Viewing affirmative mentions of positive regulation of CD8A (H. sapiens) in T cells

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Casazza et al. (2001)CD8T cellsDiscontinuation of treatment resulted in a rapid increase in HIV-specific CD8(+) T cells.
Acres et al. (1987)CD8T cellCD8 phosphorylation is induced upon addition of heterologous, Epstein-Barr virus-transformed B cells, which cause proliferation and are target cells for a cytotoxic CD8+CD4+ T cell line and a CD8+CD4- T cell clone.
Kosor Krnic et al. (2007)CD8T cellsHLA-A*0201(+) PTSD patients (n = 10) showed a significant increase of influenza-specific CD8 T cells after vaccination.
Jansen et al. (2004)CD8T cellsIn slow progressors, perforin expression of HIV-specific CD8(+) T cells slightly increased over time.
Nagaraj and Gabrilovich (2008)CD8T-cellRecent findings indicate that myeloid-derived suppressor cells can induce antigen-specific CD8(+) T-cell tolerance through a posttranslation mechanism which involves modification (nitration) of CD8 and the T-cell receptor itself on the T-cell surface.
Stéphan et al. (2001)CD8T lymphocyteHowever, interestingly, we found that pulmonary CMV infection was associated with only minor modifications in the respective alveolar lymphocyte subpopulations limited to a slight increase in the CD8+T lymphocyte subpopulation.
Cho et al. (2003)CD8T-lymphocyteHeat-aggregated noninfectious influenza virus induces a more balanced CD8(+)-T-lymphocyte immunodominance hierarchy than infectious virus.
Ratnofsky et al. (1987)CD8T cellCD8 was then expressed in an HLA class II-specific T cell, thus separating the ligand requirements of the TCR and CD8.
Kondo et al. (2004)CD8T lymphocytesVigorous response of cytotoxic T lymphocytes associated with systemic activation of CD8 T lymphocytes in fulminant hepatitis B.
Vossen et al. (2005)CD8T cellsNK cells and CD8(+) T cells were activated during acute infection, and VZV-specific CD4(+) T cells were detected at high frequencies.
Scherrenburg et al. (2008)CD8T cellHowever, 6 months after IM, BZLF1-specific CD4(+) T cell responses had declined, but CD8(+) T cell responses had increased.
Drake et al. (2000)CD8T cellsWe investigated whether dendritic cells and macrophages are permissive for polyomavirus infection and examined their potential for inducing antiviral CD8(+) T cells.
Hafalla et al. (2002)CD8T cellThese findings strongly suggest that the most efficient strategy for the induction of primary CD8(+) T cell responses is the delivery of a maximal amount of antigen in a single dose, thereby ensuring a clonal burst that involves the largest number of precursors to become memory cells.
Rotoli et al. (1995)CD8T cellSerum IgE levels were elevated (1000 IU/ml), and T cell subsets showed an increase in CD8+ and a decrease in CD4+ with an inversion of CD4+/CD8+ ratio (= 0.78).
Anichini et al. (2004)CD8T cellHere, we review recent results indicating that CD8(+) T cell-mediated antitumor immunity is activated at the systemic and tumor level in the early clinical stages (AJCC stages I and II) and continues to be promoted, in a fraction of patients, even in metastatic disease (stages III and IV).
Wang and Borysiewicz (1995)CD8T-cellCD8+high (CD57+) T-cell numbers are increased in human cytomegalovirus (HCMV)-seropositive subjects, and there is substantial evidence that HCMV is integral in the development of this subset in health and disease.
Paliard et al. (1988)CD8T-cellInterleukin-4 mediates CD8 induction on human CD4+ T-cell clones.
Hermann et al. (2010)CD8T cellsIn vivo induction of KIR expression on cord blood T cells was also observed during a human congenital infection with Trypanosoma cruzi which triggers activation of fetal CD8(+) T cells.
Frasca et al. (2010)CD8T cellAlthough FLT-3L-DCs were the least effective at inducing CD8 T cell proliferation, FLT-3L-DCs promoted better CD8 T cell survival and increased Bcl-2 and MCL-2 expression in CD8 T cells.
