Viewing affirmative mentions of gene expression of Il10 (R. norvegicus) in T cells

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Xiao et al. (2006)IL-10T cellIntraperitoneal administration of IL-10-DC suppressed clinical scores, anti-acetylcholine receptors (AChR) antibody secreting cells, antigen-specific IL-10/IFN-gamma production and T cell proliferation compared to control EAMG rats.
Matar et al. (2001)IL-10T-cellDown regulation of T-cell-derived IL-10 production by low-dose cyclophosphamide treatment in tumor-bearing rats restores in vitro normal lymphoproliferative response.
Matar et al. (2001)IL-10T-cellMoreover, our results suggest that the shift from immunosuppression to immunopotentiation induced by treatment of tumor-bearing rats with a single low-dose of Cy is mediated by a reduction in T-cell derived IL-10 production, which would account, to some extent, for the antimetastatic effect of Cy treatment.
Kim et al. (2002)Interleukin-10T cellsInterleukin-10 (IL-10), an immunosuppressive cytokine, is produced by monocyte/macrophage lineage cells, T cells, and B cells in the immune system.
Brandt et al. (2005)vIL-10T-cellLewis rat T-cell lines specific for DA rat alloantigens were engineered to express vIL-10 by using a retroviral gene expression system.
Satpute et al. (2009)IL-10T cellsThe production of interferon-gamma (but not IL-4/IL-10) was increased, with concurrent down-regulation of IL-17 expression by mycobacterial Hsp65-primed T cells.
Urosevic et al. (2002)interleukin-10T-cellHLA-G protein up-regulation in primary cutaneous lymphomas is associated with interleukin-10 expression in large cell T-cell lymphomas and indolent B-cell lymphomas.
Urosevic et al. (2002)IL-10T-cellBecause the up-regulation of HLA-G, a nonclassical class Ib molecule inducible by IL-10, might account for the immunescape of the malignant clone, HLA-G and IL-10 expression has been investigated in 45 cases of primary CL (10 of B-cell and 35 of T-cell origin) with quantitative polymerase chain reaction (PCR) and immunohistochemistry.
Li et al. (2005)IL-10T cellsPurified DCs from S2-16:IFA-treated rats promoted S2-16-reactive CD4+ T cells to produce increased IL-10 and reduced interferon-gamma.
Yao et al. (1997)Interleukin-10T-cellInterleukin-10 expression and cytotoxic-T-cell response in Epstein-Barr-virus-associated nasopharyngeal carcinoma.
Monari et al. (1997)IL-10T cellIL-10, abundantly produced during AIDS progression, could be a negative factor that affects the T cell response through its own immunosuppressive action on antigen-presenting cells.
Choudhry et al. (1999)IL-10T cellsThe present study ascertained the role of PGE2 in sepsis associated modulation of IL-2 and IL-10 production by T cells.
Choudhry et al. (1999)IL-10T cellsSplenic T cells were obtained 48 h after septic or sterile implantations, and their IL-2 and IL-10 production was measured.
Kawakami et al. (2001)IL-10T-lymphocytesInterleukin 10 (IL-10) is an immuno-suppressive cytokine produced by T-lymphocytes, and a regulatory molecule for angiogenesis in various cancers.
Tanaka et al. (1999)IL-10T cellsThese findings suggested that T cells recognizing peptide 234-252 may play a regulatory role in inflammation during AA via the production of suppressive cytokines including IL-10.
Köksoy et al. (2004)IL-10T cellsChronic heart allograft rejection in rats demonstrates a dynamic interplay between IFN-gamma and IL-10 producing T cells.
Alcocer-Varela et al. (1996)IL-10T cellsIn systemic lupus erythematosus (SLE), increased IL-10 production by non-T cells might exert an inhibitory effect on Thl CD4+ T cells which would explain the decreased T cell functions observed in these patients.
