Viewing negative mentions of positive regulation of CD8A (H. sapiens) in T cells

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Jubinsky et al. (2009)CD8T-cellThere was normal Foxp3 and CD25 expression, no increased CD4(-)CD8(-) T-cell population, and the AIRE and Fas genes were without mutations.
Coudert et al. (2002)CD8T cellThus, Th2 differentiation is a major pathway of alloreactive CD4 T cell development during solid organ transplant rejection, as long as host NK and CD8 T cells are not activated.
Rokicka-Piotrowicz et al. (1998)CD8T lymphocyteAbsolute CD8 T lymphocyte count was not significantly increased in the study group.
Eggena et al. (2005)CD8T cellThe presence of coinfection was associated with increased CD4(+) T cell activation but, interestingly, not with increased CD8(+) T cell activation.
Joshi et al. (2009)CD8T cellDysfunctional CD8(+) T cells could be partially rescued by in vivo B7-H1 blockade, which increased CD8(+) T cell survival but failed to restore cytokine production.
Yang et al. (1988)CD8T cellActivation via CD4 or CD8 molecules by OKT4 or OKT8 antibodies did not lead to a T cell-dependent modulation of IgE synthesis.
Sandalova et al. (2010)CD8T cellsWe detected that after 24 and 48 hours of incubation, IL-15 (at 1 and 10 ng/ml) induced CD38/HLA-DR expression in HCMV and EBV specific CD8 T cells while the other inflammatory cytokines did not activate EBV and HCMV specific CD8 T cells.
Ott et al. (2003)CD8T cellHowever, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known.
Yang (2009)CD8T-cellsThe fact that neither specific antibodies nor activated CD8+ cytotoxicity T-cells could provide primary protection in high risk populations raises the question concerning whether a specific vaccine is feasible.
Combadière et al. (2010)CD8T-cellBACKGROUND: Current conventional vaccination approaches do not induce potent CD8 T-cell responses for fighting mostly variable viral diseases such as influenza, avian influenza viruses or HIV.
Hand et al. (2010)CD8T-cellHowever, constitutive AKT activation did not enhance memory CD8 T-cell survival but rather repressed IL-7 and IL-15 receptor expression, STAT5 phosphorylation, and BCL2 expression.
Brozyna et al. (2009)CD8T cellsWe have previously reported increased intracellular Th1 cytokines in blood, BAL and intraepithelial CD8+T cells in current and ex-smokers with COPD, whereas healthy smokers showed localized Th1 response in the lung only.
Ranganathan et al. (2009)CD8T cellTwo of these strains (DeltalysA DeltapanCD Mtb and DeltaRD1 DeltapanCD Mtb) failed to induce significant levels of HIV Env-specific CD8(+) T cell responses.
Kozako et al. (2009)CD8T-cellsAdditionally, our results show that HTLV-1-specific CD8+ T-cells can be induced by peptide with HTLV-1/HBc particle from ATL patient, but not by peptide only and these HTLV-1-specific CD8+ T-cells were able to lyse cells presenting the peptide.
Smith et al. (2004)CD8T cellThe second MVA booster dose did not increase the peak CD4 and CD8 T cell responses, but increased anti-Env Ab titers by 40- to 90-fold.
Kersh et al. (2003)CD8T cellsThus, memory CD8 T cells do not increase their TCR sensitivity, but are better poised to augment downstream signals.
Rump et al. (1995)CD8T cellThere was no relationship between MxA expression and low CD4/CD8 ratios or increased CD8/CD57+ T cell counts, although both conditions are often observed in CVID as well as in chronic viral infections.
Damle and Engleman (1989)CD8T cellsThe activated CD8+ Ts lyse neither APC nor antigen-primed CD4+ inducer T cells and can be distinguished from their CD8+CD28+ CTL counterpart by their lack of expression of the CD28 molecule.
Quaratino et al. (1991)CD8T cellsThese data clearly show that the CD4 and CD8 molecules are not required for the activation of untransformed human T cells by bacterial enterotoxins.
Kostense et al. (2002)CD8T-cellThese data indicate that the loss of HIV-specific CD8(+) T-cell activity is not due to physical depletion, but is mainly due to progressively impaired function of HIV-specific CD8(+) T cells.
