Viewing affirmative mentions of gene expression of CD4 (H. sapiens) in T cells

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Lusso et al. (1995)CD4T cellsAs previously documented in mature CD8+ alpha/beta T cells and natural killer cells, HHV-6 infection induced gamma/delta T lymphocytes to express de novo CD4 messenger RNA and protein, as detected by reverse transcriptase-polymerase chain reaction and fluorocytometry, respectively.
Lusso et al. (1995)CD4T cellWhereas purified CD4- gamma/delta T cell populations were per se refractory to HIV infection, they became susceptible to productive infection by HIV-1, strain IIIB, after induction of CD4 expression by HHV-6.
Markowitz et al. (2003)CD4T cellsWith a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4(+) T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.
Sullivan et al. (2002)CD4T-cellCD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia.
Szondy et al. (2001)CD4T cellsAlthough CD4 T cell production is impaired in patients infected with HIV, there is now increasing evidence that the primary basis of T cell depletion is accelerated apoptosis of CD4 and CD8 T cells.
Schnittman et al. (1989)CD4T cellThe reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.
Schnittman et al. (1989)CD4T lymphocyteHuman immunodeficiency virus type 1 (HIV-1) selectively infects cells expressing the CD4 molecule, resulting in substantial quantitative and qualitative defects in CD4+ T lymphocyte function in patients with acquired immunodeficiency syndrome (AIDS).
Schnittman et al. (1989)CD4T cellsPrevious studies have demonstrated that in vitro infection of CD4+ T cells with HIV-1 results in downregulation of CD4 expression such that CD4 protein is no longer detectable on the surface of the infected cells.
Schnittman et al. (1989)CD4T cellWithin PBMCs, HIV-1 was expressed in vivo predominantly in the T cell subpopulation which, in contrast to the in vitro observations, continued to express CD4.
Novak et al. (2001)CD4T cellsWe have recently extended these studies to human class II-restricted CD4(+) T cell responses and now describe antigen-specific T cell responses from human peripheral blood in which elevated CD4 expression levels in human T cells following antigen stimulation identify the activated and proliferating subset of cells.
Sorice et al. (1995)CD4T lymphocytesGangliosides modulate the expression of CD4 molecules on the cell surface of T lymphocytes.
Yasukawa et al. (1995)CD4T cellsSince gangliosides and phorbol esters are known to induce selective down-modulation of cell surface CD4 expression, it might be expected that treatment with these agents would interfere with HHV-7 infection of CD4+ T cells.
Lifson and Engleman (1989)CD4T-cellSoluble forms of CD4 produced either by genetic engineering or solid phase peptide synthesis can completely block HIV infectivity and syncytia formation in vitro, remarkably without apparent effects on T-cell immunity.
Lusso et al. (1994)CD4T cellsA selective and progressive downregulation of the surface membrane expression of CD4 was observed in human CD4+ T cells in the course of HHV-7 infection.
Kawaguchi et al. (1989)CD4T lymphocytesWe have explored the possible mechanisms for selective modulation by gangliosides of CD4 on human T lymphocytes and subsequent re-expression of CD4.
Kantor et al. (2009)CD4T cellsLogistic and tree regressions examined relationships between VL and 4 variables: CD4 T cell count (hereafter CD4 cell count), percentage of T cells expressing CD4 (hereafter CD4 cell percentage), percentage decrease in the CD4 T cell count (hereafter CD4 cell count percent decrease), and percentage decrease in the percentage of T cells expressing CD4 (hereafter CD4% percent decrease).
Vermeire et al. (2003)CD4T cellsFlow cytometric evaluation of cellular CD4 receptor expression in T cells demonstrated the specific CD4 down-modulating capacity of the CADA derivatives, with IC(50) values similar to those obtained in the antiviral assays.
Crocker et al. (1987)CD4T cellsThe CD4 antigen is expressed on T cells of all mammalian species examined and appears to play an important role in the response of T cells to antigen.
Crocker et al. (1987)CD4T cellsPrevious studies have demonstrated that M phi in the rat and human also express the CD4 antigen, which is indistinguishable from that on T cells.
Crocker et al. (1987)CD4T cellsThis species heterogeneity indicates that T cells and M phi regulate CD4 antigen expression independently and that CD4 may not be essential for M phi function.
