Viewing affirmative mentions of localization of IL2 (H. sapiens) in B cells

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Mingari et al. (1984)interleukin 2B cellCytolytic clones were further analyzed for their ability to release interleukin 2 (IL2) and B cell growth factor(s) (BCGF) upon 24 h stimulation with phytohemagglutinin.
Benjamin et al. (1989)interleukin 2B cellHuman B cell lines can be triggered to secrete an interleukin 2-like molecule.
Benjamin et al. (1989)interleukin 2B cellsTo determine whether human B cells can be triggered to secrete interleukin 2 (IL-2), 19 tumor cell lines derived from patients with undifferentiated lymphomas of Burkitt's and non-Burkitt's types and 6 normal lymphoblastoid cell lines were tested.
Lagoo et al. (1990)IL 2B cellsThese data strongly suggest that the growth factor secreted by rabbit B cells is IL 2.
Cunningham-Rundles et al. (1995)IL-2B cellAlthough there appear to be intrinsic B cell defects, many have poor T cell proliferation and deficient secretion of IL-2, IL-4, IL-5 interferon-gamma, and B cell differentiation factor.
Mouzaki et al. (1995)IL-2B cellIn the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.
Mouzaki et al. (1995)IL-2B cellIn seven EBV-B cell clones or lines differing in their capacity to secrete IL-2, the activity of the IL-2 promoter correlated well with the status of IL-2 secretion.
Kindler et al. (1995)Interleukin-2B lymphocytesInterleukin-2 secretion by human B lymphocytes occurs as a late event and requires additional stimulation after CD40 cross-linking.
Kindler et al. (1995)IL-2B lymphocytesThis approach showed that B lymphocytes secreted IL-2 in the culture medium, but only if they were first activated for more than 24 h in the anti-CD40 system before exposure to PMA plus ionomycin.
Corbo et al. (1987)IL2B-cellWe have obtained, by transfection of mouse L cells with total human DNA, clones that constitutively secreted human interleukins IL1, IL2 and B-cell grown-factor activities, as assessed by specific biological assays.
Balderas et al. (1987)interleukin 2B cellsActivation/proliferation of mouse and human T and B cells is associated with expression and subsequent release of interleukin 2 receptors (IL 2R) into the milieu.
Volkman et al. (1985)IL 2B cellPrior to infection, the T cell clone responded to antigen stimulation in the presence of histocompatible antigen-presenting cells with proliferation and secretion of multiple lymphokines, including IL 2, B cell growth factor (BCGF), B cell differentiation factor (BCDF), and interferon-gamma (IFN-gamma).
Inaba et al. (1983)IL-2B lymphocyteWe conclude that the ability of the DC to induce IL-2 release and responsiveness underlies its capacity to trigger both T and B lymphocyte reactions.
Hashimoto et al. (1986)IL2B cellsThe following results were obtained: (a) B cells activated with LPS plus anti-Ig were found to proliferate in response to either recombinant IL2, T cell SN or fresh LPS; (b) a monoclonal anti-IL2 receptor antibody (PC61) could completely inhibit the effects of recombinant IL2 or various T cell SN (cloned T helper cell SN, EL4 SN, concanavalin A-spleen cell SN or mixed leukocyte culture SN), but did not interfere with the effect of LPS; (c) B cells activated with LPS or LPS plus anti-Ig were not found to secrete detectable amounts of IL2 by themselves.
Biagi et al. (2005)interleukin-2B-cellEXPERIMENTAL DESIGN: We prepared autologous B-cell chronic lymphocytic leukemia cells that expressed both human CD40 ligand (>90% positive) and human interleukin-2 (median secretion, 1,822 pg/mL/10(6) cells; range, 174-3,604 pg).
Mouzaki et al. (1995)IL-2-secretingB cellsElectrophoretic mobility shift assays using protein extracts from EBV-B cells and the IL-2 NF-chi B probe revealed the constitutive generation of chi B complexes in IL-2-secreting cells consisting mainly of heterodimeric p50/p65 complexes.
Katano et al. (1994)IL-2B-cellA human B-cell line (Hairy-BM) constitutively secreting interleukin-2 (IL-2) was established from tumor tissue resected surgically from a patient with breast cancer.
