Viewing affirmative mentions of gene expression of Tcr (D. melanogaster) in T cells

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Coulie and van der Bruggen (2003)TCRT-cellSeveral reports describe anti-vaccine T-cell responses, evaluated with a variety of methods, for example, by assessing T-cell function or expression of specific TCR.
Dzhambazov et al. (2003)TCRT-cellThe variability in the morphology, modal number of chromosomes, TCR expression and functional reactivity of a CII-specific T-cell hybridoma at continuous subcultivation have been investigated.
Walzer et al. (2000)TCRT cellsThese results indicate that the intrinsic effector capabilities of individual CD8 T cells expressing the same TCR are heterogeneous and that cells with identical antigen specificity but increased effector capacities are generated or selected during the primary response.
Poccia et al. (1997)TCRT cellVgamma9Vdelta2-encoded T cell receptors (TCR) expressed by most human peripheral blood gammadelta T cells mediate the recognition of nonpeptidic phosphoantigens from various pathogens without any known requirement for HLA molecules.
Go and Wester (2004)TCRT-cellThe presence of HPS at diagnosis and expression of the gamma/delta T-cell receptor (TCR) by tumor cells were associated with poor survival, whereas age was not.
von Essen et al. (2004)TCRT cellModulation of TCR expression levels is a central event during T cell development and activation, and it probably plays an important role in adjusting T cell responsiveness.
Favier et al. (2001)TCRT cellWe show that: (i) surface-expressed TCR exhibit an intrinsic, actin cytoskeleton-independent, lateral mobility which allows them to passively diffuse over the entire T cell surface within approximately 60 min and (ii) non-stimulated TCR rapidly enter the signaling domain.
Menné et al. (2000)TCRT cellThus, an increase in protein kinase C activity affects TCR recycling kinetics leading to a new TCR equilibrium with a reduced level of TCR expressed at the T cell surface.
Menné et al. (2000)TCRT cellDown-regulation of TCR expression compromises T cell activation.
Menné et al. (2000)TCRT cellThus, by affecting the TCR recycling kinetics, T cells have the potential both to up- and down-regulate TCR expression and thereby adjust T cell responsiveness.
Sensi and Parmiani (1995)TCRT cellsTumor-infiltrating lymphocytes (TILs), through displaying a T-cell receptor (TCR) repertoire as heterogeneous as that of normal peripheral blood T cells, show overexpression of TCR variable-gene segments that include clonally expanded TCR sequences.
Zhu et al. (2005)TCRT cellsThe commo T cells can also be modifed to specific antitumor T cells by method of TCR gene transfer.
Schrum et al. (2003)TCRT-cellThis may be achieved by a combination of mechanisms that involve (a) controlling the quantity of surface TCR available for ligand interaction and (b) controlling the quality of surface TCR expression during T-cell activation.
Schrum et al. (2003)TCRT-cellTCR signaling itself appears to be one of the main quantitative modulators of surface TCR expression, and it can cause both downregulation and upregulation at different times of T-cell activation.
Offner et al. (1994)TCRT cellsThe striking similarities in the induction and characteristics of rodent and human T cells specific for TCR peptides support the generality of the observation, and enhance the probability that this immunoregulatory mechanism will have application in human organ-specific autoimmune diseases that are characterized by oligoclonal expression of TCR V genes.
Snoke et al. (1993)TCRT cellAn analysis of their V beta and J beta usage indicated that each of these five T cell lines expressed different TCR.
Li et al. (2010)TCRT cellsIn this study, we directly tested the hypothesis that physical forces acting on the TCR can initiate signaling in T cells by micromanipulation of individual T cells bound to artificial APCs expressing engineered TCR ligands.
Sun et al. (1997)TCRT cellIn this study, we demonstrate that sequences of the TCR CDR3 region are excellent clonotypic markers for rat MBP-reactive T cell clones and oligonucleotide probes complementary to the CDR3 region of three T cell clones specifically recognized the TCR from which they were derived, but failed to recognize syngeneic T cells that express a similar TCR beta-chain or T cells that share both V beta and J beta usage.
