Viewing affirmative mentions of gene expression of Il2ra (M. musculus) in T cells

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Matsui (1996)CD25T-cellWe designated the purified substance S. typhimurium-derived inhibitor of T-cell proliferation (STI), which, at 0.2 microgram/ml and above, inhibited proliferation and augmented CD25 expression of phytohemagglutinin-stimulated murine splenic lymphocytes.
Asano et al. (1996)CD25T cellsThis report shows that: (a) T cells expressing the interleukin 2 receptor alpha chains (CD25) ontogenically begin to appear in the normal periphery immediately after day 3, rapidly increasing within 2 wk to nearly adult levels (approximately 10% of CD3+ cells, especially of CD4+ cells); (b) NTx on day 3 eliminates CD25+ T cells from the periphery for several days; inoculation immediately after NTx of CD25+ splenic T cells from syngeneic non-Tx adult mice prevents autoimmune development, whereas inoculation of CD25- T cells even at a larger dose does not; and furthermore, (c) similar autoimmune diseases can be produced in adult athymic nu/nu mice by inoculating either spleen cell suspensions from 3-d-old euthymic nu/+ mice or CD25+ cell-depleted spleen cell suspensions from older, even 1-yr-old, nu/+ mice.
Kaminitz et al. (2010)CD25T cellIsolation of T cell subsets according to CD25 expression relies on functional assays, where CD25?
Zelenay et al. (2005)CD25T cellsExpression of the IL-2 receptor alpha chain (CD25) by peripheral CD4 T cells follows cellular activation.
Chao et al. (2007)CD25T lymphocytesDecreased expression of CD25 on decidual activated T lymphocytes is not mediated by reduced CD25 messenger ribonucleic acid.
Chao et al. (2007)CD25T cellsOBJECTIVE: To clarify whether the down-regulation of CD25 on decidual T cells occurred at the activated T cells and was governed through reduced CD25 messenger RNA (mRNA) production.
Chao et al. (2007)CD25T lymphocytesIn the coculture model, we found that the cytotrophoblast cells could induce the decreased expression of CD25 on T lymphocytes.
Chao et al. (2007)CD25T lymphocytesCONCLUSION(S): This study demonstrates the effectiveness of the coculture model to study fetomaternal interactions and provides evidence that fetal cells may contribute to the control of maternal local immunity and that the decreased expression of CD25 on decidual T lymphocytes is not through the reduced CD25 mRNA level.
Sakaguchi et al. (1995)CD25T cellsImmunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25).
Hauet-Broere et al. (2003)CD25T cellsEven though CD25 was expressed heterogeneously, both CD25(+) and CD25(-) OVA-specific T cells from MLN could transfer tolerance.
Chen et al. (2003)CD25T cellsThe expression of CD25 in peripheral T cells was identified dynamically one day before and one and eight weeks after transplantation.
Curotto de Lafaille et al. (2004)CD25T cellUpon adoptive transfer, the expression of CD25 in donor-derived cells is not stable, with CD4(+)CD25(+) cells appearing in CD4(+)CD25(-) T cell-injected animals and vice versa.
Curotto de Lafaille et al. (2004)CD25T cellsThe maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs.
Keino et al. (2006)CD25T cellsThe current study was conducted to investigate the possibility that these T regs express CD25 and are derived from natural CD4+CD25+ T cells.
Radvanyi et al. (1998)CD25T cellsAddition of exogenous IL-2 during the primary activation of 8-week-old lpr T cells overcame the defect in CD25 expression.
Radvanyi et al. (1998)CD25T cellsActivated T cells from young lpr mice (5 weeks old) underwent apoptosis in response to TCR ligation; these cells also expressed normal levels of CD25 following primary activation.
Kuniyasu et al. (2000)CD25T cellHere we show that the expression of CD25 is highly specific, when compared with other molecules, in delineating the autoimmune-preventive immunoregulatory CD4(+) T cell population.
Kuniyasu et al. (2000)CD25T cellsThird, upon polyclonal T cell stimulation, CD25(+)CD4(+) T cells express CD25 at higher levels and more persistently than CD25(-)CD4(+) T cell-derived activated T cells; moreover, when the stimulation is ceased, the former revert to the original levels of CD25 expression, whereas the latter lose the expression.
Minamimura et al. (2006)CD25T cellsNaive CD25(+) T cells expressed a higher level of intracellular Bcl-x(L) than CD25(-) T cells.
Balasa et al. (2000)IL-2 receptorT cellsFlow cytometric analysis then revealed that LPS-stimulation in vitro induced the expression of an IL-2 receptor (CD25) on CD4 T cells; this indicates that the activation of islet-specific T cells is a prerequisite to eliciting diabetes in this situation.
