Viewing affirmative mentions of positive regulation of Tcr (D. melanogaster) in T cells

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Mauri-Hellweg et al. (1996)TCRT cellThis broad or very restricted pattern of T cell reactivity was reflected in the use of TCR Vbeta-chains: while the broadly reactive T cell lines showed a heterogenous TCR usage, the highly restricted T cell lines showed an up-regulation of one TCR Vbeta-chain.
Menné et al. (2000)TCRT cellConversely, TCR up-regulation is expected to increase T cell responsiveness.
Menné et al. (2000)TCRT cellFinally, we showed that TCR up-regulation probably plays a physiological role by increasing T cell responsiveness.
Fahmy et al. (2001)TCRT cellIncreased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.
Sensi and Parmiani (1995)TCRT cellsTumor-infiltrating lymphocytes (TILs), through displaying a T-cell receptor (TCR) repertoire as heterogeneous as that of normal peripheral blood T cells, show overexpression of TCR variable-gene segments that include clonally expanded TCR sequences.
Zhu et al. (2005)TCRT cellsThe commo T cells can also be modifed to specific antitumor T cells by method of TCR gene transfer.
Du Bois et al. (1992)TCRT-cellsTo differentiate whether the T-cells accumulate in organs nonspecifically (e.g., through chemotaxis or tumorlike proliferation) or more specifically through an antigen-driven ordered immune response, the present study capitalized on the knowledge that specific antigen stimulation of T-cells requires antigen interactions with the T-cell antigen receptor (TCR), resulting in a decrease in the number of surface TCR and a concomitant increase in TCR mRNA levels, i.e., if lung T-cell accumulation in pulmonary sarcoid results from an ordered immune response, lung, but not blood, T-cells should demonstrate evidence of recent triggering of the alpha beta receptor, the most abundant type of TCR.
de Witte et al. (2008)TCRT cellAnalogous to the clinical use of recombinant high-affinity Abs, transfer of TCR genes may be used to create a T cell compartment specific for self-Ags to which the endogenous T cell repertoire is immune tolerant.
Schrum et al. (2000)TCRT cellWe report that within 24 h of stimulation, the level of surface TCR expression becomes dependent on the degree of CD28 signaling provided during T cell activation.
Rubin and Kretz-Rommel (1999)TCRT cellThe molecular basis for this increase in activation threshold is unknown, but observations on differential signaling by peptide analogs, on increased TCR expression during T cell maturation and on energy induction in the absence of costimulation provide promising leads.
Pinilla et al. (1999)TCRT cellsThe use of this approach has had four major effects: first, the definition of high affinity ligands both for T cells and antibodies; second, the application of alternative means for identifying immunologically relevant peptides for use as potential preventive and therapeutic vaccines; third, a new appreciation of the requirements for TCR interactions with peptide-MHC complexes in immunogenicity; fourth, the establishment of new principles regarding the level of cross-reactivity in immunological recognition.
Bobisse et al. (2007)TCRT cellsIn particular, the need to reduce the in vitro expansion phase and to obtain large numbers of tumour-reactive T cells, as a favourable condition for cancer regression, make TCR gene transfer a potentially ideal tool to overcome the limits of adoptive cell therapy strategies.
Das et al. (2001)TCRT-cellUsing T-cell receptor (TCR) transfer studies, we show that recognition of antigenic aminobisphosphonates that are known to stimulate human gammadelta T cells in vitro and in vivo (potency: risedronate > alendronate > pamidronate) requires expression of the Vgamma2Vdelta2 TCR and is thus Vgamma2Vdelta2 TCR-dependent.
Kakimoto and Hara (1997)TCRT cell[T cell vaccination--induction of anti-idiotypic immune response against TCR and shift of Th1/Th2 balance].
Cai et al. (1998)TCRT cellsThe results suggest that, except under extreme conditions, Signal 1 alone is unable to activate naive CD8 T cells despite the induction of marked TCR downregulation.
Favier et al. (2001)TCRT cellWe show that: (i) surface-expressed TCR exhibit an intrinsic, actin cytoskeleton-independent, lateral mobility which allows them to passively diffuse over the entire T cell surface within approximately 60 min and (ii) non-stimulated TCR rapidly enter the signaling domain.
Fahmy et al. (2001)TCRT cellsActivation-induced membrane (AIM) changes in TCR avidity represent a previously unrecognized means of increasing the sensitivity of activated T cells to small amounts of antigen in the periphery.
