Viewing affirmative mentions of binding of HLA-E (H. sapiens) in T cells

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Singh et al. (1998)MHCT cellsWe suggest that (1) the density and affinity of epitopes derived from microbial antigens that bind to MHC molecules; (2) their cross-reactivity with beta-cell antigens; and (3) the nature of immunoregulatory cytokines induced by the microbial infections are the primary factors in the induction of either effector or protective T cells in IDDM.
Bui et al. (2006)MHCT cellsBACKGROUND: T cells recognize a complex between a specific major histocompatibility complex (MHC) molecule and a particular pathogen-derived epitope.
Bui et al. (2006)MHCT cellThe population coverage estimates are based on MHC binding and/or T cell restriction data, although the tool can be utilized in a more general fashion.
Bui et al. (2006)MHCT-cellCONCLUSION: We have developed a web-based tool to predict population coverage of T-cell epitope-based diagnostics and vaccines based on MHC binding and/or T cell restriction data.
Scharnagl and Klade (2007)MHCT cellsT cells specifically recognize antigens as peptide epitope-MHC complexes on the surface of target cells.
Peters et al. (2006)MHCT lymphocytesRecognition of peptides bound to major histocompatibility complex (MHC) class I molecules by T lymphocytes is an essential part of immune surveillance.
Mehra and Kaur (2006)MHC motifT cellsSequence determination of the associated alleles and/or their extended haplotypes explains how the peptides (pathogen-derived and/or autoantigens) interact with specific pockets on the MHC motif for ultimate inspection by the T cells.
Doytchinova and Flower (2007)MHCT-cellThus, T-cell epitope prediction overlaps strongly with the prediction of MHC binding.
Reche and Reinherz (2005)MHCT-cellPrediction of peptide binding to major histocompatibility complex (MHC) molecules is a basis for anticipating T-cell epitopes, as well as epitope discovery-driven vaccine development.
Cochran and Stern (2000)MHCT-cellsBACKGROUND: T-cells are activated by engagement of their clonotypic cell surface receptors with peptide complexes of major histocompatibility complex (MHC) proteins, in a poorly understood process that involves receptor clustering on the membrane surface.
Cochran and Stern (2000)MHC-peptideT-cellOligomeric MHC-peptide complexes, including a variety of MHC dimers, trimers and tetramers, bound to T-cells and initiated T-cell activation processes in an antigen-specific manner.
Hale et al. (1989)MHCT cellThe existence of such multideterminant regions recognized by multiple MHC haplotypes suggests the possibility that use of peptides longer than a minimal determinant and containing several overlapping determinants may be a possible approach to circumvent the serious problem of MHC restriction in peptide vaccines aimed at eliciting T cell immunity.
Ridgway and Fathman (1998)MHCT cellsThis new explanation suggests that the association of MHC with autoimmunity results from "altered" thymic selection in which high-affinity self-reactive (potentially autoreactive) T cells escape negative selection.
Pietra et al. (2010)HLA-ET cellsHowever, recent evidences obtained by our and other groups indicate that HLA-E complexed with peptides can interact with alphabeta T-cell receptor (TCR) expressed on CD8(+) T cells.
Wooden et al. (2005)HLA-ET cellsHLA-E is an MHC class Ib molecule that binds nonamer peptides derived from the leader sequence of MHC class 1a molecules and is the major ligand for CD94/NKG2 receptors found on NK and T cells.
Hohlfeld (1989)MHCT-cellT-lymphocytes recognize antigen in a trimolecular complex: The T-cell receptor binds to a processed fragment of antigen that itself is bound to a major histocompatibility complex (MHC) molecule on the surface of an antigen-presenting cell.
Lundegaard et al. (2010)MHCT cellsIn the MHC class I pathway, peptides from endogenous antigens bound to class I MHCs are presented to CTLs, which are carrying the CD8 receptor (CD8+ T cells).
Edwards and Evavold (2010)MHCT cellThe functional outcomes of the T cell's interaction with the peptide:MHC complex can be dramatically altered by the introduction of a single amino acid substitution.