Mayanja-Kizza et al. (2005)CD4T cellShort-term prednisolone therapy reduced levels of immune activation and tended to produce higher CD4(+) T cell counts.
Bryl et al. (2001)CD4T cellsThe T cells of young and elderly donors with reduced expression of CD4 were examined to see whether these cells exhibit other phenotypic features suggesting their active state.
Bryl et al. (2001)CD4T lymphocytesIt was found that T lymphocytes expressing CD4 can be divided into 2 semidiscrete subpopulations: the major (CD4(+)) population, in which the level of expression of CD4 is constant and high, and a minor population (CD4(lo)), in which the expression of CD4 can be up to an order of magnitude lower than on the CD4(+) cells.
Martins et al. (2004)CD4T-cellFollowing prolonged stimulation in vitro using either allogeneic stimulator cells or viral antigens, we found that coexpression of activation markers within the CD4(+) T-cell subset occurred exclusively within a subpopulation of T cells that significantly increased their surface expression of CD4.
Kaiser et al. (2007)CD4T cellsIn conjunction with the observation that the HIV quasispecies in CD4+ and CD4-)/CD8- T cells were phylogenetically closely related, these findings provide evidence that CD4 expression is downmodulated during the transition to productive infection in vivo.
Marshall et al. (1992)CD4T-cellWe have isolated and studied CD4-expressing tumor cell clones made by expressing CD4 in the T-cell tumor line HSB.
Yuille et al. (1988)CD4T-cellIn order to improve understanding of how HIV-1 infection down-modulates cell surface membrane expression of CD4, we have measured several parameters of CD4 expression in the human tumor T-cell lines CEM and MOLT-4 at different times after infection.
Davis et al. (1998)CD4T cellsAptamers, conjugated to fluorophores, stained mouse T cells that express human CD4 on the surface, but not the control mouse T cells lacking human CD4.
Carriere et al. (1994)CD4T lymphocytesA highly sensitive two-site enzyme immunoassay (Capcellia) was developed to determine the concentration of CD4 and CD8 molecules expressed on the surface of human T lymphocytes.
Mariani and Skowronski (1993)CD4T cellsA transient expression system with human CEM T cells was used to assess the effect of nef on CD4 antigen expression on the cell surface.
Lorès et al. (1992)CD4 receptorT cellsHowever, transgenic mouse T cells expressing either the human CD4 receptor, or a hybrid human/mouse CD4 receptor alone or in conjunction with human major histocompatibility complex class I molecules, were refractory to in vitro HIV-1 infection.
Cucchiarini et al. (1995)CD4T-cellBecause of the lack of vpu in HIV-2, we investigated the effects of two HIV-2 isolates (ROD 10 and EHO) on CD4 expression in the CEM T-cell line.
Gluckman and Klatzmann (1988)CD4T lymphocytesAIDS is primarily a disease of the CD4-expressing helper-inducer T lymphocytes and is caused by human immunodeficiency virus (HIV), a retrovirus of the lentivirus subgroup.
Ohata et al. (1999)CD4T cellWe present a rare case of adult T cell leukemia (ATL) in which leukemic T cells simultaneously expressed CD4 and CD8 surface antigens and refractory cytomegalovirus (CMV)-induced gastroenterocolitis preceded its clinical onset.
Petitjean et al. (2007)CD4T lymphocytesSpontaneous HIV-1-producing CD4+ T lymphocytes in patients
Petitjean et al. (2007)CD4T lymphocytesSpontaneously HIV-1-Ag-producing CD4+ T lymphocytes were also enumerated.
Serpente et al. (1993)CD4T cellTranscriptional and post-transcriptional mechanisms are involved in the absence of CD4 surface expression in two HIV-1 chronically infected T cell lines.
Serpente et al. (1993)CD4 receptorT cellsOne possible mechanism is the production of infected T cells which are lacking in surface expression of the CD4 receptor protein.
Patterson et al. (1995)CD4 moleculeT cellsTo study the association between HIV-1 infection and modulation of cell surface expression of the CD4 molecule in vivo, we examined the CD4+ T cells harboring proviral DNA obtained from HIV-1-infected individuals who had received no antiretroviral therapy for at least 90 days.