Zhang et al. (2006)CD25T cellsAdult T-cell leukemia (ATL) consists of an overabundance of T cells, which express CD25.
Young and Matthews (1995)alpha-chain interleukin-2 receptorT cellsWhile the proportions of splenic CD4+ and CD8+ T cells isolated from control and PCPA-treated mice were similar, the level of expression of the alpha-chain interleukin-2 receptor (IL-2R) was reduced on splenic CD4+ cells but not on CD8+ cells.
Evangelidou et al. (2010)CD25T cellsFollowing TCR engagement, TNFRI knockout (KO) T cells showed significantly delayed proliferation, cell division, upregulation of interleukin 2 (IL-2) and IL-2 receptor alpha chain (CD25) mRNA and cell-surface expression of CD25 compared with wild-type (WT) cells.
Lei et al. (2008)CD25T cellsCONCLUSIONS: Penetrating ocular injury preformed shortly (24 h-48 h) after an AC injection of an antigen was able to abrogate ACAID and was associated with a decreased production of TGF-beta1 and IL-10, an increased production of IFN-gamma, and a decreased expression of CD4(+)CD25(+)Foxp3(+)T cells.
Kochetkova et al. (2008)CD25T cellsA Salmonella vector expressing colonization factor Ag I (CFA/I), shown to behave as an anti-inflammatory vaccine, stimulates the production of CD4(+)CD25(+) T cells and regulatory cytokines.
Zhang et al. (2007)CD25T cellsFlow cytometry was used to detect the expression of CD4 and CD25 molecules of the T cells which came from the tumor-bearing mice.
Li et al. (2006)CD25T lymphocytesData also revealed that CD4(+)CD25(-) T cells from mice immunized with the DNA vaccine yielded a cell population that was foxp3(+), showed increased expression of CD25 compared to control, and had immunosuppressive function in vitro, indicating that Tregs could have developed from antigen-induced, peripheral T lymphocytes.
Chen et al. (2006)CD25T cellIL-2 is crucial for the production of CD4(+)CD25(+) T regulatory (Treg) cells while important for the generation of effective T cell-mediated immunity.
Ueki et al. (2006)CD25T-cellRESULTS: DHMEQ significantly suppressed alphaCD3 + alphaCD28 monoclonal antibody-triggered T-cell proliferation, CD25/CD69 expressions, and both interleukin-2 and interferon (IFN)-gamma production in a dose-dependent fashion.
Eguchi et al. (2003)IL-2RT-cellsHuman thioredoxin (TRX), a member of the oxidoreductase superfamily, was initially identified, as a factor which augments the production of interleukin-2 receptor alpha (IL-2R alpha) in human T-cell lymphotropic virus type 1 (HTLV-1) infected patient T-cells.
Hunt et al. (1999)IL-2RT cellsActivated T cells treated with sub-lethal levels of BPD-MA and light exhibited lower CD25 levels, a temporary block in cell cycle transition, but unaltered expression of MHC Class I, CD3, CD4, CD8, CD45, CD54, CD71, CD122 (IL-2R beta-chain) or TCR beta-chain antigens 24 h afterward.
Tsukahara et al. (1998)IL-2RT cellsMRL-lpr/lpr (lpr) mice fall victim to autoimmune disease owing to a lymphoproliferative disorder mainly of double-negative (DN) CD4- CD8- alpha beta T cells expressing a low density of interleukin-2 receptor beta-chain (IL-2R beta).
Yahata et al. (1996)IL-2RT cellsThe T cells were identified as intermediate CD3+ cells with a high expression of IL-2R beta.
Burns and Munson (1993)IL-2RT cellGallium arsenide selectively inhibits T cell proliferation and alters expression of CD25 (IL-2R/p55).
Iiai et al. (1992)IL-2RT-cellThis study was possible because these T cells have T-cell receptors (TcR) of intermediate intensity (i.e. intermediate TcR cells) and constitutively express a high level of interleukin-2 receptor beta chain (IL-2R beta).
Bushell et al. (2003)CD25T cellsMETHODS: Recent studies in autoimmune models have shown that T cells with regulatory function can be isolated from unmanipulated animals on the basis of CD25 expression, and we have recently shown that pretreatment of recipient mice with donor alloantigen combined with anti-CD4 antibody therapy generates CD25+CD4+ T cells that can prevent graft rejection.
Takaoka et al. (1998)CD25T cellsThe expression of IL-2 receptor (CD25) by SEB on splenocyte T cells from collagen-preimmunized mice was inhibited by both agents in ex vivo experimentation.
