL-2B cellWhile Epstein-Barr virus (EBV)-immortalized B cell lines have been shown to secrete interleukin (IL)-2 after stimulation with either teleocidin or phorbol myristate acetate (PMA) and ionomycin, experimental conditions leading to IL-2 production by normal human B cells have not been reported.
Kindler et al. (1995)IL-2B lymphocytesLower IL-2 expression (detected only as mRNA synthesis) was also induced in the cultured B lymphocytes after incubation with cross-linking anti-IgM antibodies instead of PMA plus ionomycin.
Thrasher et al. (1990)IL2B cellsIn addition, significant increases in Ta1+, IL2+, and B cells and autoantibodies were observed.
Jego et al. (2001)IL-2B cellsCD25 (IL-2Ralpha) was increased 72 +/- 10-fold on activated B cells, but decreased and then disappeared on plasmablasts.
Rugeles et al. (1987)IL-2B-cellThe potentiation of human B-cell responses with autologous RBC can be abrogated by pretreatment of PBMNC with anti-CD2 antibodies and is associated with increased expression of IL-2 receptors and increased production of gamma interferon (IFN-gamma).
Rimsky et al. (1986)IL 2B cellsIn addition to inducing the proliferation of murine thymocytes in the co-stimulator assay. 3B6-IL 1 is active on both human T and B cells, respectively, in inducing IL 2 synthesis by cells from a subcloned HSB 2 line and promoting the proliferation of anti-IgM-stimulated human peripheral blood B lymphocytes.
Shirakawa et al. (1986)interleukin 2B lymphocytesRequirement of macrophages (monocytes) for the induction of interleukin 2 receptors on B lymphocytes.
Itoh et al. (1994)IL-2B cellsThese results indicate that IL-10 and IL-2 synergistically enhance Ig production of SA-activated B cells in a mechanism which is different from the upregulation of IL-2 receptors.
Inaba et al. (1983)IL-2B lymphocyteWe conclude that the ability of the DC to induce IL-2 release and responsiveness underlies its capacity to trigger both T and B lymphocyte reactions.
Decker et al. (2000)IL-2B cellsRESULTS: The CpG-ODN DSP30 caused a significantly stronger induction of the IL-2 receptor alpha chain in malignant as compared with normal B cells (p = 0.03).
Decker et al. (2000)IL-2B cellsThis resulted in the expression of functional high-affinity IL-2 receptors in B-CLL cells, but fewer numbers of receptors with less affinity were expressed in normal B cells.
Kohno et al. (1990)IL-2B cellIL-2 production by PHA-stimulated MOLT 14 cells (a TcR gamma/delta-bearing human leukemic T cell line) and MOLT 16 cells (a TcR alpha/beta-bearing human leukemic T cell line) was markedly augmented by coculturing with BALL-1 cells ( a human leukemic B cell line), or with recombinant human interleukin-1 alpha (rhIL-1 alpha).
Owen et al. (1996)IL-2B cellsOur results clearly show that the majority of peripheral blood B cells can be induced to an activated stage (blast transformation) and interleukin 2 (IL-2) receptor expression, following very simple manipulations of the lymphoid population.
Kohno et al. (1989)IL 2B cellIn sharp contrast, MOLT 16 cells co-cultured with BALL-1 cells (a human leukemic B cell line) resulted in comparable increases in IL 2 production (175 U/ml), although no IL 1 or IL 1-like activity was detected either in the supernatants or in the cell lysates of BALL-1 cells.
Lee et al. (1990)IL-2B cellsIL-4 blocks the up-regulation of IL-2 receptors induced by IL-2 in normal human B cells.
Sia (1988)IL2B cellTwo of these clones namely, SA 1.53 and SA 1.82, are found to co-produce B cell growth factor (BCGF) and interferon-gamma (IFN-gamma) in the absence of interleukin 2 (IL2) upon stimulation with phytohaemagglutinin (PHA) or the specific antigen in the presence of irradiated autologous antigen-presenting cells (APC).
Prasad et al. (1997)IL-2B cellsTogether with previous results, the data show that antigen presentation leading to IL-2 secretion by these autoreactive T cell hybridomas requires activated B cells, whereas TCR occupancy can be provided by several APC subsets.
Fluckiger et al. (1993)IL-2B cellsThe observed synergy is likely to be due to the IL-10-induced increase of high affinity IL-2 receptors on both normal and leukemic B cells.
Moreau et al. (1986)IL-2B lymphocytesOptimal growth frequency (1/13) was obtained when Epstein-Barr virus (EBV)-transformed donor B lymphocytes were used as stimulators (D-BLCL) in the presence of interleukin 2 (IL-2).
LĂȘ thi Bich-Thuy et al. (1985)IL-2B cellsPositively selected human B-cell suspensions with no detectable T cells and containing more than 99.5% B cells both at the initiation and termination of culture were shown to proliferate in response to interleukin 2 (IL-2) in a dose-dependent fashion.
Mingari et al. (1984)IL2B cellCytolytic clones were further analyzed for their ability to release interleukin 2 (IL2) and B cell growth factor(s) (BCGF) upon 24 h stimulation with phytohemagglutinin.
Tomita et al. (1985)interleukin 2B cellA human T cell leukemia/lymphoma virus (HTLV)-I-infected B cell clone expressed Tac antigen on its cell surface and responded to recombinant interleukin 2 (IL-2) by increased production of IgM without any increase in proliferation.
Emilie et al. (1988)IL2B cellsThe effects of interleukin 2 (IL2) on the proliferation and differentiation of B cells were analyzed separately using cells from two patients suffering from B-type chronic lymphocytic leukemia.
Romagnani et al. (1985)IL2B cellsTaken together, these data indicate that anti-mu antibody promotes the expression by normal human B cells of distinct receptors for IL2 and a BCGF distinct from IL2.
Mingari et al. (1984)IL-2B cellsRecently, however, a monoclonal antibody reacting with the IL-2 receptor molecules expressed by activated T cells (anti-Tac) was shown to react also with certain B tumour cells; in addition, murine B cells proliferate in response to pure human IL-2.
Panayotides et al. (1986)IL-2B-cellsRecently it has been shown that activated murine and human B-cells also express IL-2 receptors and respond to IL-2 with an increase of DNA synthesis.
Panayotides et al. (1986)IL-2B-cellHere, in five of 11 B-cell leukemia/lymphoma cases, we identified cells which not only express the IL-2 receptor, but also respond to IL-2 stimulation, as shown by a marked increase of 3H-thymidine incorporation and by differentiation of lymphoma cells.
Chatenoud et al. (1986)IL-2B cellsAnti-IgM (mu chain)-stimulated uremic B cells exhibited a normal response to recombinant IL-2 and to chromatography-purified BCGF I and BCGF II.
Mouzaki et al. (1995)IL-2-secretingB cellsElectrophoretic mobility shift assays using protein extracts from EBV-B cells and the IL-2 NF-chi B probe revealed the constitutive generation of chi B complexes in IL-2-secreting cells consisting mainly of heterodimeric p50/p65 complexes.
Puett and Fuchs (1994)IL-2B cellStudies using supernatants from peripheral T lymphocytes of patients with scleroderma have shown increased levels of IL-2, IL-2 receptor, IL-4 and B cell growth factors, indications of activation of immune mechanisms.
Oudrhiri et al. (1985)IL 2B cellUsing recombinant IL 2 and anti-Tac monoclonal antibody as a probe for the IL 2 receptor, we demonstrate that the requirement of accessory cells (here an irradiated B cell line) in inducing IL 2 responsiveness relies on their enhancing effect in functional IL 2 receptor expression by the T colony progenitors.
Leanderson and Julius (1986)IL 2B cellIn B cell populations that did respond to IL 2, a population of Thy-1.2-positive cells appeared.
Drexler et al. (1988)IL-2B cellsOur data suggest that (a) B-CLL cells are able to respond to direct stimulation of the second messenger pathway (through protein kinase C) but not to the physiological stimuli IL-2 or BCDF; (b) the defect in signal transduction appears to be located upstream of protein kinase C (a possible candidate is a G protein); (c) malignant B cells may spontaneously or after treatment with inducers express the IL-2 receptor (Tac antigen) in the absence of a functional differentiating response to IL-2; and (d) signs of proliferation/differentiation in B-CLL samples after incubation with IL-2 or BCDF might be due to contamination of the cell populations with residual normal B cells.
Kabelitz et al. (1985)interleukin 2B cellsSynergistic action of phorbol ester and interleukin 2 in the induction of Tac antigen expression and interleukin 2 responsiveness in leukemic B cells.
Wallays and Ceuppens (1993)IL-2B cellsThe conditions necessary to induce proliferation and production of IL-2, TNF-alpha and GM-CSF by purified T cells, completely depleted of monocytes, B cells and NK cells, could be created by immobilizing PWM through absorption on autologous red blood cells (PWM-RBC), while soluble PWM was totally inactive.
Holder et al. (1993)IL-2B cellsWhile only 8% of cells within the GC cell-enriched fraction were CD5+ (compared with 15% of high density resting B cells), their removal led to an 83% reduction in the amount of IgM produced in response to IL-2, IL2 selectively expanded this minor CD5+ subset such that by day 6 of culture they comprised 57% of all viable cells.
Touw et al. (1987)IL2B cellTo determine the growth properties of B cell chronic lymphocytic leukemia (B CLL) and to identify possible abnormalities thereof, we examined the in vitro action of interleukin 2 (IL2) in four patients.
Kuhara et al. (1985)interleukin 2B cellsAntigen-nonspecific T cell-derived factors in B cell activation: differences in the requirements for interleukin 2 in responses of unprimed and primed B cells.
Kindler et al. (1995)IL-2B lymphocytesThis approach showed that B lymphocytes secreted IL-2 in the culture medium, but only if they were first activated for more than 24 h in the anti-CD40 system before exposure to PMA plus ionomycin.
Nakagawa et al. (1986)IL 2B cellsB cells in the earlier stage of activation only differentiated in response to IL 2 or IL 2 + IFN-gamma but not to BCDF, which was in contrast to B cells in the later stage that did not differentiate in response to IL 2 but did differentiate to BCDF.
Nakagawa et al. (1986)IL 2B cellsHowever, B cells in both stages proliferated in response to IL 2 but not to BCDF.
Tan et al. (1985)IL 2B cellMab 2A3 did not affect the T-independent B cell proliferation induced by anti-mu or SAC, but abrogated the enhancing effect of the PHA-MLR supernatant and IL 2 in this culture system.
Sinigaglia et al. (1985)IL 2B cellsIn the presence of Ni, they polyclonally activate autologous B cells, and in the presence of Ni and autologous EBV-B cells, they produce IL 2 and very high levels of IFN-gamma.
Suzuki and Cooper (1985)IL 2B cellsRelatively large B cells in fresh blood samples were found to express functional IL 2 receptors and were capable of a modest proliferative response to IL 2.
Suzuki and Cooper (1985)IL 2B cellsComparison of the expression of IL 2 receptors by human T and B cells: induction by the polyclonal mitogens, phorbol myristate acetate, and anti-mu antibody.
Suzuki and Cooper (1985)IL 2B cellsPMA induced both T and B cells to express functional IL 2 receptors before cellular proliferation.
Hashimoto et al. (1986)IL2B cellsThe following results were obtained: (a) B cells activated with LPS plus anti-Ig were found to proliferate in response to either recombinant IL2, T cell SN or fresh LPS; (b) a monoclonal anti-IL2 receptor antibody (PC61) could completely inhibit the effects of recombinant IL2 or various T cell SN (cloned T helper cell SN, EL4 SN, concanavalin A-spleen cell SN or mixed leukocyte culture SN), but did not interfere with the effect of LPS; (c) B cells activated with LPS or LPS plus anti-Ig were not found to secrete detectable amounts of IL2 by themselves.
Hashimoto et al. (1986)IL2B cellsMed. 1984. 160: 1070), it has been shown that B cells which have been activated with lipopolysaccharide (LPS) plus anti-Ig antibodies express interleukin 2 (IL2) receptors and proliferate in response to pure IL2.
Wigfall et al. (1988)IL-2B cellsThe significance of the increased IL-2 receptor expression on B cells of active SLE patients is unknown, but may represent a marker of polyclonal activation of these cells.
Emilie et al. (1987)interleukin 2B cellsUpon in vitro activation by Staphylococcus aureus Cowan I strain (SAC) human peripheral blood B cells produce only marginal amounts of Ig when cultured in the presence of interleukin 2 (IL2; 10 U/ml).
Ralph et al. (1984)IL 2B cellIn certain human IgM and IgG cell lines, immunoglobulin (Ig) secretion is highly stimulated by a B cell inducing factor (BIF) that is free of interleukin 2 (IL 2).
Lagoo et al. (1990)IL-2B cellsThe hypothesis that IL-2, which is produced in early G1, acts in late G1 and is required for G1 to S transition in B cells was supported by the following observations: (i) IL-2 production by B cells was detected as early as 6 hr after activation and preceded DNA synthesis by at least 24 hr.
Mouzaki et al. (1995)IL-2B cellIn the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.
Mouzaki et al. (1995)IL-2 promoterB cellIn seven EBV-B cell clones or lines differing in their capacity to secrete IL-2, the activity of the IL-2 promoter correlated well with the status of IL-2 secretion.
Saiki et al. (1988)IL-2B cellsH-31 antibody which recognizes Tac antigen did not inhibit the induction of Ig secretion by high concentrations of IL-2 in both Tac-negative and Tac-positive B cells, suggesting that IL-2 might induce Ig secretion through a receptor distinct from Tac antigens.
Saiki et al. (1988)IL-2B cellsAbout 50% of SAC-activated B cells, lacking Tac antigen, were also responsive to Ig secretion by IL-2, although the required dose of IL-2 was higher than that for Tac-positive B cells.
Steinberger et al. (1995)IL-2B cellsA detailed study of the IL-2 receptor of the patients' B cells, using the PCR technique and FACS analysis, showed that the cells express mainly the beta and gamma chains and at a lower level also the alpha-chain of the IL-2 receptor.
Volkman et al. (1984)IL-2B cellIn addition, some clones were also capable of producing both B cell growth factor and IL-2 following KLH stimulation.
Whisler and Newhouse (1985)IL 2B cellBoth interleukin 1 (IL 1) and IL 2 were capable of increasing the diminished B cell responses of certain elderly subjects while the responsiveness of other elderly subjects required either higher concentrations of IL 2 than young subjects or remained unchanged.
Kabelitz et al. (1985)IL 2B lymphocytesThese findings indicate that certain leukemic B lymphocytes can be induced to express IL 2 receptors and respond to IL 2.
Allavena et al. (1985)IL-2B-cellLGL in addition to mediating natural killer (NK) activity, can secrete a variety of lymphokines, depending on the stimulus used: interleukin-1 (IL-1), interleukin-2 (IL-2), interferon alpha and gamma (IFN), and B-cell growth factor (BCGF).
Sugie et al. (1991)interleukin 2B-cellSimilar induction of interleukin 2 receptor/p55 by the cross-linking of Fc epsilon RII was observed on an Epstein-Barr virus-transformed B-cell line, 3B6, and fresh leukemic cells isolated from a patient with B-cell chronic lymphoblastic leukemia.
Teranishi et al. (1984)IL 2B cellsBoth preparations of IL 2 by themselves were not enough to induce optimal IgG-production in the SAC-stimulated tonsillar B cell fraction, which was highly enriched for B cells, but effectively induced IgG production in the presence of a subeffective number of T cells or a late-acting B cell differentiation factor (BCDF).
Teranishi et al. (1984)IL 2B cellAlthough the mechanisms of this effect remain to be elucidated, a direct effect of IL 2 on B cells may be involved, because the addition of IL 2 along with SAC induced a limited but significant increase of 3H-TdR incorporation in the highly enriched B cell population, which showed very little response to PHA and Con A even in the presence of IL 2, and, as mentioned above, IL 2 induced IgG production in the B cell preparation without any supplement of T cells provided the late-acting BCDF fraction was present in the culture.
Blanchard et al. (1994)IL-2B cellsPreactivated T cells induced B cells to grow and secrete immunoglobulins preferentially in response to IL-2.
Boyd et al. (1985)IL 2B cellAnti-IL 2R antibody blocked the effect of IL 2 but not the proliferative response induced by B cell growth factor (BCGF), suggesting independent growth factor receptors.
Foa et al. (1988)IL2B-cellIn particular, evidence is provided for a likely role of interleukin 2 (IL2) on the neoplastic B-cell compartment.