Viewing affirmative mentions of gene expression of CD8A (H. sapiens) in T cells

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Haslett et al. (2003)CD8T cellIn this in vitro study, in a human autologous CD8(+) T cell/dendritic cell (DC) coculture system, thalidomide and a potent thalidomide analogue were shown to enhance virus-specific CD8(+) T cell cytokine production and cytotoxic activity.
Pantaleo et al. (1994)CD8T-cellCells expressing the expanded V beta s predominantly expressed the CD8 T-cell differentiation antigen and mediated HIV-specific cytotoxicity.
Carton et al. (2004)CD8T cellsCD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease.
Carton et al. (2004)CD8T cellsCell yield and viability were assessed and flow cytometric analysis was used to examine CD4CD8 T cells and to quantify CD8 expression.
Carton et al. (2004)CD8T cellsLevels of CD8 expression by CD4CD8 T cells in the epithelial layer were decreased significantly in patients with active coeliac disease.
Sprengers et al. (2006)CD8T-cellsAt all time points there was sequestering of HBV-specific CD8 + T-cells in the liver, and the percentage of intrahepatic HLA-DR expressing HBV-specific CD8 + T-cells was higher than in PB.
Hambor et al. (1988)CD8T cellFunctional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone.
Hambor et al. (1988)CD8T cellExpression of CD8 on this T cell clone, JH.ARL.1, was selectively and efficiently inhibited.
Terry et al. (1990)CD8T cellsWhile the two chains of CD8 have been presumed to be coordinately expressed in normal T cells, this is not always the case.
Terry et al. (1990)CD8T cellsFour distinct subpopulations of CD8+ cells have been identified based on the expression of CD8 alpha/alpha or CD8 alpha/beta complexes: (1) T-cell receptor (TcR) alpha beta+ T cells which are CD8 alpha+/beta+; (2) TcR alpha beta+ T cells which are CD8 alpha+/beta-; (3) TcR gamma delta+ T cells which are CD8 alpha+/beta- and (4) natural killer (NK) cells which are CD8 alpha+/beta-.
Terry et al. (1990)CD8T-cellThis observation demonstrates that a) a CD8+ T-cell clone can express both CD8 alpha/alpha homodimers and CD8 alpha/beta heterodimers and b) these two complexes do not have identical biological properties.
Campbell et al. (2008)CD8T-cellsIn conclusion, total lymphocyte expression of CD8 should not be used as a single antigenic marker to identify CD8(+) T-cells after an acute bout of exercise.
Rodini and Lara (2001)CD8T cellsStudy of the expression of CD68+ macrophages and CD8+ T cells in human granulomas and periapical cysts.
Schmitz et al. (1998)CD8alphaT lymphocyteMoreover, the quantitative monitoring of CD8alpha beta expression allows the detection of discrete CD8(+) T lymphocyte subsets and may be useful for assessing the immune status of individuals infected with HIV-1.
Jansen et al. (2004)CD8T cellsIn slow progressors, perforin expression of HIV-specific CD8(+) T cells slightly increased over time.
Héliot-Hosten et al. (2005)CD8T-cellThese cutaneous T-cell lymphomas express a CD8+ phenotype, rarely expressed in other cutaneous T-cell lymphomas.
Holländer et al. (1992)CD8T cellCD8 expressed in splenic T cells associated with the lymphoid-specific tyrosine protein kinase p56lck, participated in T cell activation and conferred an increased xenogeneic response to human MHC class I Ag.
Ratnofsky et al. (1987)CD8T cellExpression and function of CD8 in a murine T cell hybridoma.
Ratnofsky et al. (1987)CD8 moleculeT cellsIn general, the human CD8 molecule is expressed on T cells specific for HLA class I molecules.
Ratnofsky et al. (1987)CD8T cellCD8 was then expressed in an HLA class II-specific T cell, thus separating the ligand requirements of the TCR and CD8.
Ratnofsky et al. (1987)CD8 moleculeT cellBy this approach, the human CD8 molecule was expressed in a murine T cell hybridoma specific for human class II antigens.
