Viewing negative mentions of positive regulation of CD4 (H. sapiens) in T cells

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Eggena et al. (2005)CD4T cellThe presence of coinfection was associated with increased CD4(+) T cell activation but, interestingly, not with increased CD8(+) T cell activation.
Flores et al. (2009)CD4T cellsWe found that unlike conventional DCs, immune complex (IC) exposed murine pDCs neither up-regulated costimulatory molecules nor activated Ag-specific CD4(+) and CD8(+) T cells.
Ramachandran et al. (1996)CD4T cellSignificant elevations of CD4 T cell numbers of 30%-40% were seen after PEG-IL-2 infusions, but no additional increase in CD4 cell count was observed with thymosin alpha 1.
Redelman (1987)CD4T cellsSubsequently, the expression of CD4 and CD8 returned to the levels on resting T cells but did not increase further.
Endo et al. (2009)CD4T cellsIn contrast to other reported cases, he experienced neither increase of CD4+ T cells count nor ALT flare-ups before HCV RNA clearance.
Verhasselt et al. (2004)CD4T cellWhile immature DC did not induce significant CD4(pos) T cell activation, we observed that a significant fraction of CD4(pos) T cells cultured with mature autologous DC displayed phenotypic features of activation and produced IL-2, IFN-gamma, IL-10 and TGF-beta.
Harrington and Geballe (1996)CD4T cellUsing these hybrids it is demonstrated that expression of CD4 and CD26, the T cell activation antigen dipeptidyl peptidase IV recently proposed as a CD4 cofactor necessary for HIV-1 infection, are not sufficient for HIV-1 entry.
Watanabe et al. (1996)CD4T cellCD4+V beta 5.2/5.3+ cells in the T cell lines were not increased after stimulation with purified protein derivatives or 65-kDa heat-shock protein but significantly increased after stimulation with staphylococcal enterotoxins C1 and D.
Sékaly et al. (1991)CD4T cellThe CD4 molecule is not always required for the T cell response to bacterial enterotoxins.
Quaratino et al. (1991)CD4T cellsThese data clearly show that the CD4 and CD8 molecules are not required for the activation of untransformed human T cells by bacterial enterotoxins.
Callahan et al. (1992)CD4T cellsSoluble CD4 affinity-purified antibodies were predominantly IgG1 and were not induced to bind mCD4 after gp120 binding to T cells.
Hashimoto et al. (1997)CD4T cellsHere we demonstrate that CD4XL mediated by both, anti-CD4 monoclonal antibody (MoAb) or human immunodeficiency virus (HIV) envelope protein gp120 reduces the expression of the proto-oncogene Bcl-2 in CD4+ T cells, but not in CD8+ T cells, concurrently with the induction of CD4+ T cell-apoptosis.
Lewis et al. (2007)CD4T cellVery little increase in CD4+ T cell death was seen.
Lewis et al. (2007)CD4T cellRecent data, which examined DNA turnover in CD4+ and CD8+ T cell subsets of HIV-infected people after long-term scIL-2 therapy, are supportive of this idea because IL-2 therapy enhanced CD4+ T cell survival, but not CD8+ T cell survival [4].
Selliah et al. (1995)CD4T cellsAccordingly, T cells binding to immobilized anti-CD3 mAb but not anti-CD4 mAb undergo time-dependent F-actin assembly with concomitant formation of pseudopodia.
McCormick-Davis et al. (2000)CD4T cellThese results indicate that a membrane-bound Vpu is not required for the CD4(+) T cell loss and neurological disease in SHIV-inoculated pig-tailed macaques.
Sellier et al. (2010)CD4T cellAntiviral therapy that was started 4 hr pi did not result in CD4+ T cell depletion in lymph nodes (Figure 3).
Resino et al. (2006)CD4T-cellHowever, these high levels of IL-7 are ineffective in adults since no increase in thymic production or recuperation of the CD4+ T-cell repertoire has been observed, possibly due to the limited ability of the adult thymus to produce new T cells.
Silvestri et al. (2007)CD4T cellIn striking contrast to HIV infection, natural SIV infection of African nonhuman primates is asymptomatic and usually does not induce significant CD4+ T cell depletion despite high levels of virus replication.
Sylwester et al. (1998)CD4T-lymphocyteCD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.
