Viewing affirmative mentions of binding of KLRD1 (H. sapiens) in T cells

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Document Target Regulator Anatomy Sentence
Hausmann and Wucherpfennig (1997)cell receptorT cellsAutoreactive T cells can be activated by viral and bacterial peptides that meet the structural requirements for MHC molecule binding and T cell receptor recognition.
Emmrich (1989)cell receptorT cellT cells recognize peptides in association with self-MHC structures on antigen-presenting cells and become activated upon ligand binding to the T cell receptor.
Gumá et al. (2005)CD94T cellsCoculture with the 721.221 HLA class I-deficient lymphoma cell line transfected with HLA-E (.221-AEH) induced IL-2Ralpha expression in CD94/NKG2C+ NK cells and a minor subset of CD94/NKG2C(+) T cells, promoting their proliferation; moreover, a similar response was triggered upon selective engagement of CD94/NKG2C with a specific mAb.
Michaëlsson et al. (2002)CD94T cellIt interacts with CD94/NKG2 receptors expressed on the surface of natural killer (NK) cells and T cell subsets.
Le Dréan et al. (1998)CD94T cellWe show here that engagement of the CD94-NKG2A heterodimer inhibits both antigen-driven tumor necrosis factor (TNF) release and cytotoxicity on melanoma-specific human T cell clones.
Poccia et al. (1997)CD94T cellsThe CD94/HLA class I interaction is also involved in the cytotoxic activity of Vgamma9Vdelta2 T cells.
Zarnitsyna et al. (2007)cell receptorT cellThese include Markov sequences with positive (T cell receptor interacting with antigen peptide bound to a major histocompatibility complex) or negative (homotypic interaction between C-cadherins) feedbacks, where adhesion probability in the next test was increased or decreased, respectively, by adhesion in the immediate past test.
Archbold et al. (2006)cell receptorT cellHere we provide evidence that a single alloreactive T cell receptor interacts with analogous structural regions of its cognate ligand, HLA-B*0801(FLRGRAYGL), as its allogeneic ligand, HLA-B*3501(KPIVVLHGY).
Spits et al. (1985)cell receptorT cellCharacteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen.
Quaratino et al. (2000)cell receptorT cellTriggering T cells is not a simple on-off procedure, as T cell receptor responds to minor changes in ligand with gradations of T cell activation and effector functions.
Douillard et al. (1999)cell receptorT cellNevertheless compared with disease states such as cancer or autoimmunity the T cell receptor repertoire is still largely uncharacterized.
Naumova et al. (2005)CD94T cellsAntitumor cytotoxicity of NK cells and T cells expressing NK-associated receptors is regulated by interaction between their cell surface killer immunoglobulin-like receptors (KIRs) and CD94/NKG2 heterodimers with MHC class I ligands on target cells.
Jin and Wang (2003)CD94T cellsThis molecule binds hydrophobic peptides from other HLA class I leader sequences and interacts with CD94/NKG2 lectin-like receptors present predominately on Natural Killer and partially on CD8+ T cells which are also minimally polymorphic [44-48].
Lieto et al. (2003)CD94T cellCD94 is a C-type lectin required for the dimerization of the CD94/NKG2 family of receptors, which are expressed on NK cells and T cell subsets.
Saito et al. (2003)CD94T-cellIn the present study we demonstrate that CD3+ T cells that bind tetramers of HLA-E and express its ligand, the NK-cell inhibitory receptor CD94/NKG2A, were significantly decreased in frequency in patients with human T-cell lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) but not in asymptomatic HTLV-1 carriers.
Lieto et al. (2006)CD94T cellsCD94-T4/NKG2B is capable of binding HLA-E and, when expressed in E6-1 Jurkat T cells, inhibits TCR mediated signals, demonstrating that this heterodimer is functional.
Leca et al. (1988)cell receptorT cellThis T cell receptor for antigen is also a heterodimer composed of gamma, delta chains non-covalently associated with the three mon morphic CD3 subunits.
