Viewing affirmative mentions of gene expression of Il2 (M. musculus) in T cells

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Nihashi et al. (1985)IL2T cellSuch PtLN cells exhibited augmented proliferative responses to T cell mitogens and exogenous interleukin 2 (IL 2) and showed a great ability to produce IL2, which suggests an increase in mature T cells in the PtLN.
Dutartre and Pascal (1991)IL2T cellLymphocyte proliferation and IL2 production in response to a T cell mitogen are greatly diminished during the whole life of the animals, on the contrary B cell proliferation in the presence of lipopolysaccharide is not modified.
McGuire and Rothenberg (1987)interleukin 2T-cellExpression of the gene for the T-cell growth hormone, interleukin 2 (IL2), is subject to at least two types of control.
Yokota et al. (1985)TCGFT-cellBy assaying the supernatant fluid, IL-2 cDNA clones that express T-cell growth-factor (TCGF) activity were identified.
Fujiwara and Yokoyama (1994)IL-2T cellsIt can be assumed that activated L3T4- T cells interact with antigen-specific L3T4+ T cells and lead to enhanced IL-2 production.
Emoto et al. (1990)IL-2T lymphocytesThese results suggest that the suppression of blastogenic response of T lymphocytes to mitogens in seminal plasma is caused by an undialyzable component (or components) derived from seminal vesicle and is attributable to the alteration of receptors for mitogens or of IL-2 receptors that are expressed on stimulation by mitogens.
Cunha-Neto and Rizzo (1989)interleukin-2T cellProstaglandin E2 inhibits proliferation but not interleukin-2 production by phorbol ester plus calcium ionophore-activated murine T cell clones.
Cunha-Neto and Rizzo (1989)IL-2T cellPGE2 treatment at the same concentrations did not inhibit IL-2 production by phorbol ester plus calcium ionophore-stimulated T cell clones as assayed by CTLL proliferation. 4.
Chang et al. (1989)IL-2T cellsScid lymphocytes responded to IL-2 by becoming adherent LANK cells with potent NK-like activity, suggesting that soluble lymphokines other than IL-2 that may have been produced by T cells were not required for the generation of LANK cell activity in mice.
Stark et al. (1992)IL-2T cellsSince neither viable but nonreplicating T cells nor IL-2 alone caused GVHD, it is suggested that endogenously produced IL-2 by alloactivated T lymphocytes may be important in the development of the GVHD syndrome, independent of its main function of enhancing T lymphocyte proliferation.
Choudhry et al. (2000)interleukin-2T cellOur data demonstrated a 20-25% decrease in Con A-mediated splenic T cell proliferation (p<0.01) and 45-50% decrease in interleukin-2 (IL-2) production (p<0.01) following burn injury compared to the T cells from sham animals.
Choudhry et al. (2000)IL-2T cellsA further decrease in the proliferation (25-30%) and IL-2 production (40-45%) was detected in T cells derived from burned animals receiving alcohol as compared to burn alone.
Choudhry et al. (2000)IL-2T cellsNo significant change in the proliferation and IL-2 production was observed in splenic T cells derived from sham-injured mice regardless of alcohol exposure.
Choudhry et al. (2000)IL-2T cellThese results suggest that alcohol consumption prior to burn injury causes a greater decrease in T cell proliferation and IL-2 production compared to either burn or alcohol injury alone that may further attenuate the cell-mediated immunity and thus enhance susceptibility to infection.
Crispin and Alcocer-Varela (1998)IL-2T cellsThe IL-2 production by T cells is part of a complex network in which a discrete alteration is capable of disrupting the whole system.
Buiuklinskaia et al. (1992)interleukin-2T-lymphocytes[The effect of beta-carotene on interleukin-2 production and mitogen-induced proliferation of T-lymphocytes].
Buiuklinskaia et al. (1992)IL-2T lymphocytesInterleukin-2 (IL-2) production followed by with aftereffect of the immunosuppressive agent hydrocortisone and mitogen-induced proliferation of T lymphocytes were studied in the presence of artificial beta-carotene.
Malkovský et al. (1985)IL-2T-cellAs further evidence of the complicity of IL-2 in the inception and maintenance of tolerance, it is shown here that a solid and long-lasting state of tolerance induced by the intravenous injection into newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn)F1 hybrids can be brought to an end by the administration of exogenous IL-2 or by supplementing an otherwise normal diet with vitamin A acetate, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2.
Dennert (1985)IL-2T cellsIt appears therefore that RA has an effect on T cells that are destined to produce IL-2 upon antigenic challenge.
Knulst et al. (1992)IL-2T cellIL-2 production enhances the IL-2 receptor expression and leads to T cell proliferation.
