Viewing affirmative mentions of gene expression of FAS (H. sapiens) in T cells

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Lechner et al. (1996)CD95T cellsRegulation of CD95 (APO-1) expression and the induction of apoptosis in human T cells: changes in old age.
Lechner et al. (1996)CD95T lymphocytesIn view of the known decline of immune function in old age it seemed of interest to study the expression and inducibility of CD95 in peripheral blood T lymphocytes from young and old healthy subjects selected according to the guidelines laid down in the Senieur protocol of the European Community's Concerted Action Programme on Aging.
Lechner et al. (1996)CD95T cellT cell activation by anti-CD3 monoclonal antibody (OKT3) did, however, lead to a rapid increase in the number of CD95 expressing cells.
Lechner et al. (1996)CD95T cellUnder long-term culture conditions T cell lines derived from both young and old individuals progressively lost the capacity to decrease the expression of CD95 at the end of their activation cycle and an increasing susceptibility to activation-driven programmed cell death was noted.
Simon et al. (1996)FasT cellsExpansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.
Simon et al. (1996)FasT cellsIn contrast to the recently described lymphoproliferative/autoimmune syndrome, which is characterized by accumulation of CD4-CD8- T cells and mutations within the Fas gene, this study suggests somatic variations in Fas expression and function quite late in life.
Farre et al. (2008)FasT cellFas gene mutations, aberrant transcripts, and abundant expression of Fas have been reported in adult T cell leukemia (ATL).
Stassi et al. (1997)FasT lymphocytesHere we show that beta cells from the pancreata of newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients express Fas and show extensive apoptosis among those cells located in proximity to Fas ligand-expressing T lymphocytes infiltrating the IDDM islets.
Roessner et al. (2003)FasT cellsHigh expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritis.
Roger et al. (1999)CD95T cellWe report the case of a patient characterized by a decreased CD4+ T cell count and an overexpression of Fas/CD95 resulting in apoptosis.
Roger et al. (1999)FasT lymphocytesWe compared the patient with eight healthy controls and five HIV-infected patients in terms of the expression of Fas/CD95 and Fas-mediated apoptosis of peripheral T lymphocytes.
Delneste et al. (1996)FasT cellThiols prevent Fas (CD95)-mediated T cell apoptosis by down-regulating membrane Fas expression.
Delneste et al. (1996)FasT cellBased on the role of Fas in T cell apoptosis, we investigated the effect of thiols on Fas expression.
Delneste et al. (1996)FasT cellsIt also down-regulates in a time- and dose-dependent manner Fas expression on Fas-expressing T cells.
Zola et al. (1996)CD95T cellsCD95 was expressed by the majority of circulating blood T cells in adults, and by a smaller proportion of CD4+ and CD8+ T cells in cord blood.
Alderson et al. (1995)Fas-L mRNAT cellsStimulation of previously activated T cells resulted in the expression of Fas-L mRNA and lysis of Fas-positive target cells.
Patki et al. (1997)FasT-cellWe examined the relationships among CD4+-T-cell counts, spontaneous apoptosis, and Fas expression among peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1 (HIV-1)-infected patients.
Chan et al. (1999)fas promoterT-cellTo investigate the events involved in activation-induced Fas upregulation, we have examined mRNA accumulation, fas promoter activity, and protein expression in the Jurkat T-cell line treated with phorbol myristate acetate and ionomycin (P/I), pharmacological mimics of T-cell receptor activation.
McLeod et al. (1998)CD95T cellsHowever, while not all T cells were stimulated by superantigen, CD95 expression was found to be homogeneously up-regulated, suggesting a mechanism whereby bystander cells might be made susceptible to CD95-induced death.
Genestier et al. (1998)FasT cellsThey also trigger surface Fas (Apo-1, CD95) expression in naive T cells and Fas-ligand gene and protein expression in both naive and primed T cells, resulting in Fas/Fas-L interaction-mediated cell death.
Benvenuto et al. (2007)CD95T cellsMSC dampened also Fas receptor mediated apoptosis of CD95 expressing Jurkat leukemic T cells.
Hayashi and Mita (1997)FasT cellWhen HCV-specific T cells migrate into hepatocytes and recognize the viral antigen via the T cell receptor, they become activated and express Fas ligand that can transduce the apoptotic death signal to Fas-bearing hepatocytes.
Zipp et al. (1997)CD95T cellThe resistance of the T cell lines is not due to a lack of CD95 expression at the cell surface and is not overcome by coexposure to CD95 ligand and inhibitors of RNA or protein synthesis.
Zipp et al. (1997)CD95T cellsSurprisingly, Ag-specific T cells are rather sensitive to CD95 ligand expressed at the cell surface of N2A neuroblastoma cells.
