Viewing affirmative mentions of gene expression of CD28 (H. sapiens) in T cells

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Vallejo (2005)CD28T cellsThe loss of CD28 expression on T cells is the most consistent biological indicator of aging in the human immune system, and the frequency of CD28(null) T cells is a key predictor of immune incompetence in the elderly.
Vallejo (2005)CD28T cellsDissection of the machinery regulating CD28 expression is paving the way in elucidating the molecular events leading to immune senescence as well as providing clues into the functional rejuvenation of senescent T cells.
Hanawa et al. (2002)CD28iT cellsCD28i was found noncovalently associated with CD28 and was tyrosine-phosphorylated/PI3-kinase-complexed following the crosslinking of CD28, and the CD28 costimulatory signal was enhanced in T cells expressing CD28i.
Magistrelli et al. (1999)CD28T cellsCD28, expressed by T cells, plays a central role in providing costimulatory signals to T cells.
Magistrelli et al. (1999)CD28 mRNAT cellsWe report here that non stimulated human T cells express three additional alternatively spliced variants of CD28 mRNA (CD28a-c) in.
Magistrelli et al. (1999)CD28 mRNAT cellsActivated T cells express only the membrane CD28 mRNA.
Magistrelli et al. (1999)CD28T cellThese results suggest that resting human T cells may constitutively express both membrane and soluble CD28 which can differentially regulate the outcome of the T cell response.
Lewis et al. (2004)CD28T-cellTumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription.
Lewis et al. (2004)CD28T cellsReplicative senescence of human T cells is characterized by the loss of CD28 expression, exemplified by the clonal expansion of CD28(null) T cells during repeated stimulation in vitro as well as in chronic inflammatory and infectious diseases and in the normal course of aging.
Lewis et al. (2004)CD28T-cellCurrent models of replicative senescence involve protracted procedures to generate CD28(null) cells from CD28(+) precursors; hence, a T-cell line model was used to examine the dynamics of CD28 expression.
Lewis et al. (2004)CD28T cellsT cell lines with transient expression of CD28 are invaluable in the dissection of the biochemical processes involved in the transactivation of the CD28 INR, the silencing of which is a key event in the ontogenesis of senescent T cells.
Boucher et al. (1998)CD28T cellCD28 expression in T cell aging and human longevity.
Boucher et al. (1998)CD28T cellCohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens.
Boucher et al. (1998)CD28T cellsThe significant decline in T cells expressing CD28 (p < 10(-4) for comparisons between adults and either ELD or centenarians) affects preferentially the CD8+ subset of T cells.
Boucher et al. (1998)CD28T cellCD28 expression is modulated in T cell cultures in a growth-related fashion and this modulation is dampened in cultures from centenarians.
Bukczynski et al. (2003)CD28T cellsWith age, humans accumulate increasing numbers of CD28- T cells, and this loss of CD28 expression is exacerbated certain disease states, such as HIV infection, autoimmune conditions or cancer.
Labalette et al. (1999)CD28T lymphocytesPeripheral human CD8(+)CD28(+)T lymphocytes give rise to CD28(-)progeny, but IL-4 prevents loss of CD28 expression.
Labalette et al. (1999)CD28T cellsAt birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker.
Labalette et al. (1999)CD28T cellsIn cultures initiated with umbilical cord blood, virtually all the original CD8(+)CD28(bright) T cells lost expression of CD28, but none acquired CD57 with IL-2 alone.
Salazar-Fontana et al. (2001)CD28T cellsCD28 is a costimulatory receptor expressed in most CD4(+) T cells.
June et al. (1987)CD28T cellsCD28 is a homodimeric glycoprotein expressed on the surface of a major subset of human T cells that has recently been identified as a member of the immunoglobulin supergene family.
Kozbor et al. (1987)Tp44T lymphocytesWe have analyzed cells of the B lineage for expression of the Tp44 antigen, a 44,000 homodimer detected by monoclonal antibody 9.3 on approximately 80% of mature human T lymphocytes.
