Viewing negative mentions of gene expression of CD28 (H. sapiens) in T cells

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Chamberlain et al. (2000)CD28T cellWe noted that in most cases the expanded clones were dominated by cells that did not express CD28, a pivotal molecule in T cell activation, and these clones proliferated poorly in culture.
Parish et al. (2009)CD28T lymphocytesExpanded populations of CD8(+) T lymphocytes lacking CD28 expression are associated with a variety of deleterious clinical outcomes, including early mortality in the elderly, more rapid progression to AIDS, cardiovascular disease, and enhanced tumor cell growth.
Arosa (2002)CD28T cellsIn a number of situations ranging from chronic inflammatory conditions and infectious diseases to ageing, immunodeficiency, iron overload and heavy alcohol intake, major phenotypic changes, usually associated with an increase in CD8+ T cells lacking CD28 expression, take place.
Chapman et al. (1996)CD28T cellThree autoreactive CD4+ human T cell clones that could be activated to produce IL-2 and proliferate by anti-CD3 alone were found to lack expression of CD28.
Miyakawa et al. (2005)CD28T cellsIt was also revealed that, unlike murine NKT cells, human CD56(+) T cells and CD57(+) T cells did not constitutively express CD28, which is one of the important costimulatory molecules on T cells.
Hirokawa et al. (2001)CD28T cellsWe found that the fraction of T cells lacking CD28 expression in the CD4(+) subset was increased after transplantation, and expanded CD4(+)CD28(-) T lymphocytes carrying certain TCRBV subfamilies showed limited TCR diversity.
Nikolova et al. (2002)CD28T lymphocytesThus, we demonstrate that CD160 provides co-stimulatory signals leading to the expansion of a minor subset of circulating lymphocytes including double-negative CD4/CD8 T lymphocytes and CD8bright+ cytotoxic effector T lymphocytes lacking CD28 expression.
van Bergen et al. (2004)CD28T cellsIn contrast with regular KIR(-) CD4 T cells, the majority of KIR(+) CD4 T cells lacked surface expression of CD27, CD28, CCR4, and CCR7, but did express CD57 and 2B4.
Decrion et al. (2007)CD28T cellsUsing flow cytometric analysis, a continuous spectrum of CD28 intensity ranging from negative to high, which could be separated into CD28-negative, intermediate (int) and high, was seen for CD8(+) T cells.
Uda et al. (2002)CD28T cellsAfter 24 h of ex vivo culturing, however, the continuous spectrum was found to consist of only CD28-positive and CD28-negative CD8 T cells, because the CD28-int cells had disappeared due to apoptosis.
Berthou et al. (1995)CD28T-cellA substantial proportion of these cells (70% +/- 23%) lacked the CD28 T-cell coactivation Ag, and they were able to exert NK-like, major histocompatibility complex nonrestricted cytolytic activity.
Rowan et al. (1995)CD28T cellAnti-CD52 mAbs did not, however, synergize with anti-CD2 or CD28 mAb to induce CD4+ T cell proliferation.
Poggi et al. (1987)CD28T cellsCD3+ WT31- peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the alpha/beta heterodimer.
Houman et al. (2004)CD28T cellsBACKGROUND: Peripheral blood CD8+ T cells expressing interferon gamma and interleukin-4 (IL-4), and lacking CD28 molecules, were responsible for the dynamic interplay between peripheral blood and inflammatory sites.
Houman et al. (2004)CD28T cellsBACKGROUND: Peripheral blood CD8+ T cells expressing interferon gamma and interleukin-4 (IL-4), and lacking CD28 molecules, were responsible for the dynamic interplay between peripheral blood and inflammatory sites.
Raffeiner et al. (2005)CD28nullT cellsIn our experiments both the addition of recombinant sCD14 and autologous serum had a comparable additional effect on LPS-induced perforin production of CD4+CD28null T cells, which indicates serum LPS binding protein not to be indispensable in AS.
Hamzaoui et al. (2005)CD28T cellsAccording to these results, we can speculate that effector cytotoxic function of CD8+ T cells reside in the subpopulation lacking CD28 expression.
Speiser et al. (2001)CD28T cellsFurthermore, CD28-positive cells are known to have longer telomeres than CD28-negative T cells.
