Viewing affirmative mentions of gene expression of Il4 (M. musculus) in T cells

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Mariani et al. (2010)IL-4T cellsShort-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression Combining experiments on primary T cells and mathematical modeling, we characterized the stochastic expression of the interleukin-4 cytokine gene in its physiologic context, showing that a two-step model of transcriptional regulation acting on chromatin rearrangement and RNA polymerase recruitment accounts for the level, kinetics, and population variability of expression.A rate-limiting step upstream of transcription initiation, but occurring at the level of an individual allele, controls whether the interleukin-4 gene is expressed during antigenic stimulation, suggesting that the observed stochasticity of expression is linked to the dynamics of chromatin rearrangement.The computational analysis predicts that the probability to re-express an interleukin-4 gene that has been expressed once is transiently increased.
Mariani et al. (2010)interleukin-4T cellsGraded changes in expression level can be achieved by controlling transcription initiation, whereas binary regulation acts at the level of chromatin rearrangement and is targeted during the differentiation of T cells that specialize in interleukin-4 production.
Sideras et al. (1988)IL-4 mRNAT-cellCyclosporin A inhibited the synthesis of IL-4 mRNA in the T-cell line 2.19, which had been induced by concanavalin A.
Dix and Cousins (2003)IL-4T cellsIt is therefore possible that IL-4 synthesis by Th2 CD4+ T cells during retrovirus-induced immunosuppression serves to inhibit the perforin cytotoxic pathway that subsequently allows susceptibility to MCMV retinitis during MAIDS.
Atasoy et al. (1992)IL-4T cellsAlthough stimulated D10 cells could also be shown to express IL-4 in their cytosol, positive results were not obtained in all such studies and we have failed to detect IL-4 production by normal T cells using this method.
Shi et al. (2006)IL-4T cellsIn wild-type NOD recipients of either wild-type PLNC or IL-4-/- PLNC, the host autoantigen-specific CD4 T cells produced predominately IL-4 coincident with long-term graft survival, whereas, in NOD.IL-4-/- recipients with rejected grafts, the autoreactive T cells produced interferon gamma and low amounts of IL-4.
Grabstein et al. (1987)BSF-1T cellAnalysis of cell surface BSF-1 receptor expression indicated that although T cell activation is accompanied by a small increase in BSF-1 receptor expression, the cells also express BSF-1 receptors prior to activation at a time when they do not proliferate in response to BSF-1.
Keen et al. (2001)interleukin-4T cellsPreferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expression.
Torrentera et al. (2001)interleukin-4T cellsIn contrast, susceptibility of BALB/c mice to Leishmania major has been shown to depend on the early production of interleukin-4 (IL-4) by T cells which react to the parasitic LACK antigen.
Torrentera et al. (2001)IL-4T cellsThe latter result was observed despite the fact that (i) LACK was expressed by L. mexicana, (ii) splenocytes from BALB/c mice were able to stimulate LACK-specific T-cell hybridoma cells when incubated with live L. mexicana promastigotes, and (iii) LACK-specific T cells contributed to IL-4 production in L. mexicana-infected BALB/c mice.
Bix et al. (1998)interleukin 4T cellGenetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism.
Bix et al. (1998)IL-4T cellsAs compared to cells from most strains of mice, activated CD4(+) T cells from BALB mice show a bias towards IL-4 production and T helper 2 commitment in vitro and in vivo.
Bix et al. (1998)IL-4T cellsHere, we show that this bias arises not from an increase in the amount of IL-4 produced per cell, but rather from an increase in the proportion of CD4(+) T cells that commit to IL-4 expression.
Poulton and Baxter (2001)IL-4T cellsNKT cells are a subset of T cells that are distinct in being able to produce cytokines such as IL-4 and IFN-gamma extremely rapidly following activation.
Mulé et al. (1987)IL-4T cellInterleukin 4 (IL-4) expresses multiple biologic activities, including B cell, mast cell, and T cell stimulation.
Barthelson (1993)IL-4T cellsStudies of the expression of IL-4 by T cells present in inflammatory reactions would be facilitated by using polymerase chain reaction (PCR) coupled to reverse transcription of mRNA to amplify the small quantity of mRNA present in these cells.
Barthelson (1993)IL-4T cellThis method was used to demonstrate that platelet activating factor increases the expression of IL-4 in mouse thymocytes and in a mouse T cell line.
Barthelson (1993)IL-4T cellsThe expression of IL-4 by thymocytes exposed to platelet-activating factor (PAF) may reveal an important link between inflammation and the maturation of T cells in the thymus.
