Viewing negative mentions of gene expression of CD8A (H. sapiens) in T cells

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Su and Hsieh (1992)CD8T cellBoth the CD4 and CD8 T cell subsets, and a hitherto undefined T lineage lacking CD4/CD8 expression have been involved.
Menaa et al. (1999)CD8T-cellFurthermore, FACS(R) analysis of T-cell subpopulations treated with fluorescein-labeled AXII suggested that the CD4(+), but not CD8(+), subpopulation of T cells express an AXII receptor.
Lee et al. (1998)CD8T cellsThe majority of the thymocytes are immature T cells that express neither CD4 nor CD8 molecules, indicating that T cells are affected at an early stage of thymic differentiation.
Aust et al. (1996)CD8T cellsCD4 and CD8, gamma/delta TCR bearing T cells and CD45R0 on CD4+ T cells as a marker for memory cells, on TL no differences could be detected between patients with or without anti-TPO.
Renard et al. (1996)CD8T cellHere, we analyzed both early (intracellular Ca2+ mobilization), and late (interleukin-2 production) signal transduction events induced by a cognate peptide or a corresponding altered peptide ligand using T cell hybridomas expressing or not the CD8 alpha and beta chains.
Thiel et al. (1989)CD8T-cellThe T-cell surface antigens CD5 and/or CD2 and focal acid phosphatase were additional markers of this subgroup traditionally called pre-T ALL, whereas thymocyte antigen CD1 as well as CD4 and CD8 antigens were not expressed.
Brennan et al. (1988)CD8T-cellWhereas the majority of T cells use alpha and beta chains to form their T-cell receptor, a small minority of T cells, which do not express the CD4 or CD8 surface markers, use other chains termed gamma and delta to form their receptor.
Wu et al. (2004)CD8T cellsAfter immunization with a protein Ag, Ag-specific CD8(+) T cells initially proliferate, but quickly disappear and fail to produce Ag-specific memory CD8(+) T cells.
Wahn et al. (1991)CD8T cellsA major proportion of the patient's peripheral T cells expressed a CD8+ and TCR-gamma/delta+ phenotype while CD4+ T cells were virtually absent.
Shivakumar et al. (1989)CD8T cellsAnother minor set of T cells found in the periphery are CD4-/CD8- (double negative) and express the gamma/delta TCR; these cells can manifest MHC-restricted or nonrestricted cytotoxicity but no helper function.
Sell et al. (1992)CD8T-cellThese suppressor cells expressed CD3, CD8, CD45RO, and the alpha, beta T-cell receptor, but not CD4 or CD56.
Knowles (1989)CD8T cellOnly in exceptional circumstances do normal, non-neoplastic T cell populations express the CD4- CD8- or the CD4+ CD8+ phenotype and/or lack one or more pan-T cell antigens.
Hori et al. (1991)CD8T cellUsing 2ST8-5H7 mAb that detects CD8 beta expression, we found that double positive T cell clones isolated with IL-4 express CD8 alpha but not beta, in contrast to CD8+ CTL cell clones, which express both chains of CD8.
Spencer et al. (1989)CD8T cellIn normal human jejunum approximately 6% of the intraepithelial T cells expressing CD3 (an antigen associated with the T cell receptor) do not express the T cell subset antigens CD4 or CD8.
Spencer et al. (1989)CD8T cellsApproximately 20% of CD7+ cells (T cells and null cells) do not express CD4 or CD8 and 14% of the CD7+ cells do not express CD3 and are therefore not T cells.
Lin et al. (1999)T-cell receptorT-cellThe lymphoma expressed CD2, CD3, CD7, CD8 and CD56, and the gammadelta T-cell receptor and did not express CD5, CD4 and the alphabeta T-cell receptor.
van der Veken et al. (2006)CD8T cellsBecause most gammadelta T cells do not express CD4 and CD8, we subsequently transferred these coreceptors.
Elrefaei et al. (2009)CD8T cellspositive CD8+ T cells were FOXP3 negative and CD25 negative.
