Viewing affirmative mentions of gene expression of CD69 (H. sapiens) in T cells

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Morgan et al. (1999)CD69T-lymphocytesInduction of surface antigen CD69 expression in T-lymphocytes following exposure to actinomycin D.
Morgan et al. (1999)CD69T-lymphocytesPretreatment of PBMC suspensions with low, non-toxic levels of actinomycin D stimulated CD3+ T-lymphocytes to express CD69 in a concentration-dependent manner.
Cambiaggi et al. (1992)CD69T-cellConstitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12.
Hutchinson et al. (1999)CD69T-cellMitogen-induced T-cell CD69 expression is a less sensitive measure of T-cell function than [(3)H]-thymidine uptake.
Hutchinson et al. (1999)CD69T-cellRecent reports have suggested that flow cytometric analysis of CD69 expression may be a simpler and faster means of measuring T-cell function.
Hutchinson et al. (1999)CD69T-cellWe address this issue by concurrently measuring mitogen-stimulated T-cell CD69 expression and [(3)H]-thymidine incorporation in a normal population and five immunocompromised patients negative for the human immunodeficiency virus (HIV).
Hutchinson et al. (1999)CD69T-cellHowever in 7 out of 8 of the patient tests, mitogen-induced T-cell CD69 expression was within the normal range.
Hutchinson et al. (1999)CD69T-cellThis study indicates that measurement of mitogen-induced T-cell CD69 expression lacks sensitivity in determining T-cell dysfunction in HIV-negative immunodeficient patients.
Lina et al. (1998)CD69T lymphocytesThe presence of staphylococcal superantigenic toxins in the supernatants of liquid cultures was detected by an easy and rapid method assessing the activation of T lymphocytes by cytofluorimetric measurement of CD69 expression.
Lina et al. (1998)CD69T cellsSupernatant fluids from all S. aureus strains producing superantigen-related toxins, including enterotoxins A to E, toxic shock syndrome toxin, and exfoliative toxins A and B, induced CD69 expression in a significantly higher number of T cells than a cutoff of 2%.
López-Cabrera et al. (1995)CD69T-lymphocytesAlthough the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T-lymphocytes located in the inflammatory infiltrates of several human diseases.
Brush et al. (2006)CD69T cellsThe results demonstrate that Echinacea, Astragalus and Glycyrrhiza herbal tinctures stimulated immune cells as quantified by CD69 expression on CD4 and CD8 T cells.
Cheel et al. (2010)CD69T cellsAlthough the effect of LI on the CD69 expression was moderate, this fact could be hypothetically interpreted as beneficial, given that increased level of CD69 expression on T cells has been associated with some autoimmune diseases.[2224] Licorice has multiple constituents and not one active ingredient; therefore, it is possible that they are able to act in a regulatory way, both activating and modulating the immune response.
Cheel et al. (2010)CD69T cellsRecently, tinctures of Echinacea purpurea, Astragalus membranaceus, and G. glabra were shown to stimulate T cells, determined by CD69 expression.
Serra et al. (1996)CD69T cellsThe expression of CD69, the earliest inducible antigen which appears with T lymphocyte activation, was assessed in T cells cultured with medium, anti-CD3 or PMA.
Serra et al. (1996)CD69T cellsIn elderly people, the expression of CD69 was lower in T cells cultured with medium [3.4% (1.65-5.9; 25-75 percentiles) vs. 10% (6-18), p < 0.0003] and anti-CD3 activated [28.1% (16.5-53.8) vs. 79.5% (73-89), p < 0.0002] T cells.
Serra et al. (1996)CD69T cellsWith PMA at 10 ng/ml, CD69 expression was higher in both groups of T cells, though still lower in the aged [84.5% (70.9-94.9) vs. 99% (65.7-100), p = 0.051].
Serra et al. (1996)CD69T cellsCD69 T cells expression was equal in both groups with 2 ng/ml of PMA, but the co-stimulatory responses to CD69 under these conditions and in the presence of anti-CD3 were lower in the aged (16914 vs. 28904 cpm, p < 0.02) and (6944 vs. 14370 cpm, p < 0.02) respectively.