Kozbor et al. (1987)Tp44 moleculeT cellsThe m.w. of the Tp44 molecule expressed on plasma cells and on T cells is identical, as determined by immunoprecipitation of radioiodinated cell surface proteins with monoclonal antibody 9.3.
Parish et al. (2009)CD28T lymphocytesHere, we show that modulation of TNF-alpha levels in long-term cultures of human CD8(+) T lymphocytes, by chronic exposure either to a neutralizing Ab or to an inhibitor of the TNF-alpha receptor-1, increases proliferative potential, delays loss of CD28 expression, retards cytokine profile changes, and enhances telomerase activity.
Parish et al. (2009)CD28T cellsIn cell culture, irreversible loss of CD28 expression correlates with increased production of TNF-alpha as CD8(+) T cells are driven to the nonproliferative end stage of replicative senescence by multiple rounds of Ag-driven cell division.
Walker et al. (1998)CD28T-cellSince antigen-presenting cells may express Fas-L under certain circumstances, the maintenance of T-cell CD28 expression may be crucial for the prevention of Fas-mediated apoptosis during the course of antigen engagement.
Weekes et al. (1999)CD28T cellsAt birth, almost all human peripheral blood CD8+ T cells express the costimulatory molecule CD28.
Vallejo et al. (2002)CD28T cellsMolecular basis for the loss of CD28 expression in senescent T cells.
Parish et al. (2010)CD28T lymphocytesProlonged expression of CD28 expression was also documented in studies on long-term cultures of CD8 T lymphocytes in which tumor necrosis factor alpha (TNF-?)
Parish et al. (2010)CD28T cellsIndeed, the decline in telomerase activity as CD8 T cells progress in culture to replicative senescence precisely parallels the loss of CD28 expression, and blocking CD28 signaling abrogates activation-induced telomerase upregulation [4].
Parish et al. (2010)CD28T cellsPrevious research on long-term cultures of CD8 T cells has demonstrated that by the third and all subsequent stimulations telomerase activity was undetectable, and the progressive reduction with each stimulation parallels the decline in CD28 expression [4].
Parish et al. (2010)CD28T cellsPrevious research has shown that CD28 is essential for optimal telomerase activity, and that, not only do CD8 T cells lose telomerase in parallel with the loss of CD28 expression, but also inhibition of the B7 ligands on APC significantly reduces telomerase activity [4].
Parish et al. (2010)CD28T cellsAs T cells approach replicative senescence in culture, not only is CD28 expression lost, but there is a dramatic alteration in the profile of various cytokines.
Thompson et al. (1989)CD28T cellsCD28 is a 44-kDa glycoprotein expressed as a homodimer on the surface of a major subset of human T cells.
Simon et al. (1994)CD28T-cellExpression of the B7/BB1 activation antigen and its ligand CD28 in T-cell-mediated skin diseases.
Simon et al. (1994)CD28T cellsCD28 expression was observed in the majority of dermal and epidermal CD3+ T cells in contact dermatitis and lichen planus.
Simon et al. (1994)CD28T cellsIn normal skin and basal cell carcinoma, CD28 was expressed only occasionally by perivascular T cells.
Mathew et al. (2000)CD28T cellsRESULTS: The yield of RdD cells ranged from 0.1 to O.9% of the starting material with the majority being TcRalphabeta, CD3 positive T cells, a substantial percentage of which coexpressed CD28.
Niehues et al. (1998)CD28T lymphocyteIn this study it was investigated at which stage of the disease and in which T lymphocyte subpopulation (CD4+ or CD8+) protection against apoptosis may be lost as measured by decreased CD28 expression.
Borthwick et al. (1994)CD28T cellsIn HIV-1-positive individuals the expression of CD28 was greatly reduced and the proportion of CD3+CD28- T cells expanded.
