Viewing affirmative mentions of protein catabolism of IL2 (H. sapiens)

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Fleischmann et al. (1990)IL-2IL-2-IN activity is susceptible to bacterial and endogenous urinary proteolysis.
Shaw et al. (1988)IL-2 mRNAThe decline occurs despite a high rate of synthesis, and appears to be due to an enhanced rate of IL-2 mRNA degradation.
Shaw et al. (1988)IL-2 mRNAThe degradation of IL-2 mRNA is selectively sensitive to cycloheximide and actinomycin D, inhibitors of protein and RNA synthesis, respectively.
Fujii et al. (1986)IL-2The internalized IL-2 was rapidly degraded and the products were excreted into the culture fluid.
Fujii et al. (1986)IL-2The t1/2 of IL-2 degradation in these cells was estimated as 60-80 min at 37 degrees C.
Fujii et al. (1986)IL-2The internalization and degradation of IL-2 were both temperature dependent.
Ohmura and Onoue (1990)IL-2 mRNAIL-2 mRNA produced was rapidly degraded when the stimulants were washed out at 12 h and the cells further cultured in the presence of actinomycin D, which stops mRNA synthesis.
Legrue et al. (1991)IL-2These observations support the hypothesis that IL-2/IL-2R endocytosis and ligand/receptor processing or degradation may be important steps in lymphokine signal transduction.
Robb et al. (1981)TCGFIn addition, at 37 degrees C, a receptor- and lysosome-dependent degradation of TCGF occurred.
Wang et al. (2008)IL-2During storage, both glycosylated and unglycosylated IL-2 mutein form aggregates (soluble and insoluble) and other degradation products.
Tanaka et al. (1988)IL-2The acid-wash technique revealed that more than 60% of 125I-labeled IL-2 bound to the cells became acid-unremovable in the first 30 min of incubation at 37 degrees C and degradation products of 125I-IL-2 increased after 30 min of incubation.
Legrès et al. (1995)IL-2The degradation of uncomplexed 125I-rhIL-2 has also been observed in the presence of trypsin, whereas 125I-rhIL-2 bound to alpha 2M-MA is protected.
Noma et al. (1984)IL2Bestatin therefore increases both IL2 sensitivity and IL2 production.
Kolosov et al. (1992)interleukin-2In the course of translation of mRNA the interleukin-2 becomes aggregated due to the adsorption of this protein onto the ribonucleoprotein complex.
Yamada et al. (1995)interleukin-2[Wilson-Jones type angiosarcoma with marked response to intrapleural administration of interleukin-2].
D’Alessandria et al. (2009)99mTc-HYNIC-IL2Stability of 99mTc-HYNIC-IL2
Soiffer et al. (1994)IL-2We have previously shown that IL-2 administered to patients at very low doses after BMT is both clinically tolerable and immunologically active.
Corbo et al. (1987)IL2All the four IL2-secreting clones integrated in the mouse genome the human IL2 gene.
Yen et al. (2000)IL-2Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin.
Liang et al. (1989)IL-2In addition, the degradation of IL-2 in the cells was enhanced by GSH treatment.
Fallon et al. (2000)IL-2We demonstrate here that the internalization kinetics of 2D1 via the high affinity IL-2 receptor are equivalent to those of WT but that a significantly increased fraction of internalized 2D1 is sorted to recycling instead of to lysosomal degradation.
Borth and Teodorescu (1986)IL-2Soybean trypsin inhibitor coupled to Sepharose 4B was capable of absorbing the IL-2 degrading activity from the trypsin solution.
Podtschaske et al. (2007)IL-2Control steps in activation-induced IL-2 expression and relevant for this switch decision influenced by ionomycin or CsA could be (i) the IL-2 mRNA formation and its degradation, (ii) IL-2 promoter accessibility for the initiation of IL-2 mRNA transcription, (iii) cooperative and synergistic interaction between the transcription factors NFAT, NF-?