Goodman et al. (1992)interleukin-10T cellsSynthesis and characterization of rat interleukin-10 (IL-10) cDNA clones from the RNA of cultured OX8- OX22- thoracic duct T cells.
Sakamoto et al. (2006)Interleukin-10T-cellInterleukin-10 expression significantly correlates with minor CD8+ T-cell infiltration and high microvessel density in patients with gastric cancer.
Sakamoto et al. (2006)interleukin-10T lymphocyteWe aimed to investigate the relationships between interleukin-10 (IL-10) expression and both the clinicopathological findings and prognoses in patients with gastric cancer and to compare IL-10 expression with microvessel (MV) density and CD8+ T lymphocyte infiltration to evaluate its effects on angiogenesis and immune responses in gastric cancer.
Sakamoto et al. (2006)IL-10T-lymphocyteIL-10 expression inversely correlated with CD8+ T-lymphocyte infiltration.
Chiapello et al. (2001)IL-10T cellsThe results presented here indicate that at least two mechanisms mediate the nonspecific suppression in this model of cryptococcosis: IL-10 production and diminution of the number of T cells.
Li et al. (2005)interleukin-10-producingT cellsProtection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells.
Köksoy et al. (2005)IL-10T cellsCD4+CD25+ T cells from secondary long-term graft survivors inhibited donor-specific proliferative responses in vitro that was associated with high IL-10 production.
Weiss et al. (2004)IL-10T-cellIL-10 can influence and potentially treat T1/T2 differentiation, antigen-presenting cell functioning, antigen-presenting cell-mediated T-cell activation, and T-cell, B-cell, and mast cell growth and differentiation that is aberrant in various disease processes.
Qian et al. (2005)IL-10T cellsWe conclude that commensal luminal bacterial components induce exaggerated in vitro IFN-gamma responses in HLA-B27 TG T cells, which may in turn inhibit the production of regulatory molecules, such as IL-10.
Jander et al. (1998)IL-10T cellsBoth in situ hybridization and double labeling immunocytochemistry in combination with confocal microscopy identified T cells, macrophages/microglia, and astrocytes as major cellular sources of IL-10 in vivo.
Mosser and Zhang (2008)IL-10T cellsNew work showing IL-10 production from regulatory T cells and even T-helper 1 T cells has reinvigorated the field and revealed the power of this cytokine to influence immune responses.
Kreft et al. (1992)interleukin-10T cellIn this report we demonstrate that we can detect specific intracellular interleukin-10 (IL-10) in the HT-2 T cell line only after membrane permeabilization.
Brandt et al. (2005)IL-10T lymphocytesLike T regulatory 1 cells, vIL-10 transgenic T lymphocytes express the phenotype CD4(+)25(+) and secrete, in addition to vIL-10, rat IL-10 and IFN-gamma but no IL-4.
Horibe et al. (2008)IL-10T cellsCirculating T cells in hosts with long-surviving grafts were hyporesponsive to donor alloAg stimulation, but proliferated in response to third-party stimulation and produced IFN-gamma and IL-10.
Llorente et al. (1994)IL-10T lymphocytesIn each group, both B lymphocytes and monocytes, but not T lymphocytes, produced IL-10.
Maynard and Weaver (2008)IL-10T-cellIn this review, we highlight established and emerging roles for IL-10 produced by distinct CD4(+) T-cell lineages that underlie its non-redundant role in curbing immune responses to the intestinal microbiota at steady state and its role to limit T-cell-driven inflammation in responses to pathogens.
Adam et al. (2003)interleukin-10T cellsAnalysis of cellular distribution and circulating cytokines demonstrated the persistence of CD4+/CD25+ T cells and high expression of circulating interleukin-10 (IL-10) during the progression of infection in young-susceptible rats, whereas high levels of CD8+ T cells and natural killer T cells are detected in adult-resistant rats.
Tangsinmankong et al. (2002)IL-10T-lymphocytesRecently, we demonstrated that HIV-1 Nef induces IL-10 production in monocytes and that staphylococcal enterotoxin A (SEA) induces IL-10 production in T-lymphocytes.
