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Zheng et al. (1989)CD4T-cellNevertheless, Cr:NIH-nu/nu rats, which are deficient in T-cells, possess virtually identical numbers of CD4 positive staining uterine cells as compared to their nu/+ littermate controls, indicating that the expression of immunoreactive CD4 is associated with a resident non-T-cell population.
Morrison et al. (1989)CD4T lymphocytesSpecific ganglioside binding to receptor sites on T lymphocytes that couple to ganglioside-induced decrease of CD4 expression.
Rabanal et al. (2003)CD4T cellThe aim of the present study was to inhibit CD4 expression in lymphocytes without promoting CD4 synthesis and to determine the effect of this inhibition on CD4+ T cell function.
Liu et al. (2008)CD4T-lymphocytesWe analyzed expression of CD3, CD4, CD8 T-lymphocytes in peripheral blood by flow cytometry and in colonic mucous by immunohistochemistry.
Shu et al. (2008)CD4T cellsThis study was aimed to investigate the expression level of CD4(+) CD25(high) T cells in peripheral blood of patients with idiopathic thrombocytopenic purpura (ITP) before and after treatment and to explore its significance in pathogenesis of ITP.
Shu et al. (2008)CD4T cellsThe expressions of CD4(+) CD25(high) T cells in peripheral blood of 20 ITP patients before treatment, 20 ITP patients after treatment and 14 normal individuals (control) were detected by immunofluorescence and flow cytometry.
Shu et al. (2008)CD4T cellsIn conclusion, the expression of CD4(+) CD25(high) T cells in the ITP group before treatment was evidently lower than that in the control group, which becomes higher than before when the patients showed effective response to the treatment.
Kenny et al. (2000)CD4T cellsAmong peripheral T cells, the expression of CD4 and CD8 is almost mutually exclusive.
Kenny et al. (2000)CD4T cellsPrevious reports of double positive T cells have also suggested that coexpression of CD4 and CD8 is linked to the activation state of the cell.
Kenny et al. (2000)CD4T cellsIn conclusion, these studies show that peripheral T cells expressing both CD4 and CD8 can be detected in the rat and that they are phenotypically distinct from CD4 and CD8 single positive T cells.
Biddison and Shaw (1989)CD4T cellsCD4 expression and function in HLA class II-specific T cells.
Biddison and Shaw (1989)CD4T-cellOur studies of CD4 expression and function on class II-specific T cells indicate that: 1) CD4 expression is generally a marker of T cells that are committed to class II antigen recognition, even when they have cytotoxic function; 2) CD4 is typically involved in the proliferative and cytotoxic function of such cells, which we hypothesized to be due to interaction with a nonpolymorphic determinant on class II; 3) the importance of CD4 to the recognition is most prominent in T-cell interactions with low "avidity"; and 4) although CD4 may play a role in adhesion per se, the majority of its function seems to be in a post-adhesion phase of cytotoxic T-cell recognition.
Seth et al. (2005)CD4T cellChronic infection with the HIV results in poor HIV-specific CD4 T cell proliferation, but more recent analyses using intracellular cytokine staining demonstrated that IFN-gamma-producing, HIV-specific CD4 T cells can be detected for years in HIV-infected subjects.
Saunders and Cooper (2000)CD4T cellsThe generation of prolonged immunity to Mycobacterium tuberculosis requires not only an antigen-specific IFN-gamma-producing T cell response, including both CD4 and CD8 T cells, but also the generation of protective granulomatous lesions, whereby the close apposition of activated T cells and macrophages acts to contain bacterial growth.
van Rossum et al. (2001)CD4T cellCONCLUSIONS: Normalization of the CD4 cell counts in children treated with HAART is independent of age, indicating that children of all age groups can meet their CD4 T cell production demands.
Lannes-Viera et al. (1995)CD4-CD8T cellsEncephalitogenic, myelin basic protein-specific T cells from naive rat thymus: preferential use of the T cell receptor gene V beta 8.2 and expression of the CD4-CD8- phenotype.
Leposavi? et al. (1996)CD4T-cellRats aged 30 days or 75 days were gonadectomized; 30 days later the thymic cellularity was estimated and the expression of the cell surface antigens (CD4 and CD8) and the T-cell receptor (TCR) alpha beta was analyzed by flow cytometry.
