Viewing affirmative mentions of gene expression of Il10 (M. musculus) in T cells

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Mosmann (2001)IL-10T cellsInterleukin 10 (IL-10) is a multifunctional cytokine produced by T cells and other cell types.
Oh et al. (2002)IL-10T cellsOBJECTIVE: The purpose of our studies was to determine whether T cells producing IL-10 regulate the development of asthma.
Kundu and Fulton (1997)IL-10T-cellWe had shown previously that the antimetastatic activity of IL-10 is expressed in T-cell-deficient mice but is lost when NK activity is suppressed.
Bai et al. (2009)IL-10T cellsMoreover, CD4(+) T cells produce copious amounts of IL-10, and may be an important cellular source of IL-10 during WNV infection in vivo.
Battaglia et al. (2006)IL-10T-cellTr1 cells that produced high levels of IL-10 and suppressed T-cell proliferation were isolated from splenocytes of rapamycin plus IL-10-treated mice after treatment withdrawal.
Blum et al. (2004)IL-10T cellsSome IL-10 was produced but only from non-T cells.
Bai et al. (2009)IL-10T cellsIn addition, recent studies showed that lymphocytic choriomeningitis virus (LCMV) clone 13 elicits high levels of IL-10 production from the infected host, thereby resulting in exhaustion of virus-specific T cells and viral persistence [7]–[9].
Bai et al. (2009)IL-10T cellsWe found that CD4+ T cells produce a significant amount of IL-10 and may be a major cellular source of IL-10 in vivo during WNV infection.
Agarwal et al. (2008)IL-10T cellsIn contrast, expression of IL-10 in activated T cells only partially protected from EAU and marginally reduced Ag-specific responses.
Agarwal et al. (2008)IL-10T cellsAPC from Tg mice constitutively expressing IL-10 in macrophages exhibited decreased ability to prime naive T cells, however, Ag presentation to already primed T cells was not compromised.
Murray and Young (1999)IL-10T cellsWe previously showed that transgenic mice which produce excess IL-10 from T cells are susceptible to infection, even though these mice continue to produce gamma interferon (IFN-gamma) at levels similar to those in controls.
Blenman et al. (2006)IL-10T cellsWe first investigated in this model the source of elevated IL-10 and shown that it results from a larger number of CD4+ T cells producing the cytokine, and from a greatly increased B1-a cell pool, which is the main IL-10 producing compartment.
Palmer et al. (2010)IL-10T cellThese studies suggest IL-10 production is the result of further differentiation of an antigen-specific CD8+ T cell that is governed by signals present in infected lung tissue.
Calado et al. (2006)IL-10T cellsStochastic monoallelic expression of IL-10 in T cells.
Calado et al. (2006)IL-10T cellsUsing a newly generated IL-10 reporter mouse model, which easily allows the study of IL-10 expression from each allele in a single cell, we report here for the first time that IL-10 is predominantly monoallelic expressed in CD4+ T cells.
Calado et al. (2006)IL-10T cellsIn vivo Ag-experienced T cells show a higher basal probability to transcribe IL-10 when compared with naive cells, yet still show mostly monoallelic IL-10 expression.
Calado et al. (2006)IL-10T cellsWe conclude that CD4+ T cells have a low probability for IL-10 allelic activation resulting in a predominantly monoallelic expression pattern, and that IL-10 expression appears to be stochastically regulated by controlling the frequency of expressing cells, rather than absolute protein levels per cell.
Shiokawa et al. (2009)IL-10T cellsIL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance.
Shiokawa et al. (2009)IL-10T cellsThese results suggest that IL-10 and IL-27 producing DC are increased by interaction with antigen specific T cells in PP, and these DC act as an inducer of IL-10 producing T cells in oral tolerance.
Ejrnaes et al. (2006)IL-10T cellCD8alpha- DCs supported IL-10 production and subsequent dampening of antiviral T cell responses.
Lyons et al. (1997)IL-10T-cellMETHODS: Peripheral blood mononuclear cells from 14 burn and 12 trauma patients and 16 healthy individuals were studied at serial intervals for IL-10 production stimulated by a T-cell mitogen, phytohemagglutinin, and by bacterial lipopolysaccharide.
Schreiber et al. (2009)IL-10T cellsSince macrophages rather than T cells were reported to be the major source of IL-10 in TB, we analyzed the consequences of a macrophage-specific overexpression of IL-10 in transgenic mice (macIL-10-transgenic) after aerosol infection with Mycobacterium tuberculosis (Mtb).
Kawamura et al. (2002)IL-10T cellThe present study showed that production of IL-10 from tumor cells impaired T cell- and non-T cell-mediated systemic antitumor immunity in hosts.
Pauza et al. (1999)interleukin-10 transgeneT-cellT-cell production of an inducible interleukin-10 transgene provides limited protection from autoimmune diabetes.
