Viewing affirmative mentions of binding of IL2 (H. sapiens) and IL2 (H. sapiens)

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Tanaka et al. (1987)IL 2-bindingIL 2It is conceivable that IL 2 exerts its effect through its interaction with these novel IL 2-binding molecules in SKW 6-4 cells.
Horst and Flad (1987)interleukin 2interleukin 2Corticosteroid-interleukin 2 interactions: inhibition of binding of interleukin 2 to interleukin 2 receptors.
Smith (2006)IL2IL2Consequently, they then hypothesized that perhaps the IL2-reactive mAb functioned to actually increase biological activity of endogenous IL2 via the formation of immune complexes with IL2, thereby preserving and promoting IL2 activity.
Smith (2006)IL2IL2The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs.
Lorberboum-Galski et al. (1988)IL2IL2-PE40IL2-PE40 is a powerful reagent for studying IL2 receptor interactions and for analyzing pathways of the immune response and its regulation.
Moreau et al. (1995)IL-2IL-2Characterization of a monoclonal antibody directed against the NH2 terminal area of interleukin-2 (IL-2) and inhibiting specifically the binding of IL-2 to IL-2 receptor beta chain (IL-2R beta).
Bubeník et al. (1987)IL-2IL-2 moleculeThe present study was performed to localize in the IL-2 molecule the active site responsible for interaction with the IL-2 receptor.
Taki et al. (1989)IL-2IL-2The b-IL-2 bound to both low and high affinity IL-2Rs, but the binding to the latter was more intense.
Bich-Thuy et al. (1987)IL 2IL 2Because these stimulatory effects of IL 2 occurred in the absence of detectable Tac+ cells, the possibility that IL 2 might be initially interacting with an IL 2 binding protein distinct from the Tac protein was studied.
Adamovic et al. (2008)IL2IL2Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.
Reiher et al. (1986)IL-2interleukin 2A region of homology has been found between the envelope (env) protein of the acquired immunodeficiency syndrome (AIDS) virus and a portion of interleukin 2 (IL-2) that purportedly binds to the IL-2 receptor.
Watson et al. (1988)IL2-bindingIL2If IL2 signal transduction involves binding to a surface heterodimeric receptor for IL2, it is argued that FD.huIL2R-2 cells contain an IL2 receptor complex of murine p70 and human p55 IL2-binding proteins.
Miedel et al. (1988)interleukin-2interleukin-2Based on assignment of the disulfide bonds, a structural model of the interleukin-2 receptor for interleukin-2 binding is proposed.
Cheng et al. (2000)IL-2IL-2OBJECTIVES: To establish a novel bioassay method for quantitative analysis of human IL-2 based on the specific binding of Interleukin-2 receptor alpha subunit (IL-2R alpha) with IL-2.
Suminami et al. (1998)IL-2IL-2We have previously reported that human carcinoma cell lines are inhibited in growth by exogenous IL-2, which binds to the IL-2 receptor beta (IL-2Rbeta) chain ubiquitously expressed on the surface of tumor cells.
Caligiuri et al. (1990)IL-2IL-2This strongly suggests that additional structural or functional components are involved in generating the proliferative response following the binding of IL-2 to the high affinity heterodimeric form of the IL-2 receptor.
Hatakeyama et al. (1989)IL-2IL-2Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.
Pan et al. (1990)interleukin-2interleukin-2An immobilized interleukin-2 receptor which is capable of binding interleukin-2 and suitable for direct N-terminal sequence analysis was employed to study interleukin-2/receptor interactions.
Konigsberg et al. (1998)IL-2SUV-IL-2SUV-IL-2 bound to the high affinity IL-2 receptor as measured by competitive binding assays and Scatchard analysis using 111InCl2-loaded liposomes The preparation exhibited a binding constant of 30 pM, consistent with values for free IL-2 cited in the literature.
Kitamura et al. (1989)IL-2interleukin-2A fluorescence sandwich ELISA was developed for the quantitation of human interleukin-2 (IL-2) using a combination of two anti-human IL-2 antibodies, L61 and biotinylated anti-IL-2 rabbit IgG.
Kirchner et al. (1991)IL-2IL-2The case is reported of a patient with metastatic rectal carcinoma who was treated with long-term subcutaneous IL-2 and a combination of subcutaneous IL-2 and interferon-alpha 2b (IFN-alpha 2b).
