Viewing affirmative mentions of gene expression of Ifng (R. norvegicus) in T cells

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Charteris and Lightman (1992)IFN-gammaT cellsThe in vivo production of interferon-gamma (IFN-gamma) by these T cells was investigated immunohistochemically and by in situ hybridization using a cDNA probe to rat IFN-gamma mRNA.
Thyagarajan et al. (1999)IFN-gammaT lymphocytesRelative to saline-treated controls, treatment with deprenyl reduced tumor growth, increased NE concentration, IFN-gamma production and percentage of the CD8+ T lymphocytes in the spleen.
West et al. (1998)gamma-interferonT-cellThe morphine injection suppressed measures of splenic natural killer (NK) cell activity, mitogen-stimulated T-cell proliferation, and gamma-interferon (IFN) production in rats that received saline via the minipump.
Faas et al. (2006)IFNgammaT-lymphocytesThis increased IFNgamma production in pregnant T-lymphocytes was accompanied by an increase during pseudopregnancy, and therefore may result from increased sex hormone concentrations.
Chen et al. (2001)IFN-gammaT cellsMemory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV).
Isogai et al. (2007)interferon-gammaT cellsWe have previously shown that CD8(+)gammadelta T cells decrease late allergic airway responses, airway eosinophilia, T helper 2 cytokine expression and increase interferon-gamma (IFN-gamma) expression.
Hauer et al. (2006)IFN-gammaT lymphocytesThe manufacturers of immunologic test methods such as the QuantiFERON-TB Gold In-Tube (ELISA assay) and the T SPOT-TB Test (ELISPOT assay), which are based on the Interferon-gamma (IFN-gamma) production of sensitized T lymphocytes, offer their products as possible alternatives.
Suda et al. (1995)IFN-gammaT cellsThese results suggest that various pathological conditions causing the local production of IFN-gamma may increase class II antigen expression on BECs, which in turn may modulate the airway mucosal immune response by the presentation of antigens to T cells.
Mustafa et al. (1991)IFN-gammaT cellsTo study the numbers of primed T cells that in response to myelin antigens produced IFN-gamma, mononuclear cell suspensions from peripheral lymphoid organs were precultured to allow for antigen uptake, presentation and T cell triggering, followed by enumeration of IFN-gamma-sc.
Shi et al. (2004)interferon-gammaT lymphocytesBy observing the production of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) released by peripheral T lymphocytes in asthmatic rat models, this study was designed to clarify the changes of T lymphocytes during the course of airway inflammation.
Shi et al. (2004)IFN-gammaT lymphocytesThe influence of dexamethasone pre-treatment on the production of IFN-gamma and IL-4 by T lymphocytes was also investigated in the study.
Al-Zamel (2009)IFN-gammaT lymphocytesImmunologic tests (QuantiFERON and T-SPOT.TB), which measure the production of IFN-gamma by TB-specific T lymphocytes after encountering M. tuberculosis antigens, have certain advantages over the conventional tests, but they also have their disadvantages and unanswered questions.
Denkers (1999)IFN-gammaT lymphocytesImmunity to the opportunistic pathogen, Toxoplasma gondii, is highly dependent upon the effector activity of IFN-gamma-producing T lymphocytes.
Vikingsson et al. (1994)IFN-gammaT cellFurthermore, we suggest that analysis of ex vivo IFN-gamma production at the single cell level may reflect more accurately T cell IFN-gamma production, by avoiding the polyclonal stimulation of IFN-gamma production observed after short term in vitro stimulation.
Kloppenburg et al. (1993)IFN-gammaT-cellsThe antiproliferative effect of minocycline in cloned synovial T-cells is demonstrated; moreover IFN-gamma production in cloned synovial T-cells is inhibited by minocycline.
Schmidt et al. (1992)gamma-interferonT-cellTransient cellular expression of gamma-interferon in myelin-induced and T-cell line-mediated experimental autoimmune neuritis.
Ribera et al. (1988)interferon gammaT-lymphocytesIt has been observed that T-lymphocytes of patients with tuberculosis produce interferon gamma (IFN gamma) in vitro.