Hadrup and Schumacher (2010)MHCT cellThese technologies are based on the joint binding of differentially labelled MHC multimers on the T cell surface, thereby providing each antigen-specific T cell population with a unique multicolour code.
von Boehmer (2009)MHCT-cellOf considerable interest is the notion that several epitopes recognized by disease-causing T-cell clones exhibit poor class II MHC binding consistent with the notion that the limited availability of such epitopes in the thymus could lead to failing recessive tolerance, while more abundant quantities in peripheral lymphoid tissues could result in activation of T cells that have escaped central tolerance.
Jacob and Vert (2008)MHCT-cellMOTIVATION: In silico methods for the prediction of antigenic peptides binding to MHC class I molecules play an increasingly important role in the identification of T-cell epitopes.
Sebestyén et al. (2008)MHCT cellTransfer of either TCRalpha:CD3zeta or beta:CD3zeta genes alone does not result in surface expression, whereas transfer of both modified TCR chains results in high surface expression, binding of peptide-MHC complexes and Ag-specific T cell functions.
Kabelitz et al. (2007)MHCT cellsVdelta1 T cells recognize MHC class I chain-related molecules A and B and UL-16-binding proteins expressed at variable levels on epithelial tumor cells and some leukemias and lymphomas.
Fathman and Lineberry (2007)MHCT cellsFull activation of CD4+ T cells requires the binding of peptide-MHC complexes coupled with accessory signals provided by the antigen-presenting cell.
Benoit and Tan (2007)MHCT cellsXenogeneic beta 2-microglobulin substitution affects functional binding of MHC class I molecules by CD8+ T cells.
Bakács et al. (2007)MHCT cellsT cells survey the stability of the self: a testable hypothesis on the homeostatic role of TCR-MHC interactions.
Nicholson et al. (2006)MHCT cellsHLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules.
Parra-López et al. (2006)MHCT cellsIn this study we have evaluated the specificity of the T* sequence with regard to its binding to the human class II MHC protein DR4 (HLA-DRB1*0401), its interactions with antigen receptors on T cells, and the effect of natural variants of this sequence on its immunogenicity.
Rajapakse et al. (2006)MHCT-cellIdentification of the subset of peptides that bind MHC molecules comprising the H-2g7 haplotype of NOD mouse and thereby representing potential NOD T-cell epitopes is important for research into the pathogenesis and immunotherapy of T1DM.
Tine et al. (2005)MHCT cellsWe could rescue T cells responses against poorly immunogenic epitopes after introducing appropriate point mutations to enhance their interaction with MHC Class I molecules.
Thierse et al. (2005)MHCT cellsCHS is T cell mediated, and hapten-specific T cells have been shown to interact with hapten-modified, MHC-associated peptides.
Thierse et al. (2005)MHCT cellsIn other cases, Ni ions unlike classical haptens, may activate T cells by crosslinking their receptors to MHC molecules, independent of the nature of the associated peptide.
Bachinsky et al. (2005)MHCT cellThe subdominant epitopes, however, can elicit robust T cell responses if optimized for their ability to bind to class I MHC molecules.
Redmond and Sherman (2005)MHCT cellsWhereas high-avidity recognition of peptide-MHC complexes by developing T cells in the thymus results in deletion and promotes self-tolerance, such recognition by mature T cells in the periphery results in activation and clonal expansion.
Jameson (2005)MHCT cellIn this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool.
Holtmeier and Kabelitz (2005)MHCT cellsThus, human Vdelta2 T cells recognize small bacterial phosphoantigens, alkylamines and synthetic aminobisphosphonates, whereas Vdelta1 T cells recognize stress-inducible MHC-related molecules MICA/B as well as several other ligands.
Mahajan et al. (2005)MHCT cellThe fundamental feature throughout T cell development is the interaction between the TCR and either self or foreign peptides in association with MHC molecules.
Walter and Santamaria (2005)MHCT cellsCD8(+) T cells can kill target cells directly, by recognizing peptide-MHC complexes on target cells, or indirectly, by secreting cytokines capable of signaling through death receptors expressed on the target cell surface.
