Viewing affirmative mentions of binding of IL2 (H. sapiens) in T cells

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Duprez et al. (1988)IL2T cellWe have described a human tumor T cell line, IARC 301, which constitutively expresses high affinity interleukin 2 (IL2) receptors, and showed that after binding to its receptors, IL2 is endocytosed and degraded.
Wickremasinghe et al. (1987)Interleukin-2T lymphocytesInterleukin-2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates.
Hall and Wolf (1997)IL-2T cellsBoth ibuprofen and naproxen interfered with the binding of IL-2 to T cells.
Waldmann (1986)IL-2T-cellBecause IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor.
Mills and May (1987)IL-2T cellsIn contrast to IL-2-induced proliferation of human IL-2-sensitive T cells, interaction of IL-2 with a low affinity binding site was sufficient to activate the Na+/H+ antiport.
Ruscetti and Gallo (1981)TCGFT cellsRecent results have shown that a major defect of the athymic nude mouse is the inability to produce TCGF and that some immunosuppressive agents, such as glucocorticosteroids and cyclosporin-A, exert their effects on T cells by disrupting the TCGF-T-cell interaction.
Miyawaki et al. (1982)TCGFT cellsBased on the view that TCGF interacts with activated T cells via specific membrane receptors, these observations suggested that anti-Tac antibody might specifically block the binding of TCGF to the corresponding membrane binding sites, resulting in the inhibition of TCGF-dependent proliferation of CTC.
Johnson et al. (1992)interleukin-2T-cellGlucocorticoid, interleukin-2, and prostaglandin interactions in a clonal human leukemic T-cell line.
Sawami et al. (1992)IL-2T-cellThe early events of signal transduction associated with interleukin-2 (IL-2) binding to its receptor were examined using a human IL-2 dependent T-cell line, Kit225.
Tsudo et al. (1983)TCGFT-cellAnti-Tac monoclonal antibody, which blocks the membrane binding and action of human T-cell growth factor (TCGF), is strongly proposed to recognize TCGF receptor.
Yang et al. (1994)IL-2T-cellFurthermore, the results also showed that triptolide at higher concentration had a slight inhibitory effect on the interaction of IL-2 and IL-2 receptors, and addition of exogenous IL-2 did not reverse the inhibiting action of triptolide on T-cell proliferation.
Mills et al. (1990)IL2T-lymphocytesWe demonstrate herein that suramin induces a concentration-dependent decrease in binding of 125I-labeled IL2 to its receptor complex on human and murine T-lymphocytes.
Cantrell and Smith (1983)interleukin 2T lymphocyteT lymphocyte mitosis results from the interaction of interleukin 2 (IL-2) with specific receptors that appear only after appropriate immune stimulation.
Cantrell and Smith (1983)IL-2T cellsUsing biosynthetically radiolabeled IL-2 and anti-Tac, a monoclonal antibody that blocks IL-2 receptor binding, IL-2 receptors were found to accumulate slowly and asynchronously among lectin-stimulated T cells and to precede the onset of DNA synthesis.
Ohike et al. (1986)IL-2T cellTaking advantage of the ability of monoclonal antibodies to detect IL-2 that had bound to the receptor, a radioimmunoassay was developed that sandwiched IL-2 between the radiolabeled monoclonal antibody and the receptor on a hematopoietic cell line infected with human T cell leukemia virus Type I.
Plitnick et al. (2001)IL-2T cellsFlow cytometric analysis revealed that IL-2 binding to T cells is inhibited in the presence of purified LTA but not LTA plus anti-LTA monoclonal antibody.
Torsella et al. (1992)TCGFT-cellsThese results show that the binding of very few TCGF molecules is required for activation of T-cells and that the probability of the secondary events leading to cell proliferation is much smaller than the probability of TCGF binding to T-cells.
Pauza (1987)interleukin 2T lymphocytesAntigen-stimulated human T lymphocytes must bind the immunoregulatory hormone interleukin 2 (IL-2) if they are to transit from the G1 to the S phase of the cell cycle.
Pauza (1987)IL-2T lymphocytesThese genes thus constitute a set which is coordinately regulated in the course of the transition from G1 to S phase of human T lymphocytes, and their expression depends on IL-2 binding.
LeGrue (1988)IL 2T-lymphocytesThe binding of interleukin 2 (IL 2) to specific cell surface receptors provides a unique proliferative stimulus to sensitive T-lymphocytes.