Ko et al. (2001)IL-4T cellsStudies of animals with spontaneous autoimmune diabetes have revealed that autoreactive T cells that mediate islet beta-cell destruction belong to the Th1 subset (producing IL-2 and IFN-gamma), whereas regulatory T cells are Th2 type (producing IL-4 and IL-10).
Falcone et al. (2001)IL-4T cellsAmong them, there is our previous report that pancreatic expression of IL-4 activated islet antigen-specific BDC2.5 T cells and rendered them able to trigger insulin-dependent diabetes mellitus in ins-IL-4/BDC2.5 mice (Mueller et al., Immunity, 7, 1997).
Shaw et al. (1997)interleukin 4T cellsWe demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice.
DeKruyff et al. (1995)IL-4T cellsIL-4 synthesis by in vivo-primed memory CD4+ T cells: II.
DeKruyff et al. (1995)IL-4T cellsPresence of IL-4 is not required for IL-4 synthesis in primed CD4+ T cells.
DeKruyff et al. (1995)IL-4T cellsPrevious studies have shown that the presence of IL-4 is required for the development of IL-4 synthesis in naive CD4+ T cells.
DeKruyff et al. (1995)IL-4T cellsOur results with such primed resting CD4+ T cells programmed to produce IL-4 indicated that the production of IL-4 did not require the presence of IL-4 (although the presence of IL-2 was absolutely necessary), and was only slightly limited by the presence of anti-IL-4 MAb.
DeKruyff et al. (1995)IL-4T cellsThese results with resting memory T cells were not biased by the presence of activated T cells already producing substantial quantities of IL-4, since we demonstrated that high-density memory T cells could produce IL-4 in the absence of IL-4, and because T cells that actively produce IL-4 do not persist in vivo very long after antigen exposure.
DeKruyff et al. (1995)IL-4T cellsThese results indicate that IL-4 synthesis in T cells committed to IL-4 production can indeed occur in the absence of IL-4 when culture conditions have been optimized and suggest that therapies with anti-IL-4 MAb or with soluble IL-4 receptors designed to control the development of IL-4 synthesis in memory T cells from individuals exhibiting excessive IL-4 synthesis will be unsuccessful.
Vallera et al. (2000)IL-4T cellsTransduced T15 T cells expressed intracellular DT and IL-4 as determined by immunofluorescence.
Sherman et al. (1999)IL-4T cellThe acquisition of an IL-4-producing phenotype in Th2 cells requires IL-4 signaling through the STAT6 pathway during T cell differentiation.
Schmitz et al. (1994)IL-4T cellIn mice in which only CD4+ cells are able to express IL-4, antigen-specific IgE is produced in a T cell-dependent immune response.
Mueller et al. (1997)IL-4T cellsWe have recently shown that transgenic expression of the Th2 cytokine IL-4 by pancreatic beta cells completely protects nonobese diabetic (NOD) mice from autoimmune diabetes by inducing functional tolerance among autoreactive T cells.
Mueller et al. (1997)IL-4T cellsTo investigate whether local IL-4 production could also induce functional tolerance among alloreactive T cells and thus prevent allograft rejection, we transplanted pancreata from transgenic neonatal mice and their nontransgenic littermates into allogeneic hosts.
Gross et al. (1993)IL-4T cellsAnti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells.
Gross et al. (1993)IL-4T cellsTreatment of mice with neutralizing monoclonal anti-IL-4 antibodies at the time of immunization with keyhole limpet hemocyanin causes significant inhibition of priming of T cells for the production of IL-4 upon subsequent in vitro challenge.
Gross et al. (1993)IL-4T cellsIn the 6- to 7-day group, IL-4 production in response to keyhole limpet hemocyanin among the recipients of anti-IL-4 was reduced by more than twofold in four of four experiments, when low density T cells were challenged.
Gross et al. (1993)IL-4T cellsMeasurement of frequency of IL-4-producing, keyhole limpet hemocyanin-specific T cells indicated a twofold reduction in the anti-IL-4-treated mice.
Gross et al. (1993)IL-4T cellsT cells from boosted donors that had received a single injection of anti-IL-4 at the time of priming showed diminished production of IL-4 in each experiment.
Gross et al. (1993)IL-4T cellsThese results indicate that IL-4 is important in vivo in priming T cells to develop into IL-4-producing cells and indicate an important physiologic role for IL-4 in the establishment of lymphokine-producing phenotype.
Noben-Trauth et al. (2002)IL-4T cellNaive CD4(+) T cell populations rapidly produce small amounts of IL-4 in response to T cell receptor-mediated stimulation and may undergo Th2 differentiation without exogenous IL-4.
Noben-Trauth et al. (2002)IL-4T cellsHere we show that single CD4(+) T cells from RAG2-/- T cells receptor transgenic mice primed with their cognate antigen give rise to IL-4-producing cells at a similar frequency whether primed with or without added IL-4, but not if anti-IL-4 is added to the culture.