Suchard et al. (2010)CD4T cellWe noted that FOXP3 positivity was not limited to the CD4+ T cell subset but was also observed on other CD4?
Jones et al. (2009)CD4T-cellThis variant failed to stimulate the corresponding CD4(+) T-cell clone and thus constitutes an escape mutant.
Kim et al. (2004)CD4T lymphocytesIn encephalitic brains of SIV-infected monkeys with acquired immunodeficiency syndrome (AIDS), we found a significant accumulation of CD8+ T lymphocytes but little-to-no accumulation of CD4+ T lymphocytes.
Demeure et al. (1996)CD4T-cellThe CD31 antigen (PECAM-1) has been reported to be a stable marker for a human CD4 T-cell subpopulation unable to produce interleukin-4 (IL-4).
Bao et al. (2009)CD4T cellsUnexpectedly, we failed to generate influenza hemagglutinin-specific CD4 T cells rather than T cells specific for fetal calf serum (FCS).
Baskar et al. (2004)CD4T cellsSynthetic peptides corresponding to hypervariable, but not framework, regions of Ig heavy chain specifically stimulated CD4(+) and CD8(+) T cells to proliferate and secrete proinflammatory cytokines in an MHC-associated manner.
Simpson et al. (2010)CD4T-cellsTelomeres in CD8+ T-cells displayed an increased relative length immediately after exercise, whereas no change occurred for CD4+ or the overall CD3+ T-cells.
Amarnath et al. (2010)CD4-conditionedT cellIn marked contrast, recipients of control CD4-conditioned DC did not have increased responder T cell PD-L1 expression.
Barbour et al. (2007)CD4T cellThat neither the viral load nor CD4+ T cell effects were augmented among carriers of Bw4Ile80/KIR3DS1 suggests that Bw4Ile80 and KIR3DS1 do not synergize to confer greater protective effects on HIV-1 disease markers in early infection, a period in which innate immunity ought to be active.
Ndhlovu et al. (2010)CD4T cellHowever, after IL-2 treatment, the frequency of TH17 cells declined, while counts of TH17 cells did not change due to an expansion of the CD4+ naďve T cell population (CD27+CD45RA+).
Smith et al. (2004)CD4T cellThe second MVA booster dose did not increase the peak CD4 and CD8 T cell responses, but increased anti-Env Ab titers by 40- to 90-fold.
Katsikis et al. (1997)CD4T cellWe show that z-VAD-fmk, a tripeptide inhibitor of ICE homologues, can inhibit Fas-induced apoptosis of peripheral blood CD4(+) and CD8+ T cells from asymptomatic HIV+ individuals. z-VAD-fmk also inhibited activation (anti-CD3)- induced CD4+ and CD8+ T cell apoptosis (AICD) in some but not all asymptomatic HIV+ individuals.
Mizuguchi et al. (2009)CD4T-cellsTax2 exhibited little, if any, or no induction of the IL-21 transcription in CD4+ T-cells, in contrast to Tax1.
Esser et al. (2001)CD4T lymphocytesNoninfectious CXCR4-tropic HIV-1 virions, but not microvesicles, partially activated freshly isolated CD4(+) and CD8(+) peripheral blood mononuclear cell T lymphocytes to express FasL and Fas, but not CD69 or CD25 (interleukin-2 receptor alpha) and eventually die via apoptosis starting 4 to 6 days postexposure.
Larsson et al. (2000)CD4T cellFinally, mature DCs pulsed with matrix peptide induced CTLs from highly purified CD8+ T cells without requiring CD4+ T cell help.
Naujokat et al. (2007)CD4T cellsAs a functional consequence, DCs fail to stimulate allogeneic CD4(+) and CD8(+) T cells and autologous CD4(+) T cells sufficiently in response to inhibition of chymotrypsin-like peptidase activity.
Scholzen et al. (2009)CD4+T cellssecretion subsequently act on responder/bystander T cells), thereby further promoting TCR-independent induction of CD4+CD25hiFoxp3hi T cells (summarized in Figure 12).
Zavialov et al. (2010)CD4T cellsWe demonstrate that ADA1 and ADA2 increase the rate of proliferation of monocyte-activated CD4+ T cells independently of their catalytic activity.
Höllsberg et al. (1996)CD4T cellThis was not caused by lack of B7 costimulation since the APCs expressed B7-1 and B7-2 and failed to induce anergy in an MBP peptide 84-102-reactive CD4 T cell clone.
