Viewing affirmative mentions of gene expression of Pdcd1 (M. musculus) in T cells

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Mueller et al. (2010)PD-L1T cellWe found that PD-L1 expression on hematopoietic cells inhibited CD8+ T cell numbers and function after LCMV CL-13 infection.
Wang et al. (2007)PD-L1T cellProgrammed cell death-1 (PD-1, CD279) and its widely expressed, inducible ligand, PD-L1 (CD274), together dampen T cell activation, but whether they are essential for allograft tolerance is unknown.
Agata et al. (1996)PD-1T cellsFurthermore, the PD-1 antigen expression was strongly induced in distinct subsets of thymocytes and spleen T cells by in vitro stimulation with either anti-CD3 mAb or concanavalin A (Con A) which could lead T cells to both activation and cell death.
Lee et al. (2009)PD-L1T cellMore importantly, we found that decreased PD-L1 expression on mDCs is related with the increased T cell immune responses in CAD patients.
Lee et al. (2009)PD-L1T cellIn addition, stimulation of PD-L1 expression in vitro could attenuate the stimulatory ability on allogeneic T cell proliferation and its cytokine production, including IFN-gamma and IL-2, and also influence the production of IL-10 and IL-12 by mDCs.
Schoop et al. (2004)PD-L1T-cellSuppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells.
Keir et al. (2006)PD-L1T cellTissue expression of PD-L1 mediates peripheral T cell tolerance.
Trautmann et al. (2006)PD-1T cellsUpregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction.
Trautmann et al. (2006)PD-1T cellsHere, we found that PD-1 was upregulated on HIV-specific CD8(+) T cells; PD-1 expression levels were significantly correlated both with viral load and with the reduced capacity for cytokine production and proliferation of HIV-specific CD8(+) T cells.
Wang et al. (2008)PD-L1T-cellProgrammed death 1 ligand 1 (PD-L1), the interacting ligand for PD-1, widely expressed in many cell types, acts as a tissue-specific negative regulator of pathogenic T-cell responses.
Carter et al. (2002)PD-1T cellProgrammed death-1 (PD-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor expressed upon T cell activation.
Carter et al. (2002)PD-L1T cellExperiments using TCR transgenic CD4(+) or CD8(+) T cells stimulated with antigen-presenting cells expressing PD-L1 show that both T cell subsets are susceptible to this inhibitory pathway.
Oikawa et al. (2007)PD-1T cellsPD-1 was expressed on more than half of the liver-infiltrating T cells within the portal tract.
Liu et al. (2007)PD-1T cellsPhenotypic and functional analysis of LCMV gp33-41-specific CD8 T cells elicited by multiple peptide immunization in mice revealed the up-regulation of PD-1 expression on antigen-specific CD8 T cells.
Thompson et al. (2007)Programmed Death-1T cellsB7-H1 is known to impair host immunity via interaction with the Programmed Death-1 (PD-1) receptor, which is expressed by activated T cells.
Wang et al. (2008)PD-L1T-cellProgrammed death 1 ligand 1 (PD-L1), the interacting ligand for PD-1, widely expressed in many cell types, acts as a tissue-specific negative regulator of pathogenic T-cell responses.
Wang et al. (2008)PD-L1T-cellBased on these findings, we hypothesize that transgenic expression of PD-L1 in an islet-specific manner may help in preventing T-cell–mediated islet destruction in NOD mice.
Xerri et al. (2008)PD-1T-cellPD-1 expression was recently reported in some T-cell non-Hodgkin lymphoma (NHL) subtypes, but the expression profile of PD-1 and its ligands (PD-L1 and PD-L2) in B-NHLs remains largely to be characterized.
Oestreich et al. (2008)PD-1T cellNFATc1 regulates PD-1 expression upon T cell activation.
Hokey et al. (2008)PD-1T cellRecent data supports that increased expression of PD-1, a negative regulator of immune function, is associated with T cell exhaustion during chronic viral infection.
Hokey et al. (2008)PD-1T cellsEx vivo peptide stimulation of PBMC from DNA-vaccinated uninfected macaques revealed a temporal increase in PD-1 expression in proliferating antigen-specific CD8(+) T cells.