Komatsu et al. (1996)TCRT cellsComparative analyses of TCR V alpha and V beta expression in the epidermal T cells and the paired peripheral blood lymphocytes (PBL) by quantitative polymerase chain reaction (PCR) demonstrated that the epidermal T cells, but not the paired PBL, utilized a very limited range of V alpha and V beta genes.
Geisler (2004)TCRT-cellDynamic regulation of TCR expression levels plays important roles in modulating T-cell responses during T-cell development and in mature T cells.
Seki et al. (1989)TCRT cellT cell lines or clones from two patients, one with a partial DiGeorge syndrome and one with severe common variable immunodeficiency expressed disulfide-linked gamma delta T cell antigen receptor (TCR) comprised of a gamma-chain polypeptide of 40-43 kD, and a delta-chain polypeptide of 37-40 kD.
de Witte et al. (2008)TCRT cellAnalogous to the clinical use of recombinant high-affinity Abs, transfer of TCR genes may be used to create a T cell compartment specific for self-Ags to which the endogenous T cell repertoire is immune tolerant.
Xiong and Raulet (2007)TCRT-cellTwo main lineages of T cells develop in the thymus: those that express the alphabeta T-cell receptor (TCR) and those that express the gammadelta TCR.
Zehn et al. (2007)TCR repertoireT cellsTCR-revised T cells are functional and express a diverse TCR repertoire.
Marguerie et al. (1992)TCRT-cellNow, however, polymerase chain reaction (PCR)-based methods are being used to analyse T-cell receptor (TCR) gene expression in such lesions.
Jorritsma et al. (2007)TCRT cellsHere we show that TCR surface expression can be improved by modification of TCR alpha and beta sequences and that such improvement has a marked effect on the in vivo function of TCR gene-modified T cells.
Ueno et al. (2004)TCRT cellsThese data suggest that the reconstitution of HIV-specific immunoreactive T cells engineered by genetic transfer of HIV-specific TCR is a potential alternative to immunotherapeutic applications against HIV infections.
Alberti (1996)TCRT cellThe actual production of specific affinity TCR may also prove crucial for a soluble T cell receptor-based immunotherapy and for the co-crystallization of TCR with MHC and peptides.
Kakimoto and Hara (1997)TCRT cell[T cell vaccination--induction of anti-idiotypic immune response against TCR and shift of Th1/Th2 balance].
Qadri et al. (2000)TCRT cellsThe modified TCR has been expressed in transfected T cells, and the phenotype following stimulation has been compared with that of cells expressing the wild-type TCR.
MacDonald and Wilson (1998)TCRT-cellT cells belong to two mutually exclusive lineages expressing either alpha beta or gamma delta T-cell receptors (TCR).
Matis (1990)TCRT cellsFinally, the identification of T-cell superantigens and their ability to stimulate T cells on the basis of TCR V beta expression alone has defined a new and distinct type of TCR/ligand interaction.
Liu et al. (2000)TCRT cellsHere, we analyzed the dynamics of TCR:CD3 cell surface expression on resting and antigen-activated T cells.
Shigematsu et al. (1998)TCRT-cellTo clarify whether TCR expression could be restricted on lung T-cell and associate with the HLA type in an organic antigen-driven hyperimmune status, we examined three cases of summer-type HP in one Japanese family.
Shigematsu et al. (1998)TCRT-cellsMETHODS: TCR expression on bronchoalveolar lavage (BAL) fluid T-cells was analyzed with 13 TCR V gene specific monoclonal antibodies.
Yachie et al. (1989)TCRT cellsThe results suggested that double-negative T cells expressing the TCR gamma/delta might play an ontogenically unique role in the development of the T cell functions.
