Viewing affirmative mentions of gene expression of Ifng (M. musculus) in T cells

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Dillon et al. (1998)IFN-gammaT-lymphocyteThus, long-term T-lymphocyte responses and the production of IFN-gamma can be generated using a single inoculation of PPD-pulsed DC.
Watanabe and Sakata (1988)IFN-gammaT cellIn the IFN-gamma-producing cells, the expression of the major histocompatibility complex class I genes was augmented; this augmentation was remarkable in T cell lines tested in this work, regardless of their poor IFN-gamma production.
Gao et al. (2003)IFN-gammaT cellWe then used bone marrow chimeras and fetal liver reconstitutions to create mice with an intact gammadelta T cell repertoire but one that was specifically deficient in the capacity to produce IFN-gamma.
Gao et al. (2003)IFN-gammaT cellMoreover, genetic deficiency of gammadelta T cells resulted in impaired IFN-gamma production by tumor antigen-triggered alphabeta T cell upon immunization with tumor lysate.
Kang and Suzuki (2001)IFN-gamma mRNAT cellsIFN-gamma mRNA was also detected in brains of infected SCID mice depleted of NK cells by treatment with anti-asialo GM1 antibody, and such animals did not develop TE after receiving immune T cells.
Kang and Suzuki (2001)IFN-gammaT cellsThus, IFN-gamma production by non-T cells, in addition to T cells, is required for prevention of reactivation of T. gondii infection in the brain.
Kang and Suzuki (2001)IFN-gammaT cellsThe IFN-gamma-producing non-T cells do not appear to be NK cells.
Wang et al. (2004)Gamma interferonT cellsGamma interferon production, but not perforin-mediated cytolytic activity, of T cells is required for prevention of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease.
Wang et al. (2004)gamma interferonT cellsWe previously showed the requirement of both T cells and gamma interferon (IFN-gamma)-producing non-T cells for the genetic resistance of BALB/c mice to the development of toxoplasmic encephalitis (TE).
Wang et al. (2004)IFN-gammaT cellsIn order to define the role of IFN-gamma production and the perforin-mediated cytotoxicity of T cells in this resistance, we obtained immune T cells from spleens of infected IFN-gamma knockout (IFN-gamma(-/-)), perforin knockout (PO), and wild-type BALB/c mice and transferred them into infected and sulfadiazine-treated athymic nude mice, which lack T cells but have IFN-gamma-producing non-T cells.
Wang et al. (2004)IFN-gamma mRNAT-cellIn addition, the amounts of IFN-gamma mRNA expressed in the brains of PO T-cell recipients did not differ from those in wild-type T-cell recipients.
Wang et al. (2004)IFN-gammaT cellsThese results indicate that IFN-gamma production, but not perforin-mediated cytotoxic activity, by T cells is required for the prevention of TE in genetically resistant BALB/c mice.
Autenrieth et al. (1994)gamma interferonT cellsSplenic T cells from Yersinia-infected C57BL/6 mice exhibited marked proliferative responses and produced gamma interferon (IFN-gamma) upon exposure to heat-killed yersiniae.
Autenrieth et al. (1994)IFN-gammaT-cellBy contrast, the Yersinia-specific T-cell response in BALB/c mice was weak, and IFN-gamma production could not be detected before day 21 postinfection.
Autenrieth et al. (1994)IFN-gammaT cellsThese results indicate that the cellular immune response, in particular the production of IFN-gamma by Yersinia-specific T cells, is associated with resistance of mice to Y. enterocolitica.
Ruiz and Becker (2007)IFN-gammaT cellsMurine models of leishmaniasis suggest that CD8 T cells participate through IFN-gamma production, yet their cytotoxic capacity also plays an important role, as has been found in patients infected with various Leishmania strains, where CD8 T cell cytotoxicity and apoptosis of autologous Leishmania-infected macrophages correlate with cure.