Farag et al. (2002)IL-2PURPOSE: The purpose of the study is to investigate the tolerability of interleukin 2 (IL-2) after intensive chemotherapy in elderly acute myeloid leukemia (AML) patients in first complete remission (CR).
Wu et al. (1986)IL-2In addition, there was no evidence of an age-related change in IL-2 mRNA degradation or the post-transcriptional processing of IL-2 mRNA.
Itescu et al. (1997)IL-2Following treatment with TNFa at 1 u/ml, IL-2 activated human NK lysis of PAEC was inhibited at every effector:target (E:T) ratio tested.
Makedonas et al. (2010)IL-2, IL-2, and degranulation.
Miedel et al. (1989)interleukin-2Limited proteolysis of a recombinant, soluble form of the Tac protein, a human interleukin-2 receptor (rIL-2R), was performed using trypsin, Staphylococcus aureus V8 protease and proteinase K to study the structural requirements of interleukin-2 receptor (IL-2R) for interleukin-2 (IL-2) binding.
Ke et al. (2002)IL-2It is concluded that after MLR, B 7 increased IL-2 secretion by decreasing the degradation of IL-2 mRNA and upregulating IL-2 transcription factors.
Cha et al. (1997)IL-2Since both GFP and IL-2 were rapidly degraded by protease activity during the fourth day post-infection (another disadvantage with larvae), we found an accurate determination of harvest time was critical.
Kenney et al. (1986)IL-2Parameters for the evaluation of IL-2 stability.
Kenney et al. (1986)interleukin-2Recombinant DNA derived interleukin-2 stability in accelerated and long term studies was evaluated using biological and protein chemical methods.
Cadée et al. (2002)rhIL-2In contrast with non-degradable dex-MA hydrogels, degradable dex-lactate-HEMA gels with comparable network characteristics (degree of methacrylate substitution and initial water content) showed an almost zero-order, degradation controlled release of rhIL-2 in a time period of 5-15 days.
Roifman et al. (1985)IL-2Comparative studies are necessary to demonstrate the efficacy, species specificity, and stability of recombinant IL-2.
Safar and Junghans (2000)IL2The manufacturer's data indicate stability of the IL2 for a period of 6 days.
D’Alessandria et al. (2009)IL2Due to the limited stability of IL2 at pH?
Hopkins and Failla (1999)IL-2 mRNAIL-2 mRNA stability in parental Jurkat cells was independent of Cu status.
Smith (2006)IL2-bound IL2 being stabilized by binding to isolated ?
Ohmura and Onoue (1990)IL-2 mRNAHowever, the stability of IL-2 mRNA was increased by the addition of PDB or A23187.
Ohmura and Onoue (1990)IL-2 mRNAThe effect of PDB was dose-dependent and inhibited by the inhibitors of protein kinase C (PKC), staurosporine, and K252a, suggesting the involvement of PKC in the control of IL-2 mRNA stability.
Ohmura and Onoue (1990)IL-2 mRNAThe involvement of protein phosphorylation in the regulating mechanism of IL-2 mRNA stability was supported by the fact that the addition of okadaic acid, which inhibits serine/threonine protein phosphatases, resulted in an increase in the stability of IL-2 mRNA.
Ohmura and Onoue (1990)IL-2 mRNAThese results indicate the presence of a mechanism controlling the stability of IL-2 mRNA that is regulated by PKC.
Lowenthal et al. (1986)IL2These results provide ultrastructural information on the intracellular pathway of IL2 and on its probable site of degradation within the cell.
Hua et al. (1993)IL2 mRNAThe mRNase cleaves IL2 mRNA at a small number of sites in the coding region, and IL2 mRNA containing only the coding region and 36 nucleotides of the 3'-noncoding region competes efficiently with full-length IL2 mRNA for the mRNase, whereas beta-globin mRNA does not.