DiMeo et al. (2008)IL-10T-cellThis may be in part secondary to increased IL-10 production and its effects on dendritic cell function resulting in altered T-cell differentiation.
DiMeo et al. (2008)IL-10T cellsThese findings indicate that, in addition to the central role leukotrienes play in the acute inflammatory response, endogenous leukotrienes are also important regulators of inflammatory cytokine production, via regulation of IL-10 production and in vivo differentiation of T cells.
Schultz et al. (2007)IL-10T lymphocytesReduced IL-10 production and -receptor expression in neonatal T lymphocytes.
Schultz et al. (2007)IL-10T lymphocytesRESULTS: After anti-CD3/anti-CD28 costimulation, IL-10 production of neonatal T lymphocytes was profoundly reduced (median 247 pg/mL vs. 1062 pg/mL, p < 0.0001).
Schultz et al. (2007)IL-10T lymphocytesCONCLUSION: The strongly reduced IL-10 receptor expression on the main immune regulative T lymphocytes in conjunction with a significantly impaired synthesis of IL-10 may play a crucial role in the formerly demonstrated deficient anti-inflammatory immune response in neonates.
Liu et al. (2010)IL-10T lymphocytesIL-10 is produced primarily by macrophages and T lymphocytes.
Lee et al. (2001)IL-10T cellsInterleukin (IL)-2 receptor expression and intracellular IL-10 production were measured using monoclonal antibodies and flow cytometry in CD4 and CD8 T cells.
Fujioka et al. (1998)IL-10T cellsIn order to further analyze the role of these T cells and their corresponding cytokines in EAN, we studied the expression of mRNA for IFN-gamma, IL-4, and IL-10 in the cauda equina of rats with EAN using a quantitative competitive reverse transcriptase PCR method.
Dieleman et al. (2004)IL-10T cellT cell depletion abolished IFN-gamma and decreased IL-12 production, but did not affect IL-10 and TGF-beta production.
Li et al. (2006)IL-10 geneT lymphocyteOn day 21, HE staining was performed to detect the myocardial inflammation and T lymphocyte proliferation assay was used to determine the effects of IL-10 gene transfected iDC on autoreactive T cell proliferation.
Sommandas et al. (2005)IL-10T cellHere we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor apoptosis, a low MHC class II expression, a reduced IL-10 production and a reduced T cell stimulatory capacity of DC.
Caraher et al. (2000)IL-10T-cellsHere we report the optimisation of immunofluorescent staining for cell surface and intracellular antigens using three-colour flow cytometric analysis to measure the frequency of rat CD3(+)4(+) T-cells that produce IFN-gamma, IL-4 and IL-10.
Caraher et al. (2000)IL-10T-cellsIn vitro priming of splenic T-cells with antibodies against CD3 and CD28 and recombinant cytokines (IL-2 and IL-4) for 5 days followed by restimulation with PMA and ionomycin was required to stimulate cells to produce either IL-4 or IL-10.
Tanaka et al. (1999)IL-10T cellsT cells from rats pretreated with peptide 234-252 produced a significant amount of IL-10 in response to the epitope.
Tanaka et al. (1999)IL-10T cellsT cells from rats pretreated with the peptide and immunized with M.tb produced the larger amount of IL-10 in response to the peptide, but only a marginal level of IFN-gamma in response to purified protein derivative of M.tb.
Bento et al. (2009)interleukin-10T-cellFurthermore, high levels of interleukin-10 were produced both systemically and by activated T-cell cultures from G1 patients.
Burastero et al. (2008)interleukin 10T-cellEffect of sublingual immunotherapy with grass monomeric allergoid on allergen-specific T-cell proliferation and interleukin 10 production.
Brandt et al. (2005)IL-10T cellsThese data demonstrate that intra-graft IL-10 over-expression is not sufficient to prolong allograft survival in a high-responder strain combination and that the regulatory capacity of T cells in vitro does not predict their in vivo efficiency.