Kitazawa et al. (2008)interferon-gammaT-cellThe increase of Foxp3 expression and polarization toward a Th2 cytokine profile correlated with decreased production of interferon-gamma and increased production of interleukin-4 and -10 in the expanded CD4(+)CD25(+) Treg subset, which was capable of suppressing CD4(+)CD25(-) T-cell proliferation after purification.
Taieb et al. (2007)IFN-gammaT cellFL DC-activated T cells produced large amounts of IFN-gamma/IL-10 and exhibited late T cell apoptosis/necrosis.
Zheng et al. (2006)IFN-gammaT cellModification of the CCL2 DNA vaccine by replacing a surface loop region of CCL2 sequence with tetanus toxoid T helper epitope P30 elicited a strong self-specific CCL2 autoantibody production, as well as an IFN-gamma-producing T cell cellular response.
Xystrakis et al. (2004)IFN-gammaT cellsUpon in vitro stimulation, in an Ag-presenting cell-independent system, CD45RC(high) CD8 T cells produce IL-2 and IFN-gamma while CD45RC(low) CD8 T cells produce IL-4, IL-10, and IL-13.
Chiffoleau et al. (2002)IFNgammaT-cellFurthermore, when T cells from naive animals were stimulated in vitro, using anti-CD3 and anti-CD28, LF15-0195 also increased T-cell proliferation in a dose-dependent fashion: however, these cells expressed less of the Th1 -related cytokines, IFNgamma and IL2, compared with untreated cells, suggesting that LF15-0195 could act on T-cell differentiation.
Weissert et al. (2001)IFN-gammaT cellsHowever, CNS-infiltrating lymphoid cells displayed high IFN-gamma, TNF-alpha, and IL-4 mRNA expression suggesting a localization of peptide-specific reactivated T cells in this compartment.
Wolf and Swanborg (2001)IFN-gammaT-cellThe purified NK cells inhibit T-cell proliferation in a dosage-dependent fashion and suppressed production of the proinflammatory Th1 cytokine, IFN-gamma.
Saoudi et al. (1995)IFN-gammaT cellAn anti-ovalbumin T cell line that produced IL-4 and low amounts of IFN-gamma was used as a control and did not induce autoimmunity.
Mustafa et al. (1994)IFN-gammaT cellsWe discovered the following: 1) The class II region of the MHC a haplotype permits EAE and a Th1 type of immune response as measured by IFN-gamma production after in vitro challenge of in vivo-primed T cells with MBP 63-88. 2) The class II region of the u haplotype is associated with a disease-protective immune response characterized by production of not only IFN-gamma, but also of IL-4 mRNA expression by the MBP 63-88-activated cells. 3) The class I region upstream of the class II region of the u haplotype is associated with a disease-protective effect and the expression of mRNA for TGF-beta after MBP 63-88-induced activation.
Karin et al. (1994)interferon gammaT cellReversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.
Mathieson et al. (1993)interferon gammaT cellsThe monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon gamma and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly producing IL-4 and -5 and responsible for providing B cell help.
Xiao et al. (2004)IFN-gammaT cellsIFN-gamma-DC triggered an antigen-specific IFN-gamma production, and induced apoptosis of CD4(+) T cells possibly through DC expressing indoleamine 2,3-dioxygenase and/or an IFN-gamma-dependent pathway.
van der Meide et al. (1993)IFN-gammaT cellThe data stress the importance of GSH in the enhancement of IL-2-mediated IFN-gamma production and are most consistent with a model in which mercury interferes with T cell IFN-gamma production by affecting the intracellular availability of GSH.
Nishimura et al. (2004)interferon-gammaT cellsTrypanosome-derived lymphocyte-triggering factor (TLTF) produced by Trypanosoma brucei brucei stimulates production of interferon-gamma (IFN-gamma) by CD8+ T cells, and it is reported that, in turn, IFN-gamma stimulates proliferation of T. b. brucei.
Blanc et al. (2008)interferon gammaT cellsIn vitro assays that measure the interferon gamma production by T cells incubated with specific antigen of Mycobacterium tuberculosis may be useful in the diagnosis of tuberculosis in children.