Wucherpfennig (2005)MHCT cellBy considering the structural requirements for peptide binding to MHC molecules and TCR recognition of MHC-peptide complexes, we demonstrated that human T cell clones could recognize a number of peptides from different organisms that were remarkably distinct in their primary sequence.
Mallone and Nepom (2004)MHCT cellsThe same tetramer reagents also provide a new mean of stimulating T cells, more closely reproducing the MHC-peptide/TCR interaction.
Watts (2004)MHCT cellMHC molecules typically bind peptides to create ligands for the T cell antigen receptor.
Sarobe et al. (2004)MHCT cellTo overcome the poor immunogenicity of CEA-derived peptide determinants, a common feature of self-antigens, their sequence has been modified to improve binding to MHC molecules or recognition by T cell receptors.
Arnon and Aharoni (2004)MHCT cellsThe mode of action of GA is by initial strong promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells.
Riddell (2004)MHCT cellsT cells can discriminate diseased cells based on subtle alterations in peptides displayed in association with MHC molecules at the cell surface.
Hill et al. (2003)MHCT-cellWe also applied this model to determine whether cross-reactive T-cell epitopes can be predicted based on known MHC-peptide-TCR interactions.
Hill et al. (2003)MHCT cellsThese MHC molecules may participate in disease pathogenesis by selectively binding arthritogenic peptides for presentation to autoreactive CD4(+) T cells.
Hüe et al. (2003)MHCT cellsPotential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells.
Mogemark et al. (2003)MHCT cellsGlycopeptides that bind to MHC molecules on antigen presenting cells may elicit carbohydrate selective T cells.
Katz (2003)MHCT cellsIn recent years, newer methods that detect single cell production of cytokines and binding of tetrameric MHC-peptide complexes by antigen-specific T cells have become available.
Margalit et al. (2003)MHCT cellIn the absence of a particular antigenic peptide, the chimeric product associates with different endogenous MHC class I heavy chains and triggers T cell activation upon heavy chain cross-linking.
Pichler (2002)MHCT-cellDrugs are not only immunogenic because of their chemical reactivity, but also because they may bind in a labile way to MHC-molecules and fit into available T-cell receptors.
Basu et al. (2001)MHCT cellsKRN T cells can recognize two self MHC alleles with differing biological consequences.
Moris et al. (2001)MHCT cellsThe vast majority of alloreactive T cells recognize foreign MHC molecules in a peptide-dependent manner.
Godkin et al. (2001)MHCT cellsClearance of HCV has a strong association with the MHC class II antigen HLA-DR11 suggesting a key role for CD4+ T cells.
Tikhonov et al. (2001)MHCT lymphocytesSuperantigens and toxins produced by Staphylococcus aureus are capable of activating leucocytes via binding to MHC-II antigens on monocytes and T-cell receptor molecules on T lymphocytes.
Boytim et al. (2000)MHCT cellsMHC molecules bind antigenic peptides and present them to T cells.
Papageorgiou and Acharya (2000)MHCT cellRecent structural studies have provided a wealth of information regarding these complex interactions, and it is now emerging that, despite their common 3-D architecture, superantigens are able to crosslink MHC class II molecules and T cell receptors in a variety of ways.
Willemsen et al. (2000)MHCT lymphocytesImportantly, each type of transduced T lymphocytes that bound specifically to peptide/MHC complexes also showed specific antitumor reactivity as well as lymphokine production.
Gao and Jakobsen (2000)MHCT-cellMolecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor.
Jensen et al. (1999)MHCT cellsMajor histocompatibility complex (MHC)-encoded glycoproteins bind peptide antigens through non-covalent interactions to generate complexes that are displayed on the surface of antigen-presenting cells (APC) for recognition by T cells.
Santambrogio et al. (1999)MHCT cellsThe ability of the empty cell-surface class II MHC proteins to bind peptides and present them to T cells without intracellular processing can serve to extend the spectrum of antigens able to be presented by DC, consistent with their role as sentinels in the immune system.
