Viewing affirmative mentions of gene expression of CD40LG (H. sapiens) in T cells

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Carlsen et al. (2006)CD40T cellsMulticolor immunofluorescence in situ staining was performed to determine the percentage of subepithelial macrophages expressing CD40 and that of lamina propria T cells expressing CD154 while avoiding cells in lymphoid aggregates.
Reul et al. (1997)CD40T-cellInduced expression of CD40 was strongly associated with the presence of CD3+ T-cell infiltrates, acute rejection, and ischemic injury (P<0.05).
Reul et al. (1997)CD40LT-cellOverall, the expression of CD40L correlated with the presence of CD3+ T-cell infiltrates and rejection (P<0.05), but not ischemic injury (P=0.9).
Danese et al. (2003)CD40LPBTSurface CD40L expression level was measured by flow cytometry in resting and thrombin activated platelets, and unstimulated and CD3/CD28 stimulated PBT before and after coculture with human intestinal microvascular endothelial cells (HIMEC).
Kornbluth (2002)CD40LT cellsEvidence has accrued indicating that HIV infection either selectively depletes those CD4(+) T cells that express CD40L in response to antigen or down-regulates CD40L expression by these cells.
Hsu et al. (1997)CD40LT lymphocytesCD40 ligand (CD40L), a 33-kDa type II membrane glycoprotein expressed primarily on activated CD4+ T lymphocytes, is responsible for the helper function of T cells on resting B cells in a non-antigen-dependent, non-major histocompatability complex-restricted fashion.
Desai-Mehta et al. (1996)CD40LT cellsActive lupus patients also had a 22-fold increase in percentage of CD8+ T cells expressing CD40L, consistent with their unusual helper activity in SLE.
Desai-Mehta et al. (1996)CD40LT cellsSurprisingly, patients with active lupus had a 20.5-fold increase in B cells that spontaneously expressed high levels of CD40L, as strongly as their T cells.
Cron (2003)CD154T cellsCell surface and soluble CD154 are primarily expressed by activated CD4 T cells.
Cron (2003)CD154T cellExpression of CD154 is tightly regulated in a time-dependent manner, and, like most T cell-derived cytokines and other members of the tumor necrosis factor (TNF) superfamily, CD154 is largely regulated at the level of gene transcription.
Cron (2003)CD154T cellsWe are exploring CD154 regulation in primary human CD4 T cells in hopes of understanding the cis- and trans-regulatory elements that control its expression in the cells that normally express CD154.
Crist et al. (2008)CD154T cellsFurthermore, using several established megakaryocyte-like cells lines, we performed promoter analysis of the CD154 gene and found that NFAT, a calcium-dependent transcriptional regulator associated with activated T cells, mediated both differentiation-dependent and inducible megakaryocyte-specific CD154 expression.
Katsiari et al. (2002)CD40LT cellsTo explore the regulatory defects underlying the overexpression of CD40 ligand (CD40L, CD154) in human lupus we studied the effects of cyclosporin-A (CsA), which blocks Ca2+/calcineurin-dependent CD40L gene expression, on peripheral blood-derived T cells and monocytes.
Katsiari et al. (2002)CD40LT cellsIn contrast to control subjects, CsA failed to inhibit the prolonged CD40L expression observed in vitro on anti-CD3-activated lupus T cells.
Katsiari et al. (2002)CD40LT cellsLupus monocytes clearly overexpressed CD40L comparing to healthy and disease-control monocytes, and, similarly to lupus T cells, displayed a prominent resistance to CsA inhibitory effects.
Wingett and Nielson (2002)CD40LT cellsCyclic AMP differentially modulates CD40L expression on human nai;ve and memory CD4(+) T cells.
Wingett and Nielson (2002)CD40LT cellIn view of the central role of CD40L expression in immunity as well as the pathophysiology of common diseases, it is of interest that cAMP can either increase or decrease CD40L expression depending upon the T cell subtype and mechanism of cell activation.