Zipp et al. (1997)CD95T cellsAccessory molecules expressed by the CD95 ligand-expressing effector cell are dispensable for apoptosis since the T cells are equally sensitive to agonistic APO-1 Ab.
Schmitz et al. (2003)CD95T cellsFreshly activated human T cells (initiation) are resistant toward CD95-mediated AICD despite high expression of CD95.
Monleón et al. (2002)FasT-cellWe generated previously hyperproliferative sublines derived from the human T-cell leukemia Jurkat, Jurkat-ws and Jurkat-hp, which lost Fas/CD95 surface expression.
Klas et al. (1993)APO-1T lymphocytesTo investigate apoptosis in activated T cells we studied expression of APO-1 and sensitivity to APO-1 mediated apoptosis in human peripheral T lymphocytes.
Qian et al. (1997)Fas cDNAT cellMETHODS: CD3-induced Jurkat cell line was used as the activated T cell apoptosis model,and the antisense Fas cDNA was introduced into Jurkat cells with retroviral vector.
De Maria et al. (1996)FasT lymphocytesFunctional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes.
De Maria et al. (1996)FasT lymphocytesThe expression and function of Fas (CD95/APO-1), a cell surface receptor directly responsible for triggering cell death by apoptosis, was investigated on human T lymphocytes resident within the intestinal lamina propria, a major site of antigen challenge and persistent lymphocyte activation.
Katsikis et al. (1995)FasT cellsSurface expression of Fas on T cells was also found to be higher in HIV-infected individuals.
Wang and Adegboyega (2002)FasT-cellRESULTS: In the reactive lymph nodes of seronegative patients, expression of Fas was diffuse in the germinal centers and also in immunoblast-like cells in the T-cell regions.
Garnett et al. (2004)FasT-cellSeventy-two hours postirradiation, changes in surface expression of Fas (CD95), as well as expression of other surface molecules involved in T-cell-mediated immune attack such as intercellular adhesion molecule 1, mucin-1, CEA, and MHC class I, were examined.
Bäumler et al. (1996)FasT cellsWe have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-infected children.
Bäumler et al. (1996)CD95T cellsCD95 expression in HIV-1+ children is not restricted to previously activated CD45RO+ T cells but is also increased on freshly isolated naive CD45RA+ T cells.
Vakhitova et al. (2004)Fas receptorT-lymphocytes[The effect of ladasten on the activation-induced expression of Fas receptor on T-lymphocytes and their sensitivity to Fas-induced apoptosis].
Vakhitova et al. (2004)Fas-receptorT-lymphocytesThe effects of ladasten on the activation-induced expression of Fas-receptor on T-lymphocytes, their sensitivity to Fas-induced apoptosis, and the expression of mitogen-activated ERKI/ERK2 protein kinases have been studied.
Vakhitova et al. (2004)Fas-receptorT-lymphocytesAt the same time, ladasten virtually did not change the activation-induced expression of Fas-receptor on T-lymphocytes, but reduced the rate of the Fas-induced apoptosis.
Dyrhol-Riise et al. (2000)FasT cellsThe majority of CD4+ T cells contributing to this expansion expressed CD28, CD45RO and Fas, whereas the expanded CD8+ T cells were predominantly CD28-, CD45RO+, CD38+, Fas+ and Fas+ (CD95).
Walker et al. (1998)Fas-LT-cellSince antigen-presenting cells may express Fas-L under certain circumstances, the maintenance of T-cell CD28 expression may be crucial for the prevention of Fas-mediated apoptosis during the course of antigen engagement.
Parlato et al. (2000)CD95T lymphocytesIn fact, CD95 co-immunoprecipitates with ezrin exclusively in lymphoblastoid CD4(+) T cells and primary long-term activated T lymphocytes, which are prone to CD95-mediated apoptosis, but not in short-term activated T lymphocytes, which are refractory to the same stimuli, even expressing equal levels of CD95 on the cell membrane.
Capri et al. (2006)CD95T lymphocytesNevertheless, after RF exposure we observed a slight, but significant, downregulation of CD95 expression in stimulated CD4+ T lymphocytes from elderly, but not from young donors.
Sloand et al. (1999)CD95T-cellFifteen patients with advanced HIV disease on treatment showed dramatically decreased CD4(+) T-cell ICE expression, diminished apoptosis, and increased numbers of CD4(+) cells within 6 weeks of institution of protease inhibitor therapy, and before down-modulation of Fas-R (CD95) expression was evident.
Sloand et al. (1999)FasT cellsIn the presence of ritonavir, CD4(+) T cells from HIV-infected patients showed similar changes in ICE intracellular levels without alteration of Fas expression.
Sloand et al. (1999)FasT-cellIn conclusion, protease inhibitors appear to decrease CD4(+) T-cell ICE expression and apoptosis before they affect Fas-R expression in HIV-infected patients.