Harkin et al. (2003)IL-10T-lymphocyteNiCl2 suppressed T-lymphocyte proliferation and Th1 (IFN-gamma) and Th2 (IL-10) cytokine production in a dose- and time-dependent fashion.
Huang et al. (2009)IL-10T-cellUsing an antibody array and enzyme-linked immunosorbent assay, we found that GSK-3-inhibitor treatment blocked LPS-induced upregulation of regulated on activation normal T-cell expressed and secreted (RANTES) and increased IL-10 expression.
Correa et al. (2009)IL-10T cellsStudy of IL-10 production by isolated cell subsets showed that DCs, but not CD4(+) T cells, from penetrating Crohn's disease produced significantly less IL-10 in response to LPS.
Walker et al. (2010)IL-10T cellsSplenocyte characterization indicated an increase in the number and proliferative rate of CD4+ T cells as well as an increase in IL-4 and IL-10 production in stimulated splenocytes isolated from the MAPC treatment groups.
Marshall et al. (1996)IL-10T cellIL-10 is recognized as an important immunoregulatory cytokine with effects on T cell development and the production of inflammatory cytokines.
Ohga et al. (2002)IL-10T cellsIL-10 was exclusively expressed in DN alphabeta but not (gamma)(delta)T cells.
Dong et al. (2010)IL-10T cellsCONCLUSIONS: Intestinal bifidobacteria could promote the maturation of dendritic cells and its expression of IL-12 locally in the gut, influence the development of T cells in the thymus, favour the development of T-helper cell type 1 response by increasing the local and systemic expression of interferon-gamma and ensure the intestinal regulatory T cell response by promoting the local expression of IL-10.
Vendrame et al. (2006)IL-10T-cellAdditionally, splenocyte proliferation assays demonstrated that HUCBC treatment opposed MCAO-associated T-cell proliferation by increasing the production of IL-10 while decreasing IFN-gamma.
van Eden et al. (2003)IL10T cellsSuch T cells were found to produce regulatory cytokines like IL10, in contrast to T cells induced with other conserved microbial proteins that are not upregulated by stress.
Wendling et al. (2000)IL-10T cellsA conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue.
Wendling et al. (2000)IL-10T cellsUpon analysis of cytokines produced by these peptide-specific T cells, high IL-10 production was found, as was the case with T cells responsive to whole hsp70 protein.
Zhang et al. (2004)IL-10T cellsMBP-specific T cells cocultured with E2-treated DCs (E2-DC) produced more IL-10 and less IFN-gamma in the supernatant than those without E2 pretreatment (ctr-DC).
Flores-Mendoza et al. (2008)interleukin-10T-cellThe infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.
El-Sheikh et al. (1999)IL-10T cellsThese results demonstrate that islet infiltration by both CD4(+)and CD8(+)T cells is required for IFN-gamma and IL-10 production in islets and beta-cell destruction.
El-Sheikh et al. (1999)IL-10T cellsDepletion of either CD4(+)or CD8(+)T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and increasing IL-4 and TNF-alpha production systemically.
Noble et al. (1993)IL-10T cellsElimination of IgE regulatory rat CD8+ T cells in vivo increases the co-ordinate expression of Th2 cytokines IL-4, IL-5 and IL-10.
Paul et al. (2000)IL-10T cellsHighly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/IL-10 and IFN-gamma and are protective in adjuvant arthritis.
Subra et al. (2001)IL-10T cellsIn this study, we found that the antiinflammatory cytokines, IL-4, IL-10, and IL-13, are exclusively produced by the CD45RC(low) CD4 T cells.
Taieb et al. (2007)IL-10T cellFL DC-activated T cells produced large amounts of IFN-gamma/IL-10 and exhibited late T cell apoptosis/necrosis.