Rigby et al. (1999)CD154T cellsAs such, identifying these proteins will help us understand the signals that are necessary for CD154 expression by activated T cells.
Xu et al. (2006)CD154T cellsCD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs.
Horner et al. (1995)CD40LT cellsNeither CD40L surface expression nor CD40L mRNA were detected in unstimulated gamma/delta T cells.
Horner et al. (1995)CD40LT cellsStimulation with phorbol ester and ionomycin induced CD40L mRNA and surface CD40L expression by gamma/delta T cells.
Gaweco et al. (1999)CD154T-cellMETHODS: The expression of CD40, CD154, CD68, and T-cell receptor (TCR)alpha/beta was analyzed by immunohistochemistry.
Sipsas et al. (2002)CD40LT cellsCD40 ligand (CD40L or CD154) is a costimulatory molecule expressed mainly on activated CD4(+) T cells.
Ford et al. (1999)CD154 proteinT cellsThe CD154 protein (CD40 ligand), which is critical to the regulation of both humoral and cellular immune responses, is expressed transiently on the surface of activated CD4+ T cells.
Ford et al. (1999)CD154T cellsTo determine whether control of mRNA stability contributes to the highly regulated expression of CD154 during T cell activation, CD4+ T cells were isolated from human peripheral blood and stimulated for various lengths of time with plate-bound anti-CD3 mAb.
Ford et al. (1999)CD154T cellsTogether, these data support a role for posttranscriptional regulation in the control and overall expression of CD154 in activated T cells.
Carbone et al. (1995)CD40LT-cellAlthough CD40 has been extensively studied in B- and T-cell non-Hodgkin's lymphomas (NHLs)/leukemias, and more recently in Hodgkin's disease (HD), little is known about the expression of its ligand (CD40L) in lymphoproliferative disorders other than T-cell NHLs/leukemias.
Carbone et al. (1995)CD40LT-cellA series of 121 lymphoma/leukemia samples, including 35 cases of HD, 34 T-cell and 39 B-cells NHLs, 2 cases of adult T-cell leukemia/lymphoma, and 11 cases of T-cell acute lymphoblastic leukemia, were evaluated for CD40L expression by immunostaining of frozen tissue sections and flow cytometry with the anti-CD40L monoclonal antibody M90.
Carbone et al. (1995)CD40LT-cellOur data indicate that in human lymphomas CD40L is preferentially expressed by a restricted subset of T-cell lymphomas, mostly with CD4 immunophenotype.
Inghirami et al. (1994)T-BAMT-cellTherefore, we investigated T-BAM expression immunohistochemically in 87 well-characterized T-cell non-Hodgkin's lymphomas and lymphoid leukemias (LL).
Inghirami et al. (1994)T-BAMT cellsOur studies clearly show that T-BAM is constitutively expressed in a large number of T-cell neoplasms with a relative mature phenotype (CD4+CD8-) and that only CD4+ neoplastic T cells can be induced in vitro to express this molecule.
Liu et al. (2001)CD40LT cellsAfter in vitro stimulation, T cells from RA patients had higher and longer CD40L expression than T cells from normal peripheral blood.
Srahna et al. (2001)CD154T cellsNF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells.
Srahna et al. (2001)CD154T cellsWe have studied the regulation of CD154 expression in human T cells after activation with anti-CD3 and anti-CD28 antibodies or after pharmacological activation of protein kinase C with phorbol 12-myristate 13-acetate, and the calcium ionophore ionomycin.
Srahna et al. (2001)CD40LT cellsThese observations demonstrate a role of NF-kappaB transcription factors in the regulation of CD40L expression in activated primary human T cells.
Zhou et al. (2009)CD40LGT cellT cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus.
Zhou et al. (2009)CD40LGT cellHerein, we investigated the effect of DNA demethylation on T cell CD40LG expression and the production of IgG by autologous B cells in lupus.
Häkkinen et al. (2000)CD40LT-cellsMacrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions.