Ustinov et al. (1993)interferon-gammaT cellsThe induction of major histocompatibility complex antigens is thought to be mediated by interferon-gamma produced by activated T cells during the infection.
Matsubayashi et al. (1990)IFN gammaT cellThus, increased in vivo production of IFN gamma in Graves' disease as evidenced in these serum concentrations might reflect T cell activity, but does not appear to be an accurate reflection of intrathyroidal events.
Nie et al. (2009)IFN-gammaT cellIn conclusion, our data demonstrated that application of statins could induce immunosuppressive effect and prolong allografts survival through inhibiting activation and proliferation of T cell and reducing production of IL-2 and IFN-gamma.
Madden et al. (2000)IFN-gammaT cellIn 3-month-old rats, no alterations in spleen cell Con A-induced T cell proliferation, IL-2 or IFN-gamma production were observed up to 15 days after sympathectomy, when splenic NE was maximally depleted.
Pang et al. (2004)IFN-gammaT lymphocytesThe expression pattern of IFN-gamma and IL-4 were observed at mRNA level in T lymphocytes isolated from spleen by RT-PCR.
Doukas and Mordes (1993)IFN-gammaT cellsIt was acquired before the onset of insulitis but subsided after the onset of diabetes. 3) In contrast, neither unsorted total T cells nor in vitro-purified RT6- T cells activated EC. 4) Older DR rats depleted of RT6+ T cells did not become diabetic and their RT6- T cells did not activate EC. 5) T cell IFN-gamma production correlated with the intensity of EC activation. 6) direct T cell-EC contact was required for maximal IFN-gamma production and EC activation.
Miyake et al. (2002)IFN-gammaT cellsWe used flow cytometric detection of intracellular cytokines to identify CD4(+) T cells producing IFN-gamma.
Miyake et al. (2002)IFN-gammaT cellsThe level of IFN-gamma and the percentage of IFN-gamma-producing CD4(+) T cells were lower in individuals with genotype 114 +/+ than in individuals with genotype 114 -/-.
Mustafa et al. (1993)IFN-gammaT cellsFurthermore, anti-myelin and anti-MBP secreting cells were increased as were numbers of primed T cells that produced IFN-gamma in response to myelin antigens.
Pahlavani and Harris (1997)IFN-gammaT cellsThe ConA-induced lymphocyte proliferation and IL-2 expression were significantly lower and induction of IFN-gamma production was significantly higher in splenocytes and purified T cells isolated from old rats compared to splenocytes and T cells isolated from young rats.
Eneroth et al. (1992)interferon-gammaT-cellsThe extracellular haemoflagellate Trypanosoma brucei brucei releases a factor, which can induce CD8+ T-cells to produce interferon-gamma.
Klemm et al. (1998)IFN-gammaT cellsThus, there is an accumulation of T cells with an increased potential to produce IFN-gamma in the lung interstitium and the bronchoalveolar space during pulmonary immune responses.
Shi et al. (2004)IFN-gammaT lymphocytesOBJECTIVE: To observe the production of IFN-gamma and IL-4 released in peripheral T lymphocytes in asthmatic patients and rat models and to clarify the dynamic changes of proliferation and differentiation of T lymphocytes during the progress of airway inflammation.
Koehne et al. (2002)interferon-gammaT cellsQuantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon-gamma production and growth of cytotoxic precursors.
Koehne et al. (2002)IFN-gammaT cellsWe compared frequencies of Epstein-Barr virus (EBV)-specific and major alloantigen-reactive T cells as measured by flow cytometric analysis of responding T cells producing intracellular interferon-gamma (IFN-gamma) and by limiting-dilution analysis (LDA) of cytotoxic T-cell precursors (CTLp) at sequential time points during the generation of EBV-specific T-cell lines.
Koehne et al. (2002)IFN-gammaT cellsThe assay that quantitated T cells producing IFN-gamma yielded more reproducible and precise results than LDA.