Menezes et al. (2004)CD28T-cellsCorrelation analysis between the frequency of cytokine expressing cells, and the frequency of CD4+ T-cells with differential expression of CD28 demonstrated that CD4+CD28- T-cells were positively correlated with TNF-alpha in cardiac and with IL-10 in indeterminate CP, suggesting that these cells might have an important regulatory role in human Chagas' disease.
Pagès et al. (1996)CD28T-cellDisruption of this binding site by site-directed mutagenesis abolishes CD28-induced activation events in a murine T-cell hybridoma transfected with human CD28 gene.
Lloyd et al. (1997)CD28T cellsDuring HIV disease progression, CD28 expression is lost, particularly on CD8+ T cells.
Lloyd et al. (1997)CD28T cellsTreatment of CD8+ T cells with IL-4 decreased levels of both CD28 surface expression and message and increased CD8 expression.
Lloyd et al. (1997)CD28T cellThese results suggest that loss of CD28 expression and CD8 T cell function can be regulated by the cytokine environment, which may be altered during HIV disease progression.
Williams et al. (1992)CD28T cellsCD28 is a glycoprotein expressed as a homodimer on the surface of a major subset of human T cells.
Ghiotto-Ragueneau et al. (1996)CD28T cellsComparison of CD28-B7.1 and B7.2 functional interaction in resting human T cells: phosphatidylinositol 3-kinase association to CD28 and cytokine production.
Dennett et al. (2002)CD28T cellsAge associated decline in CD25 and CD28 expression correlate with an increased susceptibility to CD95 mediated apoptosis in T cells.
Dennett et al. (2002)CD28T cellsOne major biomarker of aged T cells is a decrease in expression of CD28 and since this is an essential co-stimulatory molecule, its decreasing expression with age could compromise their activation and apoptotic capacity.
Dennett et al. (2002)CD28T cellsActivation of T cells resulted in initial up-regulation of CD25, CD95 and CD28, although expression of CD25 and CD28 subsequently decreased with increasing PD.
Dennett et al. (2002)CD28T cellsCD4 and CD8 T cells expressed similar CD25 profiles although CD28 expression was unique in each subset.
Uda et al. (2002)CD28T cellsThese results suggest that there is an unusual CD28 expression pattern in patients with AIM, namely, the presence of a functional CD28-int subset among CD8 T cells.
Choremi-Papadopoulou et al. (1994)CD28T lymphocytesA progressive significant decrease of CD28 surface antigen expression on CD4+ (mean, 90, 86, 79, 68% in stages I, II, III, and IV, respectively, versus 96% in normals), as well as on CD8+ T lymphocytes (mean, 38, 32, 31, and 29% in stages I, II, III, and IV, respectively, versus 47% in normals) was observed during HIV-1 infection.
Choremi-Papadopoulou et al. (1994)CD28T-lymphocyteFurthermore, a positive significant correlation within the CD4+ but not the CD8+ subset was observed between the percentage of cells lacking the CD28 antigen and the percentage of cells expressing the HLA-DR and CD38 antigens, a finding suggesting that the loss of CD28 antigen expression on CD4+ lymphocytes may be associated with T-lymphocyte activation.
Barbey et al. (2007)CD28T cellsBecause CD28 can mediate strong costimulatory signals, tight cytotoxicity control, as shown in this study through IL-12, may be particularly important for subsets of T cells expressing CD28.
Park et al. (1997)CD28T cellsIn patients with rheumatoid arthritis and infrequently in normal individuals, CD4+ T cells lacking CD28 expression are expanded and contain clonogenic populations.
Mazzatti et al. (2007)CD28T-cellsThese clones were not markedly different in any way from the majority of such clones that we have obtained from numerous different donors, and at isolation express markers of effector memory cells (CD45RO++, CD45RB+, CD45RAlo, CD28lo, CD95++, CCR7lo, and in addition, carry typical markers of activated T-cells (CD80, CD86, PD-L1, MHC class II).
Clay and Sperling (2007)CD28T cellsSince proteins of the CD28 family members are expressed on T cells, blockade of these proteins has become a possible target for potential therapies.
