Viewing negative mentions of gene expression of Tcr (D. melanogaster) in T cells

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Yachie et al. (1989)TCRT cellDouble-negative T cells in adult peripheral blood were shown to lack the alpha/beta heterodimers of the T cell antigen receptor (TCR alpha/beta) but express the gamma chain of the TCR (TCR gamma), when examined using the corresponding monoclonal antibodies.
Saito et al. (1989)TCRT cellThese data imply that alpha- and beta-chains do not form well-expressed TCR in a random manner and that limitations on the useful combinatorial association of these chains may significantly affect the functional T cell repertoire.
Torres et al. (2003)TCRT cellsIn contrast to gamma(-) mutants of the human T cell line Jurkat, which were selected for their lack of membrane TCR and are therefore constitutively surface TCR negative, these natural gamma(-) T cells constitutively expressed surface TCR, mainly through biosynthesis of new chains other than CD3gamma.
Meydan et al. (1997)TCRT-cellNo hybrid TCR genes were detected in ten proliferating T-cell clones, indicating that the rate of hybrid TCR gene formation is < 2.0 x 10(-8) per cell per cell division.
Morice et al. (2004)TCRT-cellA normal or reactive conventional T-cell immunophenotype was present in 36 cases; TCR-Vbeta flow cytometric and molecular TCR analyses were negative for clonality in 32 and 27 of these cases, respectively.
Aarnoudse et al. (2002)TCRNFATFor this purpose, a TCR-negative Jurkat T-cell line was equipped with a nuclear factor of activated T cells (NFAT)-luciferase reporter construct to allow measurement of TCR-mediated activation.
Chim et al. (2001)TCRT-cellThe other patient was EBER negative with rearranged TCR, consistent with NK-like T-cell lymphoma.
Raulf et al. (1994)TCRT-cellsA small population of T-cells does not express the conventional T-cell receptor (TCR), characterized by the alpha and beta polypeptide chains (alpha/beta TCR) but two polypeptides termed gamma and delta (gamma/delta TCR).
Leignadier et al. (2008)TCRT-cellTm cells have the ability to survive in the absence of the T-cell receptor (TCR)-MHC interaction.
Glaichenhaus et al. (1991)TCRT cellMutant T cell lines that do not express the endogenous alpha- and/or beta-chain genes of the TCR were generated from the alpha beta TCR/CD3+ tumor cell line C6VL with a combination of classical mutagenesis methods and selection of somatic hybrid variants.
Sumida et al. (1997)TCRT cellsStudies on the TCR repertoire of T cells in several inflamed lesions of SS patients have shown that there exist no unique TCR V family genes, although TCR V gene usage is relatively restricted.
Arnaud et al. (1997)TCRT-cellT-cell antigen receptor (TCR) membrane-negative T-cell mutants can be divided into two groups: 1) those which lack one of the six TCR polypeptides and 2) those which contain a mutated TCR chain.
Wolff et al. (1993)TCRT cellsThis was examined in CD4-negative T cells transfected with cDNA encoding the D10 TCR.
Taniguchi et al. (1996)TCRT cellsSurprisingly, the invariant V alpha 14+ TCR is exclusively expressed on NK T cells but not on conventional T cells.
Petersson et al. (2003)TCRT cellsIn this study, RT-PCR was used to show that SEH stimulates human T cells via the Valpha domain of TCR, in particular Valpha10 (TRAV27), while no TCR Vbeta-specific expansion was seen.
Caldwell et al. (1995)TCRT cellsEarly in the course of antibiotic treatment (48-72 hours), the lymphocytopenia corrects itself and is rapidly followed by a lymphocytosis of T cells that express CD3, but are negative for CD4 and CD8, as well as the major form of the TCR formed by the alpha/beta heterodimer.
Simark-Mattsson et al. (1994)TCRT cellsIn contrast, T cells in Candida-induced lesions did not express a biased TCR distribution, and most V-families studied appeared in frequencies of 0-6%.
Roskrow et al. (1998)TCRT-cellAlthough these lines had an abnormal pattern of expansion comparable to EBV-specific CTLs generated from normal donors, their phenotype was normal except for reduced expression of the zeta chain of the T-cell receptor (TCR).
Poppema and Hepperle (1991)TCRT-cellAn additional, unexpected finding was that most large cell T-cell lymphomas did not express TCR despite the presence of cytoplasmic CD3.
