Viewing negative mentions of gene expression of CD4 (H. sapiens) in T cells

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Wilson et al. (2000)CD4T cellsIn contrast, HIV-1-specific proliferative responses were absent in most individuals with progressive HIV-1 infection, even though interferon-gamma-producing HIV-1-specific CD4(+) T cells were detectable by flow cytometry.
Podolin et al. (2000)CD4T-cellUpon administration of these mAbs to mice that express a human CD4 transgene, but not mouse CD4 (HuCD4/Tg mice), clenoliximab and keliximab exhibited similar kinetics of binding to CD4, and induced the same degree of CD4 modulation from the cell surface, although only keliximab mediated CD4+ T-cell depletion.
Lyons et al. (2007)CD4T cellsThis is not unexpected, as monocytes express surface CD4, but clearly suggests that for optimal purities CD4+ T cells should be isolated from a monocyte-depleted sample.
Falini et al. (1997)CD4T cellsNotably, the nuclei of reactive CD3+/ CD4+ T cells near to and rosetting around L&H cells in NLPHD were also strongly bcl-6+, but lacked CD40 ligand (CD40L) expression.
Falini et al. (1996)CD4T cellsNotably, the nuclei of reactive CD3+/CD4+ T cells nearby to and rosetting around L&H cells in NLPHD were also strongly BCL-6+, but lacked CD40 ligand (CD40L) expression.
Hebbeler et al. (2008)CD4T cellsVgamma2-Jgamma1.2Vdelta2 T cells provide a convenient model for assessing the impact of antiretroviral therapy on cell populations that are not susceptible to direct infection because they do not express CD4 and depletion occurs by indirect mechanisms.
Jiang et al. (1999)CD4T lymphocytesSuch particles allowed efficient infection of CD4-positive human T lymphocytes, and, at a lower efficiency, also cells expressing CXCR4 without CD4.
Lanier et al. (1986)CD4T lymphocytesHuman CD3+ T lymphocytes that express neither CD4 nor CD8 antigens.
Jones et al. (2009)CD4T-cellHuman immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations.
Sell et al. (1992)CD4T-cellThese suppressor cells expressed CD3, CD8, CD45RO, and the alpha, beta T-cell receptor, but not CD4 or CD56.
Mookerjee et al. (1989)CD4T-cellThe proliferating cells predominantly expressed the T-cell antigens (CD3, CD4 and CD8), but not antigens of natural killer (NK) cells, B cells or mononuclear phagocytic cells.
Spencer et al. (1989)CD4T cellIn normal human jejunum approximately 6% of the intraepithelial T cells expressing CD3 (an antigen associated with the T cell receptor) do not express the T cell subset antigens CD4 or CD8.
Spencer et al. (1989)CD4T cellsApproximately 20% of CD7+ cells (T cells and null cells) do not express CD4 or CD8 and 14% of the CD7+ cells do not express CD3 and are therefore not T cells.
Schnittman et al. (1989)CD4T cellsPrevious studies have demonstrated that in vitro infection of CD4+ T cells with HIV-1 results in downregulation of CD4 expression such that CD4 protein is no longer detectable on the surface of the infected cells.
Schnittman et al. (1990)CD4T-cellWe determined that transformed T-cell and thymocyte cell lines completely lacking CD4 were not susceptible to infection by HIV-1, whereas all of the following lines were: UF thymocytes (70-90% CD4hi+); DP thymocytes (99% CD4hi+); TN thymocytes (0% CD4hi+); and TCR alpha beta +, TCR gamma delta +, or CD16+ CD3- (natural killer) thymocyte clones expressing variable levels of CD4 and representing the progeny of TN thymocytes.
Maek-A-Nantawat et al. (2007)CD4T cellsIncreased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection.
Hirokawa et al. (2001)CD4T cellsWe found that the fraction of T cells lacking CD28 expression in the CD4(+) subset was increased after transplantation, and expanded CD4(+)CD28(-) T lymphocytes carrying certain TCRBV subfamilies showed limited TCR diversity.
Barbour et al. (2007)CD4T cellWe detected no expansion of any CD4+ T cell differentiation subset between HSV-2+ and HSV-2- persons.
Roncarolo et al. (2003)CD4T cellSuppressive CD4+CD25+ T cell clones do not synthesize IL10 but produce TGFbeta which contributes to the suppression of proliferation mediated by these cells.
