Viewing affirmative mentions of gene expression of Il12a (M. musculus) in T cells

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Uekusa et al. (2002)IL-12T cellsThese results indicate that endogenously produced IL-12 has dual roles in anti-tumor-immune resistance: One is to confer T cells with a tumor-migratory capacity, and the other is to allow tumor masses to develop the capacity to accept tumor-migrating T cells.
Utsunomiya et al. (2001)IL-12T cellsLPS-stimulated IL-12 production was also impaired in normal mice inoculated with burn-associated type 2 T cells.
Tourkova et al. (2001)IL-12T cellFinally, Staphylococcus aureus-mediated activation of DC significantly increased T cell proliferation and this effect was not dependent on IL-12 production of DC since DC generated from IL-12 knockout mice were not different from wild type DC.
Hofer et al. (2004)IL-12T cellsThey further suggest that expression of IL-12 in the central nervous system may lead to localized recruitment of T cells that recognize antigens expressed in the brain.
Suzumura et al. (1998)IL-12T cellThus, it is possible that some population of microglia induce helper 1 type T cell response via producing IL-12 in the CNS.
Wang et al. (1999)interleukin-12T cellGene transfer of interleukin-12 had little effect on tumor volumes and survival of tumor-bearing athymic nude mice, emphasizing the requirement for T cell directed cellular immunity.
Iwasaki et al. (2000)IL-12RT cellsThese results indicate that a fundamental difference exists in IL-12 responsiveness of T cells between IL-12-responsive and -unresponsive tumor models, and that such a difference is associated with the expression of IL-12R on T cells.
Shibata et al. (2006)IL-12T-cellCONCLUSIONS: In vivo electrogene transfer of IL-12 exerts strong anti-tumorigenic and anti-metastatic effects likely due to T-cell-mediated immune responses as well as anti-angiogenic action.
Vetter et al. (2009)IL-12T cellsHowever, glioma rejection was significantly enhanced in mice expressing IL-12 in the CNS and was predominantly dependent on the presence of CD8+ T cells while CD4+ T cells had less impact.
Mara?da and Robak (1998)IL-12T-cellIL-12 production is induced by bacteria, intracellular pathogens, fungi, viruses, or their products in a T-cell-independent pathway or a T-cell-dependent pathway, the latter mediated through CD40 ligand-CD40 interaction.
Rizzitelli et al. (2002)IL-12T lymphocytesT lymphocytes potentiate murine dendritic cells to produce IL-12.
Rizzitelli et al. (2002)IL-12T cellsIn conclusion, B and T cells exert balanced actions on DCs by respectively inhibiting or promoting IL-12 production.
Kelleher et al. (1999)IL-12T cellNormal DC produced IL-12 and IL-10 and stimulated primary allogeneic T cell proliferation.
Kelleher et al. (1999)IL-12T cellExposure of DC to RLV caused reduced production of IL-12, production of IL-4 was seen in DC for the first time and T cell stimulation was inhibited.
Bright et al. (1999)IL-12T cellsOn binding to IA(S), SEB induces IL-12 production in macrophages, which in turn augments antigen-induced proliferation of HS-17 T cells.
Bright et al. (1999)IL-12T cellTreatment with anti-IA(S) nmAb 10-3.6 inhibited the antigen- and SEB-induced IL-12 production and T cell proliferation.
Bright et al. (1999)IL-12T cellThese results suggest that SAgs augment antigen-specific T cell responses by inducing IL-12 production in macrophages.
Szeliga et al. (1997)IL-12T cellsIL-12 was produced only during nonspecific cytotoxic reaction of CD4+ and CD8+ T cells.
Pagenstecher et al. (2000)IL-12T cellWe conclude that localized expression of IL-12 by astrocytes can 1) promote the spontaneous development of activated type 1 T cell and NK cellular immunity and cytokine responses in the CNS, and 2) promote more effective Ag-specific T cell dynamics but not activity in experimental autoimmune encephalomyelitis.
Moran et al. (2003)IL-12T cellsBoth IL-12 expressing tumors, however, grew progressively in nude mice indicating an important role for T cells in each case.
Utsunomiya et al. (2001)IL-12T cellsAlso, IL-12 production was induced by LPS in TI-mice inoculated with CD4+T cells from spleens of GR-treated normal mice (GR-CD4+T cells, 5x10(6)cells/mouse).