Rivas et al. (1989)TCRT cellsRecent reports indicate that a small subpopulation of CD3+ T cells does not express alpha, beta TCR and lacks CD4 and CD8 molecules, but expresses another TCR heterodimer designated gamma, delta.
Sun et al. (1992)TCRT-cellThe first case expressed natural killer (NK) cell, some T-cell (CD 2, CD 5, CD 8), and HLA-DR antigens, but was negative for other T-cell (CD 3, CD 4, CD 7), T-cell receptor (TCR), B-cell, and myeloid antigens.
Fischer et al. (1995)TCRT cellsEighty-three to ninety-three percent of the patient's CD4+ T cells in the peripheral blood and 70% of the CD4+ T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2).
Boulland et al. (1997)TCRT-cellIn order to investigate this possibility, 60 cases of PTCL, including 27 cases expressing the alpha beta T-cell receptor (TCR alpha beta), 15 TCR gamma delta cases and 18 cases expressing neither TCR (TCR silent), as well as 14 cases of NK-cell lymphomas, were studied by immunohistochemistry for the expression of TIA-1, perforin, and granzyme B proteins.
Shivakumar et al. (1989)TCRT cellsAnother minor set of T cells found in the periphery are CD4-/CD8- (double negative) and express the gamma/delta TCR; these cells can manifest MHC-restricted or nonrestricted cytotoxicity but no helper function.
Fischer et al. (1995)TCRT cellsAlthough mRNA for the TCR constant region beta 1 was found in the patient's purified CD4+ TCR-CD3- T cells, no intracytoplasmic TCR beta protein was detectable.
Caspar-Bauguil et al. (1994)TCRT cellsFunctionally important amino acids in the TCR revealed by immunoselection of membrane TCR-negative T cells.
Schaft et al. (2003)TCRT lymphocytesThe finding that two gp100-specific TCR, derived from two different CTL, can be functionally introduced into primary human T lymphocytes without loss of the Ag reactivity and peptide fine specificity, holds great promise for the application of TCR gene transfer in cancer immunotherapy.
de Waal Malefyt et al. (1990)TCRT cellThis HTLV-I-infected T cell clone (827-p19-II) that could be cultured in the absence of IL-2 lacked the CD3 proteins but did express the TCR-alpha and -beta proteins intracellularly.
Spruyt et al. (1991)TCRT cellHowever, CD2 seems unlikely to interact directly with the second messenger pathways since signaling via CD2 is poor in T cells that lack the T cell receptor (TCR) and is absent in L cells or insect cells that express CD2.
Waaga et al. (1998)TCRT-cellAdoptive transfer of T-cell clones expressing TCR Vbeta9 or Vbeta8.2, but not Vbeta4, to naive LEW animals elicited significant delayed-type hypersensitivity responses after challenge with the RT1.Dubeta20-44 peptide or allogeneic WF (RT1u) splenocytes.
Höhn et al. (2002)TCRT cellsMonoclonal TCR transcripts could be detected exclusively in CD8+, but not in CD4+ T cells.
Strickland et al. (1996)TCR-associatedT cellsHowever, the 'suppressed' T cells fail to up-regulate CD2, and do not re-express normal levels of TCR-associated molecules after initial down-modulation; moreover, they are unable to transduce IL-2 signals leading to phosphorylation of IL-2R-associated proteins, and remained locked in G0/G1.
Joyce et al. (1997)TCRT-cellTR signaling was enhanced in a TCR-negative Jurkat line and in T-cell lines deficient in the tyrosine kinase lck or the tyrosine phosphatase CD45, both of which are essential for normal TCR function.
Gounari et al. (2001)TCRT cellsWe report here that conditional stabilization of beta-catenin in immature thymocytes resulted in the generation of single positive T cells that lacked the alpha beta TCR and developed in the absence of pre-TCR signaling and TCR selection.
Okada et al. (2003)TCRT-cellThe lymphoma cells were positive for CD2, CD3, CD5, CD8, and T-cell receptor (TCR) beta F1, but negative for CD4, CD19, CD20, CD103, and CD56.
Kato et al. (1999)TCRT-cellNK cells also have phenotypic and genotypic characteristics; they express the NK-related antigen CD56 and T-cell markers such as CD2 and CD3 epsilon, but their T-cell receptor (TCR) locus is not rearranged.
