Viewing affirmative mentions of positive regulation of CD4 (H. sapiens) in T cells

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Bartholomew et al. (1995)CD4T cellsIn order to down-modulate CD4 on resting, normal CD4 T cells there was an absolute requirement for FcR-mediated cross-linking of the anti-CD4 antibody, and only CD4 levels were affected.
Vogt et al. (2008)CD4T cellsInterestingly, TC vaccination induced both effector CD4 and CD8 T cell responses, whereas i.m. injection induced strong effector CD4 in the absence of CD8 T cells, as assessed by intracellular cytokine staining and tetramer analyses.
Herndler-Brandstetter et al. (2007)CD4T-cellWe demonstrate here that the increase in the number of peripheral CD4(+) CD8(+) T cells in the elderly is the result of an increase of the CD4(lo) CD8(hi) T-cell population.
Lusso et al. (1995)CD4T lymphocytesInfection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection.
Lusso et al. (1995)CD4T cellWhereas purified CD4- gamma/delta T cell populations were per se refractory to HIV infection, they became susceptible to productive infection by HIV-1, strain IIIB, after induction of CD4 expression by HHV-6.
Roger et al. (2002)CD4T cellAn increase in CD4(+) T cell count > or = 100 cells/microL over baseline was considered to be a satisfactory immune reconstitution.
Feller et al. (2008)CD4T-cellThe sequential serological tests showed a progressive increase in CD4(+) T-cell counts that paralleled the rapid clinical worsening of the KS disease.
Hoffmann et al. (2007)CD4T-cellAfter a mean follow up of 39 months, however, a sustained increase of the mean CD4(+) T-cell count was observed (from 0.232 x 10(9) to 0.523 x 10(9) cells/l) without changes of plasma viraemia.
Hoffmann et al. (2007)CD4T-cellWe conclude that ATT combined with highly active antiretroviral therapy is safe and leads to a considerable increase in CD4(+) T-cell numbers.
Gazzola et al. (2009)CD4T cellThe aim of our review is to provide a thorough assessment of the clinical implications of a lack of increase in the CD4(+) T cell count in immunological nonresponders, to examine the immunological gaps limiting recovery of the CD4(+) T cell count, and to note possible therapeutic avenues, which may offer clinicians guidance regarding how to most efficaciously treat these critical patients.
Cao (2006)CD4T cellsHAART fundamentally alters the course of HIV-1 infection by decreasing the plasma viral load to the undetectable level and increasing the number of CD4 + T cells.
Novak et al. (2001)CD4T cellsWe have recently extended these studies to human class II-restricted CD4(+) T cell responses and now describe antigen-specific T cell responses from human peripheral blood in which elevated CD4 expression levels in human T cells following antigen stimulation identify the activated and proliferating subset of cells.
Liu et al. (2009)CD4T cellThe CD4(+) T cell counts were statistically higher in the 201 - 350 group during the entire follow-ups (P < 0.01) though CD4(+) T cell count increases were similar in these two groups.
Sung et al. (2009)CD4T-cellThe annual increase in CD4 T-cell count in the combination group was significantly higher than that in the group treated with HAART alone (P < 0.05).
Hellerstein et al. (1999)CD4T cellsAfter viral replication was suppressed by highly active antiretroviral therapy for 12 weeks, the production rates of circulating CD4+ and CD8+ T cells were considerably elevated; the kinetic basis of increased CD4 levels was greater production, not a longer half-life, of circulating cells.
Mayanja-Kizza et al. (2005)CD4T cellWe performed a phase 2, randomized, double-blind, placebo-controlled clinical trial in Kampala, Uganda, to determine whether immunoadjuvant prednisolone therapy in HIV-infected patients with TB who have CD4(+) T cell counts >/=200 cells/ mu L is safe and effective at increasing CD4(+) T cell counts.Results.
Martins et al. (2004)CD4T-cellFollowing prolonged stimulation in vitro using either allogeneic stimulator cells or viral antigens, we found that coexpression of activation markers within the CD4(+) T-cell subset occurred exclusively within a subpopulation of T cells that significantly increased their surface expression of CD4.
Li et al. (2008)CD4T cellThe increase in CD4+T cell count was divided into two phases: a rapid increase in the first 12 weeks constituted the first phase and a slow increase after week 12 constituted the second phase.
Hoxie et al. (1991)CD4T-cellIn addition, our study documents strong selection pressures for viruses with increased CD4 affinity during propagation in immortalized T-cell lines, thus emphasizing the need to study HIV envelope biology in natural target cells.