Patterson et al. (1995)CD4T cellsSimultaneous immunophenotyping of CD4 cell surface expression and PCR-driven in situ hybridization for HIV-1 DNA were used to resolve the CD4+ T cells into distinct populations predicted upon the presence or absence of proviral DNA.
Barzaga-Gilbert et al. (1992)CD4T cellIn mice expressing lower levels of human CD4, T cell responses to human class II molecules were enhanced up to threefold, whereas allogeneic responses were unaltered.
Barzaga-Gilbert et al. (1992)CD4T cellThis indicates that species-specific interactions between class II molecules and CD4 expressed on peripheral T cells are not sufficient to account for the low xenogeneic response and that intrinsic differences in T cell receptor structures or the need for species specificity in the interaction between CD4 and class II molecules during positive selection are also important.
Zarling et al. (1990)CD4T cellsTargeting pokeweed antiviral protein to CD4+ T cells by conjugating it to monoclonal antibodies reactive with CD5, CD7 or CD4 expressed on CD4+ cells, increased its anti-HIV potency up to 1,000-fold.
Olive and Mawas (1993)CD4T cellIn humans, CD4 mAbs are, or could be, used and evaluated in AID (lupus, diabetes, rheumatoid arthritis, etc.), transplantation, leukemias and lymphomas expressing CD4, and, finally, in AIDS patients, in whom CD4 mAbs can block HIV-CD4 binding and deliver a negative signal to T cell, thus blocking T-cell activation and HIV transcription.
Morrison et al. (1994)CD4T cellSurface expression of the CD4 glycoprotein molecule is postulated to facilitate antigen recognition through the T cell receptor (TCR) and is itself a receptor for human immunodeficiency virus (HIV)-gp120 glycoprotein.
Morrison et al. (1994)CD4T cellSelective CD4 modulations have independently redefined the specific contributions of CD4 surface expression during T cell activation and may establish a role for CD4 receptor subtypes during HIV-1 infection of CD4+ cells.
Golding et al. (1995)CD4T-cellThe fusion inhibition was seen in a variety of cells, including T-cell transfectants expressing engineered CD4 receptors (CD4.401 and CD4.CD8) which are not susceptible to down modulation by PMA treatment.
Boritz et al. (2003)CD4T cellDiverse repertoire of HIV-1 p24-specific, IFN-gamma-producing CD4+ T cell clones following immune reconstitution on highly active antiretroviral therapy.
Weyand et al. (1987)CD4T cellCell surface expression of CD4, an invariant membrane glycoprotein, is characteristic of the MHC class II-restricted T cell helper/inducer subset.
Weyand et al. (1987)CD4T cellsIn this manuscript, we have shown that the cell surface expression of CD4 is correlated with activation of T cells.
Weyand et al. (1987)CD4T cellData presented in this paper have demonstrated, for the first time, that antigenic stimulation of human T cell clones caused a decrease in the expression of the CD4 marker (as well as to the CD3 marker) to about 50% of the constitutive level.
de Leòn et al. (2006)CD4T cellsRole of tumour-associated N-glycolylated variant of GM3 ganglioside in cancer progression: effect over CD4 expression on T cells.
de Leòn et al. (2006)CD4T cellsThe present work demonstrates, for the first time, the capacity of NGcGM3 ganglioside to down-modulate CD4 expression in murine and human T lymphocytes, especially in non-activated T cells.
de Leòn et al. (2006)CD4T lymphocytesThirty and tenfold reductions in CD4 expression were induced by purified NGcGM3 ganglioside in murine and human T lymphocytes, respectively.
Cruikshank et al. (1991)CD4T cellIn the present study, we demonstrate that CD4 affinity-purified natural and recombinant LCF induced a rise in intracellular calcium and increased inositol trisphosphate generation in normal human CD4+ lymphocytes and murine T cell hybridomas infected to express human CD4.
Thedrez et al. (2007)CD4T cellsCD4 is also expressed by invariant natural killer T cells (iNKT), which recognize natural and synthetic lipid antigens, such as alpha-galactosyl ceramide (alpha-GalCer), in association with the MHC class I-like CD1d molecule.
Moutouh et al. (1998)CD4T-cellTo do this, wild-type and mutant forms of the CD4 cytoplasmic tail were stably expressed in the lymphoblastoid T-cell line A2.01.