Geleziunas et al. (2001)FasT cellsIncreased killing of such bystander cells is mediated in part through Nef induction of Fas ligand (FasL) expression on the surface of the virally infected T cells.
Loose and Van de Wiele (2009)FasT-cellsFinally, malignant cells may actively eliminate T-cells via activation-induced cell death or by mounting a counterattack through Fas ligand expression.
Kassahn et al. (2009)CD95T cellsDistinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells.
Vignes and Carcelain (2009)CD95T cellsThe mean expression of CD95/Fas on CD4(+) T cells was significantly higher in patients than in controls, 83+/-16% versus 45+/-13% (p<0.0001).
Ishimaru et al. (2008)FasT cellsConstitutive expression of Fas ligand within the privileged site might also prevent immune-mediated damage by eliminating Fas-expressing T cells (6).
Prado-Garcia et al. (2008)FasT lymphocytesIt has been hypothesized that tumor cells expressing Fas Ligand (FasL) induce in T lymphocytes: (a) apoptosis (tumor counterattack) and (b) down-regulation of CD3zeta expression.
Prado-Garcia et al. (2008)FasT-cellsFasL mRNA expression was detected in NSCLC cell lines using RT-PCR, and functional FasL was evaluated on Fas-expressing Jurkat T-cells by annexin-V-FITC staining and by SubG(1) peak detection.
Kiang et al. (2008)FasT-cellThe inhibition of iNOS limited T-cell apoptosis by decreasing the activity of caspase-3 without affecting the expression of Fas/Apo-1/CD95 on the surface membrane of T cells.
Steinmann et al. (2008)FasT lymphocytesTumor cells strategically down-regulate Fas receptor expression to evade immune attack and up-regulate expression of Fas ligand to promote apoptosis of infiltrating T lymphocytes.
Buonocore et al. (2008)CD95T cellOverexpression of CD95 (Fas/Apo-1) ligand (CD95L) has been shown to induce T cell tolerance but also, neutrophilic inflammation and rejection of allogeneic tissue.
Alfonzo et al. (2008)FasT lymphocytes[Altered expression of survival (CD127) and death (Fas) receptors in total, naïve and memory CD8 T lymphocytes from human immunodeficiency virus infected patients: possible implications for progression of infection].
Méndez et al. (2007)FasT cellWe analysed six cell lines established from different metastases of melanoma patient UKRV-Mel-20 for specific characteristics known to have an impact on the tumor-T cell interaction: (1) alterations in the HLA class I phenotype, (2) expression of Fas/CD95, and (3) expression of specific cytokines and chemokines.
Méndez et al. (2007)FasT cellsOne of the cell lines, UKRV-Mel-20f, exhibited an HLA class I haplotype loss and just this cell line was also characterised by the expression of Fas/CD95 and of relatively high levels of proinflammatory chemokines suggesting that the cytotoxic activity of tumor-infiltrating T cells might have selected the outgrowth of this tumor cell variant.
Strauss et al. (2007)CD95T cellMembrane-bound CD95 ligand expressed on human antigen-presenting cells prevents alloantigen-specific T cell response without impairment of viral and third-party T cell immunity.
Walker et al. (2006)FasT-cellIn particular, we found that T cells expressing Fas ligand (Fas-L, CD95L) were eight times more vulnerable to apoptosis than those not expressing Fas-L, which suggests that the T-cell apoptosis is induced by overactivation of the T-cell receptor, possibly in the absence of appropriate costimulation.
Luzina et al. (2006)FasT lymphocytesThe infiltrates consisted almost exclusively of T lymphocytes that were minimally activated, with a minimal increase in the expression of CD69 and no changes in the expression of CD25, Fas, FasL, or CD40L.
Cipriani et al. (2006)FasT lymphocytesMETHODS: We studied peripheral a/b and g/d T lymphocytes of 22 patients with SSc and 22 healthy controls for their spontaneous and stimulated (phytohemagglutinin, dexamethasone) apoptotic rate and surface phenotype including expression of Fas (CD95) and Bcl-2, determined by flow cytometry. sFas and sFas ligand in sera and supernatants were measured by ELISA.
Kim et al. (2005)FasT cellsOBJECTIVE: In patients with oral squamous cell carcinoma, a high proportion of T cells in the tumor undergo apoptosis, which correlates with Fas ligand (FasL) expression on tumor cells.
Zhang et al. (2005)FasT lymphocytesCONCLUSION: The expression of FasL is upregulated in colon cancer and the functionally expressed FasL can induce apoptosis of Fas-expressing T lymphocytes.
Chahlavi et al. (2005)FasT-cellThe GBM lines were characterized for their expression of CD70, Fas ligand (FasL), and tumor necrosis factor-alpha (TNF-alpha), and the possible participation of those molecules in T-cell killing was assessed by doing GBM/T cell cocultures in the presence of anti-CD70 antibodies, Fas fusion proteins, or anti-TNF-alpha antibodies.