Hivroz et al. (1993)CD4T cellThe pattern of proteins phosphorylated on tyrosine residues in response to gp120 activation was distinct from that induced by anti-CD4 antibodies. p56lck activation required its association with CD4, since p56lck activity was not modified in HUT78 T cell lines expressing a truncated or mutated form of CD4 unable to associate with p56lck.
Clementi et al. (2006)CD4T cellsMutations decreasing function of the Fas death receptor cause the autoimmune lymphoproliferative syndrome (ALPS) with autoimmune manifestations, spleen/lymph node enlargement, and expansion of CD4/CD8-negative T cells.
Koelle et al. (2000)CD4T cellsHSV-specific CD4 T cells were enriched in three of the five HSK specimens and were not detectable in the control specimens.
Miyanishi and Ohno (1992)CD4T-cellThe SMZ-1 cells, as well as the parental lymphoma cells, were of helper/inducer T-cell immunophenotype; they were positive for CD2, CD3, and CD4 antigens, and negative for CD8.
Sun et al. (1992)CD 4T-cellThe first case expressed natural killer (NK) cell, some T-cell (CD 2, CD 5, CD 8), and HLA-DR antigens, but was negative for other T-cell (CD 3, CD 4, CD 7), T-cell receptor (TCR), B-cell, and myeloid antigens.
Pantaleo et al. (1991)CD4T lymphocytesHuman immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission.
Chang et al. (2010)CD4T-cellThis tumor expresses CD4 and CD56 with no obvious evidence of B- or T-cell differentiation.
Su and Hsieh (1992)CD4T cellBoth the CD4 and CD8 T cell subsets, and a hitherto undefined T lineage lacking CD4/CD8 expression have been involved.
De Berardinis (1991)CD4T cellThese cells were CD4 and CD8 negative and expressed the alpha/beta T cell receptor instead of the expected gamma/delta heterodimer.
Knowles (1989)CD4T cellOnly in exceptional circumstances do normal, non-neoplastic T cell populations express the CD4- CD8- or the CD4+ CD8+ phenotype and/or lack one or more pan-T cell antigens.
Lin et al. (1999)CD4T-cellThe lymphoma expressed CD2, CD3, CD7, CD8 and CD56, and the gammadelta T-cell receptor and did not express CD5, CD4 and the alphabeta T-cell receptor.
Sneller et al. (1994)CD4T cellsIn addition, the majority (85%) of this patient's T cells did not express either CD4 or CD8 but did express the alpha/beta T cell receptor.
Oka et al. (1992)CD4T-lymphocytesAll cell lines established were CD4+/CD8 divided by T-lymphocytes, except for one cell line of CD4+/CD8+.
Herbein et al. (1998)CD4T cellsUsing flow cytometry, we have determined the incidence of apoptosis by either terminal transferase dUTP nick end labeling or annexin-V assays in different cell subpopulations, i.e., in CD4+ or CD8+ T cells that were GFP positive or negative.
Zolla-Pazner et al. (1995)CD4T cellsAnti-CD4bd MAbs stained only CD4-negative T cells because the CD4bd of gp120 appeared to be complexed with membrane CD4.
Bani et al. (1997)CD4T lymphocytesWe show by FACS analysis that the IL-2R gamma subunit is not detectable at the cell surface of peripheral CD4 T lymphocytes.
Shivakumar et al. (1989)CD4T cellsAnother minor set of T cells found in the periphery are CD4-/CD8- (double negative) and express the gamma/delta TCR; these cells can manifest MHC-restricted or nonrestricted cytotoxicity but no helper function.
Lim et al. (1998)CD4T cellInterfollicular areas were expanded and populated by T cell receptor-alphabeta CD3+ CD4-CD8- (double-negative, DN) T cells that were negative for CD45RO.
David et al. (1988)CD4T cellIn the present study we describe one CD2+CD3+ clone termed DS6 which expressed neither CD4 nor CD8 differentiation antigens and failed to react with WT31, a monoclonal antibody directed against the T cell antigen receptor alpha/beta heterodimer.
Xu et al. (2007)CD4T cellsAllopeptide-induced surface TGF-beta1 expression was found primarily in Forkhead box P3 (FoxP3)-negative CD4(+)CD25(low) T cells, which could adoptively transfer suppression of donor-specific DTH.
Stoebner et al. (2006)CD4T cellsHere, we show that T cells isolated from non-treated allergic contact dermatitis (ACD) reactions, 48 h following nickel challenge and propagated for 7-10 days in the presence of IL-2, were mainly CD4(+) and produced IL-10, but little interferon-gamma.