Gutt et al. (2001)CD4T lymphocytesWe investigated CD25, CD4, CD8 expression and CD4/CD8 ratio of systemic and peritoneal T lymphocytes in a rat model.
Leposavic et al. (1995)CD4T cellThe relative proportion of thymocytes expressing CD4, CD8 and T cell receptor (TCR)alpha beta was measured in the adult rats castrated at 1, 7 and 30 days.
Bevan and Chisholm (1986)CD4T cellsCo-expression of CD4 and CD8 molecules and de novo expression of MHC class II antigens on activated rat T cells.
Bevan and Chisholm (1986)CD4T-cellRat T-cell populations were analysed for their surface expression of CD4, CD8 and class II MHC antigens using monoclonal antibodies (McAbs) W3/25, Ox8 and Ox6 in immunofluorescence and immunoenzyme cytochemistry.
Bevan and Chisholm (1986)CD4T cellsIn addition, T cells activated by either alloantigen or lectin expressed CD4 (W3/25) and CD8 (Ox8) molecules simultaneously: 30% of cells activated in MLR and 50% of Con A-activated cells expressed both markers within 48 hr of activation.
Shao et al. (2004)CD4T cellIn the present study, we showed that, although a panel of long-term cultured rat uveitogenic T cell lines specific for the interphotoreceptor retinal-binding protein peptide, R16, all expressed CD4, approximately 40% of the R16-specific uveitogenic T cells freshly prepared from Ag-immunized rats were CD8(+)alphabetaTCR(+), as demonstrated by CFSE staining.
Ramirez et al. (1992)CD4T lymphocytesRat T lymphocytes, activated in vitro with concanavalin A (Con A), were shown by flow cytofluorographic analysis to contain a population of cells that simultaneously expressed CD4 and the alpha chain of CD8.
Doolabh et al. (2002)CD4T-lymphocyteFlow cytometric analysis verified that the T-lymphocyte population was maintained, while CD4 expression was downregulated by RIB 5/2.
Ford et al. (1996)CD4T cellsAssessment of these T cells for expression of a range of surface molecules after completion of the isolation procedure revealed almost complete loss of expression of CD4 and CD25 and reduced expression of a number of other surface antigens.
Watanabe et al. (1998)CD4T cellsThey implicate that a therapy targeting mucosal T cells expressing CD4 may be feasible in the treatment of human Crohn's disease.
Beschorner et al. (1988)CD4T cellsMore than 90% of these cells were T cells, as detected by OX-19, and expressed both CD4 and CD8 markers.
Moriguchi et al. (1998)CD4T cellsIn addition, the expressions of both CD4 and CD8 antigens on CD+CD8+ T cells, immature T cells existing in thymic cortex, were also decreased in SHR, and significantly improved by high vitamin E diet.
Konishi et al. (1988-1989)W3/25T-cellFluorescence-activated cell sorter (FACS) analysis of primary and transplantable lymphomas revealed cells of the T-cell lineage, with tumor cells expressing both OX-8 (CD8) and W3/25 (CD4) antigens.
Moriguchi (1998)CD4T-cellsIn addition, the expressions of both CD4 and CD8 antigens on CD4+ CD8+ T-cells were also decreased in SHR, which was significantly improved by a high vitamin E diet.
Hazenberg et al. (2003)CD4T cellMETHODS: CD4 and CD8 T cell activation marker expression was analysed by FACScan before and after seroconversion (1 and 5 years after seroconversion); T cell proliferation and T cell numbers were also measured.
Hazenberg et al. (2003)CD4T cellsThe predictive value of CD8 T cell activation was confirmed and, in addition, in the course of infection low CD4 T cell counts and increasing proportions of dividing CD4 T cells, dividing CD8 T cells or elevated CD4 T cell activation marker expression became independent predictors of progression to AIDS.
Lawrence et al. (1996)CD4T cellsT cells expressing CD4 can be further subdivided by their expression of CD45R.
Louie et al. (1996)CD4T-cellReduced T-cell stimulation by HIV-infected monocytes was related to down-modulation of CD4 expression on helper T-cells and was not affected by the inclusion of anti-HIV-gpl20 Ab, indicating the involvement of soluble or cell-associated viral envelope protein to be less likely.
