Viewing negative mentions of positive regulation of Tcr (D. melanogaster) in T cells

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Alexander et al. (1994)TCRT cellTCR antagonism and T cell tolerance can be independently induced in a DR-restricted, hemagglutinin-specific T cell clone.
Naramura et al. (2002)TCRT cellWe found that c-Cbl Cbl-b double knock-out (dKO) T cells became hyperresponsive upon anti-CD3 stimulation, even though the major T cell antigen receptor (TCR) signaling pathways were not enhanced.
Purtic et al. (2005)TCRT cellIn addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models.
Chen et al. (2010)TCRT-cellIn addition, three of the five tested precursor T-cell lymphoblastic lymphomas showed no TCR gene clonality, probably because the immature T-cells in this type of TCL had not undergone TCR gene rearrangements.
Blanchard et al. (2004)TCRT cellMoreover, we show, in CD4(+) T cell blasts, that strong TCR clustering is required for neither TCR down-modulation nor optimal IFN-gamma production.
Circosta et al. (2009)TCRT cellsWe investigated the possibility of introducing exogenous T cell receptor (TCR) genes into T cells by lentiviral transduction, without prior stimulation of endogenous TCR with anti-CD3.
Circosta et al. (2009)TCRT cellsBoth naive and unfractionated CD8(+) T cells could be transduced without requiring endogenous TCR triggering.
Bischof et al. (2000)TCRT cellsShortcutting of TCR-dependent CD28 recruitment by stimulation with monoclonal antibodies specific for mobilized CD28 results in maximum proliferation and IL-2 secretion in primary resting T cells without activation of ZAP-70, a central component of the TCR's signal transduction machinery.
Castelletti and Colombatti (2005)TCRT-cellThe analogue E177A/A178D not only prevented the agonist from stimulating anti-RTA human T-cell clones but also failed to induce down-regulation of surface-expressed TCR, thus suggesting its possible use for in vivo immune modulation of anti-RTA responses.
Weng et al. (2002)TCRT cellsRecent studies of CD8 T cells suggest that generation of CD8 memory T cells requires the engagement of T cell antigen receptors (TCR) with antigen, yet the maintenance of CD8 memory T cells appears to be dependent on cytokines, such as IL-15, independent of TCR.
Iancu et al. (2011)TCRT-cellResults from such studies have a strong impact on the design of antigens for vaccination as well as on the choice of optimal TCRs for adoptive T-cell therapy, with or without TCR gene transfer.
Joshi et al. (2006)TCRT cellMoreover, CIK T cell activation by mDC and their destruction of iDC are independent of the TCR.
Bostik et al. (2001)TCRT cellsIn vitro TCR stimulation with or without CD28 costimulation of CD4(+) T cells did not lead to the enhancement of gene transcription of these PTKs.
Tien et al. (1992)TCRT-cellNo cross-lineage rearrangements of immunoglobulin (Ig) or T-cell receptor (TCR) genes were detected in these karyotypic subgroups of patients who underwent gene analysis.
Guidos (2006)TCRT cellRecent studies reveal that Notch signaling is not essential for pre-T cell receptor (TCR) expression or gammadelta lineage choice.
Philips et al. (1997)TCRT-cellSimilarly, in T-cell hybridomas, TCR activation induced NurRE but not NBRE reporters.
Bartelt et al. (2009)TCRT cellsInterestingly, Jurkat E6.1 T cells and APBTs had no detectable difference in the TCR-induced phosphorylation of tyrosine 775 on PLC?
Verschelde et al. (2003)TCRT cellsTherefore, in naive, activated and posteffector T cells, expression of A1 is dependent on TCR but not on cytokine receptor engagement, indicating that A1 is differently regulated from Bcl-xl and Bcl-2.
Katamura et al. (2000)TCRT cellsRecently, it was reported that IL-7 induces the ability to produce IL-4 as well as interferon (IFN)-gamma and IL-5 in naive CD4+ T cells without TCR stimulation.
Clayton et al. (1992)TCRT-cellDespite the identity of the amino-terminal 121 amino acids of CD3 zeta, CD3 eta, and CD3 theta and an additional 31 amino acids shared between CD3 eta and CD3 theta, transfection of CD3 theta into the CD3 zeta- eta- T-cell hybridoma, MA5.8, failed to restore detectable surface TCR expression in contrast to transfection with CD3 zeta or CD3 eta.
Charvet et al. (2005)TCRT cellsWe report here that phosphorylation of Vav3 on tyrosine residue Tyr(173) is not required for T cell receptor (TCR)-induced Vav3 membrane translocation or immunological synapse (IS) recruitment, but mutation of this residue enhanced TCR-induced nuclear factor of activated T cells (NFAT) activation.
Suzuki et al. (1997)TCRT cellCommitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains.
Kanzaki et al. (1997)TCR geneT-cellsThe affected neck lymph node showed a preponderance of T-cells, predominantly CD4+ over CD8+ T-cells and all V beta gene families were expressed in the T-cells without enhancement of any particular TCR gene usage.