Pauza et al. (1999)IL-10T-cellOur results show that indeed, regulated T-cell production of IL-10 does not accelerate diabetes and instead can provide significant protection from disease.
Umetsu and Winandy (2009)Il10T cellsIkaros is a regulator of Il10 expression in CD4+ T cells.
Umetsu and Winandy (2009)IL-10T cellsUpon initial stimulation of the TCR, T cells deficient in Ikaros express significantly lower levels of IL-10 compared with wild-type T cells.
Umetsu and Winandy (2009)IL-10T cellsIn addition, under Th2 skewing conditions, which induce IL-10 production by wild-type T cells, Ikaros null T cells are unable to properly differentiate, producing only low levels of IL-10.
Umetsu and Winandy (2009)Th2 cytokines IL-10T cellsFurthermore, expression of Ikaros in Ikaros null T cells restores expression of the Th2 cytokines IL-10 and IL-4 while reducing production of the Th1 cytokine, IFN-gamma.
Vissers et al. (2004)IL-10T cellsBACKGROUND: Human studies have demonstrated that allergen immunotherapy induces memory suppressive responses and IL-10 production by allergen-specific T cells.
Adris et al. (1999)IL-10T cellsExpression of IL-10 also elicited an antitumor immune response involving both CD4+ and CD8+ T cells.
Sharma et al. (1999)IL-10T cellTo assess the impact of enhanced T cell-derived IL-10 on antitumor immunity in vivo, we utilized transgenic mice expressing IL-10 under the control of the IL-2 promoter.
Dalal et al. (1997)IL-10T lymphocytesFinally, MBP-specific T lymphocytes derived from dihydrotestosterone-implanted females produced significantly higher levels of IL-10 than those from placebo.
Dalal et al. (1997)IL-10T lymphocytesTogether these data indicate that testosterone exerts a protective effect in EAE that is mediated at least in part by enhanced production of IL-10 by autoantigen-specific T lymphocytes.
Rivera et al. (2009)IL-10T cellsAberrant tissue localization of fungus-specific CD4+ T cells in IL-10-deficient mice.
Siegel et al. (2008)IL-10T cellWe next examined whether loss of M2 expression and the concomitant reduction in IL-10 expression might alter the CD8 T cell response to MHV68 since IL-10 is known to suppress T cell responses [18].
Rouleau et al. (1999)IL-10T cellThese results demonstrate that IL-10 regulates T cell maturation and that dysregulation of IL-10 expression can lead to severe T cell immunodeficiency.
Bolpetti et al. (2010)IL-10T cellTumor associated macrophages and myeloid derived suppressor cells express IL-10, among other cytokines, as part of the mechanism of suppression of T cell anti-tumor responses [26-28].
Maris et al. (2007)IL-10T cellsIn order for IL-10 to directly effect CD8 T cells, they must express the IL-10 receptor.
Micallef et al. (1998)IL-10T cellsAlthough IL-18-treated normal mouse enriched T cells stimulated with anti-CD3 and anti-CD28 antibodies failed to produce IL-10, the cytokine was also undetectable in culture supernatants of IL-18-treated nude mouse spleen cells, indicating that T cells were directly involved in the induced production of IL-10.
Micallef et al. (1998)IL-10T cellsFlow cytometry for intracellular IL-10 confirmed that CD8+ T cells and other, as yet unidentified spleen cell sub-sets were secreting IL-10, but only a small percentage of CD4+ cells produced IL-10.
Kobayashi et al. (1996)IL-10T-lymphocytesCD4+ T-lymphocytes from mice infected with the lethal variant were a major source of IL-10, although non T-cells were also involved in the production of IL-10 during this malaria infection.
Petersson et al. (1998)IL-10T cellIn vitro-established mouse tumor lines were screened for IL-10 expression and production, and a large proportion of plasmocytomas or T cell lymphomas were found to produce IL-10.
Wang et al. (1994)IL-10T cellUsing purified CD4+ T cells from mice immunized in the presence or absence of IL-10, we have shown that the loss of alloreactivity as a consequence of IL-10 expression results from the inhibition of CD4+ T cell function.
Ohman et al. (2002)interleukin 10T cellsPP T lymphocytes showed highly elevated production of interferon gamma in response to the enteric flora compared with PP T cells from wild-type mice, which produced predominantly interleukin 10.
Roth et al. (1996)IL-10T cellsThe expression of the B7-2 and/or B7-1 costimulatory molecules, as well as specificity to a self Ag, cyt c, enabled B cells to activate T cells to proliferate and to express IFN-gamma, IL-4, IL-5, and IL-10 cytokine mRNAs.
Deckert-Schlüter et al. (1997)IL-10T-cellsIn Toxoplasma encephalitis (TE), CD4+ and CD8+ T-cells also contributed to the upregulated IL-10 production.