Xystrakis et al. (2004)IL-10T cellsUpon in vitro stimulation, in an Ag-presenting cell-independent system, CD45RC(high) CD8 T cells produce IL-2 and IFN-gamma while CD45RC(low) CD8 T cells produce IL-4, IL-10, and IL-13.
Zipris (1996)IL-10 mRNAT lymphocytesIncubation of 10 wk old DP islets for 48 h in the presence of anti-CD3 antibody, followed by an incubation with rIL-2 for an additional 5-7 days, results in an expansion of T lymphocytes, and these cells express high levels of IFN-gamma and IL-10 mRNA.
Ikeguchi et al. (2008)IL-10-secretingT-cellAlloAg-pulsed Rapa DC induced T-cell hyporesponsiveness and promoted the generation of IL-10-secreting CD4 T cells upon ex vivo challenge.
Blewett et al. (2009)IL-10T-cellsObese rats had lower proportions of MLN T-cells, new T-cells (CD3+CD90+) and cytotoxic T-cells, but higher proportions of helper cells that were CD45RC+, CD25+ and CD4lo, and produced higher concentrations of IL-2, IL-10, interferon gamma and TNFalpha in response to ConA compared with lean rats.
Noble and Kemeny (1995)IL-10T cellsPurified rat splenic CD8+ and CD4+ T cells and CD4-CD8- cells were stimulated with phorbol myristate acetate (PMA) and ionomycin for 6 h and expression of mRNA for IL-2, IL-4, IL-5, IL-6, IL-10 and IFN-gamma determined using a quantitative PCR technique.
Hara et al. (2007)IL-10T cellExposure of DCs to NK026680 downregulated the interleukin (IL)-12 (p40, p35), interferon-gamma mRNA expression and upregulated IL-10, transforming growth factor-beta, in which impaired the ability of DC to stimulate T cell proliferation.
Goodwill et al. (2009)interleukin-10T-cellHowever, using multivariate discriminant analyses, plasma RANTES (regulated on activation, normal T-cell expressed and secreted), interleukin-10, monocyte chemoattractant protein-1, and tumor necrosis factor alpha were determined to be the strongest contributors to differences between groups, although their relative importance varied with time.
Pettersson et al. (2004)IL-10T cellsAdministration of estrogen-exposed DC prevented the expansion of CD4+ T cells and increased proportions of regulatory T cells producing IL-10 and CD4+CD28- suppressor T cells, accompanied with increased IL-10 and IFN-gamma, and reduced TNF-alpha production.
de Dios et al. (2002)Interleukin-10T-cellsInterleukin-10 was produced by T-cells 6 h after PDO only after PMA/Ionomycin stimulation.
Rudwaleit et al. (2000)IL10T cellsCONCLUSIONS: During treatment of RA with MTX the percentage of TNFalpha producing T cells decreases whereas that of IL10 producing T cells increases.
Drannik et al. (2003)IL-10T-lymphocytesStudies were conducted on effects of different doses of the drug preparations erbisol and super erbisol on the functional activity of type II helpers T-lymphocytes in healthy subjects in respect of in vitro production of interleukine-4 (IL-4) and interleukine-10 (IL-10).
Wang et al. (2009)IL-10T cellsSplenic T cells were isolated and the production and mRNA expression of interleukin (IL)-2, interferon-gamma, IL-4, and IL-10 were assayed.
Liang et al. (2008)IL-10T-cellRESULTS: Posttransplantation treatment of recipients with rh-G-CSF alone prolonged allograft survival, improved allograft biopsy grading scores, and induced alloreactive T-cell hyporesponsiveness accompanied by high levels of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) production in MLR.
Brennan and Foey (2002)IL-10T cellOther workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction.
Langer et al. (2005)IL-10T cellsThe frequencies of IL-10-expressing T cells were lower in cultures from SLE patients.
Langer et al. (2005)IL-10T cellsSmD183-119-induced increases in IL-10-expressing T cells were associated with low anti-dsDNA and anti-SmD183-119 antibody levels in culture supernatants.