Fox et al. (2010)CD8T cellVirus was cleared despite profound CD4 T cell depletion and aberrant CD8 T cell activation but this may have increased susceptibility to a fatal secondary infection.
Hessel et al. (2010)CD8T cellsIn the lungs, a rapid increase of HA-specific CD4- and CD8 T cells was observed in vaccinated mice shortly after challenge with influenza swine flu virus, which probably contributes to the strong inhibition of pulmonary viral replication observed.
Desmarets et al. (2009)CD8T-cellMoreover, we generated a novel transgenic mouse with RBC-specific expression of a model mHA and demonstrated that transfusion of RBCs induced a CD8(+) T-cell response.
Perrella et al. (2009)CD8T-cellCONCLUSION: A clinically silent persistent exposure to HCV, through some as-yet undetermined mechanism, may induce a virus-specific IFN-gamma-producing CD8(+) T-cell response in healthy aviremic HCWs.
Zhang et al. (2009)CD8T cellThe role of CD4 T cell help for CD8 CTL activation.
Arneth (2009)CD8T cellIn vitro model for the activation of CD4 and CD8 T cell receptors.
Choy and Pober (2009)CD8T cellsNitric oxide (NO), generated by inducible NO synthase (iNOS) in bystander human CD8 T cells, augments the accumulation of allogeneically activated human CD8 T cells in vitro and in vivo.
Jandus et al. (2009)CD8T cellsWe have previously shown that vaccination of HLA-A2 metastatic melanoma patients with the analogue Melan-A(26-35(A27L)) peptide emulsified in a mineral oil induces ex vivo detectable specific CD8 T cells.
Wang et al. (2009)CD8T cellUV light did not alter early CD8 T cell activation in the lymph nodes, but rather reduced CD8 T cell expansion at later time points.
Leung-Theung-Long et al. (2009)CD8T cellsImpaired NFAT transcriptional activity in antigen-stimulated CD8 T cells linked to defective phosphorylation of NFAT transactivation domain.
Eguchi and Watanabe (2009)CD8T cellsDetailed analysis for inducing specific CD8 T cells via a CpG-DNA adjuvant.
Kawashima et al. (2008)CD8T cellsOut of 110 HIV-1 peptides carrying HLA-A( *)26 anchor residues, only the Gag169-177 peptide, which had been previously identified as an HLA-A( *)2601- and HLA-A( *)2603-restricted immunodominant epitope, induced Gag169-177-specific CD8(+) T cells from only two of six HLA-A( *)2602(+) HIV-1-infected individuals.
Liu et al. (2008)CD8T cellOur results demonstrated that NCRT and hsp synergistically exhibited significant increases in E7-specific CD8(+) T cell responses and impressive antitumor effects against E7-expressing tumors.
Lou et al. (2008)CD8T cellsFurthermore, tumor-bearing animals inoculated with AdhTpn demonstrated a significant increase in CD8(+) and CD4(+) T cells and CD11c(+) dendritic cells infiltrating the tumors.
Dorn et al. (2008)CD8T cellsCo-cultivation of chimeric VLP-primed hDCs with autologous peripheral blood leukocytes resulted in the activation of MUC1 epitope-specific CD8(+) T cells.
Schildberg et al. (2008)CD8T cellLiver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells.
Graham et al. (2008)CD8T-cellInfected males showed increased CD8(+) T-cell proportions in islets.
Whittington et al. (2008)CD8T cellsTo further test if T cells alone can mediate tumor rejection, mice were immunized with pcytneu encoding full-length cytoplasmic neu that is rapidly degraded by the proteasome to activate CD8 T cells without inducing antibody response.
Yoshikawa et al. (2008)CD8T cellsFurthermore, in vivo longevity of the long-lived DC vaccine led to antigen-specific activation of interferon-gamma-producing CD4+ and CD8+ T cells.
Löfdahl et al. (2008)CD8T-cellsRESULTS: The number of intraepithelial CD4+ T-cells were significantly higher in COPD patients compared to smokers as well as trend towards significance in non-smokers (p=0.005 and p=0.036, respectively), whereas intraepithelial CD8+ T-cells number were increased in patients with COPD compared to non-smokers (p=0.017).