Yotsumoto et al. (2005)IFN-gammaT cellsNegatively charged phospholipids suppress IFN-gamma production in T cells.
Yotsumoto et al. (2005)IFN-gammaT cellsThe effect of phospholipids on IFN-gamma production in mouse T cells was investigated.
Tato et al. (2004)IFN-gammaT cellsThe ability of NK and T cells to produce IFN-gamma is critical for resistance to numerous intracellular pathogens but the kinetics of these responses differ.
Maruyama et al. (2003)IFN-gammaT cellsFucoidan significantly enhanced the cytolytic activity of NK cells and increased the amount of IFN-gamma produced by T cells up to about 2-fold compared with non-treated mice.
Even et al. (1995)interferon gammaT cellsFurthermore, MHV infection resulted in a long-term alteration in the proliferative response of spleen T cells to concanavalin A (ConA) and in their ability to produce interferon gamma; several times higher concentrations of ConA were required to induce a maximum proliferative response in spleen T cell populations from 5-week MHV-infected B10.A mice than in spleen T cell populations from infected companion mice but the former produced 5 times more interferon gamma than the T cells from uninfected mice.
Verbeek et al. (2005)IFN-gammaT cellsPreviously, we demonstrated that in vitro flavonoids, including luteolin and apigenin, inhibit proliferation and IFN-gamma production by murine and human autoimmune T cells.
Verbeek et al. (2005)IFN-gammaT cellsContinuous oral administration of flavonoids significantly affected antigen-specific proliferation and IFN-gamma production by lymph node-derived T cells following immunization with an EAE-inducing peptide.
Matsuzaki et al. (1999)IFN-gammaT cellsOn day 6 of primary Listeria infection, spleen T cells of the muMT-/- mice showed significantly lower levels of proliferative response and IFN-gamma production than those of normal infected mice after in vitro stimulation with listerial antigen.
Matsuzaki et al. (1999)IFN-gammaT cellsEven in the secondary Listeria infection after immunization with viable bacteria, spleen T cells of the muMT-/- mice proliferated and produced IFN-gamma against listerial antigen at significantly lower levels than those of normal immunized mice.
Slade and Langhorne (1989)IFN-gammaT cellsSimilarly, IFN-gamma production by T cells could be detected in vitro.
Slade and Langhorne (1989)IFN-gammaT cellsIn limiting dilution cultures, the production of IFN-gamma by as few as 1,000 T cells was detectable using this assay.
Lucchiari et al. (1992)IFN-gammaT cellsMonoclonal antibodies specific for IFN-gamma, CD4 and CD8 molecules were administered in vivo to deplete selectively the IFN-gamma synthesized or the appropriate subset of T cells.
Shanley et al. (2001)IFN-gammaT lymphocytesIn in vitro cell depletion and direct cell selection experiments, T lymphocytes were responsible for IFN-gamma production.
Sacha et al. (1999)interferon gammaT lymphocytes[The effect of selected antibacterial antibiotics on production of interferon gamma (IFN-G) by mouse T lymphocytes stimulated by Listeria monocytogenes].
Gribaudo et al. (1985)MuIFN-gammaT-cellMurine interferon-gamma (MuIFN-gamma), produced by the T-cell lymphoma, L12-R4, and stimulated with phorbol myristic acetate, was purified by rat monoclonal antibodies AN-18.17.24.
Yang et al. (1997)gamma interferonT cellsProtective immunity of mice against Listeria monocytogenes, which is mediated mainly by gamma interferon (IFN-gamma)-producing T cells, was induced by immunization with viable bacteria but not with killed bacteria.
Yang et al. (1997)IFN-gammaT cellsThe generation of listeria-specific IFN-gamma-producing T cells was also abolished.
Yang et al. (1997)IFN-gammaT cellsThese results clearly demonstrated that endogenous IFN-gamma, which is produced at the initial stage of immunization, actually plays a critical role in the generation of protective T cells against L. monocytogenes in vivo.