Moniuszko et al. (2002)CD69T lymphocytes[The role of monocytes stimulated with LPS on CD69 expression in T lymphocytes of patients with non-atopic asthma].
Moniuszko et al. (2002)CD69T cellsWe have studied the ex-pression of CD69 on LPS-stimulated T cells in nonatopic bronchial asthma.
Moniuszko et al. (2002)CD69T cellsWe have found that CD69 expression on freshly isolated peripheral blood T cells in nonatopic asthma patients was increased compare to control group (4.74 +/- 1.55/3.05 +/- 1.31) and the difference was statistically significant (p < 0.01).
Moniuszko et al. (2002)CD69T cellMonocytes added to nonstimulated T cell cultures increased 3-4 times the expression of CD69 and about 10-times in LPS-stimulated T lymphocytes.
Sun and Shi (2001)CD69T-cellWe have shown that apoptotic cells could inhibit the expression of CD69 during T-cell activation.
Granchi et al. (2000)CD69T lymphocytesPBMCs were cultured with the metal ions employed for implant manufacturing and the expression of CD69 activation antigen on CD3/T lymphocytes was detected by flow cytometry.
Dietzmann et al. (2002)CD69T-cellT-cell activation in response to pokeweed mitogen was analyzed by CD69 expression; cytokines were determined in cell culture supernatants.
Maino (1998)CD69T cellsMultiparameter analysis of CD69+ /cytokine + expression in T cells in response to specific antigen (e.g.
Ampel et al. (2002)CD69T lymphocytesThese data indicate that in vitro assessment of CD69 expression on T lymphocytes by using T27K may be a useful measure of cellular immune response among subjects with active coccidioidomycosis.
Santis et al. (1995)CD69 mRNAT lymphocytesThe expression time course of CD69 mRNA has previously been reported to be transient, peaking around 3 h after induction in T lymphocytes, and declining to nearly resting levels by 8 h.
Yan and Lu (2007)CD69T cellsThe expression of CD69 on T cells was analyzed by flow cytometry.
Yan and Lu (2007)CD69T cellsBoth PF and CsA could downregulate the expression of CD69 on T cells which had been stimulated by PMA plus ionomycin (PF vs CsA, P > 0.05).
Romano et al. (2000)CD69T lymphocytesInterestingly, these cells are more activated in the elderly than in young subjects; expression of CD69, an early activation marker, is increased in gammadelta T lymphocytes from old subjects after three hours of in vitro culture both with and without lipopolysaccharide stimulation.
Mardiney et al. (1996)CD69T-cellMeasurement of T-cell CD69 expression: a rapid and efficient means to assess mitogen- or antigen-induced proliferative capacity in normals.
Mardiney et al. (1996)CD69T cellsWe have analyzed the expression of the activation antigen CD69 on normal human T cells by flow cytometry following stimulation with mitogens and recall antigen.
Taylor-Fishwick and Siegel (1995)CD69T cellsRaf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells.
Taylor-Fishwick and Siegel (1995)CD69T cellsUsing transient transfection, we have shown a constitutively active form of the serine/threonine kinase Raf-1 to be sufficient to induce CD69 expression in human Jurkat T cells.
Taylor-Fishwick and Siegel (1995)CD69T cellsIn addition, studies with the calcium ionophore ionomycin identified a previously uncharacterized pathway regulating the expression of CD69 in T cells.
Taylor-Fishwick and Siegel (1995)CD69T cellsElevation of intracellular calcium induced the expression of CD69 in both Jurkat cells and peripheral blood T cells.
Taylor-Fishwick and Siegel (1995)CD69T cellsTaken together, these results define Raf-1 as the major signaling mediator of CD69 expression in T cells and suggest that multiple mechanisms exist to regulate the level of CD69 expression following TCR stimulation.
Krowka et al. (1996)CD69T-cellThe gp120, however, significantly inhibited CD69 expression in phytohemagglutinin-stimulated T cells in vitro and may also affect T-cell activation in vivo.
Hara et al. (1986)EA 1T cellsBy 3-4 h, the expression of EA 1 was detected in greater than 95% of the T cells.