Liu and Vignali (1999)MHCT cellsT cells recognize foreign Ags in the form of short peptides bound to MHC molecules.
von Greyerz et al. (1999)MHCT-cellThis review will discuss the known pathways of drug presentations by antigen presenting cells, the recognition of MHC/peptide/drug complexes by specific T-cell receptors, and the activation mechanism of drug-specific T cells.
Olsen et al. (1999)MHCT-cellSuperantigens bind directly to the MHC class II molecule on the antigen-presenting cell and crosslink the cell with T-cells expressing certain V beta-chains on their T-cell receptor which leads to a vigorous polyclonal T-cell activation.
Kwan Lim et al. (1998)MHCT cellCD8 is a T cell surface glycoprotein that participates in recognition of peptide/MHC class I molecules by binding to their alpha 3 domains.
Wang et al. (1998)MHCT cellA major issue in understanding alloreactive T cell responses is whether the Ags recognized reside in allogeneic MHC proteins themselves regardless of the structure of the associated peptides or whether specific peptides presented by allogeneic MHC proteins determine each epitope.
Gratton et al. (1998)MHCT cellAg-induced proliferation of T cell clones transfected with human CD4 was completely inhibited in the presence of gp120, even though stimulation of this clone is independent of a CD4/MHC class II interaction.
von Greyerz et al. (1998)MHCT cellsIt has been thought for many years that small molecular compounds can only be stimulating for T cells after covalent binding to MHC-embedded peptides.
Zanni et al. (1998)MHCT cellsNonreactive drugs can be recognized by specific alphabeta+ T cells via a nonconventional presentation pathway based on a labile binding of the drug to MHC-peptide complexes.
Miller et al. (1998)MHCT cellsThere is now convincing evidence that CD8+ T cells can be activated by professional antigen-presenting cells which present antigens derived from non-lymphoid tissues in association with MHC class I molecules in the draining lymph nodes.
Reyes et al. (1997)MHCT lymphocyteThe type of MHC molecules that bind the peptides in turn determine what T lymphocyte subset recognizes the peptides.
Penninger et al. (1997)MHCT cellsMurine cardiac myosin-induced myocarditis is an organ-specific autoimmune disease and mediated by CD4+ T cells that recognize a myosin-specific peptide in association with MHC class II molecules.
Yoshikawa et al. (1997)MHCT cellAnalogues of 129-145, with single residues substituted by alanine, revealed phenylalanine 135, phenylalanine 137, and glutamic acid 139 as most important determinants of Ag/MHC-II/TCR interactions; phenylalanine 137 is critical for T cell activation.
Woo et al. (1997)MHCT cellAntibodies recognizing MHC class I molecules expressed on the surface of T cells have been shown to inhibit T cell responses in vitro.
Skov et al. (1997)MHCT cellsLigation of major histocompatability complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: a novel apoptotic pathway distinct from Fas-induced apoptosis.
Johnson and Wu (1997)MHCT cellT cell receptors for antigen (TCR) V-genes are under a very restrictive evolutionary pressure in order to maintain their biological activities of interacting with MHC class I or II molecules and processed peptides at the protein level.
Wilkinson et al. (1997)MHCT-cellTheir binding to isolated H-2-Ab MHC glycoprotein as well as T-cell stimulatory capacity were assayed using a specific murine hybridoma T-cell line [38.H6], lymph node cells from the native 20-mer peptide primed C57BL/10 mice and human PBMCs from sensitised individuals.
Yao et al. (1996)MHCT cellHerpesvirus saimiri open reading frame 14, a protein encoded by T lymphotropic herpesvirus, binds to MHC class II molecules and stimulates T cell proliferation.
Bouvier and Wiley (1996)MHCT-cellThe large PEG loops are positioned to extend out of the peptide binding site, thus creating steric effects aimed at preventing the recognition of class I MHC complexes by T-cell receptors.
D'Orazio and Stein-Streilein (1996)MHCT cellOnce superantigen has bound class II MHC molecules on the surface of APC, it then can interact with the T cell receptor to induce T cell activation.