Zeddou et al. (2005)CD94T cellsWe further demonstrated that cross-linking of CD94 on CD8+ T cells expressing the CD94/NKG2A heterodimer inhibits their cytotoxic activity in a bispecific antibody redirected lysis assay.
Singer and Koretzky (2002)cell receptorT cellsEngagement of the T cell receptor is responsible for initiating the signaling events that can activate, inactivate, or eliminate T cells, depending on the magnitude and duration of the signal.
Lineberry and Fathman (2006)cell receptorT lymphocytesT cell receptor engagement activates selective signaling pathways in T lymphocytes under different conditions.
Posnett et al. (1984)cell receptorT cellThis proliferation was not associated with measurable production of IL-2 and appeared to be a direct effect of the antiidiotypic antibody, which may mimic antigen in its interaction with the T cell receptor for antigen.
Archbold et al. (2006)cell receptorT cellThe avidity of this human T cell receptor was also comparable for the allo- and cognate ligand, consistent with the modes of T cell receptor binding being broadly similar for these complexes.
Spits et al. (1985)cell receptorT cellWe conclude that WT-31 is an antibody that recognizes a common determinant on the T cell receptor for antigen.
Spits et al. (1985)cell receptorT cellThis indicates that the T cell receptor epitope recognized by WT-31 is located close to the epitopes recognized by the anti-T3 reagents anti-Leu-4 and SPV-T3b but distal from the clonotypic T40/25 epitope.
Carena et al. (1997)CD94T cellsWe studied the functional interaction between TCR-gamma/delta and CD94, this inhibitory receptor being expressed on the majority of gamma/delta T cells.
Fleischer (1994)cell receptorT cellSuperantigens use a unique mechanism: they crosslink variable parts of the T cell receptor with MHC class II molecules on accessory or target cells.
Cereb et al. (1996)cell receptorT cellThe polymorphic substitutions are mostly located in exon 2 and 3, encoding alpha 1 and alpha 2 domains, respectively, which are involved in peptide binding and T cell receptor interaction.
Krogsgaard and Davis (2005)cell receptorT cellHere we summarize some of the more recent work on alphabeta T cell receptor recognition and discuss the implications for activation.
Madrenas (1999)cell receptorT cellDifferential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation.
Gagnon et al. (2006)cell receptorT cellT cell receptor recognition via cooperative conformational plasticity.
Gagnon et al. (2006)cell receptorT cellOur findings illustrate the complex role that protein dynamics can play in TCR cross-reactivity and highlight that T cell receptor recognition of ligand can be achieved through diverse and complex molecular mechanisms that can occur simultaneously in the interface, not limited to molecular mimicry and CDR loop shifts.
Madrenas (1999)cell receptorT cellMore recently, the generation of variant T cell receptor ligands with partial agonist or antagonist properties, the determination of crystal structures for unengaged and engaged T cell receptors, and the kinetics of T cell receptor interactions with peptide:MHC molecule complexes have provided new insights on T cell receptor function.
Moulon et al. (2003)cell receptorT cellA transfectant expressing the rearranged alphabeta T cell receptor derived from one of the T cell clones unequivocally demonstrates that the T cell receptor itself is necessary and sufficient to confer HLA-independent nickel specificity.
Gober et al. (2003)cell receptorT cellHuman T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells.
Chan et al. (1990)cell receptorT cellThe T cell receptor (TcR) is a heterodimer composed of an alpha,beta- or a gamma,delta-chain.
Uherek et al. (2001)cell receptorT lymphocytesT lymphocytes recognize specific antigens through interaction of the T cell receptor (TCR) with short peptides presented by major histocompatibility complex (MHC) class I or II molecules.
Larbi et al. (2004)cell receptorT cellsIn addition, lipid rafts coalescence to the site of T cell receptor engagement was impaired in T cells from elderly donors.