Hara et al. (1986)EA 1T cellsEA 1 expression was not limited to activated T cells.
Natarajan et al. (2000)CD69T cellsCD69 is a widely expressed type II transmembrane glycoprotein related to the C-type animal lectins that exhibits regulated expression on a variety of cells of the hematopoietic lineage, including neutrophils, monocytes, T cells, B cells, natural killer (NK) cells, and platelets.
Natarajan et al. (2000)CD69T lymphocytesActivation of T lymphocytes results in the induced expression of CD69 at the cell surface.
Vidal-Rubio et al. (2001)CD69brightT cellsCD69bright is expressed in a fraction of T cells, but B cells are mainly CD69- or dull (Figure 2).
Vidal-Rubio et al. (2001)CD69T cellThe tissue location of cells expressing the CD69 antigen (in red) together with two T cell markers, CD3 or CD45RO (both in green), are shown in Figures 4 and 5 respectively.
Vidal-Rubio et al. (2001)CD69T cellScattered T-lymphocytes CD3+/CD45RO+ with a variable expression of CD69 antigen appear in the mantle zone: cells near the T cell layer (region C in Figures 4 and 5) are CD69dull, while those close to the outer zone of the mantle are CD69 - (fig 5).
Morgan and Holguin (2002)CD69T-lymphocytesWe had previously reported robust atypical CD69 expression in peripheral T-lymphocytes as concentration-dependent, phenotypic responses to actinomycin D-induced chemotherapeutic stress in the absence of secondary stimulation.
Morgan and Holguin (2002)CD69T-lymphocytesDifferences in the respective percentages of CD69 + T-lymphocytes, and the resulting numbers of CD69 surface antigens ultimately expressed by these cells, were documented following in vitro drug exposure.
Morgan and Holguin (2002)CD69T-lymphocyteStatic CD69 expression responses in CD3+ peripheral T-lymphocytes were also documented, which further suggests that the different intracellular modalities do not mediate proportional T-lymphocyte responses through elevated CD69 expression.
Risso et al. (1991)CD69T cellIn fact, not only the mitogens or the CD3-promoted activation, but also the alternative pathways mediated by CD2 or CD28 are accompanied by CD69 expression; moreover a very rapid and transient appearance of CD69 on the cell surface is observed also in response to a stimulus not specifically involved in T cell activation such as heat shock.
Gern et al. (1996)CD69T cellsIncubation of PBMC with RV also led to a dose-related increase in the expression of the early activation marker CD69 on 30 to 70% of T cells.
Clausen et al. (2003)CD69T-cellsThus, we separately assessed the proliferative and cytotoxic potential of CD56+ CD3- natural killer (NK) and CD56+ CD3+ T-cells in relation to their expression of CD25, CD69, and CD16 in vitro.
Lim et al. (1998)CD69T-lymphocyteT-lymphocyte activation was assessed by qualitative (percent CD69) and semiquantitative (anti-CD69 antibody binding capacity) measurements of CD69 surface expression.
Lim et al. (1998)CD69T-lymphocyteThe proportions of activated CD4 and CD8 T lymphocytes expressing CD69 (percent CD69) and the levels of CD69 expression on each T-lymphocyte subset (anti-CD69 antibody binding capacity) were measured.
Lim et al. (1998)CD69T-lymphocyteSimilarly, the levels of CD69 expression on each activated CD4 and CD8 T-lymphocyte subset were 48 and 51% lower, respectively.
Lim et al. (1998)CD69T-lymphocyteThese results suggest that both qualitative and semiquantitative measurements of CD69 surface expression by flow cytometry can be used to assess T-lymphocyte activation.
Risso et al. (2005)CD69T cellsHowever, very early stimulation steps of T lymphocytes are not compromised, since CD69 receptor, the earliest membrane activation marker, is expressed by T cells at a level comparable to that observed on 1 g activated lymphocytes.
Santamaria et al. (1992)CD69T-cellThus, CD25 was found on both CD4+ and CD8+ cells while CD69 molecule was selectively expressed on CD8+ T-cell subset.
Kew et al. (2004)CD69T lymphocyteDHA supplementation decreased T lymphocyte activation, as assessed by expression of CD69, whereas EPA supplementation had no significant effect.