Makino et al. (2001)CD40LT cellsWe determined the influence of CD40L expressed on various HTLV-I-infected T cells on the DC maturation.
Makino et al. (2001)CD40LT cellsAround 60% of CD4+ T cells infected with HTLV-I for 1 week, expressed CD40L molecules involved in DC maturation.
Makino et al. (2001)CD40LT-cellHTLV-I-immortalized T-cell lines established from healthy donors consistently expressed CD40L molecules for 3 months, however, some lines lost the expression soon thereafter.
Makino et al. (2001)CD40LT cellsFurthermore, T cells obtained from HAM/TSP patients expressed CD40L molecules for at least 3 weeks, whereas T cells from ATL patients did not express that.
Makino et al. (2001)CD40LT cellsTherefore, the lack of CD40L expression on HTLV-I-infected T cells may be associated with the development of ATL.
Mach et al. (1997)CD40LT lymphocytesWe report here that CD40 ligand (CD40L), an immunoregulatory signaling molecule heretofore considered largely restricted to recently activated CD4+ T lymphocytes, is expressed by human vascular endothelial cells (EC), smooth muscle cells (SMC), and human macrophages in vitro, and is coexpressed with its receptor CD40 on all three cells types in human atherosclerotic lesions in situ.
Malik et al. (1996)gp39T cellWe show that fixed cells and the cell membranes from a T cell line, BMS-2, that expresses high levels of the CD40 ligand gp39 (also called TRAP, TBAM, or CD40L) stimulate both the expression of mRNA and the production of MMPs by human monocytic cells.
Armitage et al. (1993)CD40LT cellsIn this report CD40L is shown to be stimulatory for human T cells, inducing CD25 (p55 IL-2R) and CD40L expression on resting peripheral blood T cells, enhanced expression of these molecules and CD69 on CD3-activated cells and secretion of interferon-gamma, tumor necrosis factor-alpha and interleukin (IL)-2 from T cells cultured in the presence of a sub-mitogenic concentration of phytohemagglutinin A (PHA).
Casamayor-Palleja et al. (1995)CD40LT cellsPreformed CD40 ligand (CD40L) was not detected in any CD4+ CD45RA+ T cells, but > 90% of all CD4+ T cells from the tonsil can be induced to express large amounts of CD40L on culture with phorbol myristate acetate and the calcium ionophore ionomycin.
Biedermann and Pober (1999)CD40LT cellsWe conclude that in a microenvironment in which allogeneic EC are in close contact with infiltrating CD8+ T cells, such as within a graft arterial intima, CTL subsets may emerge that display EC selectivity or express CD40L and secrete little IFN-gamma after Ag contact.
Lu et al. (2007)CD40LGT cellsWe therefore compared expression and methylation of CD40LG, a B cell costimulatory molecule encoded on the X chromosome, in experimentally demethylated T cells from men and women and in men and women with lupus.
Lu et al. (2007)CD40LGT cellsSimilar studies demonstrated that CD40LG demethylates in CD4(+) T cells from women with lupus, and that women but not men with lupus overexpress CD40LG on CD4(+) T cells, while both overexpress TNFSF7.
Lu et al. (2007)CD40LGT cellsThese studies demonstrate that regulatory sequences on the inactive X chromosome demethylate in T cells from women with lupus, contributing to CD40LG overexpression uniquely in women.
Batrla et al. (2002)CD40T-cellCD40-expressing carcinoma cells induce down-regulation of CD40 ligand (CD154) and impair T-cell functions.
Batrla et al. (2002)CD154T cellsIn the present study we demonstrate that CD154 expression density is down-regulated on activated T cells on interaction with CD40+ tumor cells.
Batrla et al. (2002)CD40T-cellIn distinction, T-cell effector lysing capacity was not impaired by CD40-expressing tumor cell targets.
Batrla et al. (2002)CD40T-cellThe present results suggest that in marked contrast to antigen-presenting cells, CD40 expression on carcinoma cells suppresses T-cell activation.