Xi et al. (2009)cell receptorT cellThe structural basis that determines the specificity of gammadelta T cell receptor (TCR) recognition remains undefined.
Baker and Wiley (2001)cell receptorT cellalpha beta T cell receptor ligand-specific oligomerization revisited.
Borst et al. (1987)cell receptorT cellComplexity of T cell receptor recognition sites for defined alloantigens.
Tuosto et al. (1994)cell receptorT cellMoreover, occupancy of the T cell receptor reverses Dex-induced apoptotic phenomena.
Walser-Kuntz et al. (1995)cell receptorT cellThe T cell receptor repertoire distinguished patients with RA from healthy HLA-DR-matched individuals, suggesting that patients share a selection mechanism that significantly distorts the composition of the T cell receptor repertoire.
Dow and Potter (1997)cell receptorT cellSuperantigens produced by transfected eukaryotic cells retained their biologic specificity for T cell receptor binding.
Stevanovi? (2002)cell receptorT cellSince T cells glean their information from the interaction between their specific T cell receptor and a MHC-peptide complex, MHC molecules are invaluable information carriers.
Amariglio and Rechavi (1996)cell receptorT cellThe T cell superantigens are infectious agents that interact with the T cell receptor and the MHC molecules outside their normal antigen-specific sites, with products of conserved sequences of the variable region chains.
Munk et al. (1990)cell receptorT cellT cell recognition of foreign antigens is a result of a ternary complex between T cell receptor, nominal peptide and major histocompatibility complex molecule.
Durandy et al. (1986)cell receptorT cellThe characteristics of this receptor suggest its identity with the T cell receptor for antigen.
Carrera et al. (1994)cell receptorT cellWe have used a human T cell line, Jurkat, and an antibody that recognizes the clonotype of its T cell receptor (TcR) to characterize the association of PI 3-kinase with the TcR and its activation in response to TcR cross-linking.
Roessig et al. (2002)cell receptorT cellThey recognize autologous EBV-infected targets through their conventional T cell receptor, and allogeneic EBV-infected targets and tumor targets through their chimeric receptor.
Saulquin et al. (2003)cell receptorT cellTherefore, the mode of recognition used by KIR largely differs from the conformational changes that characterize T cell receptor or NKG2D interaction with their respective ligands.
Wucherpfennig and Strominger (1995)cell receptorT cellThe observation that a single T cell receptor can recognize quite distinct but structurally related peptides from multiple pathogens has important implications for understanding the pathogenesis of autoimmunity.
Wyer et al. (1999)cell receptorT cellWe show that human CD8 alphaalpha binds to the MHC class I molecule HLA-A2 with an extremely low affinity (Kd approximately 0.2 mM at 37 degrees C) and with kinetics that are between 2 and 3 orders of magnitude faster than reported for T cell receptor/peptide-MHC interactions.
Wyer et al. (1999)cell receptorT cellFurthermore, CD8 alphaalpha had no detectable effect on a T cell receptor (TCR) binding to the same peptide-MHC class I complex.
Dunn et al. (2006)cell receptorT cellThe mammalian alpha/beta T cell receptor (TCR) repertoire plays a pivotal role in adaptive immunity by recognizing short, processed, peptide antigens bound in the context of a highly diverse family of cell-surface major histocompatibility complexes (pMHCs).
Wyer et al. (1999)cell receptorT cellT cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.
Brickner et al. (2001)cell receptorT cellThese studies identify a new human mHAg and provide the first evidence that minor histocompatibility differences can result from the altered processing of potential antigens rather than differences in interaction with the relevant major histocompatibility complex molecule or T cell receptor.
Armstrong and Baker (2007)cell receptorT cellA comprehensive calorimetric investigation of an entropically driven T cell receptor-peptide/major histocompatibility complex interaction.
Sandalova et al. (2004)cell receptorT cellActivation of protein kinase C and calcineurin appeared to be necessary and sufficient for Bim up-regulation after T cell receptor ligation.