Chavan et al. (2001)CD4T cellOf interest, patients who demonstrated discordant responses (i.e., increased CD4 T cell counts without significant virologic suppression) also had substantial gains in TRECs.
Equils et al. (2000)CD4T cellsAll the responding children had a significant increase in naive CD4 T cells (P<.05).
Stratov et al. (2005)CD4T cellPigtail macaques vaccinated intramuscularly with DNA/recombinant fowlpox virus exhibited a coordinated induction of first Gag-specific CD4 T cell responses and then a week later Gag-specific CD8 T cell responses following the fowlpox virus boost.
Shahabuddin et al. (1992)CD4T cellsTreatment of chronically HIV-1-infected CD4-negative T cells in vitro with the Tat antagonist Ro 5-3335 resulted in a drug dose-dependent decrease in virus protein production and a reciprocal increase in surface CD4 display.
Read et al. (2008)CD4T cellCD4 T cell survival after intermittent interleukin-2 therapy is predictive of an increase in the CD4 T cell count of HIV-infected patients.
Read et al. (2008)CD4T cellAdministration of interleukin (IL)-2 to human immunodeficiency virus (HIV)-infected patients leads to significant increases in CD4 T cell counts.
Read et al. (2008)CD4T cellsThus, an increase in the survival of CD4 T cells appears to be the critical mechanism leading to sustained increases in the CD4 cell counts of HIV-infected patients receiving intermittent IL-2 therapy.
Miao et al. (2002)CD4T cellAfter HAART, opportunistic intestinal pathogens maintain elevated MAdCAM-1 expression, which results in prominent increases in LP CD4 T cell densities in the absence of HIV-mediated CD4 T cell destruction.
Brenchley et al. (2004)CD4T cellsMemory CD8(+) T cells can also be infected upon upregulation of CD4; however, this is infrequent and HIV-specific CD8(+) T cells are not infected preferentially.
Galán et al. (2004)CD4T cellsRESULTS: We observed an increase in CD4 T cells, a statistically significant decrease in viral load and clinical benefits from 3 months after treatment.
Lieberman et al. (1997)CD4T-cellThe increase in CD4 T-cell counts in the first weeks after the infusion suggests that antiviral CTLs of diverse specificities do not play a significant role in CD4 T-cell decline.
Algeciras et al. (1998)CD4T cellMoreover, significant differences between CD3 and CD4 activation were observed with regards to the kinetics of induction of CD4+ T cell susceptibility to FasL- and TNF-mediated apoptosis.
Theodore et al. (1994)CD4T lymphocytesCD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120: contribution to the immunosuppression seen in HIV-1 infection by induction of CD4 and CD3 unresponsiveness.
Barcy and Corey (2001)CD4T cellWe have observed that infection of human B lymphoblastoid cells (B-LCL) by HSV resulted in a strong inhibition of their ability to induce CD4(+) T cell clone proliferation and cytokine secretion.
Ilboudo et al. (2009)CD4T-cellsThe issue of this study revealed that the antiretroviral therapy increased the mother CD4 T-cells, prevented the transcription of the mRNA of HHV-8 and blocked HIV vertical transmission.
Lusso et al. (1991)CD4T lymphocytesInduction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6.
Lusso et al. (1991)CD4T-cellHere, we demonstrate that infection with human herpesvirus 6 (HHV-6), a virus proposed as a potential cofactor in AIDS, dramatically upregulates the expression of CD4--the receptor for human immunodeficiency virus type-1 (HIV-1)--in a human neoplastic T-cell line.
Lusso et al. (1991)CD4T lymphocytesMore importantly, HHV-6 induces de novo expression of CD4 messenger RNA and protein in normal mature CD8+ T lymphocytes, rendering them susceptible to infection with HIV-1.
Lacabaratz-Porret et al. (2003)CD4T cellHighly active antiretroviral therapy (HAART)-induced suppression of viremia was associated with an increase in CD4(+) T cell proliferative responses.
Deeks et al. (2002)CD4T-cellBoth groups experienced a treatment-related increase in CD4(+) T-cell counts.
Vieillard et al. (1999)CD4T cellsTransferring human CD4(+) T cells containing the IFN-beta retroviral vector drastically reduced the preexisting HIV infection and enhanced CD4(+) T-cell survival and Th1 cytokine expression.
Sereti et al. (2007)CD4T cellNonresponders (NRs) were defined as patients with a <or=10% increase in CD4(+) T cell count 2 months after the third IL-2 cycle (week 24), compared with that at baseline (week 0).