Morrison et al. (1995)CD4T lymphocytesIn comparison, in vivo administration of anti-CD4 Mab into rats, 2 weeks after CFA immunization (PPD priming), saturated CD4 molecules expressed on T lymphocytes and depleted significant percentages of CD4+ T cells from blood, spleen, and lymph nodes, yet failed to cause significant inhibition of PPD-stimulated DTH ear swelling.
Morrison et al. (1995)CD4T cellPPD stimulation of T cells isolated from the draining lymph nodes of anti-CD4 Mab-treated rats produced relative phenotypic changes in CD4 coexpressions with CD45RC (inverse memory), CD49d (inflammatory adhesion integrin VLA-4), and OX40 (CD4+ blast), representative of memory CD4+ T cell blasts with reduced capacity for endothelial infiltration.
Williams et al. (1987)CD4T lymphocytesCD4 antigen is also expressed on T lymphocytes and macrophages, and thus CD2 and CD4 appear similar in their cellular expression as well as structural characteristics.
Arima et al. (1997)CD4T cellsIntraperitoneal injection of a single dose (20 mg/kg) of RIB 5/2 resulted in a decrease in CD4 surface molecule expression on peripheral CD4+ T cells without cell elimination as shown by FACS analysis.
Chai et al. (1996)CD4T-cellThe distribution of thymocyte subsets with respect to CD4 and CD8 expression in LEC-TG mice closely resembled that of LEA rat thymus and that in LEA-TG mice, suggesting that normal T-cell differentiation occurred in LEC-TG mice.
Molina-Pinelo et al. (2009)CD4T cellRESULTS: Our results showed a lower thymic activity in patients with low-level CD4 T cell repopulation, leading to a decline in CD4 T cell production.
Sano et al. (2004)CD4T lymphocytesThe numbers of CD4(+) and CD8(+) T lymphocytes and MAdCAM-1 expression in the lamina propria did not recover to a normal level after external drainage, but did so after internal drainage.
Kao et al. (2007)CD4T lymphocytesThe purpose of this study was to compare the expression of CD137, CD4(+)CD25(high) Treg cells, and CD11c(+)CD8(+) in the peripheral blood T lymphocytes of RA patients during active and remissive states, and evaluate the correlation with disease activity.
Lori et al. (2002)CD4T cellBefore therapy interruption, the PANDAs had a vigorous HIV-specific T cell immune response (median CD4VIR 1.2%), while the HAART-treated patients did not (median CD4VIR 0.2%) (CD4VIR represents the percentage of HIV-specific CD4 subpopulation expressing IFN-gamma within the total CD4 population [CD3+, CD4+, IFN-gamma+]).
Gay et al. (1988)CD4T cellT-cell responses can be strongly augmented by the concurrent expression of CD4 on the T cell and any of four different Ia proteins on planar membranes, thus supporting the idea that CD4 binds to a monomorphic region of the Ia molecule and increases the avidity with which the T cell can interact with its target.
Erdenebayar et al. (2009)CD4T cellsT cells expressing CD4 acquire helper effector functions and those expressing CD8 exert cytotoxic activity after antigen recognition.
Wei et al. (2008)CD4T cellsRESULTS: There was no significant difference in expression of CD4(+)CD25(+) T cells between patients with inactive JIA and normal controls (13.74+/-3.25% vs 12.85+/-3.68%, p>0.05).
Wei et al. (2008)CD4T cellsThe expression of CD4(+)CD25(hi) T cells was significantly lower in inactive JIA patients than in normal controls (1.89+/-1.01% vs 2.76+/-1.28%, p<0.01).
Okamoto et al. (2001)CD4T cellSequence analysis of complementarity determining region 3 of the expanded clones revealed that relatively conserved amino acids were utilized in each patient and that an identical CD4 T cell clone having Vbeta16 was present in all three patients.
Hall et al. (1992)CD4T-cellAll host animals had populations of T-cell receptor positive cells, most of which also expressed the T-cell surface antigens CD4 and CD8.
Aiello et al. (2007)CD4CD25T cellsCONCLUSIONS: DnIKK2-Treg is a unique population of CD4CD25 T cells expressing high levels of iNOS.
Matsumoto et al. (1996)CD4T cellsFurthermore, purified CD4-CD8- T cells expressed CD4 molecules after culture.