Thornton (2006)CD25T cellsIt was not until the characterization of this subpopulation of CD4+ T cells demonstrated that they co-expressed the IL-2R-alpha chain (CD25) that the puzzling phenotype observed in IL-2 deficient mice began to be truly explained.
Thornton (2006)IL-2R-alphaT cellsThe constitutive expression of the IL-2R-alpha chain on CD4+CD25+ T cells led to the obvious speculation that IL-2 signaling in CD4+CD25+ T cells was important to these cells.
Hengel et al. (1991)IL 2RT cellThe blockade of T cell proliferation by H7 was not due to an inhibition of PKC translocation, but occurred even 4-8 h after T cell induction and correlated with a significant reduction of IL 2 receptor (IL 2R) expression.
Ramilo et al. (1993)CD25T cellsThe alpha-chain of the IL-2R (CD25, Tac, p55) is expressed on activated but not resting T cells and therefore represents an ideal marker to distinguish activated from resting T cells.
Xia et al. (2006)CD25T-cellCD25 expression was dynamic in vivo: maintained CD25 expression on Treg was indicative for the preservation of allosuppression, while significantly enhanced CD25 expression on CD4+ effector T cells was most likely associated with T-cell expansion and graft rejection.
Valenzuela et al. (2002)IL-2RT cellsIn experiments examining in vitro stimulation of naive CD8 T cells, IL-12 is shown to stimulate expression of the IL-2R alpha-chain (CD25) to much higher levels than are reached in response to just TCR and costimulation and/or IL-2.
Papiernik et al. (1998)IL-2RT cellsRegulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.
Papiernik et al. (1998)IL-2RT cellWe recently characterized a CD4+ T cell population expressing the IL-2R alpha chain (CD25), producing IL-10 and resisting clonal deletion induced by viral superantigen (vSAG) encoded by mouse mammary tumor virus [MMTV(SW)].
Chang et al. (1992)IL2RT-cellsAlprazolam also reduced the production of IL2 by splenic T-cells, but did not alter the expression of IL2R on Con A-induced T-blast cells.
Simons et al. (2006)CD25T-lymphocyteThe T-lymphocyte fraction of splenocytes was assayed during the recovery period for IL-2 secretion, expansion of the T-lymphocyte population, and expression of the activation marker CD25.
d'Hennezel et al. (2010)CD25T cellsIn accordance, it was simultaneously shown that CD4+ T cells of the memory subset display higher surface expression levels of CD25 in patients harboring a predisposing allele[34].
Papiernik et al. (1997)CD25T cellsWe found that T cells recognizing viral superantigen (vSAG) can be subdivided into two distinct functional subsets based on IL-2R alpha (CD25) expression.
Izeradjene et al. (2001)IL-2RT cellsIn BALB/c mice, staphylococcal enterotoxin B (SEB)-induced cytokine secretion, IL-2R (CD25) expression and early deletion of a fraction of SEB-reactive V(beta)8(+) T cells were not impaired by either MTX (7 mg/kg/day) or tomudex (5 mg/kg/day).
Truitt et al. (1999)CD25T cellsWith selected PCT regimens, treated T cells still expressed activation markers (CD25 and CD69) and secreted IL-2 on activation, but they showed limited proliferative capacity in vitro and in vivo.
Thornton and Shevach (1998)CD25T cellsInduction of CD25 expression on CD25- T cells in vitro or in vivo did not result in the generation of suppressor activity.
Szabolcs et al. (2004)CD25T cellsRecently described depletion strategies target activation markers such as CD25 that are expressed by alloreactive T cells.
Szabolcs et al. (2004)CD25T cellsSimilarly, a second agent, denileukin diftitox, kills activated alloreactive T cells expressing CD25.
Kish et al. (2007)CD25T cellsFlow cytometry analyses of LN cells from Class II MHC-/- mice revealed a population of CD4+ T cells with a majority expressing CD25.
Suri-Payer et al. (1998)CD25T cellsFurthermore, the CD4+CD25+ T cells appear to be members of a unique lineage of regulatory T cells, as the induction of CD25 expression on a monospecific population of T cells derived from TCR transgenic SCID mice did not result in suppression of post-thymectomy autoimmunity.
Secor et al. (2009)CD25T cellsBromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro.
Secor et al. (2009)CD25T cellThe current study was designed to determine the effect of Br on CD4(+) T cell activation, specifically the expression of CD25 in vitro.
Secor et al. (2009)CD25T cellsBr treatment of anti-CD3 stimulated CD4(+) T cells reduced CD25 expression in a dose and time dependent manner.
Finkelman et al. (1986)IL 2RT cellsResponsiveness of B and T cells to IL 2 has been associated with expression of a cell membrane IL 2 receptor (IL 2R).