Bonefeld et al. (2003)TCRT cellsIn this study, we used transfected T cells expressing two different TCR to analyze whether comodulation took place.
van der Veken et al. (2009)TCRT cellsHowever, the introduction of additional TCR chains into T cells leads to the generation of T cells with unknown specificity, due to the formation of mixed dimers between the endogenous and introduced TCR chains.
Schrum et al. (2000)TCRT cellWe report that within 24 h of stimulation, the level of surface TCR expression becomes dependent on the degree of CD28 signaling provided during T cell activation.
Schrum et al. (2000)TCRT cellFurthermore, engagement of newly expressed TCR on activated T cells re-induces CD69, suggesting participation of these replenishing TCR in continued T cell signaling.
Rubin and Kretz-Rommel (1999)TCRT cellThe molecular basis for this increase in activation threshold is unknown, but observations on differential signaling by peptide analogs, on increased TCR expression during T cell maturation and on energy induction in the absence of costimulation provide promising leads.
Komatsu et al. (1996)TCRT cellsBoth epidermal T cells, termed FDE-1 and -2 cells, respectively, expressed alpha beta TCR, but displayed some phenotypic heterogeneity.
Du Bois et al. (1992)TCRT-lymphocytesControl studies utilizing normal blood T-lymphocytes stimulated with the anti-CD3 monoclonal antibody, OKT3, in the presence of autologous monocytes, demonstrated the expected down-regulation of surface alpha beta TCR expression and increased beta-chain mRNA transcript number.
Amariglio et al. (2010)TCRT-cellA comprehensive T-cell immune workup, including TCR excision circles (TRECs) and TCR repertoire analyses, was performed in three patients with various degrees of severity of T-cell immunodeficiency.
Komatsu et al. (1996)TCRT cellsNo information however, is available regarding the TCR repertoire of these T cells and their relevant physiologic and pathologic functions in vivo.
Bobisse et al. (2007)TCRT cellsIn particular, the need to reduce the in vitro expansion phase and to obtain large numbers of tumour-reactive T cells, as a favourable condition for cancer regression, make TCR gene transfer a potentially ideal tool to overcome the limits of adoptive cell therapy strategies.
Allam and Kabelitz (2006)TCRT cellsSuch trans-rearrangements increase the diversity of the immune receptor repertoire and can be expressed as functional chimeric TCR proteins on the surface of T cells.
de Wolf-Peeters and Achten (2000)TCRT-cellMoreover, these nonhepatosplenic gammadelta T-cell lymphomas are essentially not that different from their alphabeta T-cell receptor for antigen (TCR)-expressing counterparts and thus may be incorporated in the established T-cell lymphoma subclasses.
Schnyder et al. (2000)TCRT cellRapid down-regulation of TCR expression in T cell clones upon stimulation indicated a processing-independent activation irrespective of specificity for covalently or noncovalently presented Ag.
Noble (2000)TCRT cellsRearrangement of gene segments occurs in T lymphocytes during thymic development as the T-cell receptor (TCR) is first expressed, allowing T cells to become central regulators of antigen specificity in the acquired immune system.
Olive (1995)TCRT cellsFurthermore, encephalitogenic T cells express TCR with highly restricted V gene usage and consequently specific forms of immunotherapy directed against V gene products have been successful in preventing and treating EAE.
Olive (1995)TCRT cellsThese findings prompted studies into the analysis of TCR repertoire expression in human autoimmune diseases in an attempt to identify the TCR usage of autoreactive and potentially pathogenic T cells.
Utz and McFarland (1994)TCRT cellsFindings in the animal model have raised the possibility that demyelination could be produced by CD4+ T cells specific for myelin proteins and expressing a limited set of T cell receptor (TCR) molecules.
Stauss et al. (2007)TCRT cellsBoth, expression of only the introduced TCR chains and the production of naïve T cells may be possible in the future by TCR gene transfer into stem cells.
van Loenen et al. (2010)TCRT cellsBy introducing a TCR, large numbers of T cells with defined antigen (Ag) specificity can be obtained.