Wang et al. (2009)CD8T cellWe found that dermal langerin(+) cells, but not LC, were essential for the CD8 T cell response.
Villeneuve et al. (2008)CD8T cellsMore precisely, T cells with helper or cytotoxic function were sensitive to dexamethasone, but not those that were negative for the CD4 and CD8 molecules, including gammadelta and natural killer (NK) T cells.
Zhang et al. (2006)CD8T cellsMRP1 is expressed on resting memory but not on naive CD4 and CD8 T cells.
Rezvany et al. (2006)CD8T cellsThe clonally restricted pattern was significantly reduced in CD4 (P < 0.01) but not in CD8 T cells.
Clementi et al. (2006)CD8T cellsMutations decreasing function of the Fas death receptor cause the autoimmune lymphoproliferative syndrome (ALPS) with autoimmune manifestations, spleen/lymph node enlargement, and expansion of CD4/CD8-negative T cells.
Bourboulia et al. (2004)CD8T cellKSHV-specific CD8 T cell responses were absent prior to HAART but became detectable in some patients within 6 months of starting treatment, and continued to increase thereafter.
Lamant et al. (2004)CD8T-cellBoth large and small malignant cells were positive for CD43/MT1 T-cell associated antigen, perforin, granzyme B and TIA-1, but negative for CD2, CD3, CD5, CD7, CD4 and CD8 antigens.
Manel et al. (2003)CD8T lymphocytesHere we report that quiescent CD4 and CD8 T lymphocytes do not express this receptor, as monitored with a soluble receptor-binding domain derived from the HTLV envelope.
Popa et al. (2003)CD8T cellMoreover, T cell expansions were generally of small extent, and did not appear simultaneously in both CD4 and CD8 subsets.
Uda et al. (2002)CD8T cellsAfter 24 h of ex vivo culturing, however, the continuous spectrum was found to consist of only CD28-positive and CD28-negative CD8 T cells, because the CD28-int cells had disappeared due to apoptosis.
David et al. (1998)CD8T lymphocytesIn most donors, the three chains are not detectable on CD8 T lymphocytes, but for a few of them, IL-2Rbeta or IL-2Rgamma are clearly expressed.
Le Deist et al. (1996)CD8T cellsLymphoproliferation mainly involved T cells negative for the CD4 and CD8 receptors.
Kusunoki et al. (1992)CD8T lymphocytesRare T lymphocytes bearing CD3 surface antigen and T-cell receptor (TCR) alpha and beta chains, but lacking both CD4 and CD8 antigens, viz, TCR alpha beta+CD4-8- cells, appear at a frequency of 0.1% to 2% in peripheral blood TCR alpha beta+ cells of normal donors.
Sneller et al. (1994)CD8T cellsIn addition, the majority (85%) of this patient's T cells did not express either CD4 or CD8 but did express the alpha/beta T cell receptor.
Norris et al. (1998)CD8T cellsThe CD8 alpha-chain was expressed without the beta-chain (CD8alpha+beta-) by 15.4% (range 4-29.1%) of hepatic T cells, but this phenotype was undetectable among peripheral blood lymphocytes (p < 0.009).
Shankar et al. (1999)CD8T-cellFas ligand (fasL) was not detectable on antigen-specific CD8 clones, T-cell lines, or circulating HIV-specific CD8 T cells from HIV-infected donors, stained with a tetrameric HLA-A2-HIV-peptide complex.
De Berardinis (1991)CD8T cellThese cells were CD4 and CD8 negative and expressed the alpha/beta T cell receptor instead of the expected gamma/delta heterodimer.
Cruz et al. (2006)CD8T-cellCentromerically to HLA-A, a high allele diversity is observed and no association was found with CD8+ T-cell numbers (Figure 2).
Laux et al. (2000)CD8T-cellsWhile the CD4(+) subset responded with sustained proliferation, CD8(+) T-cells grew for a limited period only and failed to produce IL-2 beyond the first few days in culture.