Ratnofsky et al. (1987)CD8T cellThe resulting CD8+ hybridomas demonstrated a 10-fold increase in IL-2 production over the parent cell line when stimulated with JY, a human B lymphoblastoid cell line expressing both class I and II HLA antigens, demonstrating that expression of CD8 increases T cell activation. mAbs directed against the CD8 molecule inhibited the response of CD8+ hybridomas to JY, supporting the conclusion that the CD8 molecule was fractional.
Bucy et al. (1989)CD8T cellThe phylogenetic conservation of the CD8 expression by peripheral T gamma delta cells and of their preferential homing pattern suggests a special role in bodily defense for this T cell subpopulation.
Trautmann et al. (2003)CD8T cellsHuman CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation.
Lenkei et al. (1998)CD8T-cellIndicators of T-cell activation: correlation between quantitative CD38 expression and soluble CD8 levels in asymptomatic HIV+ individuals and healthy controls.
Peters et al. (1990)CD8T-cellThe presence of the CD3-T-cell receptor (TCR) complex, CD8 and possibly other relevant molecules on these membranes may ensure unidirectional delivery of the lethal compounds to the TC.
Norment and Littman (1988)CD8T cellsA second subunit of CD8 is expressed in human T cells.
Norment and Littman (1988)CD8T cellsWe have isolated functional cDNA clones encoding human CD8 beta, and show that the CD8 beta protein is expressed on the surface of CD8+ human T cells. cDNA clones encoding multiple forms of the human CD8 beta-chain have been isolated and characterized.
Norment and Littman (1988)CD8T cellExpression of the CD8 beta chain is thus conserved between human and rodents, and the variant CD8 beta polypeptides may have distinct roles in T cell function and development.
Su et al. (1990)CD8T-cellTwo childhood cases are reported of peripheral T-cell lymphoma; the neoplastic cells expressed activated CD8 (T8) phenotype and contained Epstein-Barr viral (EBV) DNA.
Norment et al. (1988)CD8T cellsCD4 and CD8 are cell-surface glycoproteins expressed on mutually exclusive subsets of peripheral T cells.
Norment et al. (1988)CD8T cellsT cells that express CD4 have T-cell antigen receptors that are specific for antigens presented by major histocompatibility complex class II molecules, whereas T cells that express CD8 have receptors specific for antigens presented by MHC class I molecules (reviewed in ref. 1).
Norment et al. (1988)CD8T-cellTo determine whether CD8 can interact with MHC class I molecules in the absence of the T-cell antigen receptor, we have developed a cell-cell binding assay that measures adhesion of human B-cell lines expressing MHC class I molecules to transfected cells expressing high levels of human CD8.
Joh et al. (1997)CD8alphaT cellsSince it has been reported that CD8alpha can be induced in mature CD4+ T cells by cell activation, but not CD8beta, we studied whether ATL cells which express CD8alpha may also express CD8beta.
Lusso et al. (1991)CD8T lymphocytesThe partition between CD4+CD8- and CD4-CD8+ T cells is generally considered to be irreversible, although a small percentage of circulating CD3+ T lymphocytes coexpressing CD4 and CD8 molecules has been identified.
Bullock et al. (2001)CD8T cellIn this study, we report the generation of HLA-A*0201-restricted CD8(+) T cell populations that recognize either tyrosinase(369-376) or gp100(209-217) from tolerant human class I MHC-transgenic mice by using single amino acid-substituted variant peptides.
Lambert et al. (2005)CD8T cellsThe CD8 of CD4dimCD8+ T cells expressed the heterodimeric (beta) isoform.
Lin et al. (1999)CD8T-cellThe lymphoma expressed CD2, CD3, CD7, CD8 and CD56, and the gammadelta T-cell receptor and did not express CD5, CD4 and the alphabeta T-cell receptor.
Gao et al. (1996)CD8AT cellsPost-transcriptional regulation associated with control of human CD8A expression of CD4+ T cells.
Gao et al. (1996)CD8AT cellsExpression of the CD8A gene has been shown to be regulated by post-transcriptional mechanisms when 1) CD4(-)CD8(lo) thymocytes are blocked from differentiating into CD4(+)CD8(+) cells by TCR crosslinking and 2) upon activation of mature CD8(+) T cells.
Gao et al. (1996)CD8AT-cellWe demonstrate in this paper that there is also post-transcriptional regulation of CD8A expression in a CD4(+)CD8(-) T-cell line Jurkat.