Fields et al. (1996)TCRT lymphocytesStimulation of interleukin-2 producing T lymphocytes via the T cell receptor (TCR) complex in the absence of other costimulatory factor results paradoxically not in activation but in an unresponsive state termed clonal anergy.
Anderson et al. (1989)TCRT cellNK cells do not express cell-surface CD3, or any known target recognition structure analogous to the T cell antigen receptor (TCR) heterodimers (alpha beta or gamma delta).
Aoyama et al. (2001)TCRT cellExamination for surface antigens on lymphoma cells revealed a unique phenotype, positive for CD3 and T cell receptor (TCR) gamma/delta, but negative for CD2.
Bartelt et al. (2009)TCRT cellsInterestingly, Jurkat E6.1 T cells and APBTs had no detectable difference in the TCR-induced phosphorylation of tyrosine 775 on PLC?
Riberdy et al. (2001)TCRT cellsThe great majority of these influenza-specific CD8(+)IFN-gamma(+) T cells neither stained with the cognate tetramer nor expressed the TCR Vbeta bias that is characteristic of the CD8(+) set expanded in vivo during an infection.
Larkin et al. (2007)TCRT cellsMoreover, suppression could be efficiently activated by peptide analogs that were inefficient at inducing CD69 up-regulation, and that also induced little or no proliferation of naïve CD4+ CD25- Foxp3- T cells expressing the same TCR.
Weiss et al. (1988)TCRT-cellOur results suggest that certain cases of peripheral T-cell lymphoma may lack rearrangements of TCR genes--particularly those cases expressing restricted numbers of T-lineage antigens.
Maïza et al. (1993)TCRT cellHowever, unlike gamma/delta+ T lymphocytes, NK cells do not express CD3/T cell receptor (TCR) molecules, and the receptors involved in cell-mediated cytotoxicity are unknown.
Tsutsumi et al. (1997)TCRT cellT cell receptors (TCR), surface CD3, CD4, CD5 and CD8 were not expressed.
Loh et al. (1994)TCRT cellWe have established an experimental system to analyze the recognition properties of human TCR-gamma delta on a molecular level by transferring the receptor from its original T cell into a Jurkat T cell host that does not express an endogenous TCR.
Takahashi et al. (1990)TCRT-cellAlthough S100 beta TLC expressed CD3 antigen, they were negative for the alpha/beta and gamma/delta T-cell antigen receptor (TCR) defined by monoclonal antibodies (mabs) WT-31 and delta TCS-1, respectively.
Vandenberghe et al. (1992)TCRT cellCD28-induced tyrosine phosphorylation was independent of the TCR because it occurred in a variant of the Jurkat T cell line that does not express the TCR.
Han et al. (1999)TCRT cellsInvariant or highly conserved TCR alpha are expressed on double-negative (CD3+CD4-CD8-) and CD8+ T cells.
Hassan et al. (2006)TCRT-cellNeoplastic cells had a CD45RO+, CD2+, CD7+, CD3+, CD5-, CD8+, CD56+, perforin+, FasL-negative, T-cell receptor (TCR)alphabeta-negative, TCRgammadelta+ profile.
Haregewoin et al. (1989)TCRT cellsA small percentage of T cells, however, do not express alpha beta but a second type of TCR complex designated gamma delta (ref. 2).
Bank et al. (2001)TCRT-cellsThree of four had elevated IgE, thrombotic manifestations and lung involvement (asthma and/or infiltrates), and one had deforming sero-negative arthritis of the hands. 66-95% of their peripheral T-cells expressed CD4 but not CD3 or TCR molecules on the cell surface membrane.
Hyakuna et al. (2004)TCRT cellT cell receptor (TCR) and Immunoglobulin heavy chain genes were not rearranged.
Corre et al. (2001)TCRT cellActivation of Rho is thus not sufficient to induce pre-T cell differentiation or survival in the absence of the pre-T cell receptor (TCR).
Mingari et al. (1987)TCRT-cellSince previous studies indicated that PHA may be inefficient in inducing lymphokine production by T-cell variants lacking the CD3/T cell receptor complex (TCR), CD3- clones were further stimulated with the calcium ionophore A23187 plus phorbol 12-myristate 13-acetate (PMA).