Mueller et al. (2010)TCRT cellsUsing a recombinant influenza virus expressing the LCMV gp(33-41) epitope and TCR transgenic CD8(+) T cells with a fixed TCR, we compared responses to the same Ag delivered by mucosal or systemic viral infection.
Kaufmann (1996)TCRT cellsIn humans and most animals, the vast majority of T cells express a TCR composed of an alpha chain and a beta chain, whereas a minor T-cell population is characterized by the TCR gamma/delta.
Gumperz (2004)TCRT cellsCanonical CD1d-restricted T cells have semi-invariant TCR consisting of an invariantly rearranged TCR alpha chain, paired with diversely rearranged TCR beta chains.
Dietrich et al. (2002)TCRT cellsTCR internalization takes place both in resting T cells as part of constitutive TCR cycling, after PKC activation, and during TCR triggering.
Griesser (1995)TCRT cellTCR gene probes in Southern blot experiments and TCR primers for the polymerase chain reaction (PCR) help to distinguish polyclonal from abnormal clonal T cell proliferations and to monitor clonal disease after treatment.
Matis et al. (1988)TCRT-cellExamination of specificity and TCR expression in antigen-specific long-term T-cell lines derived from these chimeras suggests that bone marrow-derived APC play a role in the selection of T cells for MHC restriction during development, and also profoundly influence the expansion of the TCR repertoire following antigen priming.
Kammertoens and Blankenstein (2009)TCRT cellsEffective adoptive T-cell therapy has become feasible by methods to identify TCR against tumor-associated (self-) antigens with high affinity and to graft a new antigen specificity to patients' T cells by TCR gene transfer.
Gaulard et al. (2003)TCRT-cellT-cell lymphomas expressing the gammadelta T-cell receptor (TCR) are uncommon, although their frequency may be underestimated.
Yamazaki et al. (2001)TCRT cellRecently, a unique subset of lymphocytes designated natural killer (NK) T cells expressing the Valpha24JalphaQ invariant T cell receptor (TCR) has been reported to have a regulatory role in certain autoimmune diseases.
Ueno et al. (2004)TCRT lymphocytesReconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes.
Das et al. (2001)TCRT-cellUsing T-cell receptor (TCR) transfer studies, we show that recognition of antigenic aminobisphosphonates that are known to stimulate human gammadelta T cells in vitro and in vivo (potency: risedronate > alendronate > pamidronate) requires expression of the Vgamma2Vdelta2 TCR and is thus Vgamma2Vdelta2 TCR-dependent.
Hale and Fink (2010)TCRT cellsT-cell receptor (TCR) revision is a process of tolerance induction by which peripheral T cells lose surface expression of an autoreactive TCR, reinduce expression of the recombinase machinery, rearrange genes encoding extrathymically generated TCRs for antigen, and express these new receptors on the cell surface.
Lee et al. (1999)TCRT-cellTo evaluate the function of the transmembrane region of TCR alphabeta chains in TCR internalization, we generated T-cell transfectants expressing the wild type and glycosylphosphatidyl inositol (GPI)-linked form of 2C TCR.
Gardner and Kearse (1999)TCRT cellMost T lymphocytes express on their surfaces a multisubunit receptor complex, the T cell antigen receptor (TCR) containing alpha, beta, gamma, delta, epsilon, and zeta molecules, that has been widely studied as a model system for protein quality control.
Said et al. (1990)TCRT-cellTwenty-nine of 44 cases of T-cell lymphoma expressed TCR (66%).
Alexander-Miller et al. (1994)TCRT cellIn a previous study, T cell clones specific for Ld-tum- complexes displayed very restricted TCR usage and a characteristic TCR motif in the V alpha CDR3 region, predicted to interact with peptide.
Schrum et al. (2000)TCRT cellsWhen T cells are stimulated with high concentrations of strong TCR agonist, engaged TCR are internalized and degraded, resulting in greatly reduced surface TCR levels for up to several days post-stimulation.