Stämpfli et al. (1999)IL-10T cellsHowever, IL-10 coexpression did not prevent expansion of CD4 and CD8 T cells or expression of the early activation marker CD69 on T cells.
Segal et al. (2002)IL-10T cellsHence, our findings demonstrate that IL-10-producing CD4+ T cells can manifest antitumor functions and suggest that IL-10 may have proinflammatory effects in disease states.
Ganapamo et al. (1996)IL-10T lymphocytesAccording to these observations, we conclude that the reduction of T-cell proliferation in response to Con A observed in lymph node cells from infested mice, may be due to the combined effect of laminin interaction with T lymphocytes during migration and IL-10 production by these lymphocytes.
Mendel and Shevach (2002)IL-10T cellsStudies with myelin basic protein-specific T cells derived from an IL-4-deficient mouse confirmed the absolute requirement for IL-4 for the generation of IL-10 producers under all culture conditions.
Saito et al. (1999)IL-10T cellsTransgenic expression of IL-10 induced apoptosis of glandular tissue destruction and lymphocyte infiltration consisting primarily of Fas-ligand (FasL)+ CD4+ T cells, as well as in vitro up-regulation of FasL expression on T cells.
Flesch and Kaufmann (1994)IL-10T cellsElevated IL-10 production in RAG-1 mutants and TCR beta mutants, but not in TCR delta mutants, is consistent with an inhibition of macrophage IL-10 release by alpha beta T cells.
Van Overtvelt et al. (2008)IL-10-expressingT cellsCONCLUSIONS: Both VitD3/Dex and L. plantarum polarize naïve T cells towards IL-10-expressing T cells, through distinct mechanisms.
Bjursten and Hultgren Hörnquist (2005)IL-10T cellsRecall dietary antigen stimulation of G(alpha)i2+/- PP T cells did not result in increased IL-10 production above the spontaneous production in the absence of antigenic stimulation.
Kim et al. (1999)IL-10T-lymphocyteFurther, MBP-specific T-lymphocyte responses from estriol-treated EAE mice were characterized by significantly increased production of the Th2 cytokine interleukin 10 (IL-10).
Frenkel et al. (2003)IL-10T cellsNasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells.
Ly et al. (2005)IL-10T cellsIt has been reported that the inhibitory cytokine interleukin (IL)-10 acts directly on T cells which up-regulate IL-10 receptor (IL-10R) expression following stimulation via CD28 by efficiently blocking proliferation and cytokine production.
Vissers et al. (2004)IL-10T cellsIn vitro studies showed that OVA-Mphi start to produce IL-10 upon interaction with allergen-specific T cells, which might mediate their immunosuppressive effects.
Holán et al. (1998)IL-10T cellsUrocanic acid enhances IL-10 production in activated CD4+ T cells.
Holán et al. (1998)IL-10T cellsThe principal cell population displaying the cis-UCA-induced elevated production of IL-10 was CD4+ T cells, which were shown to be a direct target of cis-UCA action.
Holán et al. (1998)IL-10T cellsThe enhanced production of IL-10 by activated CD4+ T cells may represent a novel pathway of UVB radiation-induced, cis-UCA-mediated immunosuppression.
Lochner et al. (2008)IL-10T cellstogether with IL-6 induces CD4+ T cells to produce both IL-17 and IL-10, a population that is not able to induce inflammation in mice (13).
Lochner et al. (2008)IL-10T cellst+ T cells producing IL-10 and CCL20 recruit CCR6+ ROR?
Lochner et al. (2008)IL-10T cellst+ T cells expressing both IL-17 and IL-10, as observed previously (13, 17).
Frenkel et al. (2005)IL-10T cellsNeuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke.
Frenkel et al. (2005)IL-10T cellsUsing immunohistological methods and IL-10 -/- mice, we demonstrate the importance of IL-10-producing CD4+ T cells in the reduction of the ischemic infarct volume following middle cerebral artery occlusion (MCAO).
Chou et al. (2010)IL-10T cellsSince, under certain conditions, IL-10 has proinflammatory functions in vivo, stimulating CD4+, CD8+ T cells, and/or NK cells, it is possible that the anti-IL-10 shRNA used in the current work blocked profoundly IL-10 production in several cell types, leading to less inflammation and lower mortality rates in mice exposed to toxic shock.
Stallmach et al. (1999)IL-10T cellsAn increase in the number of colonic CD4(+)/CD25(+) T cells and increased synthesis of the immunosuppressive cytokine IL-10 also occurred.
Takayama et al. (2001)vIL-10T-cellOur aim was to evaluate and compare the influence of vIL-10 and mIL-10 gene transfer on the T-cell and natural killer (NK) cell stimulatory activity of DC, and their impact on the growth of transplantable tumors.