Nan et al. (2007)CD8T lymphocytesNeu1 was present on the surface of freshly isolated and activated CD4 and CD8 T lymphocytes, as determined by staining intact cells with anti-Neu1 IgG and analysis by flow cytometry and by Western blot analysis of biotin-labeled cell surface proteins.
Cortez-Gonzalez and Zanetti (2007)CD8T cellIn the past seven years, there has been considerable interest in assessing telomerase as substrate for vaccination in cancer patients to induce CD8 T cell responses.
Uenaka et al. (2007)CD8T cellAn increase in the CD8 T cell response was also observed in 2 of 2 sero-positive and 5 of 7 sero-negative patients after vaccination.
Avigan et al. (2007)CD8T-cellVaccination resulted in antitumor immune responses in 10/21 evaluable patients as manifested by an increase in CD4 and/or CD8 T-cell expression of interferon-gamma after ex vivo exposure to tumor lysate.
Zeng et al. (2006)CD8T-cellVaccines designed to induce CD8(+) T-cell along with antibody response might be ideal.
Watkins et al. (2006)CD8T cellsFive on seven Tat Oyi vaccinated macaques showed a better control of viremia compared to control macaques and an increase of CD8 T cells was observed only on Tat Oyi vaccinated macaques.
Roy et al. (2005)CD8T-cellAnalysis of T cells infiltrating the lungs revealed only small increases in CD8(+) but not CD4(+) T-cell numbers in hdIVIg-treated mice.
Mussini et al. (2005)CD8T cellsMETHODS: Mitochondrial DNA content was measured in platelet-free CD4 and CD8 T cells by real-time polymerase chain reaction; flow cytometry was used to identify and quantify activated CD4 and CD8 T lymphocytes.
Kanokogi et al. (2004)CD8T cellsWhile donor lymphocytes in graft MLNs were rapidly replaced to host-derived lymphocytes independent of FK treatment, increase in CD8(+) T cells in host population was seen only in recipients without FK506 treatment.
Claerhout et al. (2004)CD8T cellsCD3CD4 cells, mainly monocytes and macrophages, were the predominant subpopulation 2 days after transplantation, followed by a successive relative increase of CD4 T cells, CD8 T cells, CD161 T cells, and NK cells.
Galhardo et al. (2004)CD8T lymphocytesWhen all HIV+ individuals were compared as a group to the control group, a significant increase in dermal CD8+ T lymphocytes (P < 0.01) and lower CD4-CD8 ratios (P < 0.01) were observed in the HIV+ individuals.
Wysocka et al. (2004)CD8T cellsIn such cases, IL-15 was capable of producing levels of NK activation that were superior to CpG-A, while the combined effects of CpG-A plus IL-15 induced maximal activation of NK cells and further enhanced activation of CD8 T cells.
Krug et al. (2003)CD8T cellsCpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells.
Kubota et al. (2003)CD8T cellsThese data suggest that HTLV-1-specific CD8(+) T cells with degenerate specificity are increased during viral replication and control the viral infection.
Rohrlich et al. (2003)CD8T lymphocyteExpression of the HLA-B7(m alpha 3) molecules resulted in a 3- to 4-fold increase in peripheral CD8(+) T lymphocyte numbers compared to H-2 Cl I-a(-/-) knockout mice.
Chattergoon et al. (2003)CD8T cellThe manner in which apoptotic bodies are generated, their abundance in relation to local DCs, and the milieu in which they are generated appear to be the major factors determining whether apoptotic bodies will induce CD8(+) T cell activation or anergy.
Morales et al. (2002)CD8T-cellIncreased CD8(+)-T-cell expression and a type 2 cytokine pattern during the muscular phase of Trichinella infection in humans.
Jin et al. (2002)CD8T-cellAmong 11 patients who had increased CD8(+) T-cell responses, seven had responses to more than one HIV-1 antigen.
Oertli et al. (2002)CD8T cellTetramer staining also revealed significant increases in specific CD8(+) T cell numbers.
Wong et al. (2002)CD8T cellHowever, B chain peptide 15-23 bound to K(d) shows excellent T cell stimulation and the induction of CD8 cytotoxic T cells.