Kew et al. (2004)CD69T lymphocyteCONCLUSIONS: Supplementation with DHA, but not with EPA, suppresses T lymphocyte activation, as assessed by expression of CD69.
López-Cabrera et al. (1993)CD69T lymphocytesThe activation of T lymphocytes, both in vivo and in vitro, induces the expression of CD69.
Bogunia-Kubik et al. (2002)CD69T cellsIncubation of peripheral blood mononuclear cells (PBMC) in the CB sera enhanced CD69 expression on alloactivated T cells (p<0.05).
Takizawa et al. (2005)CD69T lymphocytesThe enhanced expression of CD69 was observed on CD8+ T lymphocytes but not on CD4+ T lymphocytes.
González-Amaro et al. (1998)CD69T lymphocytePTX had a significant inhibitory effect on the T lymphocyte expression of the activation Ags CD25 (IL-2R alpha-chain), CD69 (activation-inducer molecule), and CD98 (4F2) induced by PHA.
Caras et al. (2005)CD69T lymphocytesStimulation of whole blood cultures with CS increased both the frequency and the expression of CD69 on the surface of T lymphocytes and NK cells.
Litvinov et al. (2009)CD69T-cellsThe expression of CD69 molecules on the surface of T-cells depended only on the presence of phorbol myristate acetate, occurred at [Ca2+]e higher than 0.2 mM, and did not require the presence of ionomycin.
Litvinov et al. (2009)CD69T-cellsIn this work we comparatively analyzed interleukin-2 (IL-2) and interferon gamma production (IFN-gamma) and also CD69 and CD25 expression by activated T-cells depending on extracellular calcium concentration ([Ca2+]e), which was varied with EGTA.
Bren et al. (2009)CD69T cellsThe expression of activation markers as CD69 and HLA-DR on resting CD4 T cells were determined by flow cytometry.
Lin et al. (2003)CD69T-cellT-cell activation was analyzed with the expression of surface markers (CD45RO/CD69/CD25).
Lin et al. (2003)CD69T cellsAlthough activated CB CD4+ T cells expressed comparable level of CD69/CD25 expression to adults, IFN-gamma production of activated CB CD4+ T cells was markedly deficient compared with that of corresponding APB CD4+ T cells.
Sasada et al. (2002)CD69T cellsIn addition, in CD2-/- animals, lymph node CD4 SP T cells manifest a 10- to 100-fold attenuated activation response to cytochrome c (CytC) agonist peptides as judged by induction of CD25 and CD69 cell surface expression or [(3)H]TdR incorporation; differences in the magnitude of responsiveness and requisite molar peptide concentrations were even greater for altered peptide ligands.
Marriott et al. (2002)CD69T lymphocytesThe extent of co-stimulation by Thd/IMiDs (assessed by CD69/CD25 expression and IL-2/sIL-2Ralpha production) was similar for CD4+ and CD8+ T lymphocytes and correlated with TNFR2 inhibition.
Wu and Xu (2000)CD69T cell[Effect of transforming growth factor - beta1 on expression of CD69(+) and CD25(+) T cell induced by allo - corneal epithelial cells in vitro].
Meyer et al. (2006)CD69T lymphocytesIn both groups, the expression of CD69 on T lymphocytes increased after yogurt consumption, especially on CD8+ (conventional: T2 +23%, T3 +27.2%, probiotic: T2 +15.7%; T3 +10.8% compared to T1) and to a lesser extent on CD4+ (conventional: T2 +7.7%, T3 +14.9%, probiotic: T2 +4% compared to T1.
Fernández-Gutiérrez et al. (1995)CD69T cellsCharacterization and regulation of CD69 expression on rheumatoid arthritis synovial fluid T cells.
Fernández-Gutiérrez et al. (1995)CD69T cellsCD69 was maintained on SF T cells cultured with SF non-T cells but not when the former were cultured alone or in the presence of different supernatants from RA SF T and non-T cells cultures with sustained CD69 expression.
Fernández-Gutiérrez et al. (1995)CD69T cellsPretreatment of T and non-T cells with anti-CD18 monoclonal antibody inhibited CD69 expression, while paraformaldehyde-"fixed" non-T cells effectively maintained it.