Mookerjee et al. (1989)CD8T-cellThe proliferating cells predominantly expressed the T-cell antigens (CD3, CD4 and CD8), but not antigens of natural killer (NK) cells, B cells or mononuclear phagocytic cells.
Bangham (2008)CD8T cellsThe results revealed a higher frequency of CD8+ T cells that were negative for these costimulatory molecules in patients with HAM/TSP than in age-matched uninfected controls, but there was no such difference between healthy HTLV-1 carriers and the uninfected controls.
Daneshbod (2006)CD8T cellReanalysis of stored paraffin blocks from 1982 showed an immunophenotype typical of peripheral T cell lymphoma with strong uniform positivity for CD5 and CD4 (Fig. 5) and negative for CD8, CD20.
Tilburgs et al. (2009)CD8T cellsUnlike peripheral CD8+CD28- T cells, decidual CD8+CD28- T cells do not express the cytolytic molecule perforin.
Klingenberg et al. (2005)CD8T cellsICOS receptor was not detected on resting CD8(+) T cells but was induced in co-cultures with HUVEC.
Lim et al. (1998)CD8T cellInterfollicular areas were expanded and populated by T cell receptor-alphabeta CD3+ CD4-CD8- (double-negative, DN) T cells that were negative for CD45RO.
Kieffer et al. (1997)CD8T cellThese sites were present in CD8 alpha beta+- but not CD8 alpha beta- T cell lines nor in a B cell line.
Koopman et al. (1999)CD8T cellsMost importantly, in marked contrast to infected humans, CD8+ T cells infiltrating the germinal center were negative for the CTL marker granzyme B.
Lishner et al. (1994)CD8T-cellRESULTS: Immunophenotyping established that the cells were CD3 positive, CD4 negative, CD8 negative, T-cell receptor (TCR)-alpha/beta negative, and TCR-gamma/delta positive.
Crispe (1994)CD8T cellsA minor population of alpha beta T cells expresses neither CD4 nor CD8.
Masuda et al. (1994)CD8T cellPMT-2Y cells are positive for CD2, CD3, CD4, CD25, T cell receptor alpha beta and HLA-DR, but negative for CD1, CD7, CD8, CD19 and CD20, indicating that the clone belongs to a helper/inducer subset of T cells.
Okada et al. (2003)CD8T-cellThe lymphoma cells were positive for CD2, CD3, CD5, CD8, and T-cell receptor (TCR) beta F1, but negative for CD4, CD19, CD20, CD103, and CD56.
Caldwell et al. (1995)CD8T cellsEarly in the course of antibiotic treatment (48-72 hours), the lymphocytopenia corrects itself and is rapidly followed by a lymphocytosis of T cells that express CD3, but are negative for CD4 and CD8, as well as the major form of the TCR formed by the alpha/beta heterodimer.
Lanier et al. (1986)CD8T lymphocytesHuman CD3+ T lymphocytes that express neither CD4 nor CD8 antigens.
David et al. (1988)CD8T cellIn the present study we describe one CD2+CD3+ clone termed DS6 which expressed neither CD4 nor CD8 differentiation antigens and failed to react with WT31, a monoclonal antibody directed against the T cell antigen receptor alpha/beta heterodimer.
van de Griend et al. (1987)CD8T lymphocytesA small subpopulation (about 2%) of normal CD3+ human T lymphocytes lacks both CD4 and CD8 antigens.
Choy et al. (2008)CD8T cellsRESULTS: Resting human CD8 and CD4 T cells expressed the CXCR4, but not the CXCR7, receptor for CXCL12.
Matsumoto et al. (1991)CD8T cellHowever, a minor T cell subset, which lacks both CD4 and CD8 molecules but bears the usual form of T cell receptor (TCR) alpha beta (CD4-CD8-TCR alpha beta+ T cells), has recently been found not only in mice but also in humans, and its role in immune response is now of considerable interest.