Mouly et al. (2007)CD4 moleculeT-cellsIn humans, the CD4 molecule is expressed on a subset of T-cells and at various levels on myeloid and lymphoid cells.
Mouly et al. (2007)CD4T-cellsWe speculated that the CD4 silencer, which operates in CD8+ T-cells to repress CD4 expression, could be responsible for CD4 repression in human lymphoid non-T-cells.
Mouly et al. (2007)CD4T-cellsCollectively, our results suggest that beyond its well-characterized function in T-cells, the CD4 silencer also regulates CD4 gene expression in human lymphoid non-T-cells.
Harrington and Geballe (1996)CD4T cellUsing these hybrids it is demonstrated that expression of CD4 and CD26, the T cell activation antigen dipeptidyl peptidase IV recently proposed as a CD4 cofactor necessary for HIV-1 infection, are not sufficient for HIV-1 entry.
Sanfridson et al. (1994)CD4T cellIn this report, we examine the biosynthesis and cell surface expression of CD4 in the human T cell line, CEM-SS, that has been stably transduced with the SIV nef gene.
Marracci et al. (2006)CD4T cellWe now demonstrate that treatment of human PBMC and T cell lines with LA downmodulated CD4 expression in a concentration-dependent manner.
Truneh et al. (1990)CD4T lymphocytesThe CD4 cell surface glycoprotein which is expressed primarily by a subset of T lymphocytes plays a key role in normal immune responses.
Chan et al. (2005)CD4T lymphocytesWe show here that apart from T lymphocytes, plaque infiltrates consist of lots of NK cells and significant proportions of NKT cells that express T cell receptor (TCR) alphabeta, CD4, and the NK markers CD56 and CD161.
Pescovitz et al. (1990)CD4T-cellsIn distinction from what has been found in other species, a large percentage of peripheral T-cells simultaneously express both CD4 and CD8.
Pescovitz et al. (1990)CD4T-cellsSince 76-7-4 did not stain peripheral T-cells, we conclude that CD4/CD8 dual-expressing peripheral T-cells are not simply immature thymic emigrants.
Giolo et al. (2007)CD4T cellOf note, the function of Nef on the anterograde transport of newly synthesized CD4 molecules is irrelevant in cells with a slow constitutive CD4 turnover such as T cell lines.
Schnittman et al. (1990)CD4T-cellWe determined that transformed T-cell and thymocyte cell lines completely lacking CD4 were not susceptible to infection by HIV-1, whereas all of the following lines were: UF thymocytes (70-90% CD4hi+); DP thymocytes (99% CD4hi+); TN thymocytes (0% CD4hi+); and TCR alpha beta +, TCR gamma delta +, or CD16+ CD3- (natural killer) thymocyte clones expressing variable levels of CD4 and representing the progeny of TN thymocytes.
Schnittman et al. (1990)CD4T-cellThus, intrathymic T-cell precursors and their progeny representing many stages of T-cell ontogeny are susceptible to infection by HIV-1, including early TN thymocytes, which express very low levels of CD4.
Bachelder et al. (1995)CD4T lymphocytesWhile this Fab does not bind to CD4-positive T-cell lines or to human T lymphocytes, it recognizes cell surface-expressed CD4 following the incubation of these cells with a recombinant form of HIV-1 gp120 or with HIV-1 virions.
Peters et al. (2007)CD4T-cellIn addition, variation in R5 macrophage tropism may also have implications (1) for transmission, depending on what role macrophages or cells that express low CD4 and/or CCR5 play in the establishment of infection in a new host, and (2) for pathogenesis and depletion of CD4(+) T cells (i.e., do highly macrophage-tropic variants confer a broader tropism among CD4(+) T-cell populations late in disease and contribute to their depletion?).
Rivera-Toledo et al. (2010)CD4T cellsLimited expression of CD4 in the bystander unfused population, as well as in the newly formed syncytia, would result in limitation of further viral entry and a failure to identify these cells, and it could partially contribute to functional impairment and a decrease in the number of CD4+ T cells in AIDS.
Stamatatos and Düzgüne? (1993)CD4T cellsIn contrast, lipid mixing with CD4 expressing EL-4 mouse T cells or Mv-1-lu mink lung fibroblasts was absent or limited, suggesting that certain components of human cell membranes in addition to CD4 are involved in SIVmac envelope-cell fusion.