Braat et al. (2007)IL10T cellCONCLUSIONS: Our finding shows that FHA suppresses type 1 T helper and pro-inflammatory cytokines, and ameliorates disease activity in a chronic T cell-dependent model of colitis, an effect that was not dependent on IL10 production by T cells, but was associated with induction of anti-inflammatory cytokines in vivo.
Feng et al. (2007)IL-10T-cellIn addition, the production of IL-6 and IL-10 was improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way.
Liva and Voskuhl (2001)IL-10T lymphocytesTestosterone acts directly on CD4+ T lymphocytes to increase IL-10 production.
Liva and Voskuhl (2001)IL-10T lymphocytesAt both the RNA and protein levels, IL-10 was produced primarily by CD4+ T lymphocytes.
Liva and Voskuhl (2001)IL-10T lymphocytesCD4+ T lymphocytes were then shown to express the androgen receptor, raising the possibility that testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production.
Liva and Voskuhl (2001)IL-10T lymphocytesIn vitro experiments demonstrated increased IL-10 production following treatment of CD4+ T lymphocytes with DHT.
Liva and Voskuhl (2001)IL-10T lymphocytesThus, testosterone can act directly via androgen receptors on CD4+ T lymphocytes to increase IL-10 gene expression.
Yamada et al. (2009)IL-10T cellsRESULTS: Adoptive transfer of splenic CD8+ T cells from ovalbumin-primed mice, but not from nonprimed mice, suppressed the development of allergic diarrhea, which was associated with in vivo increased IL-10 mRNA expression and in vitro antigen-specific IL-10 production by mesenteric lymph node cells.
Yamada et al. (2009)IL-10T cellsIL-10 production by regulatory CD8+ T cells appears to be partially involved in these inhibitory mechanisms.
Nishijima et al. (1994)IL-10T cellThis study addresses the question of whether IL-10 produced by responding T cell clones would inhibit proliferation of the secreting T cells themselves.
Sher et al. (1991)IL-10T lymphocytesProduction of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.
Sher et al. (1991)IL-10T cellsBy means of ELISA measurements the production of IL-10 in schistosome infection was confirmed and shown to depend on CD4+ T cells.
Ismail et al. (2007)IL-10T-cellThe absence of CD8(+) T cells abrogated TNF-alpha and IL-10 production, reduced tissue injury and bacterial burden, restored splenic CD4(+) T-cell numbers, and increased the frequency of Ehrlichia-specific CD4(+) Th1 cells in comparison to infected WT mice.
Wesselkamper et al. (2005)IL-10T cellsFinally, IL-10 can be produced by T cells and is able to diminish PMN influx by inhibition of expression of proinflammatory chemokines [48], NF-?
Sonoda and Stein-Streilein (2002)IL-10T cellsWe also found that the number of splenic natural killer T cells were increased in anterior chamber-inoculated B6 mice and those natural killer T cells produced IL-10.
Schmidt-Weber et al. (1999)IL-10T cellThe studies reported here examine the influence of various cytokines in the regulation of T cell IL-10 production.
Meyers et al. (1998)IL-10T cellIn addition, cytokine profile analysis of MR clones indicates a Th2 pattern with IL-4 and IL-10 expression, although nephritogenic T cell clones also express IFN-gamma.
Anderson et al. (2007)IL-10T cellsIL-10 was produced by innate cells, as well as CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(-)Foxp3(-) T cells in the chronic lesion.
Anderson et al. (2007)IL-10T cellsNonetheless, only IL-10 production by antigen-specific CD4(+)CD25(-)Foxp3(-) T cells, the majority of which also produced IFN-gamma, was necessary for suppression of acquired immunity in Rag(-/-) reconstituted mice.
Pontoux et al. (2002)IL-10T cellsWe observed that this abnormal cytokine production could be controlled by the injection of natural CD4 CD25(+) T cells and that IL-10 production is needed, as CD4 CD25(+) T cells from IL-10 knockout mice do not correct cytokine over-production in vivo.
Gao et al. (1999)IL-10T-cellThese data suggest that CD40-deficient DC producing IL-10, but not IL-12 can induce T-cell hyporesponsiveness in vitro and in vivo.
Martinez et al. (1996)IL-10T lymphocytesVasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide-38 inhibit IL-10 production in murine T lymphocytes.
Yao et al. (2007)IL-10T lymphocytesAlong with the severe suppression on T-cell type cytokine transcription, the proportions of IFN-gamma, IL-4 and IL-10-producing T lymphocytes were markedly attenuated and the productions of serum IFN-gamma and IL-10 were significantly decreased synchronously.
Rhodes et al. (2008)IL-10T cellIL-10-producing Vgamma4(+) T cells also contribute to controlling CD8(+) T cell expansion and to regulating and reducing TNF-alpha secretion by activated CD8(+) T cells.