Kovacs et al. (2008)CD8T cellsWe found increased percentages of activated CD8(+) T cells (i.e., CD8(+)HLA-DR(+)38(+) cells and CD8(+)CD28(+)HLA-DR(+) cells) but not of CD4(+) T cells among women who tested positive for HIV-1, HCV antibody, and HCV RNA, compared with HIV-1-positive women who tested negative for HCV antibody.
Lewis et al. (2007)CD8T cellRecent data, which examined DNA turnover in CD4+ and CD8+ T cell subsets of HIV-infected people after long-term scIL-2 therapy, are supportive of this idea because IL-2 therapy enhanced CD4+ T cell survival, but not CD8+ T cell survival [4].
Song et al. (2007)CD8T cellHowever, anticancer drugs alone failed to induce a significant enhancement of the tumor-specific CD8(+) T cell immune response.
Pohling et al. (2010)CD8T cellsin response to the HIV peptides were almost exclusively CD8+ as no increase over control values in the percentage of non-CD8+ T cells producing IFN-?
Dung et al. (2010)CD8T cellsBy phenotyping CD8+ T cells (CD38+/HLA-DR+, CD38+/Ki-67+, or HLA-DR+/Ki-67+) in serial blood samples from children with dengue, we found no evidence of increased CD8+ T cell activation prior to the commencement of resolution of viremia or hemoconcentration.
Ponticiello et al. (2004)CD8T cellsBCG induces a massive increase in the proportion of CD4 Th1 subset followed by an increase in gammadelta T cells, while no significant variation for CD8 and NK cells is found.
Redelman (1987)CD8T cellsSubsequently, the expression of CD4 and CD8 returned to the levels on resting T cells but did not increase further.
Moretto et al. (2010)CD8T cellSplenic dendritic cells pulsed with rEhPTP1 are able to induce E. cuniculi specific CD8(+) T cell response with no effect on the CD4(+) T cell subset.
Sato et al. (2010)CD8T celleffector CD8+ T cell subsets and PerhighGraA+GraB+ cells were not induced in the mice on 7 days and 31 days after the PBMC injection (Figures S1A and S1B).
Wolthers et al. (1996)CD8T cellsThis observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8(+) T cells, but not in CD4(+) T cells.
Enose-Akahata et al. (2009)CD8T cellsIn our study, stimulation of NDs CD8+ T cells with IL-2 and IL-15 induced SAP but not CD244 expression on CD8+ T cells.
Buslepp et al. (2003)CD8T cellYet, T cell binding and cytolytic activity are independent of CD8 when stimulated with human p1049/A2 as demonstrated with anti-CD8 Abs that block CD8 association with MHC.
Esser et al. (2001)CD8T lymphocytesNoninfectious CXCR4-tropic HIV-1 virions, but not microvesicles, partially activated freshly isolated CD4(+) and CD8(+) peripheral blood mononuclear cell T lymphocytes to express FasL and Fas, but not CD69 or CD25 (interleukin-2 receptor alpha) and eventually die via apoptosis starting 4 to 6 days postexposure.
Mulligan et al. (1998)CD8T cellsThe CD8 on the B-CLL surface is immunochemically identical to the antigen on T cells, but is not accompanied by its usual signalling mechanism of p56-lck tyrosine kinase and therefore is unlikely to be a functionally active receptor.
Katsikis et al. (1997)CD8T cellWe show that z-VAD-fmk, a tripeptide inhibitor of ICE homologues, can inhibit Fas-induced apoptosis of peripheral blood CD4(+) and CD8+ T cells from asymptomatic HIV+ individuals. z-VAD-fmk also inhibited activation (anti-CD3)- induced CD4+ and CD8+ T cell apoptosis (AICD) in some but not all asymptomatic HIV+ individuals.
Rodríguez-Zapata et al. (2010)CD8T lymphocytesFlow cytometry studies showed that the intracytoplasmic expression of IFN-gamma, IL-2, and TNF-alpha, but not that of IL-4, by phorbol myristate-activated CD4(+) CD3(+) and CD8(+) CD3(+) T lymphocytes was significantly increased in untreated brucellosis patients and was also partially normalized after antibiotherapy.
Naujokat et al. (2007)CD8T cellsAs a functional consequence, DCs fail to stimulate allogeneic CD4(+) and CD8(+) T cells and autologous CD4(+) T cells sufficiently in response to inhibition of chymotrypsin-like peptidase activity.