Stauss et al. (2007)TCR geneT-cellIn future trials, it may be possible to use TCR gene transfer to equip helper and cytotoxic T cells with new antigen-specificity, allowing both T-cell subsets to cooperate in achieving improved clinical responses.
Kreslavsky et al. (2008)TCRT cellBy tracing the fate of single T cell precursors, this study shows that there is no commitment to either the alphabeta or gammadelta lineage before TCR expression and that modulation of TCR signaling in progeny of a single TCR-expressing cell changes lineage commitment.
Schrum and Turka (2002)TCRT cellsAlthough surface TCR expression can remain low for several days, T cells can still sustain antigenic signaling.
Whittaker (1996)TCRT-cellEach T cell expresses a unique membrane bound T-cell antigen receptor (TCR) which combines with specific antigenic peptides and major histocompatibility complex molecules.
Usuku et al. (1992)TCRT-cellIn addition to allelic variation of TCR genes, immune responses may also be influenced by the repertoire of the TCR molecules that are expressed by responding T-cell populations.
Usuku et al. (1992)TCR geneT-cellIn some situations, pathogenic T-cell responses may involve expression of limited numbers of TCR gene families.
Usuku et al. (1992)TCRT-cellThe efficacy of such therapies will be determined in part by the TCR repertoire expressed in individual disease situations and by the potential for plasticity in the pathogenic T-cell response that may exist.
Thurley et al. (1994)TCRT cellTo further characterize the intramucosal lymphocytes in patients with untreated CD, we compared T cell receptor (TCR) variable region gene expression in small bowel biopsies from patients with CD to that of normal small bowel.
Wagner (2007)TCRT cellRe-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad.
Chaudhri et al. (2009)TCRT cellOur data show that virus-specific CD8+ cytotoxic T lymphocytes (CTL) can transfer their T cell receptors (TCR) to recipient CTL of an unrelated specificity that, as a consequence, gain the antigen specificity of the donor T cell.
de Witte et al. (2008)TCR geneT cellsThese results demonstrate the value of TCR gene transfer to target otherwise nonimmunogenic tumor-associated self-Ags provided that adoptive transfer occurs under conditions that allow in vivo expansion of the TCR-modified T cells.
de Witte et al. (2008)TCRT cellAdoptive transfer of TCR gene-modified T cells has been proposed as an attractive approach to target tumors for which it is difficult or impossible to induce strong tumor-specific T cell responses by vaccination.
Yang et al. (2005)TCRCTLHowever, CTL are derived stochastically through the random gene rearrangements to produce T-cell receptors (TCR), and the relative impact of genetic versus stochastic processes on CTL targeting of HIV and immune-driven viral evolution is unclear.
Okamoto et al. (2009)TCRT cellsHowever, there are potential drawbacks to this strategy: mispairing of the introduced TCR alpha/beta chains with the endogenous TCR subunits and competition of CD3 molecules between the introduced and endogenous TCRs can impair cell surface expression of the transduced TCR, resulting in insufficient function and potential generation of autoreactive T cells.
Degitz and Caughman (1990)TCRT cellsThe gamma/delta TCR is found on a minor population of T cells, and its functional significance needs further characterization.
Jorritsma et al. (2007)TCRT lymphocytesA recent phase 1 trial has demonstrated that the generation of tumor-reactive T lymphocytes by transfer of specific T-cell receptor (TCR) genes into autologous lymphocytes is feasible.
Sireci et al. (2001)TCRT cellsHuman T cells expressing Vgamma9Ndelta2-encoded TCR recognize several nonpeptide phosphoantigens in the absence of major histocompatibility complex restriction.
Korthäuer et al. (1992)TCR repertoireT-cellHowever, when we selectively analysed the TCR repertoire of in vivo pre-activated, interleukin-2 (IL-2)-responsive T cells, significant T-cell/TCR clonality was found in 2 out of 4 patients.