Pandori et al. (1998)CD4 moleculeT cellsFurthermore, these residues were required for optimal infectivity even during virion assembly in T cells (A2. 01) that expressed a CD4 molecule that is unable to respond to Nef.
Zhang et al. (2004)CD4T cellsRegulation of activities of NK cells and CD4 expression in T cells by human HNP-1, -2, and -3.
Zhang et al. (2004)CD4T cellsHere we show that HNPs may inhibit T cells by downregulating CD4 expression, a molecule of critical importance for T cell's interaction with the target cell.
Xiang et al. (2009)CD4T cellsInfection of CD4(+) T cells and macrophages with YFV (17D vaccine strain) also inhibited HIV replication and decreased CD4 gene expression.
Potter et al. (1999)CD4T lymphocyteThis analysis of a wide variety of apoptotic stimuli demonstrates that diminished CD4 and CD8 surface receptor expression is a common feature of human T lymphocyte apoptosis.
Nakamura et al. (2003)CD4T cellOur results demonstrate that Ag-induced T cell activation which is normally concomitant with CD4 down-regulation may be disturbed through the aberrant regulation of CD4 expression by oxidative stress.
Heemskerk et al. (2006)CD4T cellsIn healthy donors, predominantly HAdV-specific T cells expressing CD4 are detected.
Chu et al. (1990)CD4T cellThe cells from all 5 T cell clones detected for indirect fluorescence expressed CD3 and CD4 surface markers.
Theodore et al. (1994)CD4T lymphocytesWe investigated CD4 expression as well as CD3- and CD4-mediated cell migration in normal peripheral blood T lymphocytes exposed to recombinant gp120 in long-term cultures for < or = 6 days.
Walker et al. (1989)CD4T cellsThe data also indicated that culturing enriched CD4+ cells could greatly enhance detection of infectious virus in blood specimens and demonstrated that the CD4+ molecule is expressed on infected T cells isolated directly from the peripheral blood.
Tersmette et al. (1989)CD4T-cellHuman immunodeficiency virus infection studied in CD4-expressing human-murine T-cell hybrids.
Tersmette et al. (1989)CD4T-cellHuman immunodeficiency virus (HIV) infection was studied by means of CD4-expressing human-murine T-cell hybrids, containing a variable amount of human chromosomes.
Tersmette et al. (1989)CD4T-cellFor this study, we used four hybrids containing all or several human chromosomes, which all expressed the CD4 antigen, as assessed by different anti-CD4 monoclonal antibodies (e.g., OKT4A, Leu-3a, and MT151) and, in addition, a variable number of other human T-cell antigens.
Sperber et al. (1990)CD-4T-cellIn contrast to T-cell lines, where CD-4 expression may predict susceptibility to HIV infection, in monocyte hybridomas, presence or absence of surface CD-4 does not appear to be the determining factor of susceptibility to HIV infection.
Conti et al. (2000)CD4T-cellThe effect exerted by Vpr on HIV replication and CD4 expression suggests that this protein can regulate both the establishment of a productive HIV-1 infection and CD4-mediated T-cell functions.
Kumar et al. (1999)CD4T cellsAll expressed CD2, CD4, CD58, CD69 and CD80 and therefore resembled activated T cells.
Eggena et al. (2005)CD4T cellCoexpression of CD38 and HLA-DR on both CD4(+) and CD8(+) T cell subsets was directly correlated with viral load and inversely correlated with CD4(+) T cell counts.
Bellinghausen et al. (2003)CD4T cellsIn some atopic patients preactivated CD4(+)CD25(+) T cells reproducibly showed strong proliferative responses, produced higher amounts of IL-4 and IL-10 than CD4(+)CD25(-) T cells, and suppressed only the IFN-gamma production of CD4(+)CD25(-) T cells.
Sleasman et al. (1991)CD4T cellsThe increase in CD4+CD45RA expression was a result of active proliferation by the Con A-stimulated T cells.
Kost et al. (1991)CD4T-cellThe CD4 molecule, a glycoprotein expressed primarily on the cell surface of specific T lymphocytes, is thought to function in T-cell antigen recognition and activation.