Shnyreva et al. (2004)IFN-gammaT cellsEvolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells.
Shnyreva et al. (2004)IFN-gammaT cellA DNase I hypersensitive site and extragenic transcripts at IFNgCNS2 correlated positively with the capacity of primary T cell subsets to produce IFN-gamma.
Cockfield et al. (1993)IFN-gammaT cellThis agent is known to induce IFN-gamma expression in both spleen and kidney in a T cell-independent, cyclosporine-sensitive manner.
Cockfield et al. (1993)IFN-gamma mRNAT cellThe inhibition of IFN-gamma mRNA expression by the anti-IFN-gamma mAb occurred in both T cell-deficient athymic nude mice and their normal controls, suggesting that the autoamplification of IFN-gamma mRNA in vivo is T cell independent.
Bancroft et al. (1987)IFN-gammaT lymphocyteThese results indicate the presence of an important T lymphocyte-independent mechanism of macrophage activation and IFN-gamma production in response to infection.
Sarzotti et al. (1983)IFN-gammaT cellMacromolecular synthesis of immune interferon (IFN-gamma) by the L12-R4 T cell lymphoma, stimulated by phorbol myristic acetate, was studied by using reversible inhibitors of protein synthesis, puromycin and cycloheximide, and an irreversible inhibitor of RNA synthesis, actinomycin D.
Landolfo et al. (1981)gamma-IFNT-lymphocytesLastly, using different cell depletion techniques, we demonstrate that T-lymphocytes are the cells producing gamma-IFN upon stimulation with alloantigens.
Oh et al. (2006)interferon-gammaT lymphocytesWe hypothesized that the hot water extract of PL (WEPL) exerts its significant immunostimulatory effect by inducing production of the Th1-derived cytokine interferon-gamma (IFN-gamma) by T lymphocytes.
Becker et al. (2007)IFN-gammaT cellsTherefore, the transgenic expression of IFN-gamma in specific T cells appears to be an obvious therapeutic possibility.
Becker et al. (2007)IFN-gammaT cellsTo directly examine whether IFN-gamma production can be increased in T cells, we introduced an IFN-gamma encoding cDNA into IFN-gamma(-/-) and IFN-gamma(+/+) CD8(+) effector populations by retroviral transduction.
James et al. (1984)gamma-interferonT lymphocytesIn vitro analyses of cellular defects revealed that although T lymphocytes from vaccinated P mice showed blastogenic responses to schistosome antigens that were similar in magnitude and kinetics to those of cells from the C57BL/6 animals, T cells from C57BL/6 mice produced higher levels of macrophage-activating lymphokines (LK), including gamma-interferon.
Goldbach et al. (1988)IFN-gammaT cellsAs shown in this paper, these phenomena can be explained by an Mlsa, d, e specific induction of gamma-interferon (IFN-gamma) production in the responder B10.BR (Mlsb) E11 T cells.
Yimin et al. (2001)interferon-gammaT cellsRole of T cells in granuloma formation induced by Rhodococcus aurantiacus is independent of their interferon-gamma production.
Yimin et al. (2001)IFN-gammaT cellsOn the other hand, although IFN-gamma production induced by R. aurantiacus infection was detected in nude mice, which are deficient in T cells, granuloma formation was not induced in them.
Yimin et al. (2001)IFN-gammaT cellsInduction of granuloma is probably dependent on both T cells and IFN-gamma produced by non-T cells.
Yimin et al. (2001)IFN-gammaT cellsIt is suggested that the role of T cells in granuloma formation is not dependent on their IFN-gamma production.
Mo et al. (1995)IFN-gammaT lymphocytesProlonged exposure to more virus in turn influenced the magnitude of IFN-gamma production, most of which was made by CD4+ T lymphocytes.