Gao et al. (1996)CD8AT cellsIn addition, we provide evidence that post-transcriptional mechanisms also contribute to the regulation of CD8A expression in mature CD4(+)CD8(-) T cells, challenging the assumption that the regulation is due solely to transcriptional mechanisms.
Mao et al. (2004)CD8T cells[Regulation of CD3, CD4 and CD8 expressions on PMA-activated human peripheral T cells].
Mao et al. (2004)CD8T-lymphocytesOBJECTIVE: To investigate the effect of mitogen Phorbol 12-myristate 13-Acetate (PMA) on CD3, CD4 and CD8 expression of human T-lymphocytes.
Vannucchi et al. (2001)CD8T lymphocytesBoth CD8+ and CD4+ CMV-specific T lymphocytes were selectively produced in these cultures and showed CMV-restricted cytotoxicity.
Kroger and Alexander-Miller (2007)CD8T-cellImportantly the ensuing CD8(low) and CD8(high) CTL populations were not the result of the selective outgrowth of naive CD8(+) T-cell subpopulations expressing distinct levels of CD8.
Kay et al. (1990)CD8T-cellApproximately 2% to 3% of circulating human T cells co-express CD4 and CD8 (CD4+, CD8+) T-cell antigens.
Buseyne et al. (2002)CD8T-cellIn conclusion, our results show that the ex vivo-activated IFN-gamma-producing HIV-specific CD8+ T-cell subset is dependent upon continuous antigenic stimulation.
Wang and Borysiewicz (1995)CD8T-cellFurthermore, the CD8+high (CD57+) subset is clonally derived, expressing a limited range of T-cell receptors, and are therefore likely to have restricted antigen specificity.
Paliard et al. (1988)CD8T-cellCD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex.
Paliard et al. (1988)CD8T cellsNevertheless, a small percentage of peripheral CD3+ T cells express CD4 and CD8 simultaneously.
Paliard et al. (1988)CD8T-cellThe IL-4-induced co-expression of CD8 on CD4+ T cells is reversible, in that CD8 disappeared from double positive T-cell clones isolated in IL-4, when they were cultured in IL-2.
Gulzar et al. (2010)CD8T-cellProductive infection resulted in a decrease in expression of CD8 and CXCR4 molecules on the surface of the CD8(+) T-cell clones and antibodies to these molecules abrogated viral binding and replication.
Stagno et al. (2009)CD8T-cellAberrant phenotypic expression of the T-cell-associated antigen CD8 on B-cell chronic lymphocytic leukemia cells.
Maimone and Reder (1991)CD8 moleculeT lymphocytesIn multiple sclerosis (MS), T lymphocytes exhibit decreased membrane expression of the CD8 molecule and defective suppressor function.
Geara et al. (2010)CD8T-lymphocytesThere was a linear correlation between the levels of PTH and CD8 lymphocytes and a reverse correlation between level of PTH and total T-lymphocytes, CD4 lymphocytes, and CD4/CD8 ratio.
Pietersma et al. (2010)CD8T cellsThe median percentage of perforin-expressing CD8(+) T cells in patients with high viral reactivations exceeding 1000 copies/mL (10.7%) was statistically significantly higher than that in patients with minor reactivations of 50-1000 copies (4.0%), that in patients with detectable EBV loads that did not exceed the detection limit of 50 copies/mL (2.9%), and that in patients without reactivations (0.8%).
Pietersma et al. (2010)CD8T cellsPatients with high viral reactivations reached a high percentage of perforin-expressing CD8(+) T cells (>10.2%) more often and faster than did patients with low viral loads (1000 copies/mL) or without viral reactivations.
Pietersma et al. (2010)CD8T cellsCONCLUSION: Perforin-expressing CD8(+) T cells may be useful as an easy-to-measure prognostic marker for identifying patients at risk for severe viral reactivation very soon after SCT.
Norell et al. (2010)CD8T cellsBoth CD8(+) and CD4(+) T cells could be transduced and efficiently co-expressed all introduced transgenes on their surface.
Ferguson and Engelhard (2010)CD8T cellWe hypothesized that effector CD8 T cell expression of adhesion proteins and chemokine receptors would be influenced by activation in different secondary lymphoid organs.