Mackay et al. (2009)CD4T cellsIn contrast, recognition by CD4+ T cells specific for the ILR/DRB4*01 epitope was not detectable until 36–48 h and increased quite slowly thereafter, only reaching the long-term dox plateau level on targets induced for 168 h.
Silvestri (2005)CD4T cellSimian immunodeficiency viruses (SIV) infection of sooty mangabey (SM) monkeys (Cercocebus atys), a natural host species, does not induce CD4+ T cell depletion and acquired immunodeficiency syndrome (AIDS) despite chronic high levels of virus replication.
Raffeiner et al. (2005)CD4T cellsfor 24 hours increased the expression of TLR4 and TLR2, but not of CD14 on CD4+CD28null T cells (from 9.2 ± 25.8% to 26.6 ± 27.7% for TLR4, P < 0.001 and from 1.1 ± 3.1% to 2.4 ± 4.1% for TLR2, P = 0.008; Figure 6a).
Jin et al. (2010)CD4T cellsIn the autologous MLR system, neither healthy nor SLE pDCs or pDCs + apoPMNs increased CD25 expression on CD4+ T cells (Figure 2a).
Jin et al. (2010)CD4+T cellsContrary to healthy pDCs - apoPMNs, SLE pDCs + apoPMNs did not induce Foxp3+ expression in CD4+CD25+T cells (Figure 2d).
Guan et al. (1999)CD4T lymphocytesInjection of synthetic MIP-4 into the peritoneal cavity of mice led to the accumulation of both CD4(+) and CD8(+) T lymphocytes, but not monocytes or granulocytes.
Kimpel et al. (2010)CD4T cellsDespite the strong selective advantage conferred by maC46 found in this study, no significant accumulation of gene-modified peripheral CD4+ T cells was observed in a previous clinical trial in 10 HIV-1-infected patients that had failed HAART treatment [18].
Ghanekar et al. (2007)CD4T cellMature MDDC prepared from cryopreserved PBMC were not significantly different compared to those from fresh PBMC in stimulating allogeneic CD4+ (p = 0.063, Fig. 1C, Top panel) and CD8+ (p = 0.3527, data not shown) T cell proliferation.
Yu et al. (2008)CD4T cellWe have observed a similar high basal expression level of Cyclin T1 in the CD4+ T cell lines CEM and H9, and this basal level is not further induced by activation (unpublished results).
Wang et al. (2010)CD4T cellAs shown in Table 4, the anti-HLA-I antibody in fact showed partially blocking of reactivity for some peptide epitopes (PF106 and PF141) that, according to the cell depletion experiments (Fig. 1) induced CD4+ T cell, but not CD8+ T cell, responses.
Gulzar et al. (2008)CD4T-cellsThis suggests that cell culture conditions, not HIV-1 infection per se, resulted in this observed up-regulation of CD4 on the surface of CD8+ T-cells.
Beriou et al. (2010)CD4T cellsIn contrast to the naive cells, memory CD4 T cells were induced to secrete IL-9 by simply providing TGF-beta during stimulation, as neither IL-4 nor proinflammatory cytokines were required.
Srinivasan and Wolchok (2004)CD4T cellsGp100, another melanosomal protein, conferred tumor protection through CD8+ T cells, though without a strict requirement for CD4+ help [82].
Morris et al. (1993)CD4T cellsFurthermore, the percentage of IL-2R+ cells correlated positively with the percentage of CD4+ but not of CD8+ lymphocytes, suggesting that helper/inducer T cells are in an immunologically activated state and may account for aberrations in the distribution of lymphocyte populations in peripheral blood of ARF and ARHD patients.
Brogan et al. (2008)CD4T cellThere was no significant increase in overall peripheral blood CD4 or CD8 T cell activation as determined by CD69 expression.
Gatlin et al. (2009)CD4T cellsFurthermore, it was reported that transcription of the IL-13 -1055T allele was enhanced in Th2 polarized CD4+ cells, but not in nonpolarized (i.e., Th0) CD4+ T cells [31].
Hinterberger et al. (1988)CD4T cellsCirculating numbers of activated (CD4 and CD8) T cells and serum levels of IL-2R were not increased in both untreated and treated SAA patients.