Louis et al. (2006)CD28T cellsPatients with chronic rejection also displayed CD25-CD4+T cells expressing NKG2D+CD94+ and CD57+CD27-CD28- cytotoxic-associated markers (P<0.05).
Yu et al. (2006)CD28T cellICOS, a CD28 family member expressed on activated CD4(+) and CD8(+) T cells, plays important roles in T cell activation and effector function.
Duftner et al. (2006)CD28T cellsOur group showed an increased prevalence of circulating interferon-gamma (IFN-gamma) producing CD28(-) T cells especially in smaller AAAs, thus supporting the concept of a T cell-mediated pathophysiology of AAAs, especially during the early development of AAAs.
Håkelien et al. (2005)CD28T cellsAdditionally, growth of cells in suspended aggregates, expression of CD3 and CD28 T cell surface markers, and interleukin-2 secretion by 293T cells treated with extract of adult peripheral blood T cells illustrate a functional nuclear reprogramming.
Yue et al. (2004)CD28T cellsIn addition, after HAART, HIV-1-specific CD4(+) T cells are enriched for CD27(+)CD28(-)-expressing cells, a rare phenotype, reflecting an early intermediate stage of differentiation.
Zhang et al. (2003)CD28T cellTheir interactions with CD28/CTLA-4 receptors expressed on T cell surfaces are crucial for the proper regulation of T cell activity.
Snyder et al. (2002)CD28T cellTo determine whether KIR expression is a consequence of clonal expansion and replicative senescence, multiple CD4(+)CD28(null) T cell clones expressing the in vivo dominant TCR beta-chain sequences were identified in three patients and analyzed for their KIR gene expression pattern.
Bregenholt et al. (1996)CD28T cellsExposure of T cells to immobilized anti-MHC-I Ab for 24 h induced an increased surface expression of the TCR/CD3 and CD28 molecules.
Dau (1994)CD28T cellsCD8+ T cells exhibiting CD45RA or CD11b+ suppressor phenotypes were overall unchanged; however, on follow-up a proportion of CD8+ cells expressed the activated suppressor effector (CD11b-CD28-) phenotype.
Lando et al. (1993)CD28T cellsThe SEA-C215 mAb conjugate, when presented on the CA215 antigen-expressing Colo205 cells, required either signalling with CD28 mAb or CHO cells expressing the natural CD28 ligand, B7, to activate the T cells.
Matsuo et al. (1993)CD28T cellBoth cell lines express the IL-6 receptor, CD28 T cell-associated antigen and CD33 myeloid-associated antigen.
Damle et al. (1988)Tp44T cellMolecule CD28 (Tp44) is expressed on the surface of majority of human T cells and has been implicated to play an active role in the regulation of T cell growth.
Friccius et al. (1993)CD28T lymphocyteA majority (42/62) of TCR2+ interleukin 2-dependent human T lymphocyte clones was found concordantly to express not only the CD28 co-receptor structure at the cell surface but also its ligand B7.
Lindsten et al. (1993)CD28T cellsIn a recent study we found that CD28 and CTLA-4 were coexpressed at the mRNA level on activated T cells but that only CD28 was expressed on resting T cells.
Lindsten et al. (1993)CD28T cellsHere we show that within the T cell population, CTLA-4 expression is restricted to the subset of T cells that also express cell surface CD28.
Suhoski et al. (2007)CD28T cellsFinally, the aAPCs provide an efficient platform to expand genetically modified T cells and to maintain CD28 expression on CD8 T cells.
Adibzadeh et al. (1995)CD28T lymphocytesThus, at least for a fraction of monoclonal human T lymphocytes, decreasing autocrine proliferative capacity, a measure of clonal expansion, may correlate with decreasing numbers of CD28 molecules expressed on the surface and therefore presumably with the strength of costimulatory signal delivered via this important coreceptor.
Gilani et al. (2010)CD28T-cellsRepeated cycles of antigen-induced proliferation cause T-cells to lose surface expression of CD28, and we hypothesized this process might also occur in IPF.