Tsuyuoka et al. (1996)MHCT cellTo clarify the exact mechanism underlying the antitumor effect of the anti-Id Ab, we established a T cell line that recognized Id-F2 in association with MHC class II molecules.
Bregenholt et al. (1996)MHCT lymphocytesLigation of MHC class I molecules on peripheral blood T lymphocytes induces new phenotypes and functions.
Cook et al. (1996)MHCT cellsE1A-positive, NK-susceptible target cells were also preferentially lysed by cytotoxic T lymphocytes (CTL) that recognize only foreign MHC molecules, lymphokine-activated T cells that lack recognition specificity, and CTL whose conventional recognition mechanisms were bypassed by lectin treatment of target cells.
Colovai et al. (1996)MHCT cellsT cells can recognize foreign MHC antigens by two distinct routes, either directly as intact molecules, or indirectly as processed peptides.
Bradley (1996)MHCT cellsAllograft rejection has been attributed predominantly to alloreactive T cells which recognize intact allogeneic MHC on donor antigen presenting cells (APC).
Bradley (1996)MHCT cellsFollowing transplantation, T cells may also recognize donor derived MHC antigens which have been processed and presented as antigenic peptides in the context of self-MHC by recipient APC--so called indirect allorecognition.
Amariglio and Rechavi (1996)MHCT cellThe T cell superantigens are infectious agents that interact with the T cell receptor and the MHC molecules outside their normal antigen-specific sites, with products of conserved sequences of the variable region chains.
Ohashi (1996)MHCT cellPeptide-MHC interactions govern the fate of T cells in the thymus and the peripheral T cell repertoire.
Mottershead et al. (1995)MHCT cellsThe superantigen encoded by the mouse mammary tumor virus (MMTV) is a potent stimulator of T cells when bound to MHC class II molecules.
Marshall et al. (1995)MHCT cellFinally, the ability to predict peptide binding to MHC class II molecules was shown to help in identifying T cell determinants.
Swier and Miller (1995)MHCT cellsIn Ag-presenting cells, MHC class II molecules bind antigenic peptides in endocytic compartments and transport them to the cell surface for presentation to CD4+ T cells.
Kanner et al. (1995)MHCT-lymphocytesLigation of major histocompatibility complex (MHC) class II antigens expressed on antigen-activated human CD4+ T-lymphocytes induces early signal transduction events including the activation of tyrosine kinases, the tyrosine phosphorylation of phospholipase-C gamma 1 and the mobilization of intracellular calcium.
Chaux (1995)MHCT lymphocytesAn effective immune response against tumor requires tumor-associated antigens to be processed into immunogenic peptides which are presented to T lymphocytes in association with MHC molecules.
Marshall et al. (1995)MHCT cellFinally, the ability to predict peptide binding to MHC class II molecules was shown to help in identifying T cell determinants.
Sinigaglia (1994)MHCT cellsRecent experiments have suggested that hapten-specific T cells recognize hapten-modified MHC-peptide complexes.
Herrmann et al. (1994)MHCT cellThis defect was apparently a result of weak binding to rat MHC class II molecules because presentation by human MHC class II molecules restored T cell activation.
Auchincloss (1994)MHCT cellsInstead, T cells tend to require that donor antigens be processed and presented indirectly in association with the MHC antigens on their own APCs.
Lecomte et al. (1994)MHCT cellsWe have previously reported that antigen-independent adhesion of CD45RO+ memory CD4+ T cells to B cells is negatively regulated by CD4-MHC class II interaction, whereas that of CD45RA+ naive CD4+ T cells is not.
Baldo and Pham (1994)MHCT-cellDemonstration that drugs specifically recognize T-cells from drug-allergic patients may reveal associations with HLA phenotypes, the nature and location of interaction between drug and MHC molecules, and the nature and identity of drug or drug-derived T-cell antigens.
Miller (1994)MHCT cellsCD4-positive T cells recognize foreign antigens displayed on the surface of antigen-presenting cells as small peptides bound to MHC class II molecules.