Smith et al. (1983)IL 2IL 2The unique hormonal characteristics of human interleukin 2 (IL 2), primarily the high affinity of the IL 2-receptor interaction, created several impediments to the generation of monoclonal antibodies to this lymphokine.
Mills and May (1987)IL-2IL-2By determining the effect of IL-2 on cytosolic pH in cells that express one of the two IL-2-binding molecules in the absence of the other IL-2-binding molecule, we have demonstrated that interaction of IL-2 with the 75 kDa IL-2-binding molecule is sufficient to activate the Na+/H+ antiport and thus induce cytosolic alkalinization.
Soiffer et al. (1996)IL-2IL-2Low-dose continuous infusion IL-2 was usually well tolerated; 2-h bolus infusions of IL-2 were often associated with high fevers and constitutional symptoms that resolved after several hours.
Herrmann et al. (1985)interleukin 2interleukin 2Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells.
Herrmann et al. (1985)IL-2IL-2Also, U937 IL-2 receptors bound biologically active IL-2.
Jacques et al. (1986)IL 2IL 2Finally, high affinity IL 2 receptors, as measured by the binding of 35S-labeled rec-IL 2, were found to be similarly up-regulated by antigen and rec-IL 2.
Matsuoka et al. (1993)interleukin-2interleukin-2Kinetic study of interleukin-2 binding on the reconstituted interleukin-2 receptor complexes including the human gamma chain.
Visani et al. (1987)IL2IL2Binding of a radiolabeled IL2 preparation to the in vitro activated CML cells indicated the presence of low affinity receptors for IL2.
Yang et al. (1995)IL-2IL-2BACKGROUND: Conjugation of polyethylene glycol to recombinant human interleukin-2 (IL-2) results in a compound, polyethylene glycol-modified IL-2 (PEG-IL-2) that retains the in vitro and in vivo activity of IL-2, but exhibits a markedly prolonged circulating half-life.
Bödeker and Mühlradt (1983)IL-2IL-2It could be excluded that IL-2 yields in vitro were primarily limited by protease action, inactivation of the mitogen, consumption of nutrients, "product inhibition" by IL-2 or by suppression through cell/cell interaction with hypothetic suppressor cells.
Gullberg (1987)IL-2IL-2The resulting receptor composition, which has been characterized in a previous report, contain such decreased levels of low-affinity IL-2 receptors that almost half of the surface pool of anti-IL-2 receptor antibody (anti-Tac) binding sites is associated with high-affinity receptors.
Najjam et al. (1998)IL-2IL-2IL-2 bound by heparin is still recognized by two IL-2 specific monoclonal antibodies, 3H9 and H2-8, whose epitopes lie in the amino terminal region.
Frankel et al. (1997)IL2IL2The fusion toxin-bound human leukemic cells with IL2 receptors and the binding was competed with IL2 but not asialofetuin.
Waldmann (1987)p75 IL-2IL-2We propose a multichain model for the high-affinity IL-2 receptor in which both the Tac and the p75 IL-2 binding peptides are associated in a receptor complex.
Naglieri et al. (1998)IL-2IL-2Standard interleukin-2 (IL-2) and interferon-alpha immunotherapy versus an IL-2 and 4-epirubicin immuno-chemotherapeutic association in metastatic renal cell carcinoma.
Moreau et al. (1995)IL-2IL-2This further demonstrates that the NH2 terminal area of IL-2 is critical for IL-2/IL-2R beta interactions.
Du and Wolfe (2003)C125A rhIL-2C125A rhIL-2During oxidative folding of C125A rhIL-2, both rhPDI and reduced C125A rhIL-2 aggregated in folding buffer.
Semenzato et al. (1987)IL-2IL-2Because sIL-2R is capable of binding to its ligand (IL-2), the increased serum levels of this molecule could induce a starvation of IL-2.
Polke et al. (1986)IL2IL2IL2-binding studies revealed that TPA induced an increase in not only the number of IL2 receptors per cell but also the affinity of the receptors for IL2.
Hua et al. (1993)IL2 mRNAIL2 mRNAThe mRNase cleaves IL2 mRNA at a small number of sites in the coding region, and IL2 mRNA containing only the coding region and 36 nucleotides of the 3'-noncoding region competes efficiently with full-length IL2 mRNA for the mRNase, whereas beta-globin mRNA does not.