Kuipers et al. (2004)IL-12T cellsRetrovirally mediated overexpression of IL-12 in DCs strongly polarized naive ovalbumin (OVA)-specific CD4+ T cells toward Th1 effector cells in vitro.
Schmitt et al. (1997)IL-12T-cellInvolvement of T-cell subsets and natural killer (NK) cells in the growth suppression of murine fibrosarcoma cells transfected with interleukin-12 (IL-12) genes.
Zhu et al. (2007)IL-12RT cellsIn accordance with this observation, we found that iNKT cells expressed the IL-12R constitutively, in contrast to conventional T cells.
Osorio and Ghiasi (2005)IL-12p35T-lymphocyteThe higher efficacy against ocular virus replication and explant reactivation correlated with higher neutralizing antibody titers, cytotoxic-T-lymphocyte activities, and IFN-gamma expression in recombinant HSV-1 expressing IL-12p35 compared to other vaccines.
Kennedy et al. (1996)IL-12T cellsHere, we show that the expression of CD40L by activated T cells is critical for T cell-dependent IL-12 production by mouse macrophages.
Kennedy et al. (1996)IL-12T cellsIn addition, both activated T cells and a Th1 clone derived from CD40L knockout mice failed to induce IL-12 production from splenic APC or peritoneal macrophages.
Kennedy et al. (1996)IL-12T cellsFinally, macrophages cultured in the absence of T cells produced IL-12 upon stimulation with soluble recombinant CD40L in combination with either supernatants from activated Th1 clones or with interferon-gamma and granulocyte/macrophage colony-stimulating factor.
Kennedy et al. (1996)IL-12T cellsThus, both CD40L-dependent and cytokine-mediated signals from activated T cells are required to induce the production of IL-12 by macrophages.
Fallarino et al. (1997)IL-12CTLInasmuch as IL-12 is another important factor for CTL maturation, P1.HTR transfectants expressing B7-1 and/or IL-12 were then constructed.
Anderson et al. (2004)IL-12T cellWe conclude that APCs expressing FcgammaR on their surface can respond to immune complexes by shutting off IL-12 biosynthesis, to prevent the Th1-type T cell biasing that normally accompanies innate immune activation.
Koch et al. (1996)IL-12T cellsWe have shown previously that dendritic cells (DC) produce IL-12 upon interaction with CD4+ T cells.
Macatonia et al. (1995)IL-12T cellsIn this study, we demonstrate that dendritic cells can produce IL-12, a dominant cytokine involved in the development of IFN-gamma-producing T cells.
Mazzolini et al. (2000)interleukin 12T cellAdenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level.
Mazzolini et al. (2000)IL-12T cellOur data provide evidence of a strong synergy between gene transfer of IL-12 and adoptive T cell therapy.
Gherardi et al. (2003)IL-12T cellTh1 parameters (CD8(+) T cell response and IgG2a : IgG1 ratios) were increased in mice inoculated with rVVs expressing both IL-12 and IL-18 as compared to those animals receiving a single cytokine.
Ptak et al. (2000)IL-12T cellThese results indicate that bypass of tolerance by treatment of TNP-Mphi with HA is a result of an increased production of IL-12 by these cells and an enhanced expression of costimulatory molecules important in T cell-Mphi interactions.
Palmer et al. (2001)IL-12T cellIt has been shown that intratumor administration of an adenovirus vector expressing IL-12 produces a potent T cell-mediated response that leads to significant tumor regression in a murine breast cancer model.
O'Connell et al. (2003)IL-12p70T cellThe elevated production of IL-12p70 by short-term cultured DC correlates with their enhanced expression of CD40 and other costimulatory molecules, and elevated T cell-stimulatory capacity.
Gieni et al. (1996)IL-12T cellsThe strain differences in IL-12 production were observed only in antigen-driven responses (and not in responses induced by bacterial products), and were dependent upon an interaction between CD4 T cells and lymph node adherent cells.
Gieni et al. (1996)IL-12T cellsIn addition, differences in the quantity of IL-12 produced by DBA/2 and BALB/c antigen-presenting cells (APC) was not dependent on differential production of IFN-gamma by T cells, since APC from DBA/2 mice still produced much greater quantities of IL-12 than did BALB/c APC when each was cultured with the same H-2d-restricted Th2 clones, in the complete absence of IFN-gamma, or when each was cultured with primed (BALB/c x DBA/2)F1 T cells.
