Viewing affirmative mentions of gene expression of Il5 (M. musculus) in T cells

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Strath et al. (1992)IL5 geneT cellsThe construct allows the expression of the IL5 gene under the control of its own promoter, but the DCR ensures constitutive expression by all T cells.
Macias et al. (2001)IL-5T cellsWe have developed a transgenic mouse line, NJ.1638, which expresses high levels of IL-5 from T cells, with profound hematological consequences.
Ryan et al. (2001)IL-5T lymphocytesThe data indicate that T lymphocytes are not the dominant cellular source of IL-5 in organ-conditioned media and that local IL-5 production can occur with a wide range of normal murine organs.
Lee et al. (1997)IL-5T cellTransgenic mice were generated using regulatory elements from the CD3delta gene to drive T cell expression of IL-5.
Masuda et al. (1995)IL-5T-cellThese results suggest that tumor-producing IL-5 inhibits growth of colon tumors mediated through T-cell-independent protective mechanisms of the host.
Mathew et al. (1992)IL-5T cellsThus, we determined whether granuloma T cells make IL-5 and whether VIP modulates IL-5 production.
Enokihara et al. (1990)IL-5T cellsThese results extend our recent study demonstrating that T cells from eosinophilic patients produce IL-5 with IL-2 stimulation and may support the speculation that IL-5 is an important factor which induces eosinophilia.
Apostolopoulos et al. (2000)IL-5T cellsClearly, IL-5 is produced by functional T cells, especially the Tc1 type, after M-FP immunization and is required for an optimal CTL response to this antigen.
Konno et al. (1993)interleukin-5T lymphocytesAnti-allergic activity of roxithromycin: inhibition of interleukin-5 production from mouse T lymphocytes.
Taguchi et al. (1990)IL-5T cellsDetection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay.
Taguchi et al. (1990)IL-5T cellsA sensitive method has been developed which allows detection of individual T cells that produce either IFN-gamm or IL-5, and should be useful for detection of cytokine secretion at the single cell level.
Lee et al. (1995)interleukin-5T cellInvolvement of nuclear factor of activated T cell-related factors in interleukin-5 expression.
Lohoff et al. (1989)IL5T cellsThus, the IL5 activity of culture supernatants derived from T cells simultaneously producing IFN-gamma and IL5, can only be seen with BCL1 cells in the presence of anti-IFN-gamma antibodies.
Lohoff et al. (1989)IL5T cellsIf anti-IFN-gamma antibodies are omitted, T cells which produce both, IFN-gamma and IL5, may mistakenly be grouped into the TH1 subtype producing only IFN-gamma, but no IL5.
Xu-Amano et al. (1993)IL-5T cellInterestingly, both PP and SP CD4+ T cell cultures showed increased numbers of IL-4- and IL-5 (Th2-type)-producing, spot-forming cells (SFCs) after 21 d of immunization, while essentially no interferon-gamma (IFN-gamma) or IL-2 (Th1-type) SFCs were noted.
Bao et al. (1996)Interleukin-5 mRNAT cellsInterleukin-5 mRNA expressed by eosinophils and gamma/delta T cells in parasite-immune sheep.
Inouye et al. (2005)IL-5T cellT cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Metwali et al. (1993)IL-5T cellThis observation prompted us to learn whether non-T cell elements in the granuloma can promote constitutive IL-5 production.
Kusama et al. (1995)IL-5T cellsThese results suggest that eosinophilia in both mice is caused by IL-5, and that IL-5 is produced by cells other than CD4+ T cells, in addition to CD4+ T cells.
Yamada et al. (2006)interleukin-5T-cellBecause a subgroup of patients with HES show T-cell-dependent interleukin-5 (IL-5) overexpression, we determined if expression of the F/P fusion gene in the presence of transgenic T-cell IL-5 overexpression in mice induces HES-like disease.
Nakata et al. (1998)interleukin-5T cellsEvidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin-5 synthesis by T cells.
Nakata et al. (1998)IL-5T cellThe ovalbumin-reactive murine T cell clones, FJ17, produced IL-2, IL-4 and IL-5 upon stimulation with relevant antigen.
Nakata et al. (1998)IL-5T cellsThe results clearly indicated that the suppression of IL-5 synthesis by T cells is involved in the effects of cyclosporin A and dexamethasone to inhibit allergic airway eosinophilic inflammation.
Rådinger et al. (2006)interleukin-5T lymphocytesIn particular, the expression of interleukin-5 (IL-5) by T lymphocytes has been shown to be an essential signal necessary for the induction of eosinophilia in the airway [4,5,14-17].