Kuang et al. (2010)CD8T cellsTumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.
Kuang et al. (2010)CD8T cellsThe proinflammatory IL-17-producing CD8(+) T cells (Tc17 cells) have recently been detected in tumors, but the nature and regulation of these cells in human tumors are presently unknown.
Van Tendeloo et al. (2010)CD8T cellsFurthermore, vaccinated patients showed increased levels of WT1-specific IFN-gamma-producing CD8+ T cells and features of general immune activation.
Perrella et al. (2009)CD8T-cellCONCLUSION: A clinically silent persistent exposure to HCV, through some as-yet undetermined mechanism, may induce a virus-specific IFN-gamma-producing CD8(+) T-cell response in healthy aviremic HCWs.
Karanam et al. (2009)CD8T cellFormulation of TA-CIN with GPI-0100 enhanced the production of E7-specific, interferon gamma producing CD8(+) T cell precursors by 20-fold.
Jubinsky et al. (2009)CD8T-cellThere was normal Foxp3 and CD25 expression, no increased CD4(-)CD8(-) T-cell population, and the AIRE and Fas genes were without mutations.
Yuan et al. (2009)CD8T cellWe have used this T17-biased Tbet KO model of allograft tolerance resistance to study the impact of targeting a T cell-co-stimulatory pathway, and demonstrate that targeting T cell Ig and mucin domain-1 (Tim-1) with anti-Tim-1 overcomes this resistance by specifically inhibiting the pathogenic IL-17-producing CD8 T17 cells.
Kloverpris et al. (2009)CD8T-cellData from this study showed that the T-cell response, as measured by cytolytic activity and gamma-interferon (IFN-gamma)-producing CD8(+) T cells, mainly focused on two of seven administered epitopes.
Couzi et al. (2008)CD8T cellsWe only observed a weak association between cumulative low levels of the percentage of TNF-alpha producing CD8+ T cells before CMV infection and its occurrence just afterwards (HR=1.39 for 1000 unit lower, P=0.04).
Mchenga et al. (2008)CD8T cellsThere was no significant difference in the production of IL-17 in colon tissues and CD4(+)/CD8(+) T cells between the DSS + rIL-25 treated mice and DSS treated mice.
Dvorak et al. (2008)CD8T cellsHemophagocytosis was most likely owing to maternal graft-versus-host disease, as perforin-expressing CD8 T cells, presumably of maternal origin, were prominent in the bone marrow and there was no concurrent severe infection.
La Rosa et al. (2007)CD8T cellLevels of viremia and CMV-specific interferon (IFN)- gamma -producing CD4(+) and IFN- gamma -producing CD8(+) T cell responses were prospectively measured from discontinuation of antiviral prophylaxis until 1 year after transplantation in 17 consecutive D(+)/R(-) patients.
Wahl et al. (2007)CD8T cellsIL-10-producing CD8 T cells generated under these conditions down-modulate IL-2 (and proliferative) responses of naive CD4 or CD8 T cells primed by DC.
Freyschmidt et al. (2007)CD8T cellsThis was associated with a dramatically impaired generation of IFN-gamma-producing CD8(+) vaccinia-specific T cells along with decreased secretion of IFN-gamma by VV-stimulated splenocytes.
Agarwal et al. (2007)CD8T-cellThe frequency of IFN-gamma and IL-2 expressing CD4(+)/CD8(+)T-cell subsets was significantly higher with a concomitant reduction in IL-4 and IL-10 expression in the vaccine-treated group (p<0.0001) compared with the untreated controls.
Alekshun et al. (2007)CD8T-cellImmunophenotypically, the malignant cells co-expressed CD3(+)CD8(+)CD56(+) markers and the T-cell receptor beta (TCR beta) gene demonstrated clonal rearrangement.
Rezvani et al. (2007)CD8T-cellTo monitor the kinetics of WT1(+) CD8(+) T-cell responses and disease regression after SCT, absolute WT1(+) CD8(+) T-cell numbers and WT1 expression were studied for each time point.
Avigan et al. (2007)CD8T-cellVaccination resulted in antitumor immune responses in 10/21 evaluable patients as manifested by an increase in CD4 and/or CD8 T-cell expression of interferon-gamma after ex vivo exposure to tumor lysate.