Purtic et al. (2005)TCRT cellsCentral TCR accumulation thus had a specific role in signaling integration in low-affinity T cells.
Utzny et al. (2006)TCRT-cellThe interaction of T-lymphocytes with antigen-presenting cells displaying a small number of specific peptide/major histocompatibility complexes results in the downregulation of a large number of T-cell receptors (TCR), suggesting serial TCR triggering.
Allison and Havran (1991)TCRT cellsThe epithelial gamma delta T cells exhibit highly restricted V gene use, preferential pairing of TCR chains, and lack of diversity at the junctions creating populations of cells with virtually identical TCR in particular epithelia.
Kammertoens and Blankenstein (2009)TCRT cellsEffective adoptive T-cell therapy has become feasible by methods to identify TCR against tumor-associated (self-) antigens with high affinity and to graft a new antigen specificity to patients' T cells by TCR gene transfer.
Sousa and Carneiro (2000)TCRT cellDespite the increasing knowledge on the pathways involved in TCR signal transduction and T cell activation, the molecular mechanism of TCR triggering by ligand, MHC-peptide complexes, is still elusive and controversial.
Menné et al. (2000)TCRT cellAnalyses of T cell variants demonstrated that TCR up-regulation was dependent on the presence of an intact CD3gamma L-based motif and thus acted on TCR engaged in the recycling pathway.
Alarcón et al. (2003)TCRT cellThe number of possible T cell activation outcomes resulting from T cell receptor (TCR) engagement suggests that the TCR is able to differentially activate a myriad of signaling pathways depending on the nature of the stimulus.
Ueno et al. (2004)TCRT cellsThese data suggest that the reconstitution of HIV-specific immunoreactive T cells engineered by genetic transfer of HIV-specific TCR is a potential alternative to immunotherapeutic applications against HIV infections.
Schodin et al. (1996)TCRT cellCorrelation between the number of T cell receptors required for T cell activation and TCR-ligand affinity.
van Loenen et al. (2010)TCRT cellsBy introducing a TCR, large numbers of T cells with defined antigen (Ag) specificity can be obtained.
de Witte et al. (2008)TCRT cellAdoptive transfer of TCR gene-modified T cells has been proposed as an attractive approach to target tumors for which it is difficult or impossible to induce strong tumor-specific T cell responses by vaccination.
Dietrich et al. (2002)TCRT cellsTCR internalization takes place both in resting T cells as part of constitutive TCR cycling, after PKC activation, and during TCR triggering.
Valitutti et al. (1996)TCRT cellWe have previously demonstrated that in T cell-antigen-presenting cell (APC) conjugates many T cell receptors (TCR) are serially triggered by a few peptide-MHC complexes, resulting in sustained signaling.
Offner et al. (1994)TCRT cellsThe major challenges that remain to be resolved to make the TCR peptide therapy more widely applicable include (1) establishing disease-relevant V gene biases in individual patients, (2) identifying biologically active TCR peptide sequences, and (3) demonstrating that the induction of anti-TCR peptide immunity in humans can reduce the pernicious activity of autoreactive T cells putatively directed at organ-specific target antigens.
Schrum et al. (2000)TCRT cellsThese data identify the augmentation of surface TCR replenishment during activation as a novel mechanism that likely contributes to the enhanced antigenic sensitivity of CD28-co-stimulated T cells.
McNeil and Evavold (2003)TCRT cellTCR reserve: a novel principle of CD4 T cell activation by weak ligands.
Bukowski et al. (1998)TCRT cellsFew data are available regarding the TCR structural requirements for recognition of such prenyl pyrophosphate Ags by gamma delta T cells.
Schrum et al. (2000)TCRT cellsWhen T cells are stimulated with high concentrations of strong TCR agonist, engaged TCR are internalized and degraded, resulting in greatly reduced surface TCR levels for up to several days post-stimulation.
Ueno et al. (2004)TCRT lymphocytesReconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes.
Noble (2000)TCRT cellsRearrangement of gene segments occurs in T lymphocytes during thymic development as the T-cell receptor (TCR) is first expressed, allowing T cells to become central regulators of antigen specificity in the acquired immune system.
Hale and Fink (2010)TCRT-cellT-cell receptor (TCR) revision is a process of tolerance induction by which peripheral T cells lose surface expression of an autoreactive TCR, reinduce expression of the recombinase machinery, rearrange genes encoding extrathymically generated TCRs for antigen, and express these new receptors on the cell surface.