Combadière et al. (2010)CD8T-cellCurrent conventional vaccination approaches do not induce potent CD8 T-cell responses for fighting mostly variable viral diseases such as influenza, avian influenza viruses or HIV.
Van Overtvelt et al. (2002)CD8T cellThis dysfunction appears to be linked essentially to reduced MHC class I molecule expression since the stimulation of the RT(476-484) peptide-specific CD8(+) T cell line was shown to depend mainly on the MHC class I-TCR interaction and not on the co-stimulatory signals which, however, were also inhibited by T. cruzi.
Sandalova et al. (2010)CD8T cellsSimilar to the in vivo findings, influenza-specific CD8 T cells were not or only weakly activated by addition of any of the tested cytokines (Figure 5 A and B).
Guan et al. (1999)CD8T lymphocytesInjection of synthetic MIP-4 into the peritoneal cavity of mice led to the accumulation of both CD4(+) and CD8(+) T lymphocytes, but not monocytes or granulocytes.
Ndhlovu et al. (2010)CD8T cellCD8+ T cell counts did not increase from baseline for either group (p?
Dembek et al. (2010)MIRA CD8T cellsThe absence of MIRA CD8+ T cells in 9 out of 10 PR and 3 ART-treated patients with detectable viremia together with the analysis of a group of 6 ART-treated patients undergoing a single cycle of TI demonstrated that MIRA CD8+ T cells are not induced or regulated by the in vivo levels of HIV-1 replication.
Jelley-Gibbs et al. (2007)CD8T cellPersistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response.
Woodworth et al. (2008)CD8T-cellCD4(+) and CD8(+) T-cell responses to mycobacterial antigens secreted independently of ESX-1 were unaffected, suggesting that ESX-1-dependent phagosomal escape is not required for CD8(+) T-cell priming during infection.
Pietra et al. (2010)CD8T cellsOn the other hand, donors who express HLA-Cw alleles carrying the VMAPRTLIL peptide, fail to generate HLA-E-restricted CD8+ T cells specific for this self-peptide Thus, in these donors, HLA-E-restricted CD8+ T cell precursors may have been negatively selected in the thymus by HLA-E/VMAPRTLIL self-complexes.
Leignadier et al. (2008)T-cell receptorT-cellMemory T-lymphocyte survival does not require T-cell receptor expression.
Boda et al. (2009)CD8T cellsPatients displayed no increase in the percentage of activated CD8+ T cells (HLA-DR+, CD69+ or CD25+), but memory CD8 T-cell levels (CD8+CD45RA?)
Brod et al. (1990)CD8T cellThe addition of excess rIL-4 increased the expression of CD8 on the surface of CD4+ T cell clones but did not increase CD4 expression on CD8+ T cell clones.
Ramirez and Sigal (2002)CD8T cellThis phenomenon of cross-presentation is essential in the induction of CD8(+) T cell responses to viruses that do not infect pAPC and possibly contributes to the induction of CD8(+) responses to many other viruses.
Zhong et al. (2009)CD8T cellsTCR/CD3 ligation also induced CD3 co-clustering with CD8 in well-organized nano-domains of activated CD8 T cells; CD28 co-stimulation did not enhance CD8 clustering or CD3-CD8 co-clustering in nano-domains
Tougan et al. (2008)CD8T cellsAll mononuclear cells (B cells, T cells, and monocytes) and activated CD4+ and CD19+ cells, but not activated CD8+ and mononuclear cells, also expressed c-vav.
Park et al. (2009)CD8T-cellsCD40 ligand and 4-1BB expression on the surface of CD4(+) T-cells were increased after TCR-ligation activation; however, expression on CD8(+) T-cells was not increased.
You et al. (2008)CD8T-cellsproduction, and a transient increase in HBV-specific CD4+ T-cells, but no increase in HBV-specific CD8+ T-cells.
Wang et al. (2010)CD8T cellAs shown in Table 4, the anti-HLA-I antibody in fact showed partially blocking of reactivity for some peptide epitopes (PF106 and PF141) that, according to the cell depletion experiments (Fig. 1) induced CD4+ T cell, but not CD8+ T cell, responses.
Semple et al. (2011)CD8T-cellsAgain, PPD stimulation did not induce expression of perforin in CD4+ or CD8+ T-cells from cord blood (Figures 3(a) and 3(b)) while a reduction in the levels of expression in CD56+ NK cells to 16.5% (8–33.2, P = .02) as compared to unstimulated CBMCs was noted.