Rådinger et al. (2006)IL-5T lymphocytesFor example, CD8+ T lymphocytes have been shown to produce IL-4, IL-5 and IL-13 following allergen stimulation [17-20].
Rådinger et al. (2006)IL-5T lymphocytesWe hypothesized that IL-5 producing CD8+ T lymphocytes may regulate BM responses following airway allergen exposure.
Rådinger et al. (2006)IL-5T lymphocytesTo test this, we utilized an IL-5 transgenic mouse overexpressing IL-5 in CD3+ T lymphocytes (NJ.1638; CD3IL-5+) that was bred with gene knockout mice lacking either CD4+ cells (CD4-/-) or CD8+ cells (CD8-/-) in order to produce IL-5 transgenic-gene knockout mice deficient in CD4+ and CD8+ T lymphocytes, respectively.
Rådinger et al. (2006)IL-5T lymphocytesInitially, we hypothesized that this could be due a difference in IL-5 production between the crossbred mice, since CD8+ T lymphocytes can produce several Th2 cytokines including IL-5 [19,20].
Rådinger et al. (2006)IL-5T lymphocytesImportantly, IL-5 is not only produced by CD4+ T lymphocytes, but also CD8+ T lymphocytes, as well as CD34+ cells.
Rådinger et al. (2006)IL-5T lymphocyteThe initial development of eosinophilia is induced in a complex way, including T lymphocyte independent mechanisms, as well as production of IL-5 from CD34+ cells [14,24].
Takatsu et al. (1985)TRFT cellMurine T cell replacing factor (TRF) was purified from a cellfree supernatant of a T cell hybridoma (B151K12) that constitutively produces TRF.
Crosby et al. (2002)IL-5T cellEctopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment.
Cheng et al. (2004)IL-5T cellsMETHODS: Murine asthma model was established with ovalbumin (OVA) sensitization and challenge, and the model was confirmed by histological analysis of lung tissues, cell numbers and differentiations of bronchoalveolar lavage, serum OVA-specific IgE level and interleukin (IL)-4 and IL-5 production by splenic T cells.
Cheng et al. (2004)IL-5T cellsOn the other hand, DC from OVA-sensitized and challenged mice stimulated the production of IL-4 and IL-5 by naïve T cells.
Naora et al. (1994)IL-5T cellThe strong correlation between the signal-dependent and cell-specific modulation of IL-5 and GM-CSF gene expression patterns and the binding activities of NF-IL-5A and NF-GM-CSFA suggests that these nuclear proteins are involved in the transduction of T cell activation signals to the transcriptional machinery of these genes through their interactions with their respective TCATTT-containing elements.
Metwali et al. (1993)IL-5T cellsThese highly purified T cells produced IL-5 both in the presence and absence of plate-bound anti-CD3.
Metwali et al. (1993)IL-5T lymphocyteThe requirement of IL-2 for normal IL-5 production was not dependent on an IL-2-induced expansion of the IL-5-producing, T lymphocyte population.
Ito et al. (2002)IL-5T cellsMoreover, separation and reconstitution studies showed that the TCDD-induced suppression of IL-5 production was due to the impaired function of T cells rather than that of antigen-presenting cells.
Sander et al. (1991)IL5T cellsActivation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.
Takamoto et al. (1995)IL-5T cellsProduction of IL-5 was reduced by in vivo depletion of CD4+ cells only and both CD4+ and CD8+ T cells, by intraperitoneal injection with appropriate mAb; IL-5 production was stimulated by anti-CD3 mAb.
Takamoto et al. (1995)IL-5T cellsThese results suggest that CD4- CD8- T cells, as well as CD4+ T cells, produce IL-5.
Walker et al. (1998)IL-5-producingT cellsMoreover, the inhibition of the infiltration of eosinophils was accompanied by a complete loss of IL-5-producing NK cells and significantly reduced levels of peritoneal lavage fluid IL-5, whereas the number of IL-5-producing T cells was not affected.
Coyle et al. (1995)IL-5T cellsIn vitro studies indicated that IL-4 could switch the virus-specific CD8+ T cells to IL-5 production.
Tsuruta et al. (1995)IL-5T cellsRegulation of expression of the IL-2 and IL-5 genes and the role of proteins related to nuclear factor of activated T cells.
Taguchi et al. (1990)IL-5T cellsWe have used an ELISPOT assay to detect individual T cells producing IFN-gamma or IL-5.