Cunningham and Merigan (1984)gamma-interferonT cellsLeu-3+ T cells produce gamma-interferon in patients with recurrent herpes labialis.
Cunningham and Merigan (1984)IFN-gammaT cellsAs mitogens circumvent the normal processing and presentation of antigen, the RHL system described above may provide a more accurate picture of the relative contributions of helper (Leu-3+) and cytotoxic/suppressor (Leu-2+) T cells to IFN-gamma production in herpes viral disease.
Gribaudo et al. (1985)MuIFN-gammaT-lymphocytesAn immunoadsorbent column was prepared and used for large-scale purification of MuIFN-gamma produced either by PMA-stimulated L12-R4 cells or by normal T-lymphocytes stimulated with Con A and interleukin 2.
Gribaudo et al. (1985)MuIFN-gammaT-lymphocytesBy contrast MuIFN-gamma produced by normal T-lymphocytes resulted in two proteins with Mr of 20,600 and 21,800 as determined by sodium dodecyl sulfate gel electrophoresis.
Gribaudo et al. (1985)MuIFN-gammaT-lymphocytesThese results indicate that MuIFN-gamma produced by L12-R4 tumor cells or by normal T-lymphocytes differ in their molecular weight, probably because of different degrees of glycosylation of the same molecule.
Krenger et al. (1996)IFN-gammaT cellsFurthermore, the prevention of IFN-gamma production in vivo after allogeneic BMT, by transplantation of polarized type 2 donor T cells (secreting interleukin-4 but not IFN-gamma), also prevented NO production and restored splenocyte responses to mitogen.
Ashkar and Croy (1999)IFN-gammaT cellsFurthermore, evidence is presented that IFN-gamma-producing cells exist in mesometrial regions of implantation sites that are neither NK nor T cells.
Nance et al. (2005)IFN-gammaT cellTherefore innate immune cell IFN-gamma production in the absence of T cell IFN-gamma production is sufficient for granuloma formation.
Shirahata et al. (1992)IFN-gammaT cellTo explore a possible mechanism of pregnancy-associated suppression of T cell-mediated immunity to Toxoplasma gondii, acquired resistance and gamma interferone (IFN-gamma) production in pregnant mice were compared with those in virgin mice after infection with the S-273 strain of this protozoan parasite.
Shirahata et al. (1994)IFN-gammaT cellLikewise, daily injection of cyclosporin A (Cs-A), a potent inhibitor of T cell function, during the first 3 days of Toxoplasma infection severely exacerbated the infection, in accordance with a marked suppression of the early IFN-gamma production.
Shirahata et al. (1994)IFN-gammaT cellsThese results suggest that the early IFN-gamma production by T cells is an essential event for the establishment of P. acnes-induced anti-toxoplasma resistance in mice.
Hale et al. (2004)interferon-gammaT cellsThis infiltrate included B lymphocytes, gammadelta T cells and interferon-gamma producing T cells.
Langhorne and Simon-Haarhaus (1991)IFN-gammaT cellsThis was true for T cells providing help and for those producing IFN-gamma.
Leav et al. (2005)IFN-gammaT cellsThe rapid kinetics of IFN-gamma expression and secretion by naive CD8+ T cells in response to a protozoan pathogen have not previously been demonstrated.
Fassio et al. (1988)IFN-gammaT-cellA T-cell lymphoma, EL-4, was found to express relatively high number of specific membrane receptors for IFN-gamma (60,000/cell) with a dissociation constant of around 9 X 10(-10) M.
Winter et al. (2001)IFN-gammaT cellMany reports, including ours, suggest that tumor-specific production of IFN-gamma is critical for T cell-mediated tumor regression.
Konieczny et al. (1998)IFN-gammaT cellIn vitro studies showed that endogenously produced IFN-gamma down-regulates T cell proliferation and CTL generation in MLCs.