Stüve et al. (2008)CD4T cellsIn addition, no CD4(+) T cells were detectable in this compartment.
David et al. (1998)CD4T lymphocytesThe three IL-2R components are absent or only marginally detectable on CD4 T lymphocytes.
Okada et al. (2003)CD4T-cellThe lymphoma cells were positive for CD2, CD3, CD5, CD8, and T-cell receptor (TCR) beta F1, but negative for CD4, CD19, CD20, CD103, and CD56.
Yachida et al. (2010)CD4T-cellOn immunohistochemistry, tumor cells were positive for CD3, CD4 and CD30, but negative for CD8, CD20 and CD56, implying a T-cell nature.
van der Veken et al. (2006)CD4T cellsBecause most gammadelta T cells do not express CD4 and CD8, we subsequently transferred these coreceptors.
Caldwell et al. (1995)CD4T cellsEarly in the course of antibiotic treatment (48-72 hours), the lymphocytopenia corrects itself and is rapidly followed by a lymphocytosis of T cells that express CD3, but are negative for CD4 and CD8, as well as the major form of the TCR formed by the alpha/beta heterodimer.
Takaku et al. (2005)CD4T-cellThese cells were immunohistochemically positive for CD3, CD5, CD7, CD8, CD16, CD56,T-cell receptor 33 (TCR33),T-cell intracellular antigen 1, and granzyme B but were negative for CD4, CD30, CD57, and TCR33.
Lishner et al. (1994)CD4T-cellRESULTS: Immunophenotyping established that the cells were CD3 positive, CD4 negative, CD8 negative, T-cell receptor (TCR)-alpha/beta negative, and TCR-gamma/delta positive.
Matsumoto et al. (1991)CD4T cellHowever, a minor T cell subset, which lacks both CD4 and CD8 molecules but bears the usual form of T cell receptor (TCR) alpha beta (CD4-CD8-TCR alpha beta+ T cells), has recently been found not only in mice but also in humans, and its role in immune response is now of considerable interest.
Teppler et al. (1993)CD4T lymphocyteHuman immunodeficiency virus type 1 (HIV-1)-infected individuals lack IL-2 because of low CD4+ T lymphocyte numbers.
Tapirdamaz et al. (2010)CD4T-cellVariations in T-cell PF reacting to 3rd party allo-antigens showed the same trend, although the differences in PF between subsequent time points were generally smaller, and the increases in the first week after LTx were not significant in the separate CD4+ and CD8+ T-cell subsets (Figure 6B).
Robertson et al. (1996)CD4T cellNKL cells express CD2, CD6, CD11a, CD26, CD27, CD29, CD38, CD43, CD58, CD81, CD94, CD95, class II MHC, and the C1.7.1 antigen, but do not express detectable levels of CD3, CD4, CD5, CD8, CD14, CD19, CD20, CD28, alpha/beta or gamma/delta T cell receptors on the cell surface.
Masuda et al. (1994)CD4T cellPMT-2Y cells are positive for CD2, CD3, CD4, CD25, T cell receptor alpha beta and HLA-DR, but negative for CD1, CD7, CD8, CD19 and CD20, indicating that the clone belongs to a helper/inducer subset of T cells.
Duftner et al. (2003)CD4+T cellsLow levels of inhibitory NKB1 were detected on CD4+CD28- T cells (2.8 ± 4.4% versus 0.2 ± 0.1%; P = 0.003), whereas CD158a/h (KIR2DL1/ KIR2DS1) was detected neither on CD4+CD28- nor on CD4+CD28+ T cells (0.7 ± 1.9% versus 0.1 ± 0.1%).
Poonia et al. (2009)CD4T cellsT cells [5] that are CD4 negative.
Menaa et al. (1999)CD4T-cellFurthermore, FACS(R) analysis of T-cell subpopulations treated with fluorescein-labeled AXII suggested that the CD4(+), but not CD8(+), subpopulation of T cells express an AXII receptor.
van de Griend et al. (1987)CD4T lymphocytesA small subpopulation (about 2%) of normal CD3+ human T lymphocytes lacks both CD4 and CD8 antigens.
Herasimtschuk et al. (2008)CD4T-cellWhile patients maintained a stable population of cells, at baseline a complete lack of both CD4+ and CD8+ HIV-1-specific T-cell responses was noted in 11 of 12 individuals.
Yoshida et al. (1989)CD4T-cellThe tumor cells represented T-cell markers, usually CD4, but CD25 was negative.