Finkelman et al. (1986)IL 2RT lymphocytesIL 2R expression by splenic B and T lymphocytes from GaM delta injected mice was studied by a dual label immunofluorescence technique.
Maggio-Price et al. (1993)IL-2RT cellsIncreased proliferation of T cells from anemic mice was associated with a larger percentage of T cells expressing IL-2R (p55 or CD25) at 24 and 48 hr after activation.
Yin et al. (2008)CD25T lymphocytesFluorescence conjugated monoclonal antibodies and flow cytometry were used to detect the expression of CD69, CD25 and CD 71 of the activated T lymphocytes in vitro in response to Concanavalin A (ConA).
McMurray et al. (1994)IL2RT cellsIL2R and Pgp-1 were expressed on both CD4+ and CD8+ intrathyroidal T cells.
McMurray et al. (1994)IL2RT cellsDepletion of CD8+ T cells in recipient mice did not reduce EAT severity and resulted in an increased percentage of intrathyroidal CD4+ T cells expressing IL2R.
Kaminitz et al. (2010)CD25T cellsLikewise, IL-2 protects CD25+ T cells from apoptosis in mixed cultures (p<0.01, Figure 3C), a phenomenon also associated with faster cycling of this subset (Figure 3D).
Kaminitz et al. (2010)CD25T cellsMeasurements of Treg cell apoptosis in CD3-activated mixed cultures are limited by CD25 expression in naïve/effector CD4+ T cells as a feature of activation.
Dey et al. (1998)CD25T cellsHowever, the later, GVHD-associated increase in CD25 and very late antigen-4 (VLA-4) expression on donor T cells was greatly depressed in IL-12-protected mice compared with GVHD controls.
Pénit et al. (1995)CD25T cellT cell early precursors belong to the CD3-CD4-CD8- triple negative (TN) thymocyte population that can be subdivided on the basis of CD44, CD25, and heat-stable Ag (HSA) expression.
Hardt et al. (1985)IL 2-RT cellAt various times of gestation murine fetal thymocytes were tested for IL 2 receptor (IL 2-R) and T cell differentiation antigen expression.
Zhu et al. (2006)IL-2RalphaT cellFurther studies showed PSE dose dependently inhibited anti-CD3-induced primary T cell proliferation, activation for IL-2Ralpha (CD25) expression, and cytokine (IFN-gamma and IL-2) production also at the transcriptional level.
Edinger et al. (2003)IL-2RT cellsHere we demonstrate that in host mice with leukemia and lymphoma, CD4+CD25+ regulatory T cells suppress the early expansion of alloreactive donor T cells, their interleukin-2-receptor (IL-2R) alpha-chain expression and their capacity to induce GVHD without abrogating their GVT effector function, mediated primarily by the perforin lysis pathway.
Xing et al. (2008)CD25T cellsAnisomycin down-regulated remarkably the CD69 and CD25 expression on the surface of T cells.
Kobayashi et al. (1996)CD25T cellsThe proportion of T cells expressing CD25, a lymphocyte activation marker, in the spleen and peripheral blood tended to increase in the CC treated group.
Keino et al. (2006)CD25T cellsMETHODS: Naïve T cells from DO11.10 mice were activated in vitro by ovalbumin (OVA)-pulsed, TGFbeta-treated antigen-presenting cells (APCs), and the expression of CD25 assayed by flow cytometry.
Itoh et al. (1999)CD25T cellsThymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.
Valzasina et al. (2006)CD25T cellsTumor injection in thymectomized and CD25-depleted mice shows that CD4+CD25+ T-cell expansion occurs even in the absence of the thymus and independently from proliferation of preexisting CD25+ T cells.
Velásquez et al. (2007)CD25T cellsAlthough Treg in mice are CD4+CD25+, in humans the Treg phenotype is restricted to CD4 T cells with high expression of CD25 (CD25high) and Foxp3.
Krajina et al. (2004)CD25T cellsMany DP T cells found in spleen, mesenteric lymph nodes (MLN) and colonic lamina propria (cLP) express CD25, CD103 and Foxp3.
Storni and Bachmann (2003)CD25T cellsWhereas proliferation of specific T cells was comparable in both systems, the production of IFN-gamma and the expression of CD25 showed important differences.
Bonnefoix et al. (1991)CD25T cellsWe searched for the presence of IL2 receptor (CD25) on T cells as an activation marker in lymph nodes involved by B-cell non-Hodgkin's lymphomas (B-NHL).
Sun et al. (2010)CD25T cellsProliferation of CD4(+)CD25(-) T cells was measured using a modified MTT assay.