Chen et al. (1997)CD69T cellsFour hours after a dose of 906 cGy, approximately 90% of B and 12% of T cells express CD69.
Sutkowski et al. (1996)CD69T cellsBy measuring the appearance of the early activation marker CD69 on individual T cell V beta subsets, we could demonstrate selective activation of human V beta 13- T cells.
Xu et al. (2007)CD69T cellThe T lymphocytes' activation was assessed by detecting the expression of CD69, an early signal of T cell activation.
Xu et al. (2007)CD69T cellsRESULTS: T lymphocytes with chimeric receptor directed towards CEA(+) gastric carcinoma cells were generated. 12 and 24 hours after the co-culture of these T cells and HCG-27 cells, the CD69 expression rates were 40.5% +/- 3.4% and 48.3% +/- 2.8% respectively.
Xu et al. (2007)CD69T lymphocytesHowever, the CD69 expression rates of the HGC-27 and SGC-7901 cells transfected with the T lymphocytes transfected with blank vector were both 0%.
Ramhorst et al. (2003)CD69T cellsIntracellular expression of CD69 in endometrial and peripheral T cells represents a useful marker in women with recurrent miscarriage: modulation after allogeneic leukocyte immunotherapy.
Ramhorst et al. (2003)CD69T cellsPROBLEM: To characterize in fertile women and women with recurrent spontaneous abortions (RSA) the expression and functional status of T cells expressing the CD69 molecule.
Michaëlsson et al. (2006)CD69T cellAnalysis of CD4+ and CD8(+) T cell populations revealed a large subset of cells that expressed the early activation Ag, CD69.
Prakash et al. (2001)CD69T lymphocytesActivation markers (CD69, CD25 and HLA-DR) were found to be more highly expressed on cervical than on blood T lymphocytes.
Murphy et al. (1999)CD69T cellWithin 2 h of adherence to class II+ EC early T cell activation is evidenced by translocation of nuclear factor of activated T cells (NFAT), surface expression of CD69, and synthesis of IFN-gamma and IL-2.
Murphy et al. (1999)CD69T cellsFurthermore, the concept of activation thresholds for cytokine synthesis within T cells also extends to earlier activation events: NFAT translocation is relatively easy to trigger, as is CD69 expression; fewer cells can be triggered to express IFN-gamma and fewer still to express IL-2.
Vandenberghe et al. (1993)CD69T cellsLigation of the CD5 or CD28 molecules on resting human T cells induces expression of the early activation antigen CD69 by a calcium- and tyrosine kinase-dependent mechanism.
Vandenberghe et al. (1993)CD69T cellsIn this paper, it is reported that culture of purified T cells in the presence of either immobilized anti-CD5 monoclonal antibody (mAb) (OKT1, Leu-1 or 10.2) or cross-linked anti-CD28 (9.3) mAb (but not of anti-LFA-1 alpha, anti-LFA-1 beta, or anti-CD7) induces expression of CD69, an early activation marker, in the absence of other activating stimuli.
Vandenberghe et al. (1993)CD69T cellsCD69 expression was consistently detectable after 3-24 hr on 20-50% of T cells, within both the CD4 and CD8 subsets.
Beeler et al. (2008)CD69T cellsRESULTS: All 15 LTT-positive patients showed a significant increase of CD69 expression on T cells after 48 h of drug-stimulation exclusively with the drugs incriminated in drug-hypersensitivities.
D'Arena et al. (1999)CD69T cellCD4+ and CD8+ cells were then analyzed for surface expression of the very early human activation antigen CD69 and for IFN-gamma and IL-4 intracellular production as expression of Th1-like and Th2-like T cell cytokine response, respectively.
Funderburg et al. (2008)CD69T cellsIn contrast, CD4(+) T cells rarely increase CD69 expression but instead enter cell cycle.
Dengler and Pober (2000)CD69T cellsEC caused activation and expansion of memory but not naive CD8+ T cells, which differentiated into EC-selective CTL that retained high surface expression of CD69, CD25, and CD62L and displayed low intracellular perforin content.