Eckenberg et al. (1997)IL-2IL-2Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2.
Uchiyama et al. (1984)IL-2IL-2Radiolabeled IL-2 binding experiments revealed that ATL leukemic cells could bind IL-2 although the number of IL-2 binding sites was much less than that of anti-Tac binding sites.
Ziegler et al. (1992)interleukin 2interleukin 2Using an increased apparent affinity of interleukin 2 receptor to interleukin 2 as a measure of activity, this study explores whether other 6-substituted pterins might have the same effect, and what structural features are necessary for activity.
Lipkowitz et al. (1984)IL 2IL 2The second phase is an IL 2-dependent phase that requires the interaction of IL 2 with the newly expressed IL 2 receptors.
Modiano et al. (1997)IL-2IL-2 mRNAThis reduction was not apparent at the transcriptional level: hIVIG had no effect on the levels of IL-2 mRNA or on the accumulation of firefly luciferase when its gene was linked to the IL-2 promoters.
Katoh et al. (1986)IL-2IL-2Cell-surface phenotype analysis by immunofluorescence with monoclonal antibodies (MAbs) and IL-2 binding assays revealed that one of the ATL cell lines, HPB-ATL-2, expresses only a minimal amount of IL-2 receptor (IL-2-R) on the cell surface and binds less radiolabelled human recombinant IL-2 than the other highly Tac-positive cell lines.
Murakami et al. (1988)IL2IL2Reconstitution of the IL2 levels in these cultures with recombinant IL2 completely restored antibody production.
Raimundo et al. (2004)IL-2IL-2Throughout the discovery process, biophysical methods and structural biology demonstrated that compounds bound reversibly to IL-2 at the IL-2 receptor binding site.
Flaherty et al. (1993)IL-2interleukin-2BACKGROUND: Based on prior experience with dacarbazine (DTIC) and an outpatient interleukin-2 (IL-2) regimen, the current study was conducted to improve the antitumor efficacy and assess the immunologic interactions between chemotherapy and IL-2.
Lillehoj and Shevach (1985)IL-2IL-2DEX primarily inhibited IL-2 production and did not block acquisition of responsiveness to IL-2 or interaction of IL-2 with its receptor.
Harvill and Morrison (1995)hrIL-2IgG3-IL2In contrast, IgG3-IL2 shows a greater affinity than hrIL-2 for the high affinity IL-2R, consisting of alpha, beta and gamma subunits.
Harvill and Morrison (1995)IL-2IgG3-IL2Competition studies show that IgG3-IL2 binds the intermediate affinity form of the IL-2 receptor (IL-2R), consisting of the beta and gamma subunits, with an affinity slightly less than that of hrIL-2.
Sabe et al. (1984)IL-2IL-2This mutant IL-2 receptor expressed on non-lymphoid cells also had the low affinity for IL-2.
Kehri et al. (1988)IL-2IL-2A novel IL-2 receptor, distinct from the Tac protein, has been identified on the surface of purified human natural killer (NK) cells by chemical cross-linking of 125I-IL-2.
Okamoto et al. (1990)interleukin 2Interleukin 2Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal.
Shapiro et al. (1990)IL-2IL-2These results suggest that the IL-2 autocrine loop within these cells involves intracellular IL-2/IL-2 receptor binding.
Sia (1988)IL2IL2Exogenous IL2 induces secretion of BCGF and IFN-gamma of the cloned cells, an observation which involves interaction of IL2 with IL2 receptors.
Fleischmann et al. (1990)IL-2IL-2The IL-2 bound in the IL-2-IN complex cannot be detected using a double monoclonal antibody radioimmunoassay for IL-2.
Fleischmann et al. (1990)IL-2IL-2Unlike other IL-2 binding proteins, the IL-2 binding protein of the IL-2-IN complex is not a soluble interleukin-2 receptor.
Duprez et al. (1985)IL-2IL-2It constitutively expresses biologically functional high-affinity cell-surface receptors for IL-2 as shown by the binding of both radiolabeled purified IL-2 and monoclonal antibodies to IL-2 receptors.
Touw et al. (1987)IL2IL2-bindingSpecific blocking of the IL2-binding sites with anti-IL2 receptor monoclonal antibodies almost completely inhibited the proliferation of these cells, which indicated that functional IL2 receptors were required for the autonomous proliferation.