Armstrong and Baker (2007)cell receptorT cellThe alphabeta T cell receptor (TCR) is responsible for recognizing peptides bound and "presented" by major histocompatibility complex (MHC) molecules.
Köhler et al. (2010)cell receptorT cellThe kinetic-segregation model of T cell antigen recognition proposed that signaling is initiated by size-based segregation of the engaged T cell receptor (TCR) from receptor tyrosine phosphatases with large ectodomains such as CD45 and CD148, leading to phosphorylation of the TCR/CD3 complex [22].
Cemerski et al. (2002)cell receptorT cellIn hyporesponsive T cells, T cell receptor (TCR) ligation no longer induced phospholipase C-gamma1 activation and caused reduced Ca(2+) flux.
Rothbard et al. (1988)cell receptorT cellThe model was supported by the demonstration that hybrid peptides, composed of the amino acids that interact with DR1 from one determinant and the residues that interact with the T cell receptor from the other, were recognized by each clone.
Ashwell et al. (1987)cell receptorT cellBecause of the complexity of T cell activation, modifications to the antigen that affected its stimulatory capacity (i.e., its potency) could come about by altering its interaction with either the T cell receptor or the Ia molecule.
Ashwell et al. (1987)cell receptorT cellAmino acid substitutions in the antigen that affected the interaction with the T cell receptor caused changes in the dose-response curve shifts, whereas substitutions that decreased potency by other means did not cause such changes.
Ashwell et al. (1987)cell receptorT cellThese results suggest that the antigen and the Ia molecule make physical contact during the process of antigen recognition, and that the potency of an antigen can vary as a result of its interaction with either the T cell receptor or the Ia molecule.
Mayya et al. (2009)cell receptorT cellQuantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Burrows et al. (1999)cell receptorT cellsMajor histocompatibility complex (MHC) class II molecules are membrane-anchored heterodimers on the surface of antigen presenting cells (APCs) that bind the T cell receptor, initiating a cascade of interactions that results in antigen-specific activation of clonal populations of T cells.
Yamamura et al. (2004)cell receptorT cellThey are unique in their homogeneous ligand specificity for alpha-glycosylated sphingolipid and secrete large amounts of regulatory cytokines shortly after T cell receptor (TCR) engagement.
Carrera et al. (1994)cell receptorT cellT cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck.
Reedquist and Bos (1998)cell receptorT cellIn T lymphocytes, biochemical and genetic evidence demonstrate that Ras plays an essential role in coupling T cell receptor ligation to signaling cascades required for T cell proliferation and development.
Zea et al. (2004)cell receptorT cellEngagement of the T cell receptor (TCR) by antigen or anti-CD3 antibody results in a cycle of internalization and re-expression of the CD3zeta.
Zanders et al. (1985)cell receptorT cellThis phenomenon is associated with a loss of the T3 antigen complex, presumably in association with the T cell receptor.
Ayyoub et al. (1999)cell receptorT cellThis approach is based on our understanding of the peptide interaction with the MHC and the T cell receptor and its precise degradation pathway.
Diamond et al. (1991)cell receptorT cellMajor histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives.
Scofield et al. (1994)cell receptorT cellPatients possessing a particular pair of T cell receptor beta restriction enzyme polymorphisms along with these specific HLA-DQ alleles produce quantitatively more anti-Ro as measured by a sensitive solid-phase immunoassay than patients without these T cell receptor and DQ alleles.
Esch et al. (1989)cell receptorT cellMajor histocompatibility complex (MHC)-restricted recognition of antigen by T lymphocytes involves the formation of a complex composed of the T cell receptor, antigen, and restricting MHC molecule.
Fabbi et al. (1985)cell receptorT cellFirst, peptide map analysis showed that the T cell receptor molecules recognized by the anti-clonotype and the anti-constant region heteroantisera on a given T cell clone are identical, thus supporting the view that the T cell receptor undergoes allelic exclusion.