Chang et al. (1990)IL2T cellsFurthermore, ethanol had only a minimal suppressive effect on IL2 production by T cells of both young and old mice, even at the concentration of 100 mM.
Havran et al. (1986)IL-2T lymphocyteThe subsequent decrease in IL-2 receptor expression correlated with a decrease in the levels of IL-2 remaining in the culture supernatants of cytolytic T lymphocyte cells.
Havran et al. (1986)IL-2T cellsThe daily addition of low levels of IL-2 to cultures resulted in the prolonged expression of high levels of IL-2 receptors by non-IL-2-producing cloned cytolytic T cells.
Barasoain et al. (1986)IL-2T lymphocyteAn enhancement of T lymphocyte proliferation and IL-2 production was observed in both cases.
Barasoain et al. (1986)IL-2T lymphocyteThere was no correlation between the small effect observed in T lymphocyte proliferation and the enhancement of IL-2 levels found in the supernatants of Con A activated spleen cells, specially in normal mice.
Diamantstein et al. (1985)interleukin 2T cellStudies on interleukin 2 receptor expression and IL-2 production by murine T cell lymphomas.
Gillis et al. (1979)TCGFT-cellWe found that spleen, lymph node, and bone marrow cells, isolated from nude mice, were incapable of producing TCGF yet responded normally to T-cell mitogen sensitization provided stimulation was conducted in the presence of TCGF.
Gillis et al. (1979)TCGFT lymphocytesThese results suggest that prothymocytes present in nude mice are capable of responding to immunologic stimuli by differentiating, in vitro, into cytolytic T lymphocytes and that furthermore, a major function of the thymus may be to effect the maturation of TCGF-producing cells.
Hoffenbach et al. (1983)interleukin 2T-cellDeficit of interleukin 2 production associated with impaired T-cell proliferative responses in Mycobacterium lepraemurium infection.
Hoffenbach et al. (1983)IL2T cellThese data suggest that a defect in IL2 production and utilization might contribute to the impairment of T cell-mediated immunity observed in MLM-infected mice.
Yoshii et al. (1991)IL-2T-cellsRestorative effect of neurotropin on maturation of bone marrow cells to IL-2-producing T-cells in aging BALB/c mice.
Yoshii et al. (1991)IL-2T-cellsTo clarify the mechanism by which Neurotropin restores IL-2 production, its effect on the recruitment of IL-2-producing T-cells from bone marrow cells was examined using syngenic radiation bone marrow chimeras.
Yoshii et al. (1991)IL-2T-cellsTwo fundamental lesions in recruiting IL-2-producing T-cells in aging BALB/c mice were demonstrated: (1) a drastic decline of the maturation of bone marrow cells to IL-2-producing T-cells as demonstrated by old----young chimeras; and (2) an environment unable to support bone marrow cell differentiation to IL-2-producing T-cells by young----old chimeras.
Yoshii et al. (1991)IL-2T-cellThese results suggest that Neurotropin administration restores IL-2 production through the recovery of the maturation of bone marrow cells to IL-2-producing T-cells, resulting in restoration of in vivo T-cell immune response in aging BALB/c mice.
Sekigawa et al. (1989)IL-2T cellsThe G-10 adherent B cells from the old mice also inhibited the IL-2 production of T cells from the young B/W F1 mice.
Sekigawa et al. (1989)IL-2T cellsWith aging, activation of the B cells progresses and they appear to down-regulate the IL-2 hyperresponse of B cells and the IL-2 synthesis by T cells.
Kalland (1985)IL-2T lymphocyteInhibition of T lymphocyte activation by estramustine: dose-dependent interference with IL-2 production and later proliferation events.
Kalland (1985)interleukin 2T lymphocyteThus the preferential inhibitory effect of estramustine on mitogen-induced T lymphocyte activation is apparently mediated by interference with the production or release of interleukin 2.
Turcotte and Lemieux (1989)IL-2T-cellThe depressed IL-2 utilization started to be observed about 1 to 2 weeks prior to the onset of the depressed IL-2 production and was not reversed by the addition of exogenous IL-2; thus implying that a lack of IL-2 utilization rather than a lack of IL-2 production could be directly responsible for the inhibition of T-cell proliferative responses to Con A in SC cultures of infected mice.
Cheever et al. (1984)IL 2T cellThus, the current studies highlight the potential of exogenous IL 2 to induce T cell growth in vivo and suggest that the administration of IL 2 in vivo may be useful for augmenting T cell responses that are relatively deficient in the production of endogenous IL 2.
Vie and Miller (1986)IL-2T cellsDecline, with age, in the proportion of mouse T cells that express IL-2 receptors after mitogen stimulation.