Hua and Paetkau (1996)interleukin 2 mRNAPreparations of the binding factor also protect interleukin 2 mRNA against degradation by a recently described RNasin-resistant endoribonuclease activity in Jurkat cells.
Wang et al. (2008)IL-2The thermal stability of IL-2 mutein was studied by DSC and UV.
Wang et al. (2008)IL-2SAIn summary, we found that the dual effects of Tween 80 on the stability of IL-2SA, such as that shaking-induced aggregation of IL-2 mutein was significantly inhibited in the presence of Tween 80.
Wang et al. (2008)IL-2However, this surfactant adversely affected the stability of IL-2 mutein in solution during storage in terms of both oxidation and aggregation.
Tanaka et al. (1988)IL-2Novel IL-2-binding molecules (p70 and p75) mediating internalization and degradation of IL-2 were examined by employing a human B lymphoblastoid line, SKW6-4 cells.
Shackelford and Trowbridge (1986)interleukin-2The human interleukin-2 (IL-2) receptor was quantitatively cleaved into two large disulfide-bonded fragments by either trypsin or endoproteinase lys-C (endo lys-C).
Reyes et al. (2005)interleukin-2Stability of Ala 125 recombinant human interleukin-2 in solution.
Tzannis et al. (1996)interleukin 2We studied both the bioactivity and physical stability of interleukin 2 upon delivery via continuous infusion.
Klimka et al. (2003)interleukin-2Construction of proteolysis resistant human interleukin-2 by fusion to its protective single chain antibody.
Baig et al. (2005)IL-2IL-2 degradation was completely inhibited by 1,10 phenanthroline and partially inhibited by bestatin, suggesting that a metallo-aminopeptidase was responsible.
Kojiro et al. (1989)recombinant interleukin-2[Intrapleural administration of recombinant interleukin-2 in a patient with pleural effusion due to non-Hodgkin's lymphoma].
Henics et al. (1994)lymphokineThese findings suggest a direct correlation between differential binding of cytoplasmic proteins to AU-rich 3'-UTRs in vitro and lymphokine mRNA stability in vivo.
D’Alessandria et al. (2009)99mTc-HYNIC-IL2The stability of 99mTc-HYNIC-IL2 was evaluated by incubating 100 µl of 99mTc-HYNIC-IL2 in 900 µl of either human serum or saline for 24 h at 37°C.
D’Alessandria et al. (2009)99mTc-HYNIC-IL2Fig. 5Analysis of 99mTc-HYNIC-IL2 stability in human serum, saline, and DTPA solution after purification by tC2 Sep-Pak.
Yu and Malek (2001)IL-2Therefore, a functional proteasome is required for optimal endocytosis of the IL-2R/ligand complex and is essential for the subsequent lysosomal degradation of IL-2, possibly by regulating trafficking to the lysosome.
Henics (1999)interleukin 2Our findings may explain some aspects of differential regulation of interleukin 2 (IL-2) and TNFalpha mRNA stability upon microfilament disruption in human PBMCs observed in an earlier study.
Miedel et al. (1989)interleukin-2Limited proteolysis of recombinant human soluble interleukin-2 receptor.
Ansorge and Schön (1987)lymphokineThese data, together with other features of the DP IV, support the notion that this enzyme plays a key role in the modulation of lymphokine action by X-Pro- or X-Ala-directed limited proteolysis.
Calvo (1994)IL-2In contrast, a posttranscriptional alteration of the IL-2 mRNA is shown, by demonstrating that the degradation rate of IL-2 mRNA following the addition of actinomycin D, at 4 h, was delayed in the (PHA+PMA)-activated cell cultures containing 10(-12) M of SP.
Yu and Malek (2001)interleukin-2In the present study, we investigated the role of the proteasome for ligand-dependent endocytosis and degradation of the interleukin-2 (IL-2)-interleukin-2 receptor (IL-2R) complex.