Kim et al. (2000)IL-4T cellsIn addition, the BLK/IL-4 cells were more effective than free recombinant IL-4 in decreasing OVA-specific IFN-gamma production and in increasing OVA-specific IL-4 production by splenic CD4(+) T cells.
Seder et al. (1991)interleukin 4T cellsIncreased frequency of interleukin 4-producing T cells as a result of polyclonal priming.
Seder et al. (1991)IL4T cellsA frequency of 0.98 was obtained for IL4 production by T cells of the D10.G4 cell line.
Seder et al. (1991)IL4T cellsT cells from naive donors capable of producing IL4 in response to anti-CD3 plus IL2 were quite rare, with a frequency in four experiments ranging between 0.0003 and 0.0018.
Seder et al. (1991)IL4T cellsTreatment of mice with polyclonal activators known to increase the IL 4-producing capacity of T cells when assayed in bulk culture caused striking increases in the frequency of IL4-producing cells.
Seder et al. (1991)IL4T cellsSimilarly, culturing cells in vitro with anti-CD3, IL2 and IL4 for 5 days caused a marked increase in the frequency of cells capable of producing IL4, to 0.031.IL4 production by individual T cells is dependent upon IL2.
Seder et al. (1991)IL4T cellsT cells from primed donors showed a striking inhibition in the frequency of IL4-producing cells in response to anti-CD3 when IL2 was not present.
Julia and Glaichenhaus (1999)IL-4T cellsIn both strains, IL-4 is produced by T cells which react to the parasite LACK (for Leishmania homolog of the receptor for activated C kinase) antigen.
Pingel et al. (1999)IL-4T cellsSuch altered ligands failed to activate IL-4 production from transgenic LACK-specific T cells or following injection into BALB/c mice.
Lee et al. (2002)interleukin-4T cellsHydroquinone, a reactive metabolite of benzene, enhances interleukin-4 production in CD4+ T cells and increases immunoglobulin E levels in antigen-primed mice.
Lee et al. (2002)IL-4T cellsIn this study, we determined the effect of hydroquinone (HQ), a major metabolite of benzene present in large quantities in cigarette tar, on interleukin-4 (IL-4) production by CD4+ T cells.
Lee et al. (2002)IL-4T cellsHQ significantly enhanced IL-4 production by keyhole limpet haemocyanin (KLH)-primed CD4+ T cells in a dose-dependent manner.
Lee et al. (2002)IL-4T cellsThese findings provide evidence that HQ, a major component of cigarette tar, may enhance allergic immune responses by inducing the production of IL-4 in CD4+ T cells.
Bix and Locksley (1998)IL-4T cellsCD4+ T cells from F1 mice, which allowed assignment of the parental origin of interleukin-4 (IL-4) transcripts, were divided into clones that expressed IL-4 biallelically or monoallelically from either allele.
Huang et al. (1997)IL-4T cellThus, this element, if biologically active, must function at a step in T cell responsiveness distinct from the acute production of IL-4 by Th2 cells in response to Ag or anti-CD3.
Czarneski et al. (2001)interleukin-4T-cellThe mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription.
Erb et al. (1999)interleukin 4T cellsConstitutive expression of interleukin 4 in vivo does not lead to the development of T helper 2 type CD8+ T cells secreting interleukin 4 or interleukin 5.
Erb et al. (1999)IL-4T cellTo study the effects of IL-4 on CD8+ T cell development in vivo we analysed the CD8+ T cell phenotype in mice constitutively expressing IL-4.
Wang et al. (1992)IL-4T cellsThe data support and extend those obtained through analysis of cytokine mRNA synthesis alone, thereby providing evidence that "fresh" T cells are indeed capable of producing IL-4 directly ex vivo and are consistent with the existence of IL-4-secreting cells as a normal component of the T cell repertoire of naive mice.
Hashimoto et al. (2005)IL-4T cellsHowever, the same treatment was unable to confer protection against GVHD in NKT cell-deficient CD1d knockout (CD1d(-/-)) or IL-4(-/-) recipient mice or when STAT6(-/-) mice were used as donors, indicating the critical role of host NKT cells, host production of IL-4, and Th2 cytokine responses mediated by donor T cells on the protective effects of alpha-GalCer against GVHD.
Williams et al. (1993)IL-4T cellsNevertheless, when purified by sorting, T cells and non-B, non-T (NBNT) populations produced similar amounts of IL-4 in response to parasite antigen.
Furukawa et al. (2002)IL-4T lymphocytesAfter stimulation with anti-CD3 monoclonal antibody, IL-4 (but not interferon gamma) was produced in cultures of T lymphocytes from brains of TI mice 15 days after the infection, whereas the same cell preparation from normal mice produced interferon gamma (but not IL-4).