Mussini et al. (2002)CD8T cellPatients who were treated showed a significant daily increase in CD4/CD8 T cell ratio with longer time spent on therapy (0.04% increase per day longer on antiretroviral therapy, p=0.02).
Tibaldi et al. (2002)CD8T cellsBoth activated CD4 and CD8 T cells are able to scan antigen-presenting cells surfaces in the absence of cognate antigen.
Zwaveling et al. (2002)CD8T cellIn a preclinical model of human papillomavirus (HPV)16-induced cervical cancer we show that prime-boost vaccinations with the HPV16-derived 35 amino-acid long peptide E7(43-77), containing both a CTL epitope and a Th epitope, resulted in the induction of far more robust E7-specific CD8(+) T cell responses than vaccinations with the minimal CTL epitope only.
Zwaveling et al. (2002)CD8T cellThe level of the induced E7-specific CD8(+) T cell response proved to be dependent on the interactions of these Th cells with professional APC.
Turato et al. (2002)CD8T-lymphocytesThe inflammatory process was characterized by an increase in CD8(+) and CD4(+) T-lymphocytes in the airway wall and by an increase in macrophages in the airway epithelium.
Psarra et al. (2001)CD8T lymphocytesRESULTS: The study showed: a) a statistically significant increase of the mean CD4/CD8 ratio (2.12+/-0.84 vs 1.85+/-0.63, P = 0,039); b) a statistically significant decrease of the mean value of the percentage of CD5+ CD19+ lymphocytes (0.4+/-0.6 vs 1.4+/-0.78, P < 0.0001); and c) a statistically significant increase of the percentage of T lymphocytes expressing TCRgammadelta (4.68+/-3.19 vs 2.61+/-1.14, P < 0.0001).
Ruiz et al. (2001)CD8T cellA substantial increase in HIV-specific CD8 T cell frequencies was found in four interrupter patients, whereas there were no changes in all 14 non-interrupter individuals.
Yan et al. (2000)CD8T cellsExclusive to POF patients was a statistically significant increase in CD8 density on T cells.
de Boer et al. (2000)CD8T-cellT-cell activation (IL-2 receptor and human leukocyte antigen-DR expression) can be induced, and CD4:CD8 cell ratios can be increased.
Oliver et al. (2000)CD8T cellsHistologic comparison of skin biopsies showed changes in skin fibrosis and an increase in epidermal and dermal infiltrating CD8(+) T cells with thalidomide treatment.
Masuda et al. (2000)CD8T cellsCardiopulmonary bypass transiently alters lymphocyte subsets, resulting in a reduction in CD4(+) T cells and an increase in CD8(+) T cells.
Sester et al. (2000)CD8T cellsAs specific antigen, HIV-1 Pr55gag virus-like particles were superior to soluble protein, especially for the activation of CD8 T cells.
Sun et al. (2000)CD8T-cellRESULTS: YXYDD was more effective than QDYX in improving clinical symptoms, adjusting the abnormal ECG, lowering the serum level of myocardial enzymes, improving the cardiac function of left ventricle and regulating the T-cell immunity (elevation of CD3, CD4 and CD4/CD8 ratio).
Habermehl et al. (1999)CD8T-cellsAnalysis of the expression of activation marker revealed activation of both CD4+-T-helper- and CD8+-T-cells.
Grütz et al. (1998)CD8T-cellIn a transgenic model of tumorigenesis by Lmo2, T-cell acute leukaemias arise after an asymptomatic phase in which an accumulation of immature CD4(-) CD8(-) double negative thymocytes occurs.
Agrawal et al. (1998)CD8T cellRapid induction of primary human CD4+ and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes.
Maric et al. (1997)CD8T cellsWe show that sustained accumulation of CD8 T cells in vivo requires local expression of B7-1.
Roederer et al. (1995)CD8T cellsAlthough overall CD8 T cell numbers are increased during this stage, the naive CD8 T cells are progressively lost and fall in parallel with overall CD4 T cell counts.
Schneider et al. (1994)CD8T cellsIn the large intestine of HIV-infected patients CD4 T cells were reduced and CD8 T cells were increased compared with controls.
Groettrup and von Boehmer (1993)CD8T-cellExpression of a productive T-cell receptor (TCR) beta gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCR beta-gene rearrangement.