Gilani et al. (2010)CD28T-cellsAccordingly, we characterized CD28 expression on the circulating CD4 T-cells of a well-defined IPF cohort, and correlated results of the immunologic assays with clinical features of these patients.
Gilani et al. (2010)CD28T-cellsWe found abnormally large proportions of peripheral CD4 T-cells in some IPF patients lack CD28 expression, and these CD4+CD28null cells also have unusual, and potentially pathogenic, functional alterations.
Gilani et al. (2010)CD28T-cellsNearly all normal CD4 T-lymphocytes express CD28 on their cell surfaces [38], and finding significant proportions of circulating CD4+CD28null T-cells is distinctly abnormal [19]–[34].
Miyakawa et al. (2005)CD28T cellsAdditionally, the residual CD56(+) T cells and CD57(+) T cells in the patients expressed more CD28 than in controls.
Topp et al. (2003)CD28T cellsIn human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule.
Topp et al. (2003)CD28T cellsAnalysis of the fraction of memory CD8+ T cells that continue to express CD28 revealed these cells retain the ability to produce IL-2.
Topp et al. (2003)CD28T cellsTherefore, we examined if IL-2 production by CD28- CD8+ T cells could be restored by introduction of a constitutively expressed CD28 gene.
Topp et al. (2003)CD28T cellsExpression of CD28 in CD28- CD8+ CMV- and HIV-specific CD8+ T cells reconstituted the ability to produce IL-2, which could sustain an autocrine proliferative response after Ag recognition.
Topp et al. (2003)CD28T cellsThese results suggest that the loss of CD28 expression during differentiation of memory/effector CD8+ T cells represents a decisive step in establishing regulation of responding CD8+ T cells, increasing the dependence on CD4+ Th for proliferation after target recognition, and has implications for the treatment of viral disease with adoptively transferred CD8+ T cells.
Mendes et al. (2008)CD28T lymphocytesThe high incidence of CMV viremia and disease in BMT recipients makes these patients an ideal group in which to understand the relationship between CMV viremia and CD28 and CD57 expression in CD8+ T lymphocytes.
Mendes et al. (2008)CD28T cellsThe expression of CD28 was essentially mutually exclusive with CD57 in CD8+ T cells, such that a dual positive population was very rare (Figure 1A).
Haffar et al. (1995)CD28T cellsHuman immunodeficiency virus type 1 infection of CD4+ T cells down-regulates the expression of CD28: effect on T cell activation and cytokine production.
Haffar et al. (1995)CD28T cellTaken together, our data suggest that dysregulation of normal T cell function associated with HIV-1 infection may result in part form the loss of CD28 expression.
Romero et al. (2007)CD28T cellsOur studies show that EM T cells are heterogeneous and are subdivided based on differential CD27 and CD28 expression into four subsets.
Brinchmann et al. (1994)CD28T cellsExpression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations.
Caruso et al. (1996)CD28T cellThe difference reflected the relatively higher numbers of CD8+ cells, in particular the CD8+ T cell subset lacking CD28 antigen expression.
Tam et al. (1997)CD28T cellOligonucleotide-mediated inhibition of CD28 expression induces human T cell hyporesponsiveness and manifests impaired contact hypersensitivity in mice.
Tam et al. (1997)CD28T cellIn this study, we examined the effect of inhibiting CD28 expression on in vitro and in vivo T cell responses.
Tam et al. (1997)CD28T cellInhibition of IL-2 synthesis was dependent on CD28 expression, as GR1 failed to abrogate activated IL-2 production in a CD28-deficient T cell line, HUT 78.
Nunès et al. (1994)CD28T cellCD28 is a 44-kD homodimer expressed on the surface of the majority of human T cells that provides an important costimulus for T cell activation.
Couez et al. (1994)CD28T cellFunctional expression of human CD28 in murine T cell hybridomas.
Couez et al. (1994)CD28T cellIn order to further delineate the role of CD28 in signal transduction and T cell activation, human CD28 was transfected into CD3+ murine T cell hybridomas.