Ju et al. (1987)IL-2IL-2The IL-2 analogs were then produced in Escherichia coli and assayed for the ability to induce proliferation of IL-2-dependent cells and the ability to compete for binding to the IL-2 receptor.
Smith (2006)IL2IL2The IL2 molecule is held decisively between these two receptor chains, which converge to form a Y shape, with IL2 bound in the fork of the Y.
Smith (2006)IL2IL2On the basis of these data and others, Sprent concluded that the stimulatory IL2-reactive mAb binds to a site on IL2 that occludes its binding to the ?
Bosco et al. (1995)IL-2IL-2Modulation of IL-2 binding and IL-2 receptor beta gamma chain expression.
Otero and Merrill (1997)IL-2IL-2This response was receptor-mediated in that binding of 125I-IL-2 to TC620.6A2 cells detected a single receptor class for IL-2 with an affinity of 3.6 nM.
Tanaka et al. (1988)IL-2IL-2Novel IL-2-binding molecules (p70 and p75) mediating internalization and degradation of IL-2 were examined by employing a human B lymphoblastoid line, SKW6-4 cells.
Shackelford and Trowbridge (1986)IL-2interleukin-2Evidence for two extracellular domains in the human interleukin-2 receptor: localization of IL-2 binding.
Weigent et al. (1986)interleukin-2interleukin-2The HTLV-III envelope protein contains a hexapeptide homologous to a region of interleukin-2 that binds to the interleukin-2 receptor.
Tanaka et al. (1988)IL-2IL-2We found that H-31 inhibited the binding of IL-2 to Tac antigens but not novel IL-2 binding molecules.
Zhang et al. (1995)IL-2-PE40IL-2As the region IL-2 binds with its receptor was defined in the N-terminal residues 8-54 of IL-2, such fusion proteins will have the same activity with IL-2-PE40.
Robb et al. (1981)TCGFTCGFBinding of radiolabeled TCGF to TCGF-responsive cells was specific, in that among several growth factors and polypeptide hormones tested, only TCGF competed for binding.
Rebollo et al. (1992)IL-2IL-2Immunochemical characterization of antigenic domains on human IL-2: spatially distinct epitopes are associated with binding to the p55 and p70 subunits of IL-2 receptor.
Rebollo et al. (1992)IL-2IL-2Two mAb, 3H9 and 17F4, recognize separate epitopes on IL-2 molecule, are poor inhibitors of IL-2 binding, and they are inefficient in the neutralization of its biological activity; they have been assigned to the third and fourth groups, respectively.
Siegel et al. (1987)IL-2IL-2A novel glycoprotein (IL-2R beta), identified on several lymphocytoid cell lines, has the ability to bind IL-2 alone and to associate with Tac antigen (IL-2R alpha) to form high-affinity IL-2 receptors.
Wong et al. (1990)IL-2IL-2Monoclonal antibodies were used to determine the relationships between epitopes on the p55 chain of the IL-2 receptor and high-affinity IL-2 binding.
Robb (1986)IL-2interleukin 2The cellular receptors for interleukin 2 (IL-2) exist in at least two forms, one with a particularly high affinity and a second, more numerous class, with a much lower affinity for IL-2.
Davis et al. (2010)Interleukin-2Interleukin-2Indeed, all but one of the modulators discussed in a recent review article [2] were identified by the method: Interleukin-2Interleukin-2 receptor (PDB 2ERJ:A,D; 1PY2:FRH), MDM2–p53 (1T4F:M,P; 1T4E:DIZ), HPV E2–E1 helicase (1TUE:A,B; 1R6N:434), ZipA–FtsZ (1F47:A,B; 1Y2F:WAI), and TNF- homotrimer (2TNF; 2AZ5:307).
Ishii et al. (1987)IL-2IL-2These results suggest that IL-2-IL-2-receptor interaction leads to activation of protein kinase(s), resulting in phosphorylation of certain cellular proteins such as pp67 and pp63s, and that this phosphorylation could be an early event in the transmission of intracellular growth signalling from the IL-2 receptors.
Chabannes et al. (1987)rec-IL-2IL-2In addition, CsA, did not inhibit the growth signal(s) induced by rec-IL-2/IL-2 receptor interactions when R-IL-2 is pre-expressed on clone cells.