Saiki et al. (1988)IL-2B cellsAbout 50% of SAC-activated B cells, lacking Tac antigen, were also responsive to Ig secretion by IL-2, although the required dose of IL-2 was higher than that for Tac-positive B cells.
Wörmann et al. (1987)IL-2B cellWe conclude that IL-2 has essentially no proliferative effect on B cell precursor ALL, despite the presence of high affinity IL-2 receptors and the presence of the IL-2 binding cell surface molecules similar to those on activated T cells.
Pistoia et al. (1985)IL 2B cellsThe factor released by this LGL subset was not IL 1 or IL 2 mistakenly interpreted as BCGF, because: a) cell supernatants particularly rich in BCGF activity contained very little or no IL 1 or IL 2; b) BCGF-induced B cell proliferation was not inhibitable by anti-Tac antibodies (this in spite of the expression of IL 2 receptor by a proportion of activated B cells); and c) BCGF activity was absorbed by B but not T blasts.
Tanaka et al. (1988)IL-2B cellsThese results taken together suggest that B cells may express novel IL-2 binding molecules, associated with B cell differentiation and differentiate into Ig secreting cells by IL-2 through novel IL-2 binding molecules.
Lakow et al. (1983)interleukin 2B lymphocytesAfter selection of somatic cell hybrids and cloning, hybridoma cell lines were obtained that reacted with autologous EBV-infected B lymphocytes, as detected by the release of interleukin 2 into the culture medium.
Benjamin et al. (1990)IL-2-likeB cellTNF alpha receptor regulation did not seem to be influenced by secreted IL-1 and/or B cell IL-2-like molecule as well, but correlates with coexpression of IL-1 and IL-2 receptors.
Tang et al. (1993)IL-2B lymphocytesThe intriguing question raised by these results is whether IL-2 secretion could contribute to the immune control of EBV-infected B lymphocytes by cytolytic T cells, and whether normal B lymphocytes can potentially be induced to express certain cytokines including IL-4 in response to the appropriate activation signals.
Giovarelli et al. (1988)IL-2lfB-cellIn a series of untreated patients with B-cell chronic lymphocytic leukemia (B-CLL), the capacity of the neoplastic B-cell population to release an interleukin-2 like factor (IL-2lf) was assessed.
Giovarelli et al. (1988)IL-2lfB cellsThese findings indicate that elevated quantities of IL-2lf may be released in B-CLL particularly due to the B- and T cell interconnections, and that the leukemic B cells appear capable of absorbing IL-2 and of proliferating after costimulation with IL-2.
Holen and Elsayed (1998)IL-2B cellsHigh IgE secretion, from 1% remaining B cells in one of the patients, following PHA+IL-2 stimulation, could be reduced by the drugs.
Bertolini and Benson (1990)Interleukin-2B-cellAs human T-cells secrete other lymphokines in association with IL-6 after activation we examined the interaction of Interleukin-2 (IL-2) gamma-interferon (IFN-gamma) and Interleukin-4 (IL-4) with IL-6 on B-cell immunoglobulin secretion.
Boussiotis et al. (1993)IL-2B cellsAt 24 hr postactivation, B cells express a CTLA-4 counterreceptor not recognized by anti-B7 or -BB-1 monoclonal antibodies (mAbs), which induces detectable IL-2 secretion and T-cell proliferation.
Bumgardner et al. (1993)IL-2B-cellIn vitro cell culture studies were used to analyze the effects of three copper-based dental alloys on a T-cell and B-cell line and their secretion of soluble immune mediators (IL-2) and effectors (IgG), respectively.
Huang et al. (1995)IL2B cellOther cytokines known to promote Ig secretion (IL2 and IL6) also caused a reduction in cAMP, suggesting that this pathway may be generally important in B cell differentiation.
Allavena et al. (1985)interleukin-2B-cellLGL in addition to mediating natural killer (NK) activity, can secrete a variety of lymphokines, depending on the stimulus used: interleukin-1 (IL-1), interleukin-2 (IL-2), interferon alpha and gamma (IFN), and B-cell growth factor (BCGF).
Prasad et al. (1997)IL-2B cellThe most potent Ag presentation for IL-2 secretion was found to segregate with low-density, B cell-enriched fractions while adherent cells, or purified T cells were unable to support IL-2 production.