Hokey et al. (2008)PD-1T cellsSubsequent examination of PD-1 expression on T cells from uninfected and lentivirus-infected non-vaccinated macaques revealed a significant increase in PD-1 expression with lentiviral infection, consistent with previous reports.
Hokey et al. (2008)PD-1T cellOur data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.
Nomi et al. (2007)PD-L1T cellsPD-L1 expression was inversely correlated with tumor-infiltrating T lymphocytes, particularly CD8(+) T cells.
Carter et al. (2007)PD-L1T cellInteractions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function.
Phares et al. (2009)PD-1T cellsThe majority of CNS-infiltrating CD8 T cells expressed PD-1, with the highest levels on virus-specific CD8 T cells.
Freeman et al. (2006)PD-1T cellsEngagement of PD-1 by its ligands inhibits immune responses, and recent work has shown that PD-1 is highly expressed on exhausted T cells during chronic lymphocytic choriomeningitis virus (LCMV) infection in mice.
Keir et al. (2007)PD-L1T cellPD-1:PD-L interactions also limited CD8(+) effector cells, and PD-L1 expression on parenchymal tissues protected against effector OT-I T cell attack.
Iwai et al. (2002)PD-L1T cellTransgenic expression of PD-L1, one of the PD-L, in P815 tumor cells rendered them less susceptible to the specific T cell antigen receptor-mediated lysis by cytotoxic T cells in vitro, and markedly enhanced their tumorigenesis and invasiveness in vivo in the syngeneic hosts as compared with the parental tumor cells that lacked endogenous PD-L.
Terawaki et al. (2007)PD-1T cellSpecific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
Bot et al. (2010)PD-1T cellsMoreover, although we focus on the functionality of CD8+ T cells in this review, we recognize the importance of CD4+ T cells and the possibility that these cells may influence the outcome of vaccine protocols with respect to PD-1 expression by CD8+ T cells.
Bot et al. (2010)PD-1T cellsPrevious evidence also suggested that DNA vaccination elicited specific T cells with low PD-1 expression levels [43,44].
Bot et al. (2010)PD-1T cellsIntriguingly, a rather low dose of peptide co-administered with robust doses of CpG (TLR9 ligand) resulted in Melan A/MART-1-specific CD8+ T cells with low PD-1 expression levels [48], reproducing essentially the profile achieved by DNA vaccination (Figure 2).
Bot et al. (2010)PD-1T cellsIn stark contrast, a peptide dose increase or CpG dose reduction yielded increased levels of PD-1 expression on specific CD8+ T cells.
Bot et al. (2010)PD-1T cellsThe induction of T cells with a high PD-1 expression level by peptide immunization alone may be due to co-presentation by professional and non-professional APCs alike.
Bot et al. (2010)PD-1T cellFurthermore, this nicely complements previous observations obtained with OVA-specific CD8+ T cells defective in PD-1 expression in an autoimmune setting, showing the pivotal negative regulatory role of PD-1 both at the level of T cell expansion as well as during in situ activity [52].
Bot et al. (2010)PD-1T cellsSecondly, emerging data suggests that DNA vaccines have the capability to elicit low PD-1 expressing CD8+ T cells of central-memory phenotype, a process reproduced by repeat intra-lymph node exposure to minute levels of antigen in the presence of robust TLR9 stimulation.
Quigley et al. (2010)PD-1T cellsExhausted T cells express increased amounts of multiple inhibitory receptors, such as programmed death-1 (PD-1), that contribute to impaired virus-specific T cell function.
Li et al. (2007)PD-1T cellsOBJECTIVE: To examine the expressions of B7-H1 and its receptor programmed death-1 (PD-1) on circulating T cells and myeloid dendritic cells (mDCs) in patients with chronic hepatitis B virus (HBV) infection and to investigate the correlation between their expressions and their disease status.
Li et al. (2007)PD-1T lymphocytesMETHODS: The expressions of B7-H1 and PD-1 on mDCs and T lymphocytes in 30 patients with chronic HBV infection and 28 healthy controls were analyzed by a fluorescence-activated cell sorter (FACS).
Filippi et al. (2009)PD-1T cellsDelayed T1D onset was due to transient upregulation of programmed cell death-1 ligand 1 (PD-L1) on lymphoid cells, which prevented the expansion of diabetogenic CD8+ T cells expressing programmed cell death-1 (PD-1).