Friedl and Bröcker (2002)TCRT-cellBoth static and dynamic contacts support sustained triggering of the T-cell receptor (TCR), leading to signal induction, T blast formation, and proliferation.
Elewaut et al. (2000)TCRT cellMoreover, the same TCR family was overexpressed by T cell-lines from different nodules derived from the same patient.
Müller et al. (1998)TCRT-cellActivation of the T-cell receptor (TCR) results in recruitment of tyrosine kinases and changes of tyrosine phosphorylation levels.
Romagnoli and Bron (1997)TCRT lymphocytePrevious reports suggested that T lymphocyte activation through phosphatidylinositol-based glycolipid (GPI)-anchored molecules is dependent on surface expression of the TCR.
Nanda et al. (1995)TCRT cellDistinct core residues are crucial for triggering the T cell receptor (TCR) in each case.
Felix et al. (1987)TCRT cellWe examined alpha-, beta-, and gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell development.
Kuklina (2006)TCRT-lymphocytesIt includes the revision of T-cell antigen receptor (TCR), which implies the secondary rearrangement of TCR genes in peripheral T-lymphocytes and surface expression of a new antigen receptor with altered specificity.
Usuku et al. (1992)TCRT-cellIn addition to allelic variation of TCR genes, immune responses may also be influenced by the repertoire of the TCR molecules that are expressed by responding T-cell populations.
Jambou and Cohen-Kaminsky (2003)TCRT cellsWe took advantage of myasthenia gravis (MG), a well-characterized antibody-mediated autoimmune disease, to demonstrate that without prior vaccination against TCR determinants, patients with MG present increased circulating anti-TCR antibodies directed to the dominant TCR used by pathogenic T cells.
Shang et al. (2009)TCRT-cellAltered peptide ligands with increased affinity of the peptide-MHC complex for the TCR provide an alternative strategy to natural T-cell epitopes for cancer immunotherapy, as they can recruit and stimulate stronger T-cell repertoires.
Purtic et al. (2005)TCRT cellsA micrometer-scale receptor clustering integrated the TCR and CD28 signals required for IL-2 secretion in primary 5C.C7 T cells, a low-affinity/avidity TCR system. 5C.C7 TCR signaling itself was not affected.
Morice et al. (2004)TCRT-cellA normal or reactive conventional T-cell immunophenotype was present in 36 cases; TCR-Vbeta flow cytometric and molecular TCR analyses were negative for clonality in 32 and 27 of these cases, respectively.
Clay et al. (2002)TCR geneT cellTCR gene transfer seeks to transfer the antigen specificity of a T cell clone to other T cells.
Clay et al. (2002)TCRT-cellSince the generation of T cell clones is a laborious task and it is often impossible to derive T cell clones of the desired specificity and function from many individuals, especially in a timely fashion required for therapeutic interventions, T-cell receptor (TCR) gene transfer has a lot of appeal.
Naramura et al. (2002)TCRT cellc-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.
Murtaza et al. (1999)TCRT cellsT cells require a TCR and a co-stimulatory signal for activation.
Jenkins et al. (2009)TCRT cellThe centrosome plays a key role in granule delivery, polarizing to the central supramolecular activation complex (cSMAC) within the immunological synapse upon T cell receptor (TCR) activation.
Schrum and Turka (2002)TCRT cellsThese data demonstrate that TCR triggering and consumption can occur over an extended period of time, with a significant impact on the effector responses evoked from naive CD4(+) T cells.
Bueno et al. (2007)TCRT cellsHere, we review the structural information on recognition of bacterial SAgs by T cells, the TCR signalling induced by this recognition event, and the effector functions that this recognition triggers.
Ochi et al. (2010)TCRT-cellCurrently, therefore, attention is being focused on ACT with engineered T cells produced using cancer antigen-specific T-cell receptor (TCR) gene transfer.
La Gruta et al. (2004)TCRT cellA hallmark of T cell activation is the ligation-induced down-modulation of the TCR:CD3 complex.
Purtic et al. (2005)TCRT cellIn addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models.
Weiss et al. (1988)TCR geneT cellIn immunogenotyping studies of T cell receptor (TCR) and immunoglobulin genes, 13 cases showed clonal rearrangements of the beta or gamma TCR gene; one of these cases also had clonal rearrangements of a light chain immunoglobulin gene.