Prasad et al. (1997)IL-2B cellsTogether with previous results, the data show that antigen presentation leading to IL-2 secretion by these autoreactive T cell hybridomas requires activated B cells, whereas TCR occupancy can be provided by several APC subsets.
Foa et al. (1985)IL 2B cellInterleukin 2 (IL 2) and interferon-gamma production by T lymphocytes from patients with B-chronic lymphocytic leukemia: evidence that normally released IL 2 is absorbed by the neoplastic B cell population.
Foa et al. (1985)IL 2B cellThe capacity of T lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) to release interleukin 2 (IL 2) and interferon (IFN)-gamma was assessed following various stimuli.
Foa et al. (1985)IL 2B cellsThe indication that IL 2 may be adsorbed in vivo by the neoplastic B cells was further confirmed by the demonstration of the IL 2 receptor (revealed by anti-Tac monoclonal antibody) on the leukemic B cells, particularly following mitogenic stimulation, and by the evidence that exogenous IL 2 can be directly absorbed by untreated B-CLL T lymphocytes to release IFN-gamma and IL 2 is preserved, but that IL 2 may be rapidly removed by the neoplastic B-CLL cells, thus contributing to the well-documented T lymphocyte abnormalities present in this disease.
Maher et al. (1990)IL-2-inducedB cellsMitogen-induced pre-activation of B cells in the presence of IL-4 resulted in a reduction in subsequent IL-2-induced IgM secretion without significantly affecting proliferation.
Giovarelli et al. (1988)IL-2lfB-cellsWhile unstimulated purified leukemic B-cells showed no IL-2lf production, in 16 of the 27 cases tested (59.2%) significant amounts of IL-2lf (4.3-125 U) were released following activation with phytohemagglutinin (PHA) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).
Moretta et al. (1984)interleukin-2B cellAs much as 20% cytolytic T lymphocytes were found to be capable to release interleukin-2 and B cell growth factor, thus indicating that cytolytic and helper function may be associated at the single cell level.
Inaba and Steinman (1984)lymphokineB cellLyt-2-T blasts did not grow or release interleukin 2 or B cell helper factors unless rechallenged with specific alloantigen, whereupon growth (generation time of 14-18 h) and lymphokine release rapidly resumed.
Spachacz et al. (2003)IL-2B-cellThe present study aimed at immunocytochemical localisation of cytokines (IL-1alpha, IL-2, IL-6, IL-12, TNF-alpha) in B-cell lymphomas in children (n = 10).
Benjamin et al. (1990)lymphokineB cellDifferential effects of teleocidin on TNF alpha receptor regulation in human B cell lines: relationship to coexpression of IL-2 and IL-1 receptors and to lymphokine secretion.
Lahat et al. (1993)IL-2B cellsAlthough no differentiating effect was observed on resting B cells, prolactin (0.2-100 ng/ml) exhibited a dose-dependent enhancement upon both IgM and IgG secretion from B cells treated with anti-IgM and IL-2.
Gozes et al. (1987)lymphokineB cellB cell growth factor (BCGF) is a lymphokine (LK) primarily produced and secreted by activated T cells.
Kehrl et al. (1987)IL-2B cellThe addition of TNF-alpha to IL-2, a known inducer of SAC-activated B cell Ig secretion, resulted in a twofold enhancement in the amount of IL-2 stimulated B cell Ig secretion.
Ambrus et al. (1990)IL-2B cellAfter activation, B cells may be induced to proliferate by a variety of B cell growth factors (BCGF) including IL-2, IL-4, TNF-alpha, low molecular weight BCGF (LMW-BCGF), and high molecular weight BCGF (HMW-BCGF).
Calvert et al. (1990)interleukin-2B cellsImmunoglobulin G subclasses secreted by human B cells in vitro in response to interleukin-2 and polyclonal activators.
Calvert et al. (1990)IL-2B cellsThe IgG subclasses secreted by human B cells in vitro in response to IL-2 have been analysed.
Sahasrabuddhe et al. (1988)B cell growth factorB cellImmunological evidence for the relation between low MR secreted form of human B cell growth factor and an intracellular 60K protein.