Kieffer et al. (1997)CD8T cellsWe found that transgenic mice had correct developmental expression of human CD8 beta on thymocytes and mature CD8+ cells and no expression on mature CD4+ T cells or B cells.
Herbein et al. (1998)CD8T cellsUsing flow cytometry, we have determined the incidence of apoptosis by either terminal transferase dUTP nick end labeling or annexin-V assays in different cell subpopulations, i.e., in CD4+ or CD8+ T cells that were GFP positive or negative.
Elrefaei et al. (2009)CD8T cellsThese suppressor CD8+ T cells are typically CD28 negative [11], [12] and express CD25, FOXP3, and CTLA-4 [1], [4], [13], [14].
Cohen et al. (1989)CD8T lymphocytesCR1 was detected on a subset of CD4+ T lymphocytes but not on CD8+ or on Leu-7+ lymphocytes.
Banerjee et al. (2010)CD8T cellsWe show in this study that CD8(+) T cells lacking Eomes compete poorly in contributing to the pool of Ag-specific central memory cells.
Nagaraj et al. (2007)CD8-expressingT cellsThis process makes CD8-expressing T cells unable to bind pMHC and to respond to the specific peptide, although they retain their ability to respond to nonspecific stimulation.
Minegishi et al. (1988)CD8T-cellTHP-6 cells were positive for CD7 and CD5 antigens and terminal deoxynucleotidyl transferase, but negative for CD2, CD1, CD4, CD8, CD10, cytoplasmic and surface CD3 and HLA-DR antigens, suggesting a precursor T-cell line.
Voss et al. (2006)CD8T cellsUsing a human CD8 x A2.1/Kb mouse derived TCR specific for natural peptide-A2.1 (pA2.1) complexes comprising residues 81-88 of the human homolog of the murine double-minute 2 oncoprotein, MDM2(81-88), we found that the heterodimeric CD8 alpha beta coreceptor, but not normally expressed homodimeric CD8 alpha alpha, is required for tetramer binding and functional redirection of TCR- transduced human T cells.
Robertson et al. (1996)CD8T cellNKL cells express CD2, CD6, CD11a, CD26, CD27, CD29, CD38, CD43, CD58, CD81, CD94, CD95, class II MHC, and the C1.7.1 antigen, but do not express detectable levels of CD3, CD4, CD5, CD8, CD14, CD19, CD20, CD28, alpha/beta or gamma/delta T cell receptors on the cell surface.
Nitta et al. (1995)CD8T cellThe small cells stained faintly with anti-CD5 in two specimens, but were negative for the T cell specific markers, CD2, CD3, CD7, and CD8.
Carbone et al. (1995)CD8T-cellCD40L was constitutively expressed by neoplastic cells in 15 of 36 (42%) T-cell NHLs/adult T-cell leukemia/lymphomas, almost invariably those displaying the CD4+/CD8- phenotype, whereas no CD40L-expressing tumor cells could be found in B-cell NHL and HD.
Dembek et al. (2010)CD8T-cells+ CD8+ T cells did not express the chemokine receptor CCR7 and are therefore classified as effector CD8+ T-cells (Figure 5A).
Chen et al. (2001)CD8T cellsIn both healthy donors and HIV-infected donors, CCR7(+) CD8 T cells were uniformly negative for perforin.
Suzushima et al. (1993)CD8T-cellWe present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8- [double-negative, DN], T-cell receptor [TCR] alpha beta+).
Kienzle et al. (2004)CD8T cellsCD8low T cells have downregulated CD8 alpha/beta heterodimers and no preferential CD8 alpha/alpha homodimer expression.
Nikaein et al. (1993)CD8T-cellTwenty-two clones expressed alpha/beta T-cell receptors and one clone (CD4-/CD8-) expressed no T-cell receptor.
Wang et al. (2007)CD8T cellsHere, our results demonstrated that Tim-3 was expressed on activated CD8+ alloreactive T cells (CD8+CD44highCD62Llow), but not expressed on na´ve CD8+ T cells.