Taguchi et al. (1990)IL-5T cellsBoth IFN-gamma and IL-5 were produced de novo, because treatment of T cells with cycloheximide inhibited both IFN-gamma and IL-5 SFC.
Hogan et al. (1998)IL-5T cellsIn contrast, interferon-gamma, but not IL-4 and IL-5, was produced by the CD4- T cells.
Hopkins et al. (2005)IL-5T-cellsDepletion of CD4(+) or CD8(+) T-cells from SMX-NO stimulated lymph node cells revealed that CD4(+) T-cells were the major source of IL-5.
Matsumoto et al. (2003)IL-5T cellsPulmonary CD4+ T cells in Asc-immunized mice were activated and produced IL-5 upon local exposure to Asc in both wild-type (WT) and IL-5RKO mice.
Schoenbeck et al. (1989)interleukin 5T cellsVicia villosa agglutinin separates freshly isolated Peyer's Patch T cells into interleukin 5- or interleukin 2-producing subsets.
Takatsu et al. (1988)IL-5T cellTRF/IL-5 mRNA is constitutively expressed in constitutively TRF-producing B151 and is inducible in some T cell lines upon stimulation with PMA or Con A.
Klein-Hessling et al. (2003)IL-5T lymphocytesUsing primary murine CD4(+) T lymphocytes, we show in this study that inhibition of protein kinase A (PKA) activity in Th2 effector cells impairs IL-5 synthesis, whereas the expression of PKA catalytic subunit alpha enhances IL-5 synthesis in Th0 cells.
Sheehan and Swierkosz (1987)T-cell replacing factorT-cellIn addition, selected T-cell clones were found to produce both interleukin-2 (Il-2) and T-cell replacing factor (TRF), lymphokines characteristic of helper T cells.
Roth et al. (1997)IL-5T cellsThe expression of the B7-2 costimulatory molecule as well as the specificity to a self-antigen, either murine cytochrome c or murine ribonucleoproteins (the target of autoimmunity in SLE), enabled B cells as antigen-presenting cells to induce naive lymph node T cells to proliferate and to express IFN-gamma, IL-4, IL-5, and IL-10 cytokine mRNAs.
Kaminuma et al. (1997)IL-5T cellDevelopment of lung eosinophilic inflammation by the infusion of IL-5-producing T cell clones.
Kaminuma et al. (1997)IL-5T cellsTo delineate the critical role of T cells on asthma, we tested whether eosinophilic inflammation of the bronchial mucosa is induced by transfer of IL-5-producing T cell clones, in the absence of antigen-specific immunoglobulins (IgE, A and G).
Kaminuma et al. (1997)IL-5T cellOvalbumin-specific T cell clone, FI5, that produced IL-5 upon challenge with relevant antigen was established.
Takatsu and Tominaga (1991)IL-5T lymphocytesIL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms.
Rasmussen et al. (1988)interleukin 5T cellThird, it was found that interleukin 5 (IL-5, formerly known as T cell replacing factor/B cell growth factor II) is essential for these polyclonal responses by inhibition of such responses with monoclonal anti-IL-5 antibody.
Matsumoto et al. (1987)TRFT cellRole of T cell-replacing factor (TRF) in the murine B cell differentiation: induction of increased levels of expression of secreted type IgM mRNA.
Aoki et al. (1989)IL-5T cellsIL-5 expresses various biologic effects on several types of lymphocytes, including B cells, eosinophils, and T cells.
Metwali et al. (1993)IL-5T lymphocytesThe granulomas constitutively make IL-5 that originates from granuloma CD4+ T lymphocytes.
Rådinger et al. (2006)CD3IL-5T lymphocytesFirstly, mice overexpressing interleukin-5 (IL-5) in CD3+ T lymphocytes (NJ.1638; CD3IL-5+ mice) were bred with gene knockout mice lacking either CD4+ T lymphocytes (CD4-/-) or CD8+ T lymphocytes (CD8-/-) to produce CD3IL-5+ knockout mice deficient in CD4+ T lymphocytes (CD3IL-5+/CD4-/-) and CD8+ T lymphocytes (CD3IL-5+/CD8-/-), respectively.
Wada et al. (1998)IL-5T cellsIL-5-producing T cells that induce airway eosinophilia and hyperresponsiveness are suppressed by dexamethasone and cyclosporin A in mice.
Wada et al. (1998)IL-5T cellWe have recently demonstrated that airway eosinophilic inflammation can be transferred to unprimed mice by infusion of IL-5-producing T cell clones.