Bonno et al. (1996)CD8T lymphocytesRESULTS: The nonimmunotherapy group showed significant Df-specific CD25 induction on CD4+ T lymphocytes (delta CD4+ CD25+) but little induction on CD8+ T lymphocytes (delta CD8+ CD25+). delta CD4+ CD25+ was correlated with the severity of the disease.
Yan et al. (2001)CD8T-cellHowever, among the exerciser groups, no such increase and decrease in the T-cell subpopulations or an age-related increase of the CD4:CD8 ratio were observed.
Ghanekar et al. (2007)CD8T cellMature MDDC prepared from cryopreserved PBMC were not significantly different compared to those from fresh PBMC in stimulating allogeneic CD4+ (p = 0.063, Fig. 1C, Top panel) and CD8+ (p = 0.3527, data not shown) T cell proliferation.
Heit et al. (2008)CD8T cellImmunization with purified antigens is a safe and practical vaccination strategy but is generally unable to induce sustained CD8(+) T cell-mediated protection against intracellular pathogens.
Jin et al. (2010)CD8T-cellsHowever, PIKA did not activate CD4+ and CD8+ T-cells [138].
Ortiz et al. (2001)CD8T cellControl subjects (n = 4) maintained VL <400 copies per ml and stable CD4(+) T cell counts, and showed no enhancement of antiviral CD8(+) T cell responses.
Jones et al. (1990)CD8T cellsPhenotypic switch from CD45RA+ to CD45RA- by normal blood T cells is associated with increased HLA-ABC expression for CD4+ and CD8+ populations but not for the NK-associated CD4-CD8dim+ or CD4-CD8- fractions.
Jiang et al. (2009)CD8T cellNo increase in CD8+ T cell responses was detected for any of the four vaccine antigens (data not shown).
De Bruijn et al. (1992)CD8T cellsDC rapidly aggregated with unprimed T cells, which was independent of LFA-1 and CD8 molecules.
Hinterberger et al. (1988)CD8T cellsCirculating numbers of activated (CD4 and CD8) T cells and serum levels of IL-2R were not increased in both untreated and treated SAA patients.
Holvast et al. (2009)CD8T cellAs expected for a subunit vaccine, vaccination did not induce a CD8+ T cell response.
Dybul et al. (2001)CD8T cellThere was no significant change in CD4(+) T cell counts, no significant increase in CD4(+) or CD8(+) T cells expressing activation markers or producing IFN-gamma in response to HIV, no increase in CD4(+) T cell proliferation to p24 antigen, and no evidence for the development of resistance to HAART medications.
Brogan et al. (2008)CD8T cellThere was no significant increase in overall peripheral blood CD4 or CD8 T cell activation as determined by CD69 expression.
Gong et al. (2010)CD8T cellsPeripheral CD4+ and CD8+ T cells, monocyte count, and HLA-DR expression were increased significantly (p<0.05) only in the HVHF group, not in the SMT group.
Schuppler and Loessner (2010)CD8T cellIn response to L. monocytogenes infection, DCs are critical in priming the T cell response, since mice depleted of DCs are unable to generate a CD8 T cell response [103].
Wang et al. (1994)T-cell receptorT cellsThe GM-CSF gene is not expressed in resting peripheral blood T cells but is rapidly induced at the transcriptional level following activation through the cell surface T-cell receptor.
Lin et al. (1995)CD8T cellsThe anti-CD2 mAb 12-15 caused CD2 expression on purified splenic T cells to decrease from 83.4 to 22.7% total positive cells while CD3, CD4, and CD8 expression remained unchanged.
Miles et al. (2008)CD8T-cellsThe CD8 T-cells of CMV-infected infants were more differentiated but no more activated than those of CMV-uninfected infants
van Oers et al. (1993)CD8 coreceptorT cellsFurthermore, constitutive phosphorylation of TCR zeta in T cells occurred independently of antigen stimulation and did not require CD4 or CD8 coreceptor expression.
Tien et al. (1992)T-cell receptorT-cellNo cross-lineage rearrangements of immunoglobulin (Ig) or T-cell receptor (TCR) genes were detected in these karyotypic subgroups of patients who underwent gene analysis.