Minegishi et al. (1988)CD4T-cellTHP-6 cells were positive for CD7 and CD5 antigens and terminal deoxynucleotidyl transferase, but negative for CD2, CD1, CD4, CD8, CD10, cytoplasmic and surface CD3 and HLA-DR antigens, suggesting a precursor T-cell line.
Bensi et al. (2009)CD4T cellK57 substitution with a glycine in sCD38p impaired its ability to inhibit syncytia formation in MT-2/H9(IIIB) cell cocultures and gp120 binding to CD4 in a mouse T cell line expressing human but not mouse CD4.
Tageja et al. (2010)CD4T-cellImmunophenotyping revealed an abnormal T-cell population expressing CD2 (96% cells), CD4 (94%), CD5 (95%), and CD25 (81%) with absent TdT.
Rodríguez-Zapata et al. (2010)CD4T lymphocytesFlow cytometry studies showed that the intracytoplasmic expression of IFN-gamma, IL-2, and TNF-alpha, but not that of IL-4, by phorbol myristate-activated CD4(+) CD3(+) and CD8(+) CD3(+) T lymphocytes was significantly increased in untreated brucellosis patients and was also partially normalized after antibiotherapy.
Gorry et al. (2007)CD4T-cellDifferences in CD4+ T-cell cytotoxicity between the 2 isolates were evident in CD4+/CCR5- cells, but not evident in CD4+/CCR5+ cells suggesting an increased ability to use CXCR4 by the 1999 isolate.
Hene et al. (2007)CD4T-cellFACS analysis indicated that, prior to library generation, the activated T-cell clone expressed CD4, CD28, CD45 and CD69, but not CD27 or CD62L (data not shown).
Rezvany et al. (2006)CD4T cellsThe clonally restricted pattern was significantly reduced in CD4 (P < 0.01) but not in CD8 T cells.
Idali et al. (2009)CD4T cells10.5% of CD4+ cells in BALF) [6,20], we isolated BALF CD4+ T cells either expressing the TCR AV2S3 gene segment (CD4+AV2S3+) or not (CD4+ AV2S3-).
Kawahara et al. (2007)CD4T cellsAmong these candidates, we focused on cyclin-dependent kinaselike 5 (CDKL5) because it was highly expressed in several ATL cell lines and some ATL clinical samples but not in normal CD4 T cells.
Han et al. (2008)CD4T cellA2.01, a CEM-derived human T cell line that does not express CD4, was used as a negative control, whereas A3.01, HUT 78, and H9 were used as positive controls.
Bartelt et al. (2009)CD4T cellsJurkat E6.1 T cells had little to no detectable CD4 expression whereas the majority of HuT78 T cells had a low but detectable expression of this protein (Table 2).
Rout et al. (2010)CD4T lymphocyteThe frequency of NKT lymphocytes within the CD8+ and DN T lymphocyte subsets were also similar between SIV-negative and naturally SIV-infected sooty mangabeys (Figure 8B–C), indicating that there was no depletion of CD4?
Snow et al. (2008)CD4T cellsAlthough purified CD4+ and CD8+ T cells were not tested, TCR-induced death in P58 PBL could be partially rescued by Fas blockade to a similar extent as normal donor T cells, suggesting FasL function is intact.
Parsonage et al. (2008)CD4T cellsExpression of IL-17 was confined to CD4 T cells, with no expression on CD8 T cells, although there were some IL-17-expressing cells in the synovium that did not express CD4 or CD8 (Figure 1b).
Ochi et al. (2010)CD4T cellsT cells do not express the CD4 or CD8 molecule, cointroduction of these coreceptor molecules sufficiently facilitates the target-specific reactivity of TCR ?
Gong et al. (1998)CD4T cellsBecause CD1-restricted T cells lack CD4 but produce IFN-gamma in response to nonpeptide mycobacterial antigens, they could play a unique role in immunity to tuberculosis.
Chou et al. (1994)CD4T cellsCharacterization of 22 clonal isolates revealed that the responding T cells were predominantly activated CD4+CD8lo, circulating memory cells restricted by either HLA-B7 or HLA-DR2, that utilized mainly V beta 4, V beta 6, V beta 12, and V beta 14, but not V beta 5.2 in their TCR.
Crisi et al. (1996)CD4T cellsPWM, but not phytohemagglutinin (PHA), induced inhibitory activity in mitomycin-treated CD8+ T cells, but not unfractionated or CD4+ T cells, for both ISC formation and B cell proliferation. rPF4 and its C-terminal tridecapeptide alleviated the suppressive effect of PWM-activated CD8+ T cells on ISC production but not on proliferation.