Gieni et al. (1996)IL-12T cellsThe level of IL-12 produced in the cultures critically affected cytokine production in CD4 T cells, since neutralization of endogenous IL-12 in DBA/2 cultures, which are predisposed towards developing Th1 responses, reduced IFN-gamma production and enhanced IL-4 synthesis to levels normally seen in BALB/c cultures, which are predisposed toward developing Th2 responses.
Castro et al. (1995)IL-12T cellsEndogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice.
Castro et al. (1995)IL-12T cellsIn this study, we analyzed whether endogenously produced IL-12 was involved in the generation of such protective T cells.
Sherwood et al. (2001)IL-12T cellsT cells isolated from glucan-treated mice exhibited increased IFN-gamma expression in response to IL-12 and IL-18, as well as increased expression of the IL-12 and IL-18 receptors.
Ogawa et al. (1998)IL-12T-cellThese results indicate that IFN-gamma plays two distinct roles in expressing the antitumor efficacy of IL-12: one is to support the T-cell acceptability of tumor masses, and the other is to mediate the antitumor effects of migrated T cells.
Collison et al. (2007)IL-35T-cellEctopic expression of IL-35 confers regulatory activity on naive T cells, whereas recombinant IL-35 suppresses T-cell proliferation.
Hondowicz et al. (2000)IL-12T cellThus, C3H mice with a Th2 response maintain a CD4+ T cell population that expresses IL-12 receptor beta1 and beta2 mRNA and produces IFN-gamma after exposure to IL-12.
Sinha et al. (2007)IL-12T cellTherefore, MDSC impair tumor immunity by suppressing T cell activation and by interacting with macrophages to increase IL-10 and decrease IL-12 production, thereby promoting a tumor-promoting type 2 response, a process that can be partially reversed by gemcitabine.
Mattner et al. (1993)IL-12T cellsIn this system IL-12p40 inhibited only the enhancement caused by IL-12 but not IFN-gamma synthesis of CD4+ T cells stimulated with anti-CD3 alone.
Valenzuela et al. (2002)IL-12T cellsThese results suggest that when cross-priming dendritic cells present class I/Ag and costimulatory ligands, and produce IL-12, naive CD8 T cells will begin to produce IL-2 and both receptors will be optimally up-regulated to insure that an effective response is generated.
Nakajima et al. (2001)IL-12T cellsCII-specific T cells or hybridomas were transduced using retroviral vectors to constitutively express the IL-12 antagonist, IL-12 p40.
Nakajima et al. (2001)IL-12T cellsThe beneficial effect on CIA of IL-12 p40-transduced T cells required TCR specificity against CII, since transfer of T cells specific for another antigen producing equivalent amounts of IL-12 p40 had no effect.
Reis e Sousa et al. (1997)IL-12T cellsImportantly, this production of IL-12 occurs very rapidly and is independent of interferon gamma priming or of signals from T cells, such as CD40 ligand.
MacDonald and Pearce (2002)IL-12T cellThese data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC.
Holz et al. (2001)IL-12T cellsThus, the ectopic expression of IL-12 does not spontaneously break tolerance and activate antigen-specific T cells in the periphery, but it does worsen ongoing autoimmune disease.
Henry et al. (2010)IL-12T cellsListeria monocytogenes infection induces a strong inflammatory response characterized by the production of IL-12 and IFN-gamma and protective immunity against this pathogen is dependent on CD8+ T cells (CTL).
Gutiérrez-Ortega et al. (2005)IL-12T cellsMouse IL-12 expressed in tomato displays biological activity in vitro, as determined by interferon-gamma (IFN-gamma) secretion by T cells.
Kanagawa et al. (2008)IL-12T cellsTransduction of IL-12 genes into preexisting Meth-A tumors using RGD fiber-mutant adenoviral vectors (AdRGD), however, enhances tumor infiltration by T cells, thereby inducing tumor regression due to enhanced tumor infiltration by T cells.
Kanagawa et al. (2008)IL-12T cellsSome tumors, however, are resistant to IL-12; for example, in murine Meth-A fibrosarcoma, an IL-12-unresponsive tumor model, tumors do not regress following IL-12 administration due to the fact that few T cells migrate to tumor sites.