Robb et al. (1981)TCGFT cellTo examine directly the hypothesis that T cell growth factor (TCGF) interacts with target cells in a fashion similar to polypeptide hormones, the binding of radiolabeled TCGF to various cell populations was investigated.
Robb et al. (1981)TCGFT cellThe results indicate that TCGF interacts with activated T cells via a receptor through which it initiates the T cell proliferative response.
Robb et al. (1981)TCGFT cellsRadiolabeled TCGF binding was specific for activated, TCGF-responsive T cells.
Robb et al. (1981)TCGFT cellAs the extent of T cell clonal expansion depends on TCGF and on the TCGF receptor, the dissection of the molecular events surrounding the interaction of TCGF and its receptor that these studies permit, should provide new insight into the hormonelike regulation of the immune response by this lymphokine.
Lipkowitz et al. (1984)IL 2T lymphocytesThis early expression of IL 2 receptors was also shown by the direct binding of a monoclonal anti-IL 2 receptor antibody (anti-Tac) to the activated T lymphocytes.
Brunvand et al. (1993)IL-2T cellTo determine if the trans-activators documented in T cell nuclear extracts actually bind the IL-2 promoter in vivo, ligation mediated PCR (LMPCR) genomic footprinting was performed on the IL-2 promoter in both activated and non-activated T cells and HL60 promyelocytes, which do not express the IL-2 gene.
Rani et al. (1992)interleukin-2T-lymphocytesT-lymphocytes DNA replication and mitosis are determined by a critical threshold of signals generated by the interaction between interleukin-2 (IL-2) and its receptors.
Debatin et al. (1989)interleukin-2T cellsBinding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells.
Mills et al. (1985)IL 2T cellsProliferation of activated T cells requires interaction of one of these lymphokines, interleukin 2 (IL 2), with its receptor.
Onrust and Wiseman (1999)interleukin-2T lymphocytesThe chimaeric monoclonal antibody basiliximab specifically binds the alpha subunit of the interleukin-2 (IL-2) receptor on activated T lymphocytes.
Lillehoj and Shevach (1985)IL-2T cellWe have studied the mechanism by which cyclosporin A (CsA), dexamethasone (DEX), and ouabain (OUA) inhibit T cell proliferation by measuring the effects of these agents on 1) interleukin-2 (IL-2) production, 2) acquisition of IL-2 responsiveness, 3) the induction of IL-2 receptor expression, and 4) the specific interaction of IL-2 with its receptor.
Harvill and Morrison (1995)IL-2T cellA similar fusion between IgG1 and IL-2 has previously been shown to bind antigen, generate antibody-dependent cellular cytotoxicity (ADCC) and stimulate T cell proliferation and cytotoxicity.
Schwab et al. (1990)IL-2T cellsThe impaired ability of activated T cells from old donors to express high affinity IL-2R while expressing the 55 and 75 kd chains may provide insights into the mechanisms of IL-2 interactions with its receptor.
Hua and Paetkau (1996)interleukin 2 mRNAT lymphocyteJurkat cells, a human T lymphocyte line that can be induced to synthesize and secrete interleukin 2, contain a factor that binds interleukin 2 mRNA.
Graves et al. (1992)IL-2T cellThe concentration-dependence of IL-2-mediated stimulation of p21ras correlated with IL-2 stimulation of T cell proliferation, which indicates that p21ras activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor.
Gaulton and Markmann (1988)IL-2T cellThe dependence of T cell proliferation on the production, binding and utilization of the lymphokine growth factor IL-2 has fostered the development and testing of new classes of drugs which act to either inhibit IL-2 production or the interaction of IL-2 with its cellular receptor.
Boyle et al. (1993)interleukin 2T cellsAn insect metabolite containing the little known pyrimido[4,5-b][1,4]diazepine ring system has been found to act as an effective mimic of tetrahydrobiopterin in its ability to modulate the affinity of interleukin 2 (IL-2) for its receptors on human T cells.
Kumagai et al. (1988)IL-2T cellsThe early accumulation of TFR mRNA in PDB/ionomycin-stimulated T cells seemed, in part, independent of the interaction of IL-2 with its own receptor, because TFR mRNA was detectable as early as 1 hr after stimulation and addition of cycloheximide before addition of PDB/ionomycin did not abolish the PDB/ionomycin-induced accumulation of TFR mRNA.
Sharon et al. (1986)IL-2T lymphocytesInterleukin-2 (IL-2) binds to both high- and low-affinity classes of IL-2 receptors on activated T lymphocytes.