Xiong et al. (2004)CD4T cellThese data are further supported by staining of a polyclonal guinea pig T cell line that became progressively CD4 and CD8 negative in long-term culture.
Zhang et al. (2006)CD4T cellsMRP1 is expressed on resting memory but not on naive CD4 and CD8 T cells.
Willenbrock et al. (2001)CD4T cellsIn all informative cases, the clonal gene rearrangements were only detected among CD4(+), and not among CD8(+) T cells, indicating that the tumor clones in AILD usually derive from CD4(+) T cells.
Rütgen et al. (2010)CD4T-cellImmunophenotyping of these CLBL-1 cells showed positive staining for CD11a, CD79alphacy, CD45, CD45RA, MHC II and cells were negative for CD3, CD4, CD5, CD8, CD11d, CD14, CD21, CD34, CD56 and T-cell receptor-gammadelta (TCR-gammadelta).
Manel et al. (2003)CD4T lymphocytesHere we report that quiescent CD4 and CD8 T lymphocytes do not express this receptor, as monitored with a soluble receptor-binding domain derived from the HTLV envelope.
Choy et al. (2008)CD4T cellsRESULTS: Resting human CD8 and CD4 T cells expressed the CXCR4, but not the CXCR7, receptor for CXCL12.
Nylén and Gautam (2010)CD4T cellsThough a number of early reports suggested a role for CD8+ cells in immunity against L. major infection,[7374] CD8+ T cells, were for a long time thought to play a secondary role as CD8 cells alone could not induce protective immunity and CD8 defective mice, were able to control infection.[75] However, Belkaid et al. later demonstrated that CD8 cells actually were required for healing when C57BL/6 mice were infected with a low, and more physiological relevant, dose of parasites and in experimental infection with L. donovani both CD8 and CD4 can on their own cells prevent reactivation of disease.[7677]
Kanzaki et al. (1997)CD4T-cellsThe affected neck lymph node showed a preponderance of T-cells, predominantly CD4+ over CD8+ T-cells and all V beta gene families were expressed in the T-cells without enhancement of any particular TCR gene usage.
Smith et al. (2010)CD4T-cellsWhen Mtb PPD-stimulated PBMC were analysed by flow cytometry, polyfunctional CD8 or CD4 T-cells were not detected.
Sundaravaradan et al. (2007)CD4T-cellThe T-cell line A3.01 expresses CD4 and CXCR4 but no CCR5.
Bregman et al. (2005)CD4T-cellFlow cytometry performed on a subsequent subcutaneous nodule demonstrated an abnormal T-cell population with expression of CD3, CD8, CD56, and T-cell receptor alpha-beta, and no expression of CD4.
Popa et al. (2003)CD4T cellMoreover, T cell expansions were generally of small extent, and did not appear simultaneously in both CD4 and CD8 subsets.
Büchner et al. (2003)CD4T cellsThese CD40L(+) T cells were CD4(+), CD69(+), but negative for CD8, CD25, CD28, and ICOS.
Lehmann et al. (1987)CD4T lymphocytesA major subpopulation of T lymphocytes bearing a high density of CD3 (T3/Leu 4) with no detectable CD4 (T4/Leu 3a) or CD8 (T8/Leu 2a) was found in a patient with cardiomyopathy.
Yao et al. (2010)CD4T cells2 T cells usually do not express CD4.
Liu et al. (2003)CD4T-cellHistologic and immunohistochemical studies of a stereotactic biopsy of the mass showed a T-cell lymphoproliferative lesion positive for CD3, CD8, CD57, and T-cell intracellular antigen 1 and negative for CD4, CD56, CD30, anaplastic lymphoma kinase, and CD20.
Mohamed et al. (1992)CD4T-cellIn the primary sample the majority of blast cells displayed the early T-cell markers, CD7, HLA-DR, and TdT, but were negative for the common ALL antigen (CALLA), CD4 and CD8.
Kimura et al. (2001)CD4T-cellThe identified tumor cells were positive for CD4 and CD56, and negative for T-cell, B-cell, and myeloid markers.
Arber et al. (1999)CD4T-cellBoth cell types expressed T-cell-associated antigens, including CD3, CD5, CD43, and CD45RO, and were CD4- and CD30-positive and negative for all B-lineage-associated antigens.