Kuo et al. (2009)CD4T-cellsFlow cytometric analysis in Group 6 revealed a significant increase in the percentage of CD4(+)/CD25(+) and CD4(+)/foxP3(+) T-cells expression, and significant increase in the percentage of donor cells (RT1(n)) in the recipient peripheral blood.
Lundsgaard et al. (2005)CD4T-cellsIn contrast, two million CD4(+)CD25(+) cells (expressing Foxp3) prevented the accelerated diabetes when transferred both before and simultaneously with the diabetogenic T-cells.
Lundsgaard et al. (2005)CD4T-cellsIn vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3.
Liu et al. (2008)CD4T-lymphocytesIn colonic mucous, compared with normal group, in model group, Rats showed that expression of CD3, CD4 T-lymphocytes reduced and CD8 T-lymphocytes increased obviously (P < 0.05, P < 0.01).
Shu et al. (2008)CD4T cellsTherefore the expression level of CD4(+) CD25(high) T cells can be used as an effective index to judge the ITP prognosis.
Carter et al. (2006)CD4T-cellWe conclude that thymoglobulin reverses acute rejection in HIV-infected kidney recipients, but produces profound and long-lasting suppression of the CD4+ T-cell count associated with increased risk of infections requiring hospitalization.
Ghebremichael et al. (2009)CD4T-cellThere was no significant association between level of alcohol use and CD4+ T-cell counts.
Wallgren et al. (1995)CD4-expressingT lymphocytesHowever, in none of these studies it was conclusively demonstrated that the CD4-expressing cells were T lymphocytes.
Grigoryan et al. (2009)CD4T-cellKohli et al. [22] reported that HIV-infected IDUs who began taking HAART at a CD4+ T-cell count of >200 cells/µL survived longer than those who began taking HAART at a CD4+ T-cell count of ?
Grigoryan et al. (2009)CD4T-cellThe categories for CD4+ T-cell count at HIV diagnosis (first CD4+ T-cell count reported within 6 months after diagnosis) were: <50, 50–99, 100–199, and ?
Grigoryan et al. (2009)CD4T-cell200/µL (categories used in earlier prognostic models [13]); CD4+ T-cell count was missing for 68.0% of cases.
Morales Suárez-Varela et al. (2000)CD4T-cellBACKGROUND: Mycosis fungoides (MF) is a chronic cutaneous T-cell lymphoma characterized by small cells with cerebriform nuclei that usually express a mature peripheral T-helper cell (CD4+) immunophenotype.
Mannie et al. (1993)CD4T cellsThese results indicate that: 1) interactions of W3/25 with CD4 do not necessarily block class II MHC-restricted recognition of MBP; and 2) expression of CD4 is not necessary for Ag recognition by several clonotypes of MBP-reactive T cells.
Bradl et al. (2005)CD4T-cellThese effects were more pronounced for the CD4+ than for the CD8+ T-cell subset.
Tian et al. (2004)CD4T cellsCONCLUSIONS: The resistance of the peripheral CD4+CD25+ T cells to Rapa treatment might contribute to its immunosuppressive action.
Abe et al. (2009)CD4+T-cellsIn summary, our data suggest that DST administration, in the absence of allograft transplantation, induces the formation of CD4+ T-cells that are not Tregs themselves but give rise directly or indirectly to fully functional CD4+CD45RC?
Abe et al. (2009)CD4+T-cellsTaken together, we propose that DST-primed, hyperproliferative CD4+ T-cells represent a precursor population that may ultimately develop into fully functional Tregs (CD4+CD45RC?
Abe et al. (2009)CD4+T-cellsMoreover, we observed similar increases in Foxp3 and CD25 expression on CD4+T-cells obtained from the second set of recipients that received CD4+ T-cells from rats subjected DSTx4 alone when analyzed by flow cytometry(100days after LTx; data not shown).
Abe et al. (2009)CD4T-cellsWe did observe significant increases in Foxp3 and CD25 but not CD45RC expression on CD4+ T-cells obtained from rats at 30, 60 and 100 days following DSTx4+LTx compared to those from naïve rats (Fig. 4B).
Chen et al. (2009)CD4T lymphocyteOBJECTIVE: To investigate the relation between CD4(+) and CD8(+) T lymphocyte infiltration and apoptosis of the neurons in the local traumatic brain tissue after brain trauma in rats.