Woodworth et al. (2008)CD8T-cellCD4(+) and CD8(+) T-cell responses to mycobacterial antigens secreted independently of ESX-1 were unaffected, suggesting that ESX-1-dependent phagosomal escape is not required for CD8(+) T-cell priming during infection.
Goepfert et al. (2007)CD8T-cellAs expected, HIV-specific CD8 T-cell responses were not detected.
Schmitz et al. (2009)CD8T cellsIn contrast to the vervet AGM, CD4+ T cells in PTM do not express the CD8??
Posnett et al. (1986)T-cell antigen receptorT cellsWhile two of these antibodies detect the clonotypic receptor in all individuals studied, the third antibody (OT145), described herein, does not detect the T-cell antigen receptor on T cells of all individuals.
Carvalho et al. (2010)CD8T lymphocytesInterestingly, this chemokine receptor is expressed in humans on Th1 and Tc1 memory CD4+ and CD8+ T lymphocytes [24], and CXCR6 are preferentially expressed on double negative and CD8+ subsets of NKT cells [22], [23].
Patey-Mariaud De Serre et al. (2000)CD8T-lymphocytesAIMS: We recently showed that refractory sprue is distinct from coeliac disease, the former being characterized by abnormal intraepithelial T-lymphocytes expressing a cytoplasmic CD3 chain (CD3c), lacking CD3 and CD8 surface expression, and showing TCRgamma gene rearrangements.
Chang et al. (2010)CD8T-cellImmunostaining for CD3, CD6, CD8, CD20, CD30, T-cell intracellular antigen-1, myeloperoxidase, and terminal deoxynucleotidyl transferase was either weak or negative (Fig. 3).
Arimura et al. (2008)CD8T cellsWe report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically downregulated in CD4(+) and CD8(+) primary human T cells upon T cell activation.
Fuchino et al. (1996)CD8T cellsTherefore, healthy subjects and patients with various diseases can be classified according to age and to the proportion of CD8+ T cells that are DAF-negative.
Kim et al. (2005)T-cell receptorT-cellT-cell receptor gene rearrangement, EBV, CD13 and CD33 were negative.
Uebelhoer et al. (2008)CD8T cellThese results demonstrate that in vitro mutation of a CD8+ T cell epitope in hepatitis C virus can occur, that particular amino acid substitutions are not maintained over the course of in vitro infection, and that reversion of less fit viral variants to parental HCV sequence can occur when CD8+ T cell pressure is absent.
Herasimtschuk et al. (2008)CD8T-cellWhile patients maintained a stable population of cells, at baseline a complete lack of both CD4+ and CD8+ HIV-1-specific T-cell responses was noted in 11 of 12 individuals.
Sheehy et al. (1989)T-cell receptorT-cellWe suggest that the importance of HLA alleles in insulin-dependent diabetes mellitus susceptibility and the lack of importance of T-cell receptor alpha alleles result from the different strategies by which HLA and T-cell receptor molecules achieve antigen-binding diversity: multiple loci and allelic diversity in the case of HLA; combinatorial, junctional, and N-region diversity in the case of the T-cell receptor.
Whelan et al. (2009)CD8T cellPreliminary experiments performed with DC pulsed with BCG showed no detectable CD8+ T cell response in the BCG-BCG regime and so this was not investigated further.
Brod et al. (1990)CD8T cellThese results show that IL-4 can upregulate CD8 expression on CD4+ T cell clones while not effecting CD4 expression on CD8+ T cell clones.
McClanahan et al. (1999)CD8T-cellsThe majority of normal gammadelta-T-cells are negative for surface CD4 and CD8 and a subpopulation does not express CD5, two immunophenotypic findings strongly suggestive of neoplasia in alpha beta T-cells.
McKee et al. (2005)CD8 coreceptorT cellThese cells, derived from a human T cell lymphoma, do not express the CD8 coreceptor.