Wada et al. (1998)IL-5T cellAn ovalbumin-reactive T cell clone, KW29, produced IL-5 as well as IL-2 and IL-4 upon stimulation with relevant antigen.
Wada et al. (1998)IL-5T cellsWe concluded that airway eosinophilic inflammation can be controlled by agents capable of downregulating IL-5 production in T cells.
Rådinger et al. (2006)IL-5T lymphocytesThe finding that not only transfer of CD3IL-5+ CD8+ T lymphocytes but also transfer of CD8+ T lymphocytes from C57BL/6 mice restore BM eosinophilia in immunodeficient mice further argues that the role of CD8+ T lymphocytes in BM eosinophilopoiesis is independent of IL-5 overproduction.
Lu and Ghazizadeh (2007)IL-5T cellsThese responses were characterized by interleukin (IL)-4 and IL-5 production by T cells, a predominance of anti-green fluorescent protein IgG1 in serum, the presence of numerous eosinophils within rejected skin, and a lack of class I-restricted cytotoxic T lymphocyte response.
Schmidt et al. (1995)IL-5T cellEffect of phosphodiesterase inhibition on IL-4 and IL-5 production of the murine TH2-type T cell clone D10.G4.1.
Sugaya et al. (1997)IL-5T-cellsA reverse transcriptase-polymerase chain reaction (RT-PCR) assay also revealed prominent IL-5 and IL-4 mRNA expression in T-cells but not in eosinophils in CSF.
Ozegbe et al. (2004)IL-5T cellsPulsing T cells alone for a brief period with cholera toxin produced an almost identical effect to pulsing antigen-presenting cells alone, i.e. down-regulation of proliferation, down-regulation of IFN-gamma production with little effect on IL-5 production.
Sander et al. (1988)interleukin 5-producingT-cellExpression of B220 antigen on an interleukin 4- and interleukin 5-producing T-cell line.
Castro et al. (1995)IL-5T cellsOur results suggest that IL-5 may be produced by cells other than T cells that are both able to respond to infection and are under the control of IFN-gamma.
MacKenzie et al. (2001)IL-5T cellsAg-loaded eosinophils promoted the production of IL-4, IL-5, and IL-13 in cocultures with in vitro-polarized Th2 cells and induced IL-5 production in a dose-dependent manner from Ag-specific CD4(+) T cells isolated from allergic mice.
Umland et al. (1999)interleukin-5T-cellEffects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation.
MacDonald et al. (2003)IL5T cellsThe underlying mechanism of recruitment was further defined by use of mice deficient in the key Th2 cytokines IL-4 or IL5 and mice that lack T cells (nude mice).
Xu-Amano et al. (1992)IL-5T cellsThe PP and splenic (SP) CD3+ and CD3+ CD4+ T cell subsets were isolated and cultured with antigen, feeder cells, and IL-2, and were assessed at various intervals (days 0, 1, 3, and 6) for numbers of T cells producing either IFN-gamma or IL-5 by use of an enzyme-linked immunospot (ELISPOT) procedure.
Coyle et al. (1995)IL-5T cellsCross-linking of the CD3/TCR complex of FACS-sorted lung T cells revealed that only when anti-IL-4 was administered during immunization was there an inhibition of T cell-derived IL-5 and IgE production.
Iwamoto et al. (1996)IL-5T cellsWe have previously shown that antigen-induced eosinophil recruitment into the airways of sensitized mice is mediated by Th2-type CD4+ T cells that produce IL-5.
Walker et al. (1998)IL-5T cellsPeritoneal lavage fluids from these mice also contained increased numbers of T cells and NK cells, as well as significantly elevated levels of IL-4, IL-5, and IFN-gamma.
Takahashi et al. (1990)IL-5 cDNAT-cellWe purified T-cell-derived TRF and rIL-5 using anti-TRF/IL-5 antibody-coupled affinity column from supernatants of a T-cell hybridoma B151K12 and supernatants of HeLa cells, respectively, which had been transfected with murine IL-5 cDNA, and determined their partial N-terminal amino acid sequence (27 residues for B151-TRF and 13 residues for rIL-5).
Garlisi et al. (1995)IL-5T cellIn this study, we show that T cells migrate into the lungs in response to antigen challenge and are necessary for local production of cytokines (IL-4 and IL-5) important in B and T cell development as well as eosinophil activation and differentiation.
Ogawa et al. (2002)IL-5T cellsCD4+ T cells totally regulate these responses by producing IL-5.