Zhou et al. (1999)CD40LT cellsSo far, most pharmacological agents developed for that purpose target CD40L (CD154) expressed on activated T cells.
Danese et al. (2006)CD40LPBTPlasma sCD40L was measured by ELISA and platelet and peripheral blood T cell (PBT) CD40L expression by flow cytometry.
Danese et al. (2006)CD40LPBTIn vitro infliximab prevented TNF-alpha-induced CD40 and VCAM-1 expression by HIMEC, and reduced PBT, but not platelet, surface CD40L expression and sCD40L release.
Carbone et al. (1995)CD40LT-cellIn contrast, reactive T lymphocytes from patients with non-neoplastic T-cell expansions and in vitro activated CD3+ or CD4+ normal T cells were found to coexpress CD40L and CD26.
Lobo et al. (2002)CD40LT cellDeficiency in CD40 ligand (CD40L) expression is associated with impaired T cell immunity in mouse models and in humans.
Lobo et al. (2002)CD40LT cellsCD4+ T cells from female carriers of XHIM express a variable degree of normal CD40L based on random X chromosome inactivation.
Lobo et al. (2002)CD40LT lymphocyteWe have examined T cells from XHIM carriers to investigate whether CD40L supports T cell function by acting as an intrinsic costimulator or by induction of other costimulatory molecules by examining coexpression of CD40L and markers of T lymphocyte priming.
Lobo et al. (2002)CD40LT cellsOur results show that compared with CD40L-deficient T cells, T cells that express CD40L normally have a minimal advantage in becoming primed, as defined by CD45 RO isoform expression and production of IFN-gamma and TNF-alpha.
Gauchat et al. (1993)CD40-LT cellsThe human CD40-L is expressed on both CD4- and CD8-positive T cells, (CD45R0+) and (CD45RA+) subsets.
Heidt et al. (2008)CD40LT cellsMETHODS: Purified human B cells devoid of T cells were stimulated with CD40L expressing L cells, or by anti-CD40 mAb with or without Toll-like receptor triggering, all in the presence of B-cell activating cytokines.
Ferrarini et al. (1976)IgMT cellsThe specificity of the IgM receptor expressed by human T cells cultured in IgM-free media has been investigated.
Koshy et al. (1996)CD40LT cellsThe prolonged expression of CD40L was functionally significant, as 24 h-activated SLE T cells, when cocultured with target B cells, induced greater B cell surface CD80 (B7-1) expression than did 24 h-activated normal T cells.
Koshy et al. (1996)CD40LT cellsThese results document impaired regulation of CD40L expression in SLE T cells and identify an important potential target for therapy in this systemic autoimmune disease.
van Rijen et al. (2002)CD154T cellsRESULTS: Lymph nodes from patients with or without CI cyclosporine (CsA) or FK506 (FK) treatment showed comparable CD154 expression, which was present on the cell surface of T cells.
Dessureault et al. (2005)CD40LT cellPrevious reports revealed that anti-tumor T cell responses could be activated in mice when granulocyte macrophage-colony stimulating factor (GM-CSF) or CD40L are produced at tumor vaccine sites.
Dessureault et al. (2005)CD40LT cellWe sought to test the hypothesis that production of GM-CSF and CD40L by a bystander cell line could induce an anti-tumor T cell response in an in vitro human model.
Dessureault et al. (2005)CD40LT cellHowever, significant anti-tumor T cell responses were observed when bystander cells transfected with CD40L and GM-CSF were added to the cultures.
Martin-Donaire et al. (2007)CD154T cellsIndeed, CD4+ T cells from patients with RA have an increased expression of CD154 [21-24] that is still observed 5 to 12 years after disease onset, indicating augmented and prolonged activation of T cells.
Martin-Donaire et al. (2007)CD154T cellsHowever, data on these two results look similar and both seem to provide an expression of the higher content of CD154 in non-24CAs CD4 T cells.