Koehne et al. (2002)IFN-gammaT cellsFurthermore, frequencies detected by the enumeration of T cells responding to immunodominant EBNA 3a and EBNA 3c peptides by IFN-gamma production or their capacity to bind peptide-HLA tetramers were strikingly similar and represented significant fractions of T cells generating IFN-gamma in response to autologous EBV B lymphoblastoid cell line.
Nelson et al. (2000)cytokine IFN-gammaT-cellResults showed that naltrexone attenuated the surgery-induced decrease in natural killer cell cytotoxicity, B-cell proliferation, T-cell proliferation, and production of the cytokine IFN-gamma.
Hansson et al. (1988)gamma-interferonT lymphocytesThese results suggest that gamma-interferon, a secretory product of activated T lymphocytes, acts as a natural regulator of smooth muscle cell growth and Ia expression in injury-induced intimal thickenings and atherosclerotic plaques.
Kagami et al. (1998)IFN-gammaT cellsThis same cell population was depleted of CD8+ T cells and found to produce less interferon-gamma (IFN-gamma) after virus challenge.
Sawitzki et al. (2004)IFN-gamma mRNAT cellsIn contrast, anti-CD4-treated alloactivated T cells showed similar IFN-gamma mRNA expression as untreated alloactivated T cells but did not secrete any protein.
Sawitzki et al. (2004)IFN-gamma mRNAT cellsThus, the anti-CD4 antibody cannot prevent IFN-gamma mRNA expression but is interfering with posttranscriptional mechanisms that control IFN-gamma production during alloactivation of T cells.
Sawitzki et al. (2004)IFN-gammaT cellsAddition of IL-2 but not IL-15 to anti-CD4-treated alloactivated T cells restored IFN-gamma protein production without leading to enhanced IFN-gamma mRNA expression.
Lolli et al. (1993)IFN-gammaT cellsWe measured the production of interferon-gamma (IFN-gamma) from single T cells and the T cell proliferative response to different cytomegalovirus (CMV) antigens in healthy blood donors and bone marrow transplant recipients.
Lolli et al. (1993)IFN-gammaT cellThe T cells reacted to CMV na in CMV seropositive blood donors both with the production of IFN-gamma and with proliferation, while bone marrow transplant recipients had a deficient T cell response.
Suzuki et al. (2002)IFN-gammaT cellsOBJECTIVE: To test the hypothesis that the suppression of LARs and airway eosinophilia by CD8+T cells is IFN-gamma mediated, we tested the effects of adoptively transferred CD8+T cells, in which IFN-gamma synthesis was inhibited by an antisense (AS) oligodeoxynucleotide (ODN), on the airway responses of a rat model of allergic asthma.
Suzuki et al. (2002)IFN-gammaT cellsCD8+T cells (2 x 10(6)) were incubated for 6 hours with 2 micromol/L AS ODN or sense ODN and were injected intraperitoneally into recipients; inhibition of IFN-gamma expression in vitro by AS ODN was shown by means of flow cytometry.
Bernard et al. (1998)interferon-gammaT cellsFlow cytometric analysis of intracellular interferon-gamma synthesis in rat CD4 T cells.
Bernard et al. (1998)IFN-gammaT cellsIn the present work, we show that DB1, a mouse anti-rat IFN-gamma monoclonal antibody, could be used for intracytoplasmic staining of IFN-gamma producing rat CD4 T cells.
Lorenz et al. (2002)IFN-gammaT cellsELISPOT analysis showed that 25% of ASNHL patients have significant increased frequencies of inner ear specific IFN-gamma producing T cells in their PBMC.
Lorenz et al. (2002)IFN-gammaT cellsOur results implicate inner ear specific IFN-gamma producing proinflammatory T cells in the pathogenesis of ASNHL.
van der Meide et al. (1993)interferon-gammaT cellMercuric chloride down-regulates T cell interferon-gamma production in brown Norway but not in Lewis rats; role of glutathione.
Ferrara et al. (2009)IFN-gammaT cellsWhen amounts of IFN-gamma were corrected for the number of producing T cells, specific IFN-gamma production was significantly different between exposed and unexposed individuals (16.75+/-5.40 vs 2.33+/-0.71 IFN-gamma IU/1000 SFC, p=0.0001).