Medema and Borst (1999)TCRT cellBoth in thymic development and in a peripheral immune response, triggering of the T cell antigen receptor (TCR) through interaction with the MHC-antigen complex can result in T cell proliferation.
Sebestyén et al. (2008)TCRT cellTransfer of either TCRalpha:CD3zeta or beta:CD3zeta genes alone does not result in surface expression, whereas transfer of both modified TCR chains results in high surface expression, binding of peptide-MHC complexes and Ag-specific T cell functions.
Chen et al. (2008)TCRT cellsThe near-field scanning optical microscopy/quantum dot system provided a best-optical-resolution (<50 nm) nano-scale imaging of Vgamma2Vdelta2 TCR on the membrane of nonstimulated Vgamma2Vdelta2 T cells.
Davis et al. (1997)TCRT cellIn a model system involving a cytochrome c-specific I-Ek restricted T cell receptor (TCR) derived from the 2B4 hybridoma, we have studied the interaction of soluble TCR and soluble peptide-MHC complexes using surface plasmon resonance.
Risueńo et al. (2005)TCRT-cellTriggering of the T-cell receptor (TCR) can produce very different responses, depending on the nature of the major histocompatibility complex/antigen peptide (MHCp) ligand.
Zanni et al. (1998)TCRT cellAll drugs tested induced an MHC-restricted, dose- and antigen-presenting cell (APC)-dependent TCR downregulation on specific CD4(+) and CD8(+) T cell clones.
van Loenen et al. (2009)TCRT cellsTCR transfer into T cells specific for persistent viruses may enable these T cells to proliferate both after encountering with viral antigens as well as mHags, increasing the possibility of in vivo survival.
van Loenen et al. (2009)TCRT cellsMoreover, HA-2-TCR-transferred CMV-specific T cells remained dual specific after repetitive stimulation and TCR expression could be reverted after additional stimulation via the previously nonstimulated TCR, restoring high-avidity interactions.
Kuball et al. (2007)TCRT cellsThis approach should improve both the efficacy and safety of ongoing efforts to use TCR transfer as a strategy to generate tumor-reactive T cells.
Bakács et al. (2007)TCRT cellsThe new model is based on the homeostatic role of T cells, suggesting that molecular complementarity between the positively selected TCR and the self peptide-presenting major histocompatibility complex molecules establishes and regulates homeostasis, strictly limiting variations of its components.
Torres et al. (2003)TCRT cellsIn contrast to gamma(-) mutants of the human T cell line Jurkat, which were selected for their lack of membrane TCR and are therefore constitutively surface TCR negative, these natural gamma(-) T cells constitutively expressed surface TCR, mainly through biosynthesis of new chains other than CD3gamma.
Roessner et al. (1998)TCRT cellsHowever, stimulation of synovial fluid T cells with B. burgdorferi provoked active proliferation but not a statistically significant increase in expression of any TCR Vbeta, including Vbeta2 and Vbeta6.
Hanawa et al. (1994)TCRT cellResults of flow cytometry suggested that impairment of antigen recognition or T cell function by occupancy of the TCR rather than depletion of TCR was the mechanism responsible for suppression of EAM.
Brawley and Concannon (1999)TCRT cellThe ease with which a broad specificity is induced in this mutant TCR has implications for the mechanisms and frequency of alloreactivity and promiscuity in T cell responses.
de Witte et al. (2006)TCRT-cellAdoptive transfer of T-cell receptor (TCR) genes has been proposed as an attractive approach for immunotherapy in cases where the endogenous T-cell repertoire is insufficient.
Friedl and Bröcker (2002)TCRT-cellTCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells.
Viola and Lanzavecchia (1999)TCRT-cellRecent evidence, indicates that T-cell receptor (TCR) triggering and T-cell activation are dynamic processes that involve various aspects of T-cell organization.
Offner and Vandenbark (2005)TCRT cellsE2 increases the number and activity of FoxP3(+) T cells through Esr-1 signaling during TCR activation of CD4(+)CD25(-) T cells.
Manne et al. (2002)TCRT cellsWe have reported an analysis of these infiltrating T cells, indicating that certain TCR-Vbeta gene segments are greatly overexpressed.
Polic et al. (2001)TCRT cellsHow alpha beta T cells deal with induced TCR alpha ablation.