Carballido et al. (1997)cell receptorT cellThe intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells.
Cipolla et al. (2002)cell receptorT cellNeoglycopeptides 1--3 could be presented to and recognized by the T cell receptor; neoglycopeptide 3, bearing two B-epitopes, was presented to the TCR with higher efficiency, compared to neoglycopeptide 2, having only one B-epitope.
Glavas et al. (2001)cell receptorT cellWe also report the full-length sequence of human PDE8A1 and show that it also is induced in response to a combination of T cell receptor and costimulatory receptor pathway activation.
Thierse et al. (2005)cell receptorT cellT cell receptor (TCR) interaction with haptens: metal ions as non-classical haptens.
Brenner et al. (1987)cell receptorT cellThe beta F1 mAb should prove useful as a research tool for both the immunochemical characterization and isolation of virtually any alpha beta T cell receptor, whether from individual T cell clones or polyclonal populations of T lymphocytes.
Simpson et al. (1989)cell receptorT cellsFurthermore, T cell receptor usage by T cells specific for allogeneic minor H antigens appears not to be representative of T cell receptor usage in the peripheral pool.
Shen et al. (2009)Cell ReceptorT cellsWe demonstrate the use of this platform for presenting ligands to the T Cell Receptor and LFA-1 that are tethered to separate, closely juxtaposed regions of bilayer, capturing an important aspect of the natural organization observed between T cells and Antigen Presenting Cells.
Kobayashi and Urasawa (1996)cell receptorT cellsSuperantigen is characterized as a potent stimulator of T cells through its unique interaction with major histocompatibility complex class II molecule and the V beta chain of T cell receptor.
Buchwalder et al. (1994)cell receptorT cellImmunochemical and molecular analysis of antigen binding to lipid anchored and soluble forms of an MHC independent human alpha/beta T cell receptor.
Oliveira et al. (2010)cell receptorT cellTarget cell recognition depended on T cell receptor and Qa-1b interaction, and immunization with identified peptide epitopes demonstrated in vivo priming of CD8+ T cells.
D'Orazio and Stein-Streilein (1996)cell receptorT cellOnce superantigen has bound class II MHC molecules on the surface of APC, it then can interact with the T cell receptor to induce T cell activation.
Matsushita (1999)cell receptorT cellOn the contrary, the x residues are recognized by T cells through the T cell receptor (TCR).
Gao et al. (1988)cell receptorT cellA polymorphism associated with the T cell receptor V-beta-8 gene family was significantly increased in rheumatoid arthritis patients.
Rothbard et al. (1989)cell receptorT cellRather, the differential stimulation of the clone appeared to arise from sequence variations between the DR alleles in residues comprising the beta-chain helix, which either affected recognition by directly contacting the T cell receptor or modified the conformation of the bound peptide.
Voss et al. (2009)cell receptorT cellThe T cell receptor (TCR) orchestrates T cell mediated-cytotoxicity through a complex interaction that results in an antigen-specific effector-target cell conjugate formation.
Noris et al. (2007)cell receptorT cellIL-2 and activation by T cell receptor engagement are instrumental to generate and maintain Treg, but the influence of immunosuppressants on Treg homeostasis in humans in vivo has not been investigated.
Baxter et al. (2004)cell receptorT cellStrategic mutations in the class I major histocompatibility complex HLA-A2 independently affect both peptide binding and T cell receptor recognition.
Gras et al. (2009)cell receptorT cellThe shaping of T cell receptor recognition by self-tolerance.
Meyaard et al. (1995)cell receptorT cellIn the activation of T cells, the primary signal is antigen-specific and given through T cell receptor (TcR)/CD3 ligation.
Carrasco et al. (2003)cell receptorT cellEngagement of the alpha beta T cell receptor (TCR) by its ligand results in the down-modulation of TCR cell surface expression, which is thought to be a central event in T cell activation.