Wang et al. (2007)CD4T cellMAIN OUTCOME MEASURE(S): Vaginal smear, serum E2 level in recipients, grafts histologic observation, 3beta-hydroxy steroid dehydrogenase histochemistry staining, and CD4(+)/CD8(+) T cell immunohistochemistry staining.
Mojumdar et al. (2010)CD4T cellSubjects were also stratified into late and very late presenters depending on their CD4 T cell counts being below 200 cells/uL and below 50 cells/uL respectively.
Gasser et al. (2007)CD4T cellIn CMV-negative cases and controls no CMV-specific CD4+ T cell response was detected.
Gasser et al. (2007)CD4T cellAbsolute CD4+ T cell counts in samples tested from each of the controls were ?
Ramirez et al. (1992)CD4T cellIn contrast, IL-4 and dexamethasone both induced CD8 alpha chain expression on a rat CD4+ T cell clone when this was activated by specific antigen, and, although the effect with IL-4 was relatively weak, it did not antagonize the effect of the glucocorticoid.
Thygesen et al. (1994)CD4T lymphocytesCell sorting revealed that 2/3 of the primed CD4+ T lymphocytes expressed high levels of CD25.
Hershkoviz et al. (1992)CD4-CD8T cellThis conclusion is based on the following observations: (a) monoclonal antibodies directed against the CD4 molecule inhibited T cell adhesion to both FN and LN; (b) down-regulation of the CD4 molecule resulted in partial loss of the ability of CD4+ T cells to adhere to FN and LN; (c) a CD4+ T cell clone adhered to both FN and LN while a CD4-CD8- clone expressing an identical T cell receptor bound weakly to both proteins and (d) treatment of the CD4+ T cells with an inhibitor of the CD4-associated tyrosine protein kinase activity inhibited T cell adhesion to both ECM proteins.
Bell et al. (1989)CD4T-cellAt no stage in their life did uninjected or T-cell reconstituted nude rats develop endogenous cells that in any way resembled CD4+ products of the thymus.
Vidal et al. (1999)CD4T cellAlthough the responsiveness of the T cell lines to the agonist peptide was differently affected by the loss of CD4 expression, the recognition of APLs was in both cases dramatically reduced.
Bergeron et al. (2010)CD4T-cellMost guidelines for initiating antiretroviral therapy require reliable and reproducible CD4 T-cell counting.
Waaga et al. (1998)CD4T cellRT1.Du/beta20-44 peptide-specific CD4+ T helper 1 clones from the spleen and kidney of rejecting animals expressed a restricted T cell receptor (TCR) Vbeta repertoire: Vbeta4, 8.2, or 9.
Jensen et al. (1992)W3/25T cellCells were analysed for T cell subset markers CD4 (mAb W3/25) and CD8 (mAb OX8), for IL-2R (mAb OX39), and for high molecular mass leukocyte common antigen (LCA, CD45RB) expression (mAb OX22).
Rosenberg et al. (1982)W3/25T cellIL 2 enhancement of B cell responses or responses of reconstituted B cell and T cell fractions was eliminated in the presence of Mab W3/25, indicating that IL 2 mediation of B cell responses was due in part to participation of W3/25+ T cell helper function.
Gordon et al. (2010)CD4T cellWhile the levels of both CD4(+) and CD8(+) T cell proliferation were higher in the blood of untreated HIV-infected individuals, only CD4(+) T cell proliferation was significantly increased in the gut of the same patients.
Chisholm and Bevan (1988)CD4T cellsIn all three models the phenotype changes in T cells associated with the early stages of activation--i.e., induction of receptors for interleukin 2 (IL-R), induction of MHC class II expression, and coexpression of CD4 and CD8 glycoproteins--were not inhibited by CsA.
Van der Borght et al. (2009)CD4T-cellIn this cohort, study patients were followed-up for vital status, new AIDS events, CD4+ T-cell count and haemoglobin.
Beyers et al. (1991)CD4T cellChimaeric constructs from rat CD2 and CD4 antigens were expressed in the Jurkat human T cell line to examine the role of extracellular, transmembrane and cytoplasmic domains in mediating functions controlled by CD2 and CD4.
Egger (2010)CD4T cellHIV-related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence, outcome, and evolution of CD4+ T cell lymphocytes