Gnarra et al. (1990)Interleukin 2T cellsInterleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs).
Kamio et al. (1990)IL-2T cellsTaking these data together, the reappearance of high-affinity IL-2 binding was considered to be caused by the replacement of 2R-B antibody at the IL-2 binding site of beta chain by alpha chain-mediated IL-2, and it was strongly suggested that alpha chain-IL-2 complex has a key role in the formation of the ternary complex of IL-2 and high-affinity IL-2 receptor. alpha chain may function as a dimension converter of IL-2 to effectively deliver IL-2 molecules to a relatively small number of beta chains in the dynamics of the formation of high-affinity IL-2 binding in T cells.
Wustrow (1991)IL-2T cellsThus the immune response of T cells is controlled through the expression of the IL-2 receptors and the IL-2 binding.
Garrity et al. (1994)IL-2T cellsIs the developmental commitment of T cells reflected molecularly by stable interaction between available factors and the IL-2 enhancer prior to signal-dependent induction?
Dionyssopoulou et al. (2000)IL-2T cellsSynthetic peptides corresponding to these sequences were tested for their ability to compete with IL-2 for binding and, thereby, inhibit IL-2-induced proliferation of mitogen-stimulated human peripheral blood T cells.
Rameil et al. (2000)IL-2T cellsA Stat5-Ets protein complex was the major inducible DNA-binding complex bound to the human IL-2rE GASd/EBSd motif in long-term proliferating normal human T cells activated by CD2 and CD28.
Bailey et al. (1994)interleukin-2T-cellFollowing activation with concanavalin A these cells produced a T-cell growth factor (TCGF) activity which was not inhibited in the presence of a monoclonal antibody recognizing pig interleukin-2 receptors (IL-2R).
Li et al. (1992)IL-2T cellsThe effect of CsA on the induction of IL-2 receptors was examined at the levels of mRNA expression (with the aid of the polymerase chain reaction), protein (by SDS-PAGE analysis of chemically crosslinked 125I-IL-2 membrane protein complexes and by FACS), and function (by Scatchard analysis of 125I-IL-2 binding to T cells).
Birx et al. (1984)IL 2T cellsThese data suggest that the passive calcium channel plays a pivotal role in both the initial activation of T cells after ligand-receptor interaction and the ongoing signal for proliferation provided by IL 2 binding to its receptor.
Drachman (1996)IL2T cellsAgents that are now being used clinically, or are in advanced stages of development include: cyclosporin A, which interferes with synthesis of the cytokine interleukin 2 (IL2); IL2 toxin, which binds to IL2 receptors on activated T cells, is endocytosed, and kills the cells; and CTLA4Ig, which blocks costimulatory molecules, thus preventing full activation of T cells.
Burton et al. (1990)IL-2T cellsWe confirmed the physical proximity of p95/ICAM-1 to the IL-2 receptor alpha subunit by demonstrating that radiolabeled IL-2 could be cross-linked to this protein expressed on activated T cells.
Gutowski et al. (1984)IL 2T cellFurthermore, the absence of ADR in dexamethasone-treated, PHA-stimulated cells suggests that the induction of ADR is not an early event in T cell activation associated with the expression of IL 2 receptors; rather, the induction of ADR appears to be a later event resulting directly or indirectly from the binding of IL 2 to IL 2-responsive cells.
Mills et al. (1986)IL 2T lymphocytesThe mechanism whereby interleukin 2 (IL 2) binding to its receptor on activated T lymphocytes leads to cell proliferation has not been determined.
Durrant et al. (1984)IL-2T cellSeveral T4-, Lyt-1- clones produced and bound human interleukin-2 (IL-2) indicating a lack of correlation between human T cell phenotype and function in those hybrids.
Martelletti et al. (1990)IL-2T-cellsThis MAb identifies the IL-2 receptors by blocking the binding of radiolabelled IL-2 to T-cells.
Larsen et al. (1988)interleukin 2T lymphocytesPhorbol myristate acetate (PMA) and 1-oleoyl-2-acetyl-rac-glycerol (OAG) are shown to induce a rapid (within 30 min) down-regulation of the capacity of activated human T lymphocytes to bind interleukin 2.
Ferrer et al. (1993)IL2T lymphocytesThe growth factor interleukin 2 (IL2) binds to high and low-affinity receptors (Kd approximately 10-100 pM and 10 nM, respectively) present on activated T lymphocytes.