Rocha et al. (1989)Interleukin 2T cellsInterleukin 2 receptor expression and interleukin 2 production in exponentially growing T cells: major differences between in vivo and in vitro proliferating T lymphocytes.
Sorg et al. (1989)interleukin-2T cellEffect of dexamethasone on the expression of interleukin-2 in a mouse T cell line.
Sorg et al. (1989)IL-2 mRNAT cellThe effect of the synthetic glucocorticoid, dexamethasone (dex), on the production of interleukin-2 (IL-2) and IL-2 mRNA was examined in the mouse T cell line, LBRM-33.4A2. 2.
Cillari et al. (1986)IL-2T cellsFurthermore, Sephadex G-10 column-treated and plastic adherent, nonspecific esterase-positive spleen cells from mice with progressive disease were able to suppress IL-2 production by normal splenic T cells.
Nagarkatti et al. (1994)IL-2T cellsThese studies demonstrate that aberrant regulation of IL-2 production can lead to spontaneous transformation of T cells in vitro, capable of inducing tumors in vivo.
Hardy et al. (1990)IL-2T-cellSubmissive mice had lower T-cell proliferation and IL-2 production, when compared to dominant, nonfought, or witness mice.
Hardy et al. (1990)IL-2T-cellDominant mice had elevated T-cell proliferation and IL-2 production when compared to the other treatment groups.
Yamanouchi et al. (2007)Il2T cellIn order to test directly that an approximately twofold reduction in IL-2 underpins the Idd3-linked destabilization of immune homeostasis, we show that engineered haplodeficiency of Il2 gene expression not only reduces T cell IL-2 production by twofold but also mimics the autoimmune dysregulatory effects of the naturally occurring susceptibility alleles of Il2.
Donohue et al. (1984)IL-2T-cellPure human interleukin 2 (IL-2), produced by the T-cell lymphoma Jurkat, was injected in mice to study the serum half-life, toxicity, and in vivo immunological effects of IL-2.
Adolfsson et al. (2001)IL-2T cellAging is associated with reduced T cell function, as demonstrated by decreased T cell proliferation and IL-2 production.
Adolfsson et al. (2001)IL-2T cellsThere was an age-related decline in both the number of IL-2+ T cells and the amount of IL-2 produced per cell.
Adolfsson et al. (2001)IL-2T cellsDespite decreased IL-2 protein at 48 h, the expression of IL-2 mRNA at 6 h and IL-2 protein production at 6 and 16 h was greater by T cells from old mice compared with that of young.
Sileghem et al. (1986)IL-2T cellsImpairment of T cell proliferation in mice infected with the pleomorphic Trypanosoma brucei AnTat 1.1 E clone was found not to be related to a depletion of T cells or to an absence of functional accessory cells, but rather to an active suppression of interleukin 2 (IL-2) production.
Stoeck et al. (1983)IL 2T cellSince the discovery of IL 2 it has been possible to dissect the mitogenic activation of T lymphocytes into two steps: first, the production of IL 2; and second, the response of IL 2-dependent T cell blasts to IL 2.
Bubeník et al. (1984)interleukin 2T-cellPhorbol myristate acetate-stimulated production of interleukin 2 by T-cell lymphoma and constitutive production by derived hybridomas.
Bubeník et al. (1984)IL-2T-cellTo isolate a stable tumor cell line source of IL-2 (TCGF), 19 murine T-cell lines and their derivatives were screened for both constitutive and mitogen-stimulated IL-2 production.
Glotz and Zanetti (1989)IL-2T lymphocytesFunctionally, autoantibody 21G10 blocks (greater than 90%) the incorporation of [3H]TdR by T lymphocytes stimulated in vitro with Con A, and inhibits the production of IL-2 by these cultures.
Altman et al. (1981)IL-2T cellIn the studies reported here, we have analyzed the production and consumption of T cell growth factor, more recently termed interleukin 2 (IL-2), as well as some cell-mediated immune functions, in murine strains [MRL, BXSB, NZB, and (NZB x NZWF1] manifesting systemic lupus erythematosus (SLE)-like syndromes.
Altman et al. (1981)IL-2T cellsThese results indicate that the proliferating Thy-1.2+, Lyt-1+ T cells in MRL/l mice are defective in their responses to mitogenic stimuli, in IL-2 production, and in expression of acceptor sites for IL-2.
Miyajima et al. (1985)IL-2T-cellThe resulting recombinant plasmid directed the synthesis of mature mouse IL-2 in S. cerevisiae, with most of the T-cell growth-factor (TCGF) activity secreted into the culture fluid and extracellular space.
O'Riordain et al. (1993)IL-2T lymphocyteBACKGROUND: Among the fundamental immunologic abnormalities induced by serious traumatic or thermal injury are alterations in T cell activation, reduced lymphocyte interleukin-2 (IL-2) production, and associated depression of T lymphocyte proliferation.