Sereti et al. (2007)CD4T cellControl subjects experienced a >or=50% increase in CD4(+) T cell count at week 24.
de Boer et al. (2003)CD4T-cellThe mean percent increase in CD4(+) T-cell counts was 24.5% for IL-2 recipients compared with a mean percent decrease of 30.5% for control patients (P = 0.005).
de Boer et al. (2003)CD4T-cellIL-2 therapy in cycles of 5 days resulted in an optimal increase in CD4(+) T-cell counts and is the preferred cycle length for IL-2 therapy geared toward increasing CD4(+) T-cell numbers.
Levine et al. (2002)CD4T-cellThese findings indicate that expansion of the peripheral T-cell pool mediated the increase in CD4 counts and suggest that approaches to reconstitute CD4 helper cell activity and decrease CCR5 expression may augment natural immunity to HIV infection.
Wang et al. (1992)CD4T-cellsThese results suggest that increased CD4 molecules can be induced on the surface of normal human T-cells in vitro.
Ghaffari et al. (2004)CD4T cellsRESULTS: VS/IS and VF/IS groups displayed similar sustained increases in CD4 T cells, although viral levels rebounded by 48 and 96 weeks posttherapy to pretherapy levels in the discordant group.
Lewis et al. (2007)CD4T cellIn another study, a predictor of the amount of CD4+ T cell return after IL-2 therapy was being non-white; this group of individuals had almost a 200 cells/mm3 larger increase in CD4 cell counts than the white group studied from a cohort of more than 250 patients [6].
Abulafia-Lapid et al. (2005)CD4T-cellFollow-up study revealed that 7/8 subtype B and 2/4 subtype C patients (one has just received the first TCV injection) responded with a persistent increase in their blood CD4 T-cell levels and four subtype B patients manifested decreased anti-CD4 autoimmunity.
Wilkinson et al. (2002)CD4T-lymphocyteFollowing 52 weeks of HAART, significant decreases in HIV-1 and KSHV loads were associated with significant increases in CD4(+) T-lymphocyte counts and number of SFC for the three KSHV-specific peptides.
Cheng et al. (2008)CD4T-cellMice vaccinated with CTGF/E7 DNA exhibited a dramatic increase in E7-specific CD4(+) and CD8(+) T-cell precursors.
Yoshikawa et al. (2008)CD4T cellsFurthermore, in vivo longevity of the long-lived DC vaccine led to antigen-specific activation of interferon-gamma-producing CD4+ and CD8+ T cells.
Savastano et al. (2007)CD4T-lymphocyteData concerning T-lymphocyte sub-population indicates a clear increase in T-helper compared to T-cytotoxic cells, with an increase in the CD4/CD8 ratio.
Matsoukas et al. (2005)CD4T-cellThe cyclic analogue was found to induce experimental allergic encephalomyelitis (EAE), to bind HLA-DR4, and to increase CD4 T-cell line proliferation, like that of the conformationally related linear MBP(87)(-)(99) epitope peptide.
Ravli?-Gulan et al. (2005)CD4T lymphocyteThe changes in the distribution of T lymphocyte subpopulations were significant on local levels in acute RA patients, resulting in a decreased CD4/CD8 ratio in SF, but an increased CD4/CD8 ratio in SM, compared to the ratio found in PB.
Dao Nguyen and Robinson (2004)CD4T cellsFluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism.
Markovi? (2004)CD4T cellsIn HIV-1-infected adults treated with growth hormone, thymic mass and circulating naive CD4 T cells are increased.
Psarra et al. (2001)CD4T lymphocytesRESULTS: The study showed: a) a statistically significant increase of the mean CD4/CD8 ratio (2.12+/-0.84 vs 1.85+/-0.63, P = 0,039); b) a statistically significant decrease of the mean value of the percentage of CD5+ CD19+ lymphocytes (0.4+/-0.6 vs 1.4+/-0.78, P < 0.0001); and c) a statistically significant increase of the percentage of T lymphocytes expressing TCRgammadelta (4.68+/-3.19 vs 2.61+/-1.14, P < 0.0001).
Zorrilla et al. (2001)CD4T-cellBy a fixed-effects analysis, both major depression and naturally occurring acute stressors are associated with (1) an overall leukocytosis, (2) mild reductions in absolute NK-cell counts and relative T-cell proportions, (3) marginal increases in CD4/CD8 ratios, and (4) moderate decreases in T- and NK-cell function.
Stricker et al. (2000)CD4T-cellImmunologic abnormalities included antiphospholipid antibodies (32%), antithyroid antibodies (53%), antinuclear antibodies (28%), antiovarian antibodies (2%), increased natural killer cells (40%), increased immunoglobulin (Ig)M level (28%), and increased CD4/CD8 T-cell ratio (15%).