Santra and Ghosh (1997)IL-4T cellsAt the early stage of tumor growth, the splenic T cells following a 5-day incubation in vitro with killed 2C3 tumor targets, produce high levels of cytokines, namely interleukin-4 (IL-4), IL-10 and interferon gamma (IFN gamma).
Elahi et al. (2001)IL-4T lymphocytesOral immunisation with the blastospore yeast form (but not subcutaneous immunisation) induced clinical immunity, with a shift in parameters of cytokine response characterised by an early and sustained production of both IFN-gamma and IL-4 from antigen-stimulated cervical node T lymphocytes.
Stetson et al. (2002)IL-4T cellsWhen injected with unrelated antigen, Leishmania efficiently activated IL-4 expression from naive antigen-specific T cells.
Ikemoto et al. (1995)IL-4T cellsThe IL-4 was mainly produced from CD4+ T cells.
Ikemoto et al. (1995)IL-4T cellsThese results demonstrate that small amounts of exogenous IL-4 increase the severity of HSE in HSV-1-infected mice through the increased production of IL-4 from local CD4+ T cells.
Bot et al. (2000)IL-4T cellWe studied the effect of lung-specific IL-4 expression on the T cell response during primary and secondary heterologous infection with influenza virus by using transgenic mice that express IL-4 under a lung-specific promoter.
Secrist et al. (1993)interleukin 4T cellsAllergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.
Secrist et al. (1993)IL-4T cellAllergen specific CD4+ T cell clones generated from allergic individuals have been shown to produce increased levels of the cytokine interleukin 4 (IL-4), compared to allergen specific clones generated from nonallergic individuals.
Secrist et al. (1993)IL-4T cellsWe demonstrated that the quantity of IL-4 produced by allergen specific memory CD4+ T cells from allergic individuals could be considerably reduced by in vivo treatment with allergen (allergen immunotherapy).
Secrist et al. (1993)IL-4T cellsImmunotherapy reduced IL-4 production by allergen specific CD4+ T cells to levels observed with T cells from nonallergic subjects, or to levels induced with nonallergic antigens such as tetanus toxoid.
Secrist et al. (1993)IL-4T cellsThese observations indicate that immunotherapy accomplishes its clinical effects by reducing IL-4 synthesis in allergen specific CD4+ T cells.
Donckier et al. (1995)IL-4T cellsWe reasoned that the propensity of neonatal T cells to synthesize high levels of IL-4 might be involved in this polarization of the alloreactive response and thereby in the development of neonatal transplantation tolerance.
Rizzo et al. (1991)IL4T cellsThe contribution of macrophages (M phi) in enhancing the production of IL4 by T cells in high-IgE responder mice was studied.
Yagi et al. (2002)IL-4T cellsThe IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response.
Tominaga et al. (1998)IL-4T cellsThe present study demonstrated that the administration of recombinant interleukin-4 (rIL-4) prevented overt diabetes in nonobese diabetic (NOD) mice whose T cells produced relatively low amounts of IL-4.
Tominaga et al. (1998)IL-4T cellsBy measuring the cytokine production of splenic T cells after stimulation, it was shown that CD45RBlowCD4+ T cells predominantly produced IL-4 and IL-10 but produced less IL-2 and interferon-gamma (IFN-gamma).
Cameron et al. (1997)IL-4T cellsWhereas treatment of NOD mice with an anti-CD28 mAb between 2 to 4 weeks of age inhibits destructive insulitis and protects against IDDM by enhancing IL-4 production by T cells, anti-CD28 treatment between 5 to 7 weeks of age does not prevent IDDM.
Soloway et al. (1991)IL-4T cellAdministration of anti-interleukin 4 (IL-4) mAb prevents the development of hypersensitivity, and analysis of cytokine production by T cell hybridomas derived from peptide-immunized mice suggests that whether a given peptide-class II combination can induce hypersensitivity depends on its ability to induce IL-4 production.
Spencer et al. (2003)IL-4T cellsWe show here that, in contrast to our original hypotheses, IL-4 production and IL-4 receptor expression by T cells are both dispensable for T-cell-mediated host protection.
Shiroiwa et al. (2007)IL-4T cellsIL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus.
Shiroiwa et al. (2007)IL-4T cellsTo thoroughly understand the role of IL-4 in the pathogenesis of systemic lupus erythematosus (SLE), a prototypic antibody-mediated systemic autoimmune disease, we examined the potential of in vitro IL-4 production by anti-CD3 mAb-stimulated splenic T cells in SLE model of NZB, BXSB and related mouse strains.