Song et al. (2006)IFN-gammaT cellsThese findings indicate that FTY720 effectively reduced recirculation of activated donor-derived T cells and recruitment to target organs in GVHD, and was also associated with down-regulated IFN-gamma production.
Diaz-Sanchez et al. (1993)IFN-gammaT cellsIFN-gamma production by phytohaemagglutinin (PHA)- or ionomycin and phorbol myristate acetate (PMA)-stimulated splenocytes or purified splenic T cells from animals immunized with antigen and ricin was substantially reduced as compared with animals which were given saline or antigen alone (P < 0.001 Student's t-test).
Fukushima et al. (2003)IFN-gammaT cellsBN T cells contained interleukin (IL)-4 and IFN-gamma, while Lewis T cells expressed no IL-4.
Noble and Kemeny (1995)IFN-gamma-producingT lymphocytesWe have compared the ability of rat IL-4 to regulate IFN-gamma secretion in short-term cultures of spleen cells with its effect on the differentiation of T lymphocytes into IFN-gamma-producing, or Th1-type, cells.
Lilje and Armati (1999)IFN-gammaT cellsAs stimulated CD4(+) P(2) T cells produce IFN-gamma and TNF-alpha, this could exacerbate blood nerve barrier breakdown that has been increasingly implicated in inflammatory demyelinating neuropathies (IDNs).
Dong et al. (2010)interferon-gammaT cellsCONCLUSIONS: Intestinal bifidobacteria could promote the maturation of dendritic cells and its expression of IL-12 locally in the gut, influence the development of T cells in the thymus, favour the development of T-helper cell type 1 response by increasing the local and systemic expression of interferon-gamma and ensure the intestinal regulatory T cell response by promoting the local expression of IL-10.
Pahlavani et al. (2002)IFN-gammaT cellThe number of splenic T cell populations and T cell subsets was measured by flow cytometry, the proliferative response of splenocytes to Concanavalin A (Con A) and lipopolysaccharide (LPS) was measured by [(3)H]thymidine incorporation, and the induction of cytokine production (IL-2 and IFN-gamma) was measured by ELISA assay.
van der Meide et al. (1991)interferon-gammaT cellAssessment of the inhibitory effect of immunosuppressive agents on rat T cell interferon-gamma production using an ELISPOT assay.
Carvalho et al. (2002)IFN-gammaT-cellOBJECTIVES: To evaluate the T-cell response in patients with RVC and the ability of cytokines and cytokine antagonists to modulate IFN-gamma production in cultures stimulated with Candida albicans antigens.
Gonsky et al. (2009)IFNGT-cellHowever, LP T-cell DNA derived from IBD patients displayed different levels of IFNG methylation of the upstream regulatory regions compared to DNA from normal controls.
Moss et al. (2002)IFN-gammaT-cellSupernants from peripheral blood mononuclear cells (PBMCs) were assayed from newborns at 4 weeks of age for HIV-specific interferon-gamma (IFN-gamma), HIV-specific regulated on activation, normal, T-cell expressed, and secreted (RANTES), and serum for p24 antigen-specific immunoglobulin G (IgG) production.
Shi et al. (2004)IFN-gammaT lymphocytesThe production of IFN-gamma and IL-4 by T lymphocytes in the asthmatic model was inhibited significantly by dexamethasone.
Alfrey et al. (1995)IFN-gammaT cellThe in vitro responses of tolerant animals demonstrated donor-specific suppression of the MHC class II response but an intact (normal) response to third party stimulators by proliferation assays and IFN-gamma production, suggesting suppression at the CD4+ T cell subset level.
Nakamoto et al. (1993)interferon-gammaT lymphocytesIn this P. carinii pneumonia animal model, both sulfamethoxazole-trimethoprim clinically established anti P. carinii drug and interferon-gamma which is one of the lymphokines mainly produced by T lymphocytes indicated therapeutic and synergistic efficacy against P. carinii pneumonia.