Hatachi et al. (2003)PD-1T cellsIn RA SF, PD-1 was expressed more predominantly on CD4+ T cells than on CD8+ T cells.
Fourcade et al. (2009)PD-1T cellsTo investigate the role of PD-1 in impairing spontaneous tumor Ag-specific CD8(+) T cells in melanoma patients, we have examined the effect of PD-1 expression on ex vivo detectable CD8(+) T cells specific to the tumor Ag NY-ESO-1.
Fourcade et al. (2009)PD-1T cellsIn contrast to EBV, influenza, or Melan-A/MART-1-specific CD8(+) T cells, NY-ESO-1-specific CD8(+) T cells up-regulated PD-1 expression.
Agata et al. (1996)PD-1T cellA mAb J43 has been produced against the product of the mouse PD-1 gene, a member of the Ig gene superfamily, which was previously isolated from an apoptosis-induced T cell hybridoma (2B4.11) by using subtractive hybridization.
Latchman et al. (2004)PD-L1T cellsPD-L1 is expressed on antigen-presenting cells (APCs), activated T cells, and a variety of tissues, but the functional significance of PD-L1 on each cell type is not yet clear.
Lee et al. (2009)PD-L1T cellTaken together, we can draw a conclusion that PD-1/PD-L1 pathway plays a key role in the regulation of proatherogenic T cell immunity by intervening antigen presenting cell (APC)-dependent T cell activation, which associates with pro-inflammatory or anti-inflammatory cytokine production, and further studies need gain insight into that this pathway represents a strategy of immunotherapy for atherosclerosis.
Lee et al. (2009)PD-1T cellsContributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis.
Wang et al. (2008)PD-L1T-cellsBecause it is possible that the protection seen in L1C mice is due to modulation of the development of autoreactive T-cells by transgenic expression of PD-L1, we performed adoptive transfer experiments to further investigate whether PD-L1 overexpression can also protect mice from lymphocyte transfer–induced diabetes.
Xerri et al. (2008)PD-1T cellsIn reactive lymph nodes, PD-1 was mainly expressed in follicular T cells.
Kristjansdottir et al. (2010)PD-1T cellsPD-1 expression on PD-1+ cells and on CD4+CD25+ T cells was significantly lower in SLE patients and relatives compared with healthy controls.
Kristjansdottir et al. (2010)PD-1 receptorT cellsThus, PD-1.3A may contribute to abnormalities in PD-1 receptor expression on CD4+CD25+ T cells in patients with SLE, providing support for an important role of the PD-1 pathway in SLE and, possibly, in other autoimmune diseases.
Kasagi et al. (2010)PD-1T cellsPD-1 was predominantly expressed on CD4(+) T cells that infiltrated the kidney, and CD4(+)PD-1(high) T cells produced higher levels of IFN-gamma than CD4(+)PD-1(low) or CD4(+)PD-1(-) T cells.
Chikuma et al. (2009)PD-1T cellAccumulating evidence suggests that PD-1, an immuno-inhibitory receptor expressed on activated T cells, regulates peripheral T cell tolerance.
Chikuma et al. (2009)PD-1T cellWe propose that CD8(+) T cell anergy is induced by a reduction of cell-autonomous IL-2 synthesis, which is caused by the quick expression of PD-1 in response to Ag stimulation and the subsequent stimulation of this receptor by its ligands on surrounding cells.
Nakamoto et al. (2008)PD-1T cellsFunctional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.
Zha et al. (2004)PD-1T cellsPD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells following activation.
Brahmamdam et al. (2010)PD-1T cellsPD-1 expression increased beginning 48 h after sepsis, and >20% of CD4 and CD8 T cells were positive by 7 days.
Muenst et al. (2009)PD-1T-cellProgrammed death-1 (PD-1), a protein that is physiologically expressed by germinal center-associated helper T cells, has an inhibitory function on T-cell activity.
Chen et al. (2008)PD-1T cellsWe conclude that genetic engineering of T cells to express PD-1 constitutively has only a mild impact on allograft survival.
Phares et al. (2009)PD-1T cellsMoreover, despite control of infectious virus, CD8 T cells within the CNS of persistently infected mice maintained high PD-1 expression.