O'Riordain et al. (1993)IL-2T cellCONCLUSIONS: These results suggest that the principal cellular abnormalities that result in altered T cell activation and IL-2 production after thermal injury lie downstream of the initiating signal transduction events and before IL-2 gene transcription.
Motta et al. (1986)Il-2T-cellThe low level of Il-2 produced by LPS-sensitized spleen cells is sufficient for lectin-induced T-cell proliferation.
Hecht and Paul (1981)interleukin-2T-cellCell-free supernatant from a T-cell hybridoma synthesizing interleukin-2 was also effective in permitting virus growth when inoculated 3 h before infection.
Kidao et al. (1993)interleukin-2T lymphocytesRRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells.
Kidao et al. (1993)IL-2T lymphocytesRRR-alpha-tocopheryl succinate (vitamin E succinate) was studied for its effects on interleukin-2 (IL-2) production by chicken splenic derived T lymphocytes and murine EL-4 thymic lymphoma cells.
Kidao et al. (1993)IL-2T cellSupernatants from 0.1 microgram/mL vitamin E succinate-supplemented chicken splenic T cell cultures exhibited 42-72% enhanced IL-2 production over vehicle controls when tested in a chicken T cell blast bioassay.
Kidao et al. (1993)IL-2T lymphocytesSupplementation of chicken splenic T lymphocyte cultures with butylated hydroxyanisole (BHT) and butylated hydroxytoluene (BHA) also induced elevated levels of IL-2, suggesting a role for antioxidants in IL-2 production by avian splenic T lymphocytes.
Del Gobbo et al. (1990)IL-2T cellsIL-2 production was not dependent on (i) a decreased number of T cells or (ii) a primary defect in IL-1 production, but on a T-suppressor cell subpopulation.
Gautam et al. (1983)IL 2CTLThus, injection of CBA/J cells with TNP-modified syngeneic spleen cells produces IL 2 in vivo in sufficient quantity to neutralize the activity of the inhibitor as well as to facilitate the maturation of pre-CTL into hapten-altered self-specific CTL.
Hao et al. (1993)interleukin 2T-lymphocytesThe suppressive molecules inhibit interleukin 2 production by the T-lymphocytes.
Fischbach and Talal (1985)interleukin-2T cellAbility of isoprinosine to restore interleukin-2 production and T cell proliferation in autoimmune mice.
Sjöö et al. (2006)interleukin-2T cellsTreatment with treosulfan induced only interleukin-2 production in spleen cells for a short time and had no significant effect on synthesis of tumor necrosis factor-alpha and/or interferon-gamma as compared with that observed in splenic T cells isolated from mice treated with either busulfan or cyclophosphamide.
Hauser et al. (1985)Interleukin-2T cellInterleukin-2 production was measured by the proliferative response of an interleukin-2-dependent mouse T cell line to the addition of supernatant obtained from cord blood lymphocyte cultures.
O'Malley et al. (1999)IL-2CTLReducing IL-2 expression by half with a mixture of 1:1 transduced to nontransduced tumor cells eliminated the antitumor effect and decreased the CTL response.
Vidard et al. (1994)interleukin 2T-cellSurprisingly, we found that, before the establishment of specific T-cell tolerance to ovalbumin, T cells from mice that will display tolerance were responsive and synthesized interleukin 2 upon antigen challenge in vitro.
Ceredig and Corradin (1986)interleukin 2T cellHigh antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones.
Jakobovits et al. (1982)interleukin-2T cellsT cells modified by B membranes were stimulated by lipopolysaccharide (LPS) to proliferate as well as to produce interleukin-2 activity.
Calabresi et al. (1992)IL-2T-cellThis was accompanied by considerable suppression of IL-2-receptor expression, which was not attributable to the elimination of a particular T-cell subset.
Calabresi et al. (1992)IL-2T-cellsImpairment of IL-2 production was not due to a primary defect in L3T4+ T-cells, but rather to the presence of both adherent and non-adherent suppressor cells that apparently acted via prostaglandin-independent and dependent mechanisms.
MacDonald and Lees (1984)IL 2T cellIL 2-P were detected and quantitated in a sensitive limiting dilution microassay in which Lyt-2-depleted lymphoid cell populations were first cultured for 12 days with irradiated allogeneic (DBA/2) stimulating cells and a source of IL 2 and then washed and restimulated with irradiated T cell-depleted stimulating cells for an additional 24 hr.
Flomenberg et al. (1983)IL 2T cellThe lymphocytes from one child with Nezelof's T cell deficiency demonstrated absence of endogenous IL 2 production and improved proliferative responses to mitogen or alloantigen in the presence of exogenous IL 2.