Zhang et al. (2007)CD8T cellsAfter expansion in vitro, the functional IFN-gamma producing M3(271) specific CD8(+) T cells were detected in 30.8% (8/26) of HLA-A2(+)MAGE-A3(+) HCC patients.
He and Kappes (2006)CD8T-cellManipulating expression of the CD4 and CD8 coreceptors has long been a favorite method to examine the influence of T-cell receptor signalling on lineage commitment.
Duan et al. (2006)CD8T cellsAutologous T-cell proliferation assays and the enzyme-linked immunospot (ELISPOT) method for detecting interferon-gamma (IFN-gamma)-producing CD8(+) T cells were used to evaluate the efficacy of DC loaded in vitro with HBsAg or HBcAg.
Lütjen et al. (2006)CD8T cellsDepletion of CD4 T cells prior to infection did not affect frequencies of beta-Gal(876-884)-specific (consisting of residues 876 to 884 of beta-Gal) CD8 T cells but resulted in a pronounced reduction of intracerebral beta-Gal-specific gamma interferon (IFN-gamma)-producing and cytolytic CD8 T cells.
Lütjen et al. (2006)CD8T-cellAfter cessation of anti-CD4 treatment a normal T. gondii-specific CD4 T-cell response developed, but IFN-gamma production of intracerebral beta-Gal-specific CD8 T cells remained impaired.
Lütjen et al. (2006)CD8T cellsReinfection of chronically infected mice that had been depleted of CD4 T cells during either the acute or chronic stage of infection resulted in an enhanced proliferation of beta-Gal-specific IFN-gamma-producing splenic CD8 T cells.
Lütjen et al. (2006)CD8T cellsHowever, reinfection of chronically infected mice that had been depleted of CD4 T cells in the acute stage of infection did not reverse the impaired IFN-gamma production of intracerebral CD8 T cells.
Pfisterer et al. (2006)CD8T-cellsIFNgamma-expressing CA125-specific CD8+ T-cells were significantly more frequent in group L, while there was no significant difference between CD4+ T-cells in the two groups.
Macchia et al. (2006)CD8alphaT lymphocytesExpression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes.
Macchia et al. (2006)CD8alphaT cellsTaken together, these data suggest that CD4+ T cells expressing CD8alpha represent an effector/memory subset of CD4+ T cells and that this cell population can be depleted during the course of SIV infection.
Antonelli et al. (2006)CD8T cellsAlthough most T lymphocytes express the alphabeta T-cell receptor and either CD4 or CD8 molecules, a small population of cells lacking these coreceptors, CD4- CD8- (double negative [DN]) T cells, has been identified in the peripheral immune system of mice and humans.
Fann et al. (2006)CD8T cellsStrikingly, higher H3K9 acetylation levels were detected in resting memory cells, prior to their activation, for those genes that were differentially expressed following activation, indicating that hyperacetylation of histone H3K9 may play a role in selective and rapid gene expression of memory CD8(+) T cells.
Abel et al. (2006)CD8T cellsIntrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection.
Abel et al. (2006)CD8T cellsIn conclusion, HCV-specific IL-10-producing CD8 T cells, although not cytotoxic and unable to control viral replication, can attenuate hepatocellular necrosis, liver fibrosis, and inflammation mediated by bystander T cells, and may thus represent antigen-induced regulatory CD8 T cells.
Zidovec Lepej et al. (2006)CD8T-cellsGag SLYNTVATL-specific CD8+ T-cells were detectable in 18 of 26 treated patients (median 5.2 years of HAART) and in 10 of 14 untreated patients.
Rubio et al. (2005)CD8T cellsThe antitumor responses of RLI involve mainly RLI-derived IFN-gamma-producing CD8 T cells and recipient-derived CD4 T cells and do not involve donor T cells.
Karanikas et al. (2005)CD8T-cellTo our knowledge this is the first study systematically evaluating the correlation of possible parameters of disease activity such as changes in CD4 and CD8 T-cell cytokine production and of TPOAb titre.
Publicover et al. (2005)CD8T cellsThis virus was just as effective as the recombinant expressing the membrane-anchored Env protein at producing CD8 T cells and antibody responses.