Kretowski et al. (1999)IL-2B cellA significant increase of IL-2 secretion at 72 h of PHA stimulation was shown in first degree relatives of IDDM patients with a combination of 3 or more antipancreatic-B cell antibodies.
Kasprzak et al. (2010)IL-2B-cellTissue expression of interleukin 2 (IL-2) and IL-2 receptor (IL-2R(alpha)/CD25) in non-Hodgkin B-cell lymphomas in children: correlations with clinical data.
Brinkmann and Kristofic (1997)IL-2-primedB cellsImportantly, anti-CD28/IL-2-primed Th2 cells readily secreted IL-4 and induced IgE production by surface IgE- B cells in response to the first TCR signal and independent of previous contact with IL-4.
Alvarez-Mon et al. (1989)IL-2B cellsThese results demonstrate that the utilization of the BCGF pathway can be segregated from that of IL-2 in B cells from B-CLL patients.
Ambrus et al. (1990)lymphokineB lymphocytesMature human B lymphocytes perform many functions including antibody secretion, Ag presentation, preservation of memory for Ag, and lymphokine secretion.
Benjamin et al. (1986)IL-2B lymphocytesSince some Burkitt's lymphoma lines express Tac antigen and can be triggered to secrete IL-2 following activation with the new tumor promoter teleocidin, we addressed the question of whether the induction of IL-2 by B lymphocytes is accompanied by the induction of IFN-gamma.
Jelinek and Braaten (1995)IL-2-dependentB cellMoreover, when the ability of IL-12 to augment IL-2-dependent B cell Ig secretion was compared with the ability of several known auxiliary B cell differentiation factors, IL-12 was observed to be the most potent cytokine that could costimulate with IL-2.
Kitagami et al. (1987)IL-2B cellTwo responses were elicited in the responding T-cell clones: (i) high levels of IL-2 secretion (320 units/ml), and (ii) cytotoxicity directed against the antigen-presenting B cell.
Kindler and Zubler (1997)IL-2B cellsIgD+, IgG-, and IgA- (naive) B cells secreted 70-fold less Ig than IgG+, IgA+ (memory) B cells in response to anti-CD40 plus IL-2, IL-10, and IL-3.
Zhang et al. (1990)IL-2B cellsThe PMA-inducible helper activity was CsA-sensitive at the same CsA concentration that inhibited IL-2 secretion of EL-4 cells, but the murine factors in EL-4 supernatant had no effect on human B cells; the helper effect did not occur across a semipermeable membrane.
Hu et al. (1999)IL-2B cellsRESULTS: The supernatant of the cultured non-immunological cells of decidua can inhibit the immunological function of T cells, natural killer cells and B cells to different extents, their maximum inhibiting ratio were 22.7%, 52.3% and 14.8% respectively, but there is no significant effect on the IL-2 secretion by lymphocytes.
Liano and Abbas (1987)LymphokineB cellsLymphokine secretion, T cell proliferation, and antibody secretion by B cells all exhibited identical antigen dose responses.
Bohlen et al. (1993)interleukin 2B-cellsIn addition, the combined use of two CD3 x CD19 plus CD28 x CD22 bispecific antibodies induced optimal interleukin 2 secretion by Jurkat T-cell acute lymphocytic leukemia cells in the presence of target B-cells.
Benjamin et al. (1989)IL-2B cellThe following similarities in the functional biological characteristics of T cell and B cell IL-2 suggest that B cell IL-2 is not a factor which mimics IL-2 activity in the CTLL-2 assay: (i) neutralization of IL-2 by anti-IL-2 monoclonal antibody (DMS-1); (ii) elution of IL-2 following its adsorption to CTLL-2 cells; (iii) determination of the MW of IL-2 by SDS-PAGE and Western blot analysis; and (iv) ability of B cell IL-2 to support T cell proliferation and blocking of this activity by anti-tac monoclonal antibody. cDNA probes for T cell IL-2, however, did not detect IL-2 mRNA in B cells.
Teodorczyk-Injeyan et al. (1989)IL2B cellThus, the T-cell-dependent antibody response was suppressed for long periods of time, possibly from some deficiency in IL2-regulated secretion or reception of helper T-cell-derived factors necessary for B cell differentiation into Ig-secreting cells.