Haley et al. (1999)CD4T-cellClinical relapse was preceded by an increase in the CD4/CD8 ratio and by reappearance of the T-cell receptor gene rearrangement.
Choi et al. (1999)CD4T lymphocytesALPS patients, like Fas-deficient MRL lpr/lpr mice, have lymphoproliferation, autoimmunity, increased CD4(-)/CD8(-) T lymphocytes, and apoptosis defects.
Agrawal et al. (1998)CD4T cellRapid induction of primary human CD4+ and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes.
Schöndorf et al. (1997)CD4T cellsIn both, T cells were the major population, with TIL containing a slightly increased CD4/CD8 ratio.
Wakasugi et al. (1997)CD4T cellsPhenotypic analysis of splenocytes by flow cytometry revealed an increase in the CD4/CD8 ratio and in the expression of HLA-DR, CD25, and Leu M3 by splenic T cells of the patients treated with OK-432 plus fibrinogen when compared to patients treated with OK-432 alone or untreated patients.
Stricker and Goldberg (1996)CD4T-cellsA smaller but statistically significant increase in CD4 T-cells and cytotoxic CD8 T-cells was also noted.
Stachowski et al. (1994)CD4T cellsCD4 molecules and lymphocyte function antigen-1 beta/LFA-1 beta/ on helper-inducer T cells were increased before and after the culture. (4) These findings were also associated with a diminished binding capacity of IL-1 beta and IL-6 to their receptors on helper-inducer T cells. (5) IL-2, IFN-gamma and IL-4 production was decreased in uraemic non-responders, especially after 72 h of the culture. (6) Inhibited proliferation of helper-inducer T cells in uraemic non-responders was only partially reversible in the presence of exogenous IL-1 beta, IL-6, IL-2 and IFN-gamma. (7) HLA typing of uraemic non-responders was associated with extended haplotype: HLA A1,B8,DR3,DR7,DQ2.
Betjes et al. (1994)CD4T cellsActivation of the peritoneal T cells at day P was shown by the increase in MHC class II positive T cells and an increase in the CD4/CD8 ratio.
Lee et al. (1991)CD4T cellsOur results show that despite the presence of normal numbers of T cells and an increased CD4/CD8 ratio in both groups of patients compared to healthy controls (p less than 0.0001), only the group of patients who were chronic HBV carriers showed depressed lymphoproliferative responses to phytohemagglutinin (p less than 0.001) and concanavalin A (p less than 0.0001).
Leon et al. (1996)CD4T lymphocytesIt follows that activated HIBEC may also play a direct role in the activation of antigen-specific CD4+ T lymphocytes.
Lim et al. (1998)CD4T-lymphocyteA whole-blood flow cytometry-based assay was utilized to assess CD4 and CD8 T-lymphocyte activation in response to phytohemagglutinin (PHA) stimulation.
Healey et al. (2008)CD4T cellBACKGROUND: Intermittent administration of interleukin-2 (IL-2) to human immunodeficiency virus (HIV)- infected patients on antiretroviral therapy (ART) is capable of inducing significant increases in CD4 T cell counts as a result of increased T cell survival and decreased cell turnover.
Kovacs et al. (1995)CD4T lymphocytesIncreases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection.
Sloand et al. (1999)CD4T-cellSome of the benefit of protease inhibitors may be related to modification of programmed cell death, which increases CD4(+) T-cell number.
Eglinton et al. (1994)CD4T cellsMilk T cells had a more equivalent CD4:CD8 ratio than blood; milk CD4 T cells mainly expressed the CD45RO (antigen primed/memory) phenotype; milk CD8 cells had an equivalent CD11b:CD28 suppressor:cytotoxic phenotype; and milk T cells had 2-3-fold higher percentages of activated CD4 IL-2R and CD8 HML-1 or CD8 VLA-1 cells than blood.
Ohshima et al. (1996)CD4T cellsOur data did not therefore directly suggest the existence of a common superantigen model of HTLV-I which induces an increase in CD4 T cells.
Rudin et al. (2008)CD4T-cellIn an on-treatment analysis, first-line therapy with any of the PIs significantly reduced HIV-1 concentrations and increased CD4 T-cell counts and percentages from baseline throughout the 288-week study (P <or= 0.05) for ritonavir and nelfinavir and throughout 84 weeks of use for lopinavir/ritonavir, which was introduced into treatment more recently.
Sipsas et al. (2002)CD4T-cellAfter 8 to 12 months of HAART, a further threefold increase of serum sCD40L levels, which paralleled the increase of CD4(+) T-cell counts, was observed.