Prado-Garcia et al. (2005)FasT cellsOur data suggest that: (i) terminal-differentiation process of CD8+ T cells is blocked, and (ii) early Fas-expression in CD8+ T cells, which was reflected even in peripheral blood, may lead to apoptosis of naïve cells when they reach the effector stage.
Berger et al. (2004)FasT cellsThree macaques (Macaca nemestrina) received autologous T cells retrovirally engineered to express a Fas suicide-construct (LV'VFas).
Ramhorst et al. (2004)FasT-cellInvestigation of the mechanisms involved in cell growth inhibition revealed that this beta-chemokine induces T-cell apoptosis through modulation of Bcl-2 protein levels and by a caspase-independent mechanism and does not involve modulation of Fas (CD95) antigen expression.
Makrigiannakis et al. (2004)FasT lymphocytesInvasive trophoblasts promoted apoptosis of activated Fas-expressing human T lymphocytes, an effect potentiated by CRH and inhibited by the CRH antagonist.
Hoves et al. (2004)FasT cellsDendritic cells (DC) genetically engineered to express high levels of Fas ligand (FasL/CD95L) have been demonstrated to delete T cells in an antigen specific manner in several different animal models in vivo.
Torgler et al. (2004)CD95T cellsRegulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the cyclin B1/Cdk1 complex.
Pawlik et al. (2003)FasT cellsResistance to apoptosis in CD28- T cells is due to elevated expression of antiapoptotic protein Bcl-2 and Fas-associated with death domain-like IL-1-converting enzyme inhibitory protein (FLIP) [16].
Fujii et al. (2003)FasT cellPurified leukemic cells produce interleukin-12 (IL-12) simultaneously with Fas ligand (FasL) and IL-6, which may suppress T cell-mediated immunity.
Jaleco et al. (2003)FasT cellThe increased susceptibility of RTE and naive CD4(+) T cells to Fas-induced apoptosis correlates with a significantly higher IL-2/IL-7-induced Fas expression on these T cell subsets than on memory CD4(+) T cells.
Lin et al. (2003)FasT cellsSurface expression of CD69, CD25, and CD95 (Fas) on CD3+ T cells was evaluated by flow cytometry.
Makrigiannakis et al. (2003)FasT lymphocytesInvasive trophoblasts promote apoptosis of activated Fas-expressing human T lymphocytes, an effect potentiated by CRH and inhibited by the CRH type 1 antagonist, antalarmin.
Toomey et al. (2003)FasT cellsTumour expression of FasL is thought to disarm responses through the transduction of a death signal in Fas-expressing T cells.
Takayama et al. (2003)FasT cellsFurthermore, although NK-type T cells produced large amounts of soluble Fas-ligands, their cytotoxic activities appeared to be mediated by the perforin/granzyme pathway.
ten Hove et al. (2002)FasT lymphocytesRESULTS: Infusion of infliximab (5 mg/kg) in steroid refractory patients with Crohn's disease induced a clinical response in 9/10 patients but did not influence expression of activation markers, homing receptors, memory cells, Fas expression, or Bax/Bcl-2 expression on peripheral blood T lymphocytes.
Bodor et al. (2002)FasT lymphocytesThe engagement of antigen receptor can initiate apoptosis of T lymphocytes through the induced expression of Fas ligand (FasL).
Kasprzycka et al. (2002)FasT cellsFasL molecule expressed on activated T cells induces apoptosis in Fas-expressing cells.
Devadas et al. (2002)fasT cellDiscrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression.
Lee et al. (2002)FasT-cellRetinoids are potent immune modulators that inhibit Fas ligand (FasL) expression and thereby repress the activation-induced apoptosis of immature thymocytes and T-cell hybridomas.
Ohno et al. (2002)FasT cellsTissue specimens from 84 advanced gastric carcinoma patients who had undergone a curative resection were evaluated for host immune status (CD8+ T cells), tumor stromal reaction (AZAN staining), tumor Fas ligand expression and incidence of tumor cell apoptosis (by TUNEL).
Melgar et al. (2002)FasT-cellThe capacity of IEL and LPL to kill a Fas-expressing human T-cell line was also analysed.
Sharief et al. (2002)FasT lymphocytesIn a prospective study, we evaluated the expression of IAP proteins, the anti-apoptosis Bcl-2 protein, and the death receptor Fas in in vitro stimulated T lymphocytes from MS patients, before and serially after treatment with interferon-beta.
Gregory et al. (2002)FasT cellsIt has been proposed that the constitutive expression of Fas ligand (FasL) in the eye maintains immune privilege, in part through inducing apoptosis of infiltrating Fas(+) T cells.
Osame (2002)FasT cellIncreased expression of several cytokines, Fas/Fas ligand, adhesion molecules, and molecules influencing T cell migration in the lesions have been reported.