Kehrl et al. (1986)IL 2B cellThe addition of picogram quantities of TGF-beta to B cell cultures suppressed factor-dependent, interleukin 2 (IL 2) B cell proliferation and markedly suppressed factor-dependent (IL 2 or B cell differentiation factor) B cell Ig secretion.
Leca et al. (2008)B cell growth factorB cellsInterleukin 14 (IL-14) or high molecular weight B cell growth factor secreted by activated T and B cells and follicular dendritic cells promotes B cell growth, survival and memory, and antibody production.
Carpenter et al. (2009)IL-2B cellsCP-870,893-activated B cells induced T cell proliferation and T cell secretion of effector cytokines including IFN-gamma and IL-2.
Carpenter et al. (2009)IL-2B cells(p < 0.001), and IL-2 (p < 0.001) secretion compared to negative control B cells (data not shown).
Matheson et al. (1994)B-cell growth factorB-cellThese two phases appear to be under the influence of mediators released by immune cells, B-cell growth factor(s), which induce proliferation of B cells; and B-cell differentiation factor(s), which induce B-cell differentiation.
Agrewala et al. (1998)IL-2B cellsWhen ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4.
Furst (1995)IL-2B-cellCyclosporin A (CSA) Cyclosporin inhibits IL-2 release and T-cell activation and, secondarily, affects B-cell function.
Mikuni (1995)IL-2B-cellsInterleukin-2 (IL-2), mainly secreted by activated T-cells, influences other T-cells, B-cells, Macrophages, NKcells, etc. and is a major proliferating and differentiation factor of lymphocytes.
Carpenter et al. (2009)IL-2B cellsCP-870,893-activated B cells induced T cell proliferation and T cell secretion of effector cytokines including IFN-gamma and IL-2.
Eugui and Almquist (1990)IL-2B lymphocytesSome monoclonal antibodies (mAbs) against interleukin (IL) 1 alpha have been found to activate antigen-presenting cells (APC, human peripheral blood monocytes and B lymphocytes), so that unstimulated T lymphocytes cultured with them are induced to proliferate and secrete IL-2.
Smeland et al. (1989)IL-2B cellsOther cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells.
Takayasu and Brooks (1991)IL-2B cellWe have found that a neoplastic Lyl+ B cell clone (BCL1-3B3) can be stimulated to secrete IgM by a Th1-derived cytokine, IL-2, and/or by a Th2-derived cytokine, IL-5.
Hunninghake and Crystal (1981)lymphokineB cellsIn studies of function, lung T cells from patients with sarcoidosis and high-intensity alveolitis released monocyte chemotactic factor (a lymphokine critical to granuloma formation) and polyclonally activated B cells to produce immunoglobulins.
Brady et al. (1999)IL2B-cellsHere we demonstrate that these CD4+ T-cells secrete large amounts of interferon-gamma (IFNgamma) and interleukin-10 (IL10), and insignificant quantities of IL2 or IL4, in response to peptide presentation by both melanoma and autologous B-cells.
Rogers et al. (1997)IL-2B cellA minority of the Ag-specific T cells produced predominantly IL-2 mRNA and localized at the T cell/B cell junction in draining lymph nodes.
Lemire et al. (1995)IL-2B cellsTh1 secrete interferon (IFN-gamma), interleukin (IL-2) and induce B cells to produce immunoglobulin IgG2a while Th2 secrete IL-4, IL-10 and induce the production of IgG1 and IgE by B cells.
Maurer et al. (1992)IL-2B cellsAlthough CD27- B cells hardly secrete Ig of any isotype in response to Staphylococcus aureus+IL-2, these cells proliferate vigorously and express the IL-2R alpha chain (CD25) under these stimulatory conditions.
Raziuddin and Teklu (1989)interleukin-2B-cellThe patient's T cells were found to secrete elevated amounts of interleukin-2 but failed to secrete two important B-cell stimulating factors, B-cell growth factor and B-cell differentiation factor, in response to PHA.
Tuscano et al. (1996)IL-2B-cellIn addition, the HB22.7 MoAb costimulated B-cell proliferation with either anti-IgM, interleukin-2 (IL-2), IL-4, or CD40 and triggered predominantly B-cell IgG secretion with IL-2.