Liang et al. (2010)PD-1T cellsPD-1 expression in total T cells was detected by flow cytometry.
Liang et al. (2010)PD-1T cellLevels of total CD8+ T cell responses and proliferation in relation to PD-1 expression levels were analyzed with intracellular staining and PD-1/PD-L1 blockage.
Liang et al. (2010)PD-1T cellsRESULTS: The PD-1 expression in T cells was dynamically changed during the natural course of chronic HBV infection, did not significantly increase in the immune tolerance phase, and returned to normal in the inactive virus carrier stage.
Liang et al. (2010)PD-1T cellsFurthermore, the PD-1 expression level in T cells was associated with the alanine aminotransferase level during the immune clearance stage of chronic HBV infection.
Haynes et al. (2007)PD-1T cellsFinally, CXCR5(high)CCR7(low) T cells were found to have elevated IL-4 transcript and programmed cell death gene-1 (PD-1) expression, and PD-1(high) cells were reduced in the absence of T cell CXCR5 or in mice compromised in GC formation.
Bot et al. (2010)PD-1T cellsOptimization of prime-boost vaccines based on PD-1 expression and functional avidity of T cells
Borkner et al. (2010)PD-1T-cellEffective siRNA sequences resulting in the reduction of surface PD-1 expression led to improved murine as well as human T-cell immune functions in response to PD-L1 expressing melanoma cells.
Brahmer et al. (2010)PD-1T cellsPURPOSE: Programmed death-1 (PD-1), an inhibitory receptor expressed on activated T cells, may suppress antitumor immunity.
Lee et al. (2010)PD-1T cellsPD-1 is one of the inhibitory receptors which are expressed on the T cells.
Lee et al. (2010)PD-1T cellsAs in chronic LCMV infection, the expression of PD-1 is similarly upregulated on the virus-specific CD8 T cells in chronic HCV infection, and HCV-specific PD-1high T cells are functionally impaired (18-20).
Lee et al. (2010)PD-1T cellsPD-1 expression is likely to be influenced by the location of HCV-specific CD8 T cells in vivo, since HCV-specific CD8 T cells in the liver have a tendency to express higher levels of PD-1 than those found in the peripheral blood (22).
Lee et al. (2010)PD-1T cellsRecent studies showed that the progression of acute HCV infection to the chronic stage is associated with a high level of PD-1 on HCV-specific CD8 T cells during the acute infection, and the clearance of HCV infection is associated with lower levels of PD-1 expression (23,24).
Peng et al. (2008)PD-1T cellsWe measured the PD-1 expression levels on HBV-specific CD8 T cells and investigated the role of PD-1/PD-L1 pathway in T-cell responses of patients with different HBV infection statuses.
Yuan et al. (2004)PD-L1T cellsPD-L1 and PD-L2 were also expressed on the surface of the activated T cells.
Cheng et al. (2007)PD-L1T cellsSimilarly, IL-12 induces IFN-gamma and PD-L1 expression in cultured MOG-specific T cells from wild-type mice but not from IFN-gamma-deficient mice.
Zhang et al. (2009)PD-L1T cellsOne inhibitory mechanism is up-regulation of programmed death-ligand 1 (PD-L1) expressed on tumor or stromal cells which binds to programmed death-1 (PD-1) on activated T cells.
Boni et al. (2007)PD-1T cellsThese HBV-specific CD8+ T cells expressed PD-1, and their function was improved by the blocking of PD-1/PD-L1 engagement.
Wang et al. (2010)PD-1T cellsIn addition, PD-1 expression was critical to in vitro conversion of naïve myelin-specific CD4 T cells into Treg cells and was directly related to Treg suppressive activity.
Gotsman et al. (2007)PD-L1T cellsProgrammed death-ligand 1 (PD-L1) and PD-L2 are B7 family members expressed on several cell types, which inhibit T cell activation via binding to programmed death-1 (PD-1) on T cells.
Wang et al. (2008)PD-1T-cellsExpression of PD-1 and the inhibitory effect of PD-L1 on NOD T-cells.
Wang et al. (2008)PD-L1T-cellIn contrast to our results in L1C mice, it has recently been reported that expression of a rat insulin promoter-driven PD-L1 transgene in mice on a B6 background unexpectedly enhanced T-cell priming and effector function and promoted autoimmunity (12).