Jenkins et al. (1999)CD4T cellsThe induction of CD4+ T cell proliferative responses to eight synthetic peptides representing amino acid sequences of the VZV IE62 protein was assessed using T cells and DC from VZV-susceptible donors.
Aucher et al. (2010)CD4-GFPT cellsTo collect CD8+ T cells after CD4 capture more easily, we used the adherent cell line HEK-FcR stably transfected with human CD4-GFP as CD4-donor cells.
Paliard et al. (1988)CD4T cellsMature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8.
Komoto et al. (2003)CD4T lymphocytesThe apoptosis induction levels after introduction of the vpu mutations were greatly increased in primary CD4(+) T lymphocytes.
Trumpfheller et al. (2008)CD4T cellWe find that polyriboinosinic:polyribocytidylic acid (poly IC) independently serves as an adjuvant to allow a DC-targeted protein to induce protective CD4(+) T cell responses at a mucosal surface, the airway.
Braun et al. (2006)CD4T-cellsSynthetic peptide libraries of 18 or 19 amino acids in length were chosen because they have the potential for stimulating both CD4 and CD8 T-cells and also because of the ease to which positive responses can be narrowed to single peptides.
Katayama et al. (1993)CD4T cellsCa2+ response in single human T cells induced by stimulation of CD4 or CD8 and interference with CD3 stimulation.
Pau and Tavel (2002)CD4T-lymphocyteImmune-based therapy with interleukin-2 when used as adjunctive therapy to antiretroviral therapy may further improve immune responses, as demonstrated by an increase in CD4(+) T-lymphocyte counts in recent clinical trials.
Mariño-Ramírez and Jordan (2006)CD4T cellsAs such, the HS site locations in the human genome should correspond to genes that are upregulated in CD4+ T cells.
Schweizer et al. (2008)CD4T cellsTreatment of CD4 T cells from healthy donors with DARPin for 0, 1, 3 and 18 h at 37°C (to allow receptor internalization) or at 4°C (to limit internalization) yielded identical results: Neither treatment with the CD4 specific nor the unspecific DARPin resulted in down- or upregulation of CD4 (Figure 5D).
Gandhi et al. (2010)CD4T cellThis persistent immune activation may have important clinical consequences; for example, persistent T cell activation is associated with lower CD4 cell count increases in patients receiving ART [17],[18],[19] and may contribute to accelerated atherosclerosis [20] or premature immunosenescence.
Gandhi et al. (2010)CD4T cellHowever, the increased CD4 cell counts during raltegravir intensification in the current study did not reach statistical significance and were not associated with a decrease in T cell activation; therefore, the CD4 cell rise may have been due to chance and should be interpreted cautiously.
Gaulton et al. (1992)CD4T cellsTreatment with anti-CD3 or with phorbol diester also stimulated serine phosphorylation of CD4 molecules in uninfected T cells.
Doughty et al. (1989)CD4T cellFive human monoclonal antibodies specific for parasite egg antigens were used to activate CD4 and CD8 T cell subsets.
Mikolai et al. (2009)CD4T cellsRESULTS: Significant increases were observed in the expression of CD4 on CD3+ T cells after 96 hours.
Correa and Muñoz-Fernández (2002)CD4T cellsIn children, the decrease in viral load caused by antiviral therapy leads to an increase in CD4 T cells, mainly because of a recovery in the thymic production of new T cells.
Prince et al. (1994)CD4T-cellBoth CD4 and CD8 T-cell subsets within MC cultures are activated during SLP, as judged by high-density CD25 (CD25bright) expression; it is unclear, however, whether both cell subsets can directly undergo SLP.
Nicholas and Martin (1994)CD4T-lymphocyteIts predominant CD4+ T-lymphocyte tropism, its ability to activate human immunodeficiency virus type 1 (HIV-1) gene expression in vitro, and its upregulation of CD4 expression has led to speculation that HHV-6 may act as a positive cofactor in the progression of HIV infection to AIDS in individuals infected with both viruses.
Koralnik et al. (2005)CD4T-cellEvolution over 8 years was marked by symptomatic improvement corresponding to highly active antiretroviral therapy (HAART), with modest increase in CD4(+) T-cell counts.
Watchmaker et al. (2008)CD4T cellWe report that, in sharp contrast to the effector cells (CTLs) that kill DCs in a granzyme B- and perforin-dependent mechanism, memory CD8(+) T cells enhance the ability of DCs to produce IL-12 and to induce functional Th1 and CTL responses in naive CD4(+) and CD8(+) T cell populations.