Onishi et al. (1991)CD8T cellsThe effect of IFN-gamma on TIL was an increase in CD3 (pan-T cells), especially an increase in CD8 (cytotoxic/suppressor-T cells).
Chan et al. (1991)CD8T cellThe phosphorylation of ZAP-70 and its association with zeta is independent of the other TCR chains since stimulation of a functional CD8/zeta chimeric receptor in a TCR-negative T cell leads to coprecipitation of ZAP-70 with the chimeric protein.
Yarchoan et al. (1989)CD8T cellHowever, patients in the four highest dose groups (ddI at 1.6 milligrams per kilogram intravenously and then greater than or equal to 3.2 milligrams per kilogram orally at least every 12 hours or higher) had increases in their circulating CD4+ T cells (P less than 0.0005), increased CD4/CD8 T cell ratios (P less than 0.01), and, where evaluable, more than an 80% decrease in serum HIV p24 antigen (P less than 0.05).
Unzeitig et al. (1984)Leu 2T cellsHemophiliacs who had received greater than 250 CFC infusions and who had persistent lymphadenopathy had decreased Leu 3+ cells, increased Leu 2+ "suppressor" T cells, a decreased Leu 3-Leu 2 ratio, and decreased phytohemagglutinin responses.
Lilleri et al. (2007)CD8T-cellResolution of disease during HAART was associated with rescue of specific CD4(+) T-cells and a large increase in the specific CD8(+) T-cell count.
Mahnke et al. (2007)CD8T cellsCorresponding induction of DCP-specific CD4(+) and CD8(+) T cells were detectable.
Mahnke et al. (2007)CD8T cellsMoreover, after immunization of ONTAK treated patients with tumor antigen peptides, MelanA/MART-1 and gp100, significant induction of peptide specific CD8(+) T cells could be observed in 90% of the patients treated.
Lloyd et al. (1997)CD8T cellsTreatment of CD8+ T cells with IL-4 decreased levels of both CD28 surface expression and message and increased CD8 expression.
Stumpf and Büssing (1997)CD8T cellsHowever, the elimination of tumour cells was associated with a transient increase in macrophages and eosinophils, and a constant increase in CD8+T cells.
Bosque et al. (2007)CD8T cellThe mechanisms responsible for the down-modulation of the activation of separated CD4(+) or CD8(+) human T cell blasts were studied using cells obtained from healthy donors.
Shimokubo et al. (2002)CD8T cellsExpression of HTLV-Igag Ag on CD4(+) T cells was up-regulated when infected in the presence of 8-azaguanine, and these fusion DC-T cells were quite efficient in induction of higher CD8(+) T cell response.
Knutson and Disis (2005)CD8T lymphocyteCancer specific immunity elicited with vaccines has traditionally focused on the activation of the CD8 cytolytic T lymphocyte (CTL) often involving direct stimulation of immunity using HLA-class I binding peptide epitopes.
Jordan and Hunter (2010)CD8T cellWhile these particular species perhaps represent the most studied parasites in terms of understanding how T cells function during infection, it is clear that the lessons learned from this body of work are also relevant to the other protozoa known to induce a CD8(+) T cell response.
Holm and Gabuzda (2005)CD8T-cellThese results suggest that nonreplicating HIV-1 virions contribute to chronic immune activation and T-cell depletion during HIV-1 pathogenesis by activating CD4(+) and CD8(+) T cells, which then proceed to die via apoptosis.
Gregson et al. (2008)CD8T cellsPercentages of CD4 were reduced, and CD8 and activation of CD4 T cells correlated with rejection.
Ning et al. (2005)CD8T cellsThe result suggested that CD4(+)CD25(+)-regulatory T cells and CD8(+) T cells were increased apparently when cocultured with allogeneic MSCs.
Doolan and Martinez-Alier (2006)CD8T cellsIL-4 secreting CD4+ T cells are required for induction of the CD8+ T cell responses, and Th1 CD4+ T cells provide help for optimal CD8+ T cell effector activity.
Pinilla-Ibarz et al. (2005)CD8T-cellThe analog peptides generated larger immune responses (increased CD8 T-cell precursor frequency) than did the native peptides.