Kunikata et al. (2002)IFN-gammaT cellsNext we performed neutralization experiments using a monoclonal antibody (mAb) against interleukin (IL-)12 because this cytokine, which is produced by macrophages, has the direct ability to induce IFN-gamma production and the proliferation of activated T cells.
duPre' et al. (2008)IFN-gammaT cellsOnly small numbers of CD4 T cells, CD8 T cells, NK cells, and gammadelta T cells, the most likely IFN-gamma-producing cells, were seen at any time point.
Malu et al. (2003)Interferon-gammaT lymphocytesInterferon-gamma (IFN-gamma) is an important immunomodulatory and pleiotropic cytokine produced, primarily, by activated T lymphocytes and natural killer (NK) cells.
Malu et al. (2003)IFN-gammaT cellsThe increase in IFN-gamma production by activated T cells in response to CD28 costimulation was approximately 3-fold by this bioassay and approximately 5-fold by ELISA.
Tascon et al. (1998)gamma interferonT cellsProtection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon.
Kalman and Klimpel (1983)IFN gammaT-cellHigh levels of IFN gamma (170-1200 U/ml) were produced when either C57Bl/6 spleen cells or Ficoll-Hypaque-purified human peripheral blood lymphocytes (PBL) were cultured with the T-cell mitogen staphylococcal enterotoxin A (SEA).
Kalman and Klimpel (1983)IFN gammaT cellsThus, CsA inhibits the production of IFN gamma by T cells but appears to have no effect on the production of IFN alpha/beta by virus-infected cells or on the antiviral action of already produced IFN gamma and IFN alpha/beta.
Assenmacher et al. (1996)interferon-gammaT cellsSpecific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man.
Assenmacher et al. (1996)IFN-gammaT cellsHere, we show that IFN-gamma is specifically displayed at a low concentration on the cell surface of those activated T cells from mouse and man which express IFN-gamma.
Assenmacher et al. (1996)IFN-gammaT lymphocytesThus, surface IFN-gamma is the first available marker for live T lymphocytes expressing IFN-gamma, e.g.
Lee et al. (2000)IFN-gammaT cellsHowever, oral tolerance is associated with decreased production of IFN-gamma by T cells after antigen sensitization.
Lee et al. (2000)IFN-gammaT cellsIFN-gamma-deficient or wild-type DO11.10 and BALB/c mice were used to show that IFN-gamma production by donor transgenic T cells was critical for oral tolerance.
Yamaguchi et al. (1984)IFN gammaT cellsMacrophage-mediated production of IFN gamma appears to be genetically restricted because IFN gamma was only produced in cultures where the H-2 region of macrophages and T cells matched.
Yamaguchi et al. (1984)IFN gammaT cellsSecond, enhanced IFN gamma production occurred when culture supernatants of macrophages obtained from sensitized spleen cells were added to T cells.
Lugade et al. (2008)IFN-gammaT cellIn addition to inducing molecular cues necessary for T cell infiltration, surface MHC class I expression is also up-regulated in response to IFN-gamma produced after irradiation.
Lee et al. (2008)IFN-gammaT cellsAdoptive transfer of WT T cells into IFN-gamma knockout mice before primary infection restored IFN-gamma production in the lungs and prevented the development of altered airway responses on reinfection.
Culshaw et al. (1997)gamma interferonT cellsImmunological control of infection with cryptosporidia in mice is dependent on CD4+ T cells and the production of gamma interferon (IFN-gamma), but to date, the mucosal T cells which produce IFN-gamma local to the infection have not been characterized.
Culshaw et al. (1997)IFN-gammaT-cellIn further experiments, an enzyme-linked immunospot (ELISPOT) technique was used to compare frequencies of IFN-gamma-producing cells in activated T-cell populations from C. muris-immune and naive donor mice.
De Libero et al. (1988)interferon-gammaT cellSeveral T cell lines produced interferon-gamma after appropriate stimulation.
Verbeek et al. (2004)interferon-gammaT cellsThe flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells.