Viewing affirmative mentions of localization of IL2 (H. sapiens) in NK cells

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Orvieto et al. (1997)interleukin-2large granular lymphocytesIt may therefore be speculated that interleukin-2 secreted by human embryos may modulate the function and replication of large granular lymphocytes.
Hu et al. (1999)IL-2natural killer cellsRESULTS: The supernatant of the cultured non-immunological cells of decidua can inhibit the immunological function of T cells, natural killer cells and B cells to different extents, their maximum inhibiting ratio were 22.7%, 52.3% and 14.8% respectively, but there is no significant effect on the IL-2 secretion by lymphocytes.
Nagashima et al. (1998)IL-2NK cellsUpon selection in the presence of increasing G418 concentrations, transduced NK cells were able to proliferate independently of IL-2 for more than 5 months and to secrete up to 5.5 ng/10(6) cells/24 h of IL-2.
Nagashima et al. (1998)IL-2NK cellsThus, transduced NK cells secreted sufficient quantities of bioactive IL-2 to proliferate in vitro and mediated the antitumor effects both in vitro and in vivo in the absence of exogenous IL-2.
Neville et al. (2000)IL-2NK cellsThus, Oncolipin is receptor-targeted to activated T and NK cells by virtue of its surface expression of IL-2 and has the potential to release IL-2 following deposition within lymphoid organs.
Hayward et al. (1986)IL-2NK cellsThe results indicate that NK cells contribute to the lysis of VZV infected cells and suggest that IL-2 release by T cells, as a result of HLA matching or antigen representation, may amplify this mechanism.
Zeimet et al. (1996)IL-2natural killer cellsProtein 90K is a tumor-associated antigen, which is able to enhance the cytotoxic activity in lymphokine-activated and natural killer cells as well as the IL-2 release in peripheral blood lymphocytes.
Nagaraj et al. (2004)IL-2NK cellIL-2 secretion by the CIK cells enhances the NK cell antitumor activity [20].
Egilmez et al. (1998)IL-2natural killer cellsThe antitumor effect of IL-2 released by the microspheres was shown to be mediated by the mouse natural killer cells.
Manning et al. (1989)IL-2-activatedNK cellThe results of this study demonstrate that although human malignant mesothelioma cells are resistant to NK cell lysis, IL-2-activated LAK cells effectively kill these targets.
Martin et al. (2010)IL-2NK cellsIn contrast, IL-2 signaling on CD56(bright) NK cells was not inhibited by Dac and their in vivo proliferation and cytotoxicity actually increased.
Krishnaraj and Bhooma (1996)IL2NK cellIn view of the major immunomodulatory role of IL2 and the anti-tumor effects of interferon gamma (IFN-gamma), we have investigated the recombinant human IL2-induced NK cell secretion of IFN-gamma in vitro.
Krishnaraj (1997)IL-2-inducibleNK cellsTo investigate if the non-cytotoxic functions of NK cells are also spared from the influence of senescence, recombinant IL-2-inducible secretion of IFN-gamma, which serves as a first line of defense, was examined.
Armant et al. (1995)interleukin-2natural killer cellsHuman natural killer cells (NK) respond to interleukin-2 (IL-2) with augmented cytolytic activity, cytokine secretion and cell proliferation.
Wang et al. (2009)IL-2NK cellNaturally occurring CD4(+)CD25(+) T regulatory cells can inhibit NK cell cytotoxicity, while activated interleukin-2 (IL-2) secreting T cells can stimulate NK cells.
Bhat et al. (2007)IL-2NK cellsTo test whether other factors can modulate NK cell killing activity and subsequently killing frequency, we stimulated freshly isolated human NK cells with IL-2, IL-15, IFN-?
Heslop et al. (1989)IL2NK cellsIn both groups of patients, IL2 acts on CD3+ T cells and on CD16+ NK cells so that depletion of either subset incompletely abrogates IL2 dependent gamma-IFN secretion.
Jewett and Bonavida (1995)interleukin-2natural killer cellsInterferon-alpha activates cytotoxic function but inhibits interleukin-2-mediated proliferation and tumor necrosis factor-alpha secretion by immature human natural killer cells.
Bhat et al. (2007)IL-2NK cellsThe isolated NK cells were then cultured in presence of IL-2 and killing activity was examined.
Jewett et al. (2010)IL-2NK cellssecretion by the IL-2 and anti-CD16 mAb treated NK cells to the levels which were observed when these cells were cultured with monocytes and stem cells (Fig. 9).
Marzusch et al. (1997)interleukin-2large granular lymphocytesInterleukin-12- and interleukin-2-stimulated release of interferon-gamma by uterine CD56++ large granular lymphocytes is amplified by decidual macrophages.
Tomescu et al. (2009)IL-2NK cellsRetention of viability, cytotoxicity, and response to IL-2, IL-15, or IFN-alpha by human NK cells after CD107a degranulation.
Beach and Whalen (2006)IL-2NK cellsThe two compounds that retained their capacity to decrease NK lytic function in T/NK cells, oxychlordane (5 microM) and PCP (5 and 10 microM), were able to either decrease the secretion of NK-stimulatory ILs (IL-2, IL-12 and/or IL-10) and/or increase secretion of the NK-inhibitory cytokine, IL-4, at each length of exposure tested.
Jewett et al. (2010)IL-2NK cellsFinally, as expected IL-2 treated NK cells secreted moderate amounts of IFN-?
Staege et al. (2003)IL-2natural killer cellsAfter gamma-irradiation, transfected clones released bioactive IL-2 in a quantity sufficient to activate T and natural killer cells in culture.
Yang et al. (2006)IL-2NK cellsThe results showed that thalidomide enhanced the proliferations of the CD8+ T, NK cells in PHA-stimulated PBMNC from healthy volunteers, increased the secretion of IL-6 significantly, and decreased the secretion of IFN-gamma, and the secretions of IL-2 and IL-10 were not affected.
Procopio et al. (1988)IL-2LGLUnder these conditions high levels of IL-2 activity were released by the LGL.
Markham et al. (1996)IL-2NK cellsSpecifically, R-verapamil inhibited BLT esterase release from resting but not IL-2 activated NK cells.
Tseng et al. (2010)IL-2NK cellsLysis of hESCs, hiPSCs, hDPSCs, and hMSCs by untreated and IL-2 treated NK cells is inhibited by anti-CD16 antibody treatment, however, the same treatment induced significant secretion of IFN-?
Tseng et al. (2010)IL-2NK cellsLysis of hMSCs by untreated and IL-2 treated NK cells is inhibited by monocytes, however, the addition of monocytes induced significant secretion of IFN-?
Tseng et al. (2010)IL-2NK cellsHMSCs are significantly more sensitive to lysis by IL-2 treated NK cells than their differentiated counterparts and they trigger significant release of IFN-?
Tseng et al. (2010)IL-2NK cellsUndifferentiated hMSCs were significantly more sensitive to lysis by IL-2 treated NK cells when compared to their differentiated counterparts (Fig. 5F), and triggered significant secretion of IFN-?
Tseng et al. (2010)IL-2NK cellsThere was a direct correlation between secretion of bFGF by stem cells and cytotoxicity by IL-2 and IL-2+anti-CD16 mAb treated NK cells (Figs. 3C, 3F, 3I, and 3L).
Tseng et al. (2010)IL-2NK cellsAs expected IL-2 treated NK cells secreted moderate amounts of IFN-?
Carrega et al. (2009)IL-2NK cellsFor generation of polyclonal NK cell population, the highly purified magnetically selected NK cells were cultured on irradiated feeder cells in the presence of 100 U/ml recombinant interleukin 2 (IL-2) (Proleukin, Chiron Corp, Emeryville, CA) and 1.5 ng/ml phytohemagglutinin (PHA) (GIBCO BRL, Carlsbad, CA).
Tseng et al. (2010)IL-2NK cellsUntreated or IL-2 treated NK cells were added to EGFP or I?
Renard et al. (1997)lymphokinelarge granular lymphocytesNK-cells are large granular lymphocytes, which are capable of exerting two major types of effector function, cell cytotoxicity and lymphokine secretion.
Chan et al. (2010)IL2NK cellsMoreover, the addition of IL2 to NK cells led to aberrant nuclear translocation of BCL10, which is a pathological feature of ENKLs.
Nagashima et al. (1997)IL-2-secretingNK cellsTumor regression was mediated by numerous mononuclear cells, identified as murine NK cells and macrophages by immunohistochemistry, which accumulated around the IL-2-secreting, but not parental, tumors within 5-6 days after tumor cell injections.
Riederer et al. (2010)IL-2NK cellsEnriched NK cells were either un-stimulated (Figure 2, grey bars) or were stimulated with Hsp70 peptide TKD plus low dose IL-2 (TKD/IL-2) for 4 days (Figure 2, black bars).
Riederer et al. (2010)IL-2NK cellsWe have previously shown that transfection of HLA-E down-regulates the cytolytic response of TKD/IL-2-activated NK cells against tumor cells [54].
Riederer et al. (2010)IL-2NK cellsUn-stimulated NK cells or NK cells stimulated with TKD (2 g/ml) and IL-2 (100 IU/ml) were then added to the ECs at various effector to target (E?
Bricard et al. (2010)IL-2NK cells, IL-4 and IL-2 secretion from human iNKT cells [13] and possibly also for the secondary transactivation of NK cells based on findings from our study.
Pistoia et al. (1986)IL2LGLHowever, LGL released variable amounts of IL2 and gamma-interferon (gamma-IFN) after PHA stimulation.
Solerte et al. (2005)IL-2-modulatedNK cellsA decrease in spontaneous and IL-2-modulated TNF-alpha release from NK cells was also found in both groups of patients (P<0.001).
Flamand et al. (1996)IL-2NK cellThe induction of NK cell activity by HHV-6 was abrogated by monoclonal antibodies (mAbs) to IL-15 but not by mAbs to other cytokines (IFN-alpha, IFN-gamma, TNF-alpha, TNF-beta, IL-2, IL-12) suggesting that IL-15 secreted in response to viral infection was responsible for the observed effect.
Mizrahi et al. (2007)IL-2-activatedNK cells120kDa, figure 3A) and also observed that IL-2-activated NK cells secrete sCD100 (data not shown) and thus we suggest that NK cells are the early source for CD100.
Kapur et al. (1994)lymphokineNK cellThis molecule is involved in NK cell function as anti-FAM MoAbs inhibit cytotoxicity, stimulate lymphokine secretion and inhibit conjugate formation between effector cells and target cells.
Melder et al. (2005)IL-2NK cellsMETHODS: The effect of Albuleukin on lymphocyte proliferation, IL-2 receptor binding, and release of IFN-gamma from human NK cells were examined in vitro.
Johann et al. (2010)IL-2NK cellsNK cells were cocultured with TStrC for four days at a ratio of 4:1 in presence of 100 U/ml IL-2 where indicated.
Caccavo et al. (2002)IL-2natural killer cellLactoferrin exerts a bactericidal activity by damaging the outermembrane of Gram-negative bacteria, as well as immunoregulatory functions by decreasing the release of interleukin-l (IL- 1), IL-2 and tumor necrosis factor-alpha INF-alpha) and enhancing monocyte and natural killer cell cytotoxicity.
Nannmark et al. (1995)interleukin 2-activatedNK cellsTo elucidate the role of tumor vascularization on the localization of adoptively transferred, interleukin 2-activated natural killer (A-NK) cells, pulmonary B16 melanoma metastases were analyzed with respect to location, morphological appearance, origin and density of microvessels, and infiltration by A-NK cells.
Solerte et al. (2000)IL-2-inducedNK cellsIncreased spontaneous and IL-2-induced release of IFN-gamma and TNF-alpha from NK cells were found in DAT patients compared to healthy subjects (p < 0.001), whereas no difference of serum IFN-gamma and TNF-alpha was demonstrated between DAT and control groups.
De Sanctis et al. (1997)interleukin-2natural killer cellsSecretion of cytokines by natural killer cells primed with interleukin-2 and stimulated with different lipoproteins.
Wittnebel et al. (2007)IL-2-starvedNK cellsFurthermore, we show that MbIL-15 from renal cell carcinoma cells is functional and involved in rapid nuclear translocation of phosphorylated signal transducers and activators of transcription 3 in IL-2-starved NK cells.
Horowitz et al. (2010)IL-2NK cellsIn this study, we demonstrate that NK cell IFN-gamma responses to P. falciparum-infected RBCs are also crucially dependent on IL-2 secreted by CD4(+) T cells in an MHC class II-dependent manner, indicating that the innate response to infection actually relies upon complex interactions between NK cells, T cells, and accessory cells.
Sadi et al. (2008)IL-2NK cellsAutologous NK cells were sorted and either kept unstimulated in the presence of suboptimal concentration of IL-2, or activated by a combination of PHA and IL-2.
Brenner et al. (1986)interleukin 2LGLsIn the first 4-6 weeks after BMT these LGLs were found spontaneously to secrete interleukin 2, interferon gamma and B cell differentiation factor.
Ramana Rao et al. (2010)IL-2NK cellsBasal type 1 cytokine (IL-2, interferon-gamma [IFN-gamma], and tumor necrosis factor-alpha [TNF-alpha])-secreting NK cells (NK1 cytokines) were decreased significantly (P < 0.05) in TB, HIV, and HIV-TB, when compared with NHS.
Khan et al. (1988)lymphokineNK cellAccordingly, we have identified an Ag-specific subset of CD4-, CD8+, P30 responder T cells that are directly parasiticidal to extracellular T. gondii, and that exhibit cytotoxicity independent of antibody opsonization, lymphokine secretion, NK cell activity, and, apparently, MHC involvement as well.
Solerte et al. (2000)IL-2-modulatedNK cellsIn particular, hyperfibrinogenemia and the increase of erytrhocyte aggregation were correlated with the increased generation and release of TNF-alpha and IFN-gamma (spontaneous release and IL-2-modulated release) from natural killer (NK) lymphocytes (CD16+, CD56+, CD3- cells) of patients with DAT; whereas a normal cytokine release from NK cells was found in healthy old subjects and in patients with vascular dementia (VaD).
Rajagopalan et al. (2001)IL-2-inducedNK cellsThe induction by KIR2DL4 of IFN-gamma production by resting NK cells was blocked by an inhibitor of the p38 mitogen-activated protein kinase signaling pathway, in contrast to the IL-2-induced IFN-gamma secretion that was sensitive to inhibition of the extracellular signal-regulated kinase mitogen-activated protein kinase pathway.