Terada et al. (1993)IL-2T cellsThese results indicate that RAP blocks cell cycle progression of activated T cells after IL-2/IL-2 receptor interaction but prior to p110Rb phosphorylation and other key regulatory events signaling G1/S transition.
Nakamura et al. (1997)IL-2T cellsThis upregulation may compensate the gamma chain downregulation after IL-2 binding, presumably resulting in more frequent growth of HTLV-I infected T cells.
Lucas et al. (1995)IL-2T lymphocytesThus, increased accumulation of the protein and its activity begin before IL-2/IL-2 receptor interaction, suggesting that the cdk6-cyclin D2 complex might be involved in acquisition of the competent state in human T lymphocytes.
Verhagen et al. (1992)Interleukin-2T cellsInterleukin-2 (IL-2) stimulates the proliferation of activated antigen-specific T cells through its interaction with high affinity receptors.
Audrain et al. (1991)IL-2T cellTU27, a mouse IgG1 mAb directed at the p75 chain of the human IL-2R, was analyzed for its ability to interact with IL-2 binding on isolated p75 chains (YT-2C2 cells) and high affinity p55/p75 receptors (human alloreactive T cell clone 4AS), to inhibit IL-2-induced proliferation (4AS cells) and to cooperate with an anti-p55 chain mAb (33B3.1) for inhibiting IL-2 binding and proliferation.
Solomou et al. (2001)IL-2T cellsThese findings show that CREB plays a major role in the transcriptional regulation of IL-2 and that a major pathway for the activation of CREB and its subsequent binding to the IL-2 promoter/enhancer in normal T cells is mediated by PKC-theta.
Flores et al. (1996)IL-2T lymphocyteProliferation of T lymphocytes is triggered by the interaction of interleukin 2 (IL-2) with its high affinity specific receptor that is expressed on the cell surface following T lymphocyte activation.
Teshigawara et al. (1987)IL-2T cellsMoreover, when IL-2 binding to normal T cells was performed under conditions that favored the proportion of high-affinity receptors occupied, two distinct proteins identical to those already identified on the leukemic cells could be crosslinked covalently to radiolabeled IL-2.
Tanaka et al. (1985)IL-2T-cellsH-31, like anti-Tac, strongly inhibited the IL-2-dependent proliferation of normal activated T-cells, absorption of IL-2 and direct binding of IL-2 to the cells, while H-A26, like HIEI, inhibited those processes only weakly.
Kasinrerk et al. (1994)IL-2T-cellIt has been reported that the interaction between IL-2 and the IL-2R alpha subunit of several IL-2-dependent murine T-cell lines may result in a negative regulatory signal.
Chu and Sharom (1993)interleukin-2T-lymphocyteGangliosides inhibit T-lymphocyte proliferation by preventing the interaction of interleukin-2 with its cell surface receptors.
Kaplan et al. (1988)interleukin 2T cellAnalysis of surface fluorescence with flow cytometry has revealed the presence of membrane-associated interleukin 2 (IL-2) epitopes on the surface of long term human T cell clones.
Allegretta et al. (1986)interleukin-2T cellConversely, nonrecombinant T cell-derived interleukin-2 fails to compete in these assays and is not retained by protein A-Sepharose columns when mixed with high-titer antiserum.
Zu et al. (1990)interleukin 2T cellsCharacterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells.
Woods and Lowenthal (1984)IL2T-lymphocyteCellular interactions and IL2 requirements of PHA-induced human T-lymphocyte colonies.
Becker et al. (1993)IL-2T cellTransfection of the melanoma cells with an expression vector containing a B7 cDNA that resulted in subsequent expression of B7 on its cell surface rendered it into a fully competent antigen presenting cell, which is able to induce a nuclear factor binding to the IL-2 promoter in the specific T cell clone resulting in enhanced IL-2 transcription, synthesis, and T cell proliferation.
Kubo et al. (1990)IL-2T cellsHowever, weak spontaneous proliferation by non clustered T cells was enhanced after culturing with Con A or human IL-2.
Shanafelt et al. (2000)interleukin 2T-cellA T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo.
Kato and Smith (1987)IL-2T-cellInterleukin 2 (IL-2) is responsible for stimulating T-cell proliferation via interaction with specific, high-affinity membrane receptors.
GŁnther et al. (1982)interleukin 2T cellSuppression of T cell responses through competition for T cell growth factor (interleukin 2).