Kuo et al. (1998)IL-2A sequence-similarity search in the GenBank database indicates that the major sequence of 1.7-kb L1 is integrated in human retinoblastoma (Rb), IL-2, and factor VIII genes.
Robb and Greene (1987)IL-2The kinetics of IL-2 internalization mediated by the intermediate-affinity beta chain were nearly identical to those of the high-affinity alpha/beta heterodimer (t1/2 of 10-15 min), and each type of receptor targeted the bound IL-2 for intracellular degradation in lysosomes.
Hanke et al. (1992)IL-2FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA.
Zhu et al. (1995)IL2The mRNA stability assay showed that THC increased the stability of IL2 beta mRNA, and nuclear run-on experiments suggested that the increase in subunit production was not due to a drug effect on gene transcription.
Foss et al. (1994)IL2Incubation of all seven patients' cells with IL7 induced coexpression to varying degrees of IL7-R and IL2-R.
Shreffler et al. (2006)IL-2Cryopreserved PBMC from renal carcinoma patients have been shown to retain proliferative capacity to IL-2, capacity to generate cytolytic activity, and secretion of PHA-induced IFN-?
Parmely et al. (1993)lymphokineThis effect was not seen in the absence of plasminogen, was prevented by inhibitors of uPA and plasmin, and was accompanied by changes in the electrophoretic mobility of rIFN-gamma on polyacrylamide gels, consistent with limited proteolysis of the lymphokine.
Wrenger et al. (1996)IL-2Here we show that the N-terminal amino acid sequence of Tat is essential for the inhibition of DP IV-catalyzed IL-2(1-12) degradation.
Hacein-Bey et al. (1996)IL-2The expressed gamma-c was functional, because it restored high-affinity IL-2 receptor binding, IL-2 endocytosis, and IL-2-triggered phosphorylation of JAK-3 tyrosine kinase.
Ihn et al. (1995)interleukin-2Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma.
Shim et al. (2002)IL-2NF90, a previously described RNA binding protein, binds to a subregion of the 3'UTR that contains several AREs and slows down the degradation of IL-2 mRNA.
Horvat et al. (1989)lymphokinePreformed E-alpha 2-M complexes, although ineffective by themselves at cleaving IFN-gamma, degraded the lymphokine, providing AP was also present in the reaction mixture.
Quéméneur et al. (2002)IL-2Finally, MPA does not interfere with IL-2-dependent acquisition of susceptibility to CD95-mediated apoptosis and degradation of cellular FLIP.
Zhang et al. (1993)lymphokineThe degradation of some proto-oncogene and lymphokine mRNAs is controlled in part by an AU-rich element (ARE) in the 3' untranslated region.
Zhou et al. (2009)IL-2This may due to immunoloregulation activity of 1 by improving the WBC, IL-2 and INF-gamma degraded by CTX.
Sanchez-Lockhart et al. (2004)IL-2In contrast, mutation of the PI3K interaction site had no effect on the ability of CD28 to enhance IL-2 mRNA stability.
Russell et al. (1994)IL-2IL-2, IL-4, IL-7 (whose receptors are known to contain gamma c), and IL-9 (whose receptor is shown here to contain gamma c) induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases Jak1 and Jak3.
Brenu et al. (2010)IL-2Certain cytokines increase cytotoxic ability (IL-2) and IFN-?
Kuo et al. (1991)interleukin-2Proteolysis of interleukin-2, interferon and immunoglobulin by venoms.
Kuo et al. (1991)interleukin-2The venom from Crotalus atrox degraded interferon, interleukin-2, IgG, IgM, and a crude form of acetyl cholinesterase but had no effect on IgA.
Yamasawa et al. (2002)pT factorHowever, Gadd45 expression correlated significantly with the grade of the pT factor of the tumors.
Brennan et al. (2000)lymphokineAU-rich elements (AREs) present in the 3' untranslated regions of many protooncogene, cytokine, and lymphokine messages target them for rapid degradation.