Kato et al. (1996)IL-12T cellsHowever, since IL-12 plays an important role in the activation of T cells interacting with APC, it is important to study the mechanism of IL-12 production induced by T helper cell-APC interaction.
Kabashima et al. (2004)IL-12T cellsHere, we found that our recently synthesized NF-kappaB inhibitor attenuated an ovalbumin-specific delayed-type hypersensitivity response in vivo and suppressed production of IL-12 by dendritic cells and TH1 cytokines by T cells in vitro.
Nishikomori et al. (2002)IL-12RT cellsIn this study we demonstrated that CD4(+) T cells from STAT4(-/-) mice exhibit reduced IL-12R expression and poor IL-12R signaling function.
Nishikomori et al. (2002)IL-12RT cellsIn a first approach to this question we determined the capacity of CD4(+) T cells from STAT4(-/-) bearing an IL-12Rbeta2 chain transgene (and thus capable of normal IL-12R expression and signaling) to undergo Th1 differentiation when stimulated by Con A and APCs.
Bette et al. (1994)p35T cellAfter injection of LPS or SEB, p40 mRNA was strongly induced in the T cell areas all over the spleen, whereas expression of p35 mRNA and its distribution pattern did not change.
Handel-Fernandez et al. (1997)IL-12T cellThese results indicate that the down-regulation of T cell-produced IFN-gamma in this tumor model is the result of decreased IL-12 production caused by tumor-derived factors and not a shift from the Th1 to the Th2 phenotype.
Wilson et al. (2010)IL-12T cellUnlike bacterial and viral systems where multiple innate cytokines can promote CTL effector differentiation [28],[29], in T. gondii infection, IL-12 appears to singularly control CD8+ T cell differentiation and IFN-?
Van Parijs et al. (1997)interleukin 12T cellRole of interleukin 12 and costimulators in T cell anergy in vivo.
Lasarte et al. (1999)RAdIL-12T cellInterestingly, in mice immunized with recombinant adenovirus expressing core and E1 proteins of HCV in combination with RAdIL-12 at low doses (1 x 107 plaque-forming units), L -NAME inhibited T cell proliferation and CTL activity in response to HCV Ags and also production of Abs against adenoviral proteins.
Marth et al. (1999)anti-IL-12T cellWe found that the numbers of Ag-specific T cells in several lymphoid organs were significantly reduced due to T cell apoptosis following oral OVA or systemic OVA administration when combined with anti-IL-12 injection, but there was no decrease in T cell numbers for OVA-fed, OVA-injected, or anti-IL-12 alone-treated mice compared with those in untreated control mice.
Chang et al. (1999)IL-12T cellsDefective expression was not secondary to the production of suppressive cytokines, but to a failure of B10.S MBP-specific T cells to upregulate CD40 ligand expression and to induce the production of IL-12.
Lasek et al. (1997)IL-12T cellsThere is strong evidence that antitumor activity of interleukin-12 (IL-12) in vivo is mediated, in part, through interferon (IFN gamma) produced by IL-12-stimulated natural killer and T cells.
Marie et al. (2001)IL-12T cellThe effects comprise reduced hypersensitivity responses associated with impaired function of dendritic cells, decreased production of IL-12, and the loss of antigen-specific T cell proliferation.
Becker et al. (2006)IL-12T cellCutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis.
Becker et al. (2006)IL-12T cellTaken together, our data identify cross-regulation of IL-12 expression by IL-23 as novel key regulatory pathway during initiation of T cell dependent colitis.
DeKruyff et al. (1998)IL-12T cellsWe investigated the effects of corticosteroids on IL-12 production by mouse splenic adherent cells and the subsequent capacity of these cells to induce cytokine production by CD4+ T cells.
DeKruyff et al. (1998)IL-12T cellsTreatment of splenic adherent cells with dexamethasone greatly inhibited production of IL-12, a cytokine known to enhance IFN-gamma synthesis and decrease IL-4 synthesis by CD4+ T cells.
DeKruyff et al. (1998)IL-12T cellsThese results help to resolve previous conflicting observations regarding the effects of corticosteroids on cytokine production by T cells, and indicate that while corticosteroids may directly inhibit Th1 and Th2 cytokine production in T cells, corticosteroids, by reducing IL-12 production in APCs, have the potential to indirectly enhance Th2 cytokine synthesis.