Perez et al. (2007)CD3/CD28T cell1 was decreased when cells were treated with CD3/CD28 plus ICAM-2 or ICAM-3, but not ICAM-1, indicating that different ICAMs can alter cytokine production that can influence TH1/TH2 T cell development.
Touvrey et al. (2009)CD28T cellsAlthough most HLA-A*0201/influenza matrix protein(58-66)-specific CD8 T cells from healthy donors display characteristics typical of memory T cells, through our extensive phenotypic analysis we have further shown that up to 20% of these cells express neither the IL-7 receptor CD127 nor the costimulatory molecule CD28.
Elrefaei et al. (2009)CD28T cellsThese suppressor CD8+ T cells are typically CD28 negative [11], [12] and express CD25, FOXP3, and CTLA-4 [1], [4], [13], [14].
Effros (2007)CD28T lymphocytesSeveral independent studies on immune correlates of poor vaccine responsiveness have identified a novel immune biomarker of reduced antibody response to vaccination, namely high proportions of memory CD8 T lymphocytes lacking expression of the CD28 costimulatory molecule.
Inokuma et al. (2007)CD28T cellsCMV-responsive CD8(+) T cells in the same patients were broadly distributed among phenotypes, and contained a high proportion of terminal effector cells (CD27(-)CD28(-)CD45RA(+)) that were absent in the TAA responses.
Leon et al. (1996)CD28T-cellThe failure of cytokine-stimulated HIBEC to induce T-cell activation is consistent with the observation that HIBEC do not express the costimulatory CD28 ligands B7-1 or B7-2 at either mRNA or protein levels.
Bürkle et al. (2007)CD28 moleculeT cellsBy contrast, CMV infection was characterised by variable numbers of CD8+ T cells specific for two CMV epitopes that, in some subjects, were strikingly expanded and did not express the CD28 molecule.
Robertson et al. (1996)CD28T cellNKL cells express CD2, CD6, CD11a, CD26, CD27, CD29, CD38, CD43, CD58, CD81, CD94, CD95, class II MHC, and the C1.7.1 antigen, but do not express detectable levels of CD3, CD4, CD5, CD8, CD14, CD19, CD20, CD28, alpha/beta or gamma/delta T cell receptors on the cell surface.
Duftner et al. (2003)CD28T cellsLow levels of inhibitory NKB1 were detected on CD4+CD28- T cells (2.8 ± 4.4% versus 0.2 ± 0.1%; P = 0.003), whereas CD158a/h (KIR2DL1/ KIR2DS1) was detected neither on CD4+CD28- nor on CD4+CD28+ T cells (0.7 ± 1.9% versus 0.1 ± 0.1%).
Harashima et al. (2000)CD28T-cellThe immunoprofiles of MOLP-6 and MOLP-7 correspond to that seen typically in primary MM cells: positive for cytoplasmic immunoglobulin (Ig) chains, a heavy and kappa light chains, CD9, CD28, CD40, CD44, CD45, CD56, and PCA-1; the cells were negative for surface Igs and various other B-cell, T-cell and myelomonocyte associated markers.
Borchers et al. (2009)CD28T cellsFurthermore, some of the co-stimulation-independent clones established from these PDC-E2 163-176-specific CD4+ T cells lacked CD28 expression.
Makedonas et al. (2010)CD28T cellsThus, CD28, which is important mechanistically for IL-2 production, is not commonly detected on CD8+ T cells that are rapidly upregulating perforin.
Borchers et al. (2009)CD28T cellsConsequently, CX3CR1+ CD4+ T cells could not be detected in inflamed colonic tissue from IBD patients, whereas CD28–CD4+ T cells, which all express this receptor, could be demonstrated in inflamed mucosa.
Hene et al. (2007)CD28T-cellFACS analysis indicated that, prior to library generation, the activated T-cell clone expressed CD4, CD28, CD45 and CD69, but not CD27 or CD62L (data not shown).
Fülöp et al. (2007)CD28T cellsCD4+ T cells also require CD28 for adequate activation; with aging, the proportion of CD4+ cells expressing little or no CD28 increases significantly, along with telomere shortening in both CD4+ CD28?
Caccamo et al. (2009)CD28T-cellsAnother study reported expansion of effector-memory CD8 T-cells in children with TB [15], which express a CD28 and CD27 double negative phenotype.