Martin-Donaire et al. (2007)CD154T cellDirect comparison of these results should be taken with caution, because different proportions of T cell subsets could have distinct kinetic patterns of CD154 expression.
Büning et al. (2002)CD40LT cellsIn contrast, in vitro stimulated T cells of patients with colon cancer had a significantly increased expression of CD40 ligand (CD40L, CD154) compared with activated T cells of the control group; increased CD40L expression was also found in the CD4(+)- and CD8(+)-T-cell subpopulations.
Lee et al. (1999)CD40LT cellsHuman immunodeficiency virus (HIV)-infected individuals exhibit normal B-cell CD40 expression but diminished expression of CD40L on CD4 + T cells.
Mueller et al. (2010)CD154T cellMETHODS: To address this issue, a novel assay, where CD4+ T cell frequencies can be determined by de novo CD154 (CD40 ligand) expression in response to HCV antigens, was used in a cohort of chronically infected HCV patients and patients who spontaneously resolved HCV infection.
Darmochwal-Kolarz et al. (2009)CD154T lymphocytesThe expression of the CD154 antigen on CD4+ T lymphocytes and the serum concentration of soluble CD40L were significantly higher in pre-eclampsia than in normal pregnant women.
Darmochwal-Kolarz et al. (2009)CD154T lymphocytesThis study investigated the surface expression of the CD154 antigen (CD40L) on peripheral blood CD4+ T lymphocytes and the sera concentrations of soluble CD40L antigens (sCD40L) in non-pregnant women, normal pregnant women, and patients with pre-eclampsia.
Darmochwal-Kolarz et al. (2009)CD154T lymphocytesIn normal pregnancy the expression of the CD154 antigen on CD4+ T lymphocytes and the concentration of sCD40L were significantly lower than in non-pregnant women.
Darmochwal-Kolarz et al. (2009)CD154T lymphocytesThe expression of the CD154 antigen on CD4+ T lymphocytes was determined using flow cytometry.
Ruybal et al. (2008)CD154T-cellIn this paper, we demonstrated the ability of CD40L (CD154) and CD80 costimulatory molecules expression in a T-cell lymphoma to induce both T-cell dependent and independent immune responses leading to an important anti-tumor effect.
Daoussis et al. (2007)CD154T-cellsIncreased expression of CD154 (CD40L) on stimulated T-cells from patients with psoriatic arthritis.
Erbel et al. (2007)CD40 ligandT cellsMapping of activated DC demonstrated close contact between mature DC and T cells expressing the activation marker CD40 ligand (CD40L).
Aschermann et al. (2007)CD40 ligandT cellsThe expression of CD40 ligand on T cells was markedly reduced in the patient.
Thusberg and Vihinen (2007)CD154T-lymphocytesIt is caused by mutations of CD40 ligand (CD40L, CD154), expressed on T-lymphocytes.
Feghali-Bostwick et al. (2007)CD154T lymphocytesOur results show that greater proportions of peripheral CD4 T lymphocytes in IPF subjects expressed MHC class II and CD154 (CD40L), and they more frequently elaborated TGF-beta1, IL-10, and TNF-alpha.
Ueno et al. (2007)CD40 ligandT lymphocytesIncreases in circulating T lymphocytes expressing HLA-DR and CD40 ligand in patients with dilated cardiomyopathy.
Kannanganat et al. (2007)CD40 ligandT cellsVirus-specific CD4 T cells are endowed with multiple functions, such as cytokine production, CD40 ligand (CD40L) expression (associated with the costimulation of CD8 and B cells), and degranulation (associated with cytotoxic potential).
Hückel et al. (2006)CD154T cellsIt was demonstrated recently that freshly isolated synovial cells from RA patients express CD40, whereas synovial T cells express CD40L (CD154) [50].
Matthies et al. (2006)CD40 ligandT cellsCD40 ligand is an important immunoregulatory protein expressed by T cells.