Gollob et al. (1998)IL-12T cellThis T cell subset expressed high levels of CD18 and upregulated IL-12 receptor expression after IL-12 treatment in vivo.
Gollob et al. (1998)IL-12T cellsIn normal subjects, these CD3(+)CD8(+)CD18(bright) T cells expressed IL-12 and IL-2 receptors and adhesion/costimulatory molecules to a greater degree than other CD8(+) and CD4(+) T cells.
Pearce and Shen (2007)IL-12T cellIL-12 is a proinflammatory cytokine that has been shown to enhance IFN-gamma-producing T cell responses and has been widely tested as a vaccine adjuvant.
Wang et al. (2001)IL-12 P35T lymphocytesRESULTS: (1) PMphis decreased significantly on 3 postburn day (PBD) and recovered quickly thereafter. (2) The gene expressions of IL-12 P35 and P40 subunits in PMphis were enhanced obviously. (3) Splenic index increased evidently and the karyokinesis phase increased in splenic lymphocytes. (4) The expressions of IFN-gamma and IL-4 in splenic T lymphocytes increased postburn.
Wang et al. (2001)IL-12T lymphocytesCONCLUSION: The expressions of IFN-gamma and IL-4 in splenic T lymphocytes and the expressions of IL-12 in PMphis could be enhanced by burn injury.
Nagarajan and Selvaraj (2002)IL-12T cellsGPI-IL-12-induced the proliferation of concanavalin A-activated T cells and induced IFN-gamma secretion by activated and allogeneic T cells, indicating that the membrane-expressed IL-12 can stimulate T cells.
Bagaeva et al. (2003)IL-12T cellsIL-12 dependent/IFN gamma independent expression of CCR5 by myelin-reactive T cells correlates with encephalitogenicity.
Trembleau et al. (1995)IL-12T cellsAdministration of interleukin 12 (IL-12), a key cytokine which guides the development of T helper type 1 (Th1) CD4+ T cells, induces rapid onset of IDDM in NOD, but not in BALB/c mice.
Xu et al. (2003)IL-12RT-cellThe parameters measured were T-cell proliferation, IFN-gamma production, induction of IL-12R expression, triggering of pathogenicity, and expression of costimulatory molecules on antigen-presenting cells (APCs) during in vitro exposure to antigen.
Xu et al. (2003)IL-12RT cellsCONCLUSIONS: The results suggest that TGF-beta suppresses acquisition of effector functions by autopathogenic T cells, in part by interfering with their response to IL-12 through downregulation of IL-12R expression and in part through inhibition of APC function.
Curtsinger et al. (2007)IL-12T cellsIn contrast, OT-I T cells deficient for both the IL-12 and type I IFN receptors expand only transiently and rapidly disappear.
Gieni et al. (1996)IL-12T cellsWe propose therefore that differential production of antigen-driven IL-12 is a mechanism by which the genetic background in DBA/2 and BALB/c mice can affect the pattern of cytokine synthesis by T cells during the development of adaptive immune responses.
Wüthrich et al. (2005)IL-12T cellsCD4(+) T cells absolutely required IL-12 to control a live genetically engineered attenuated strain of Blastomyces dermatitidis given s.c. as a vaccine, whereas CD8(+) T cells were significantly less dependent on IL-12.
Guler et al. (1999)IL-12T cellsT cells from B10.D2 and BALB/c mice show distinct control of IL-12 receptor expression.
Guler et al. (1999)IL-12T cellsWhen activated by Ag, B10.D2 T cells express functional IL-12 receptors and maintain IL-12 responsiveness.
Guler et al. (1999)IL-12T cellsAlso, cellular analysis of F1(B10.D2 x BALB/c) T cells demonstrates that Tpm1 exerts its effect on IL-12 receptor expression in a cell-autonomous manner, rather than through influencing the extracellular milieu.
Orange and Biron (1996)IL-12T cellInfections of NK and T cell-deficient mice demonstrated that virus-induced IFN-alphabeta, TNF, and IL-12, but not IFN-gamma, were produced independently of these populations, and that IL-12 production occurred in the absence of detectable IFN-gamma.