Viewing negative mentions of gene expression of Ifng (M. musculus) in T cells

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Hatada et al. (2005)IFN-gammaT cellsNylon wool-purified "T cells", however, failed to produce IFN-gamma in response to Con A in vitro, while the production was restored by the addition of neutrophils.
Russell et al. (1989)IFN gammaT cellThe C57Bl/6-derived T cell line, L12-R4, produced murine interferon-gamma (IFN gamma) in response to mitogenic stimulation by phorbol myristate acetate (PMA) or concanavalin A (Con A), but not by staphylococcal enterotoxin A (SEA).
Baldwin and Parent (2002)IFN-gammaT cellsMoreover, by 3 weeks post-infection splenocytes from the susceptible BALB/c mice failed to produce IFN-gamma and relied on TNF-alpha as well as CD8 T cells to control infection until the end of the plateau phase around 6 weeks post-infection when IFN-gamma production resumed and clearance began.
Xiong et al. (1996)IFN-gammaT-cellTaken together, it may be concluded that NO down-regulates IFN-gamma production mainly by inhibiting T-cell proliferation.
Hamel et al. (2008)IFN-gammaT cellsFurthermore, there was a significant reduction in the PG-specific CD4(+) T cell recall response as well as significantly fewer PG-specific CD4(+) T cells producing IFN-gamma and IL-17, but not IL-4.
Carrier et al. (2007)IFN-gammaT cellsTo address this issue, we generated a TGF-beta1-transgenic (Tg) mouse in which TGF-beta is linked to the IL-2 promoter and T cells transiently overexpress TGF-beta upon TCR stimulation but produce little or no IL-2, IL-4, IL-10, IL-13, or IFN-gamma.
Weir et al. (2006)IFNgammaT cellsMOG(35-55)-specific T cells from PPNK-deficient and wild-type mice produced IFNgamma and TNFalpha but no IL-4 or IL-10, indicative of a Th1 phenotype.
Miller et al. (1999)interferon gammaT cellsRecombinant-activating gene 2 (RAG-2-/-) T cell receptor-transgenic mice repeatedly injected with the superantigen staphylococcal enterotoxin A entered a tolerant state in which splenic CD4+ T cells produced little interleukin (IL)-2, interferon gamma, or IL-4.
Maggi et al. (1988)IFN-gammaT cellAlthough 21 out of 503 (4%) CD4+ T cell clones produced IL 4, but not IFN-gamma or IL 2, and 208 (41%) produced IL 2 and/or IFN-gamma, but not IL 4, a total number of 185 (37%) CD4+ clones showed the ability to produce IL 4 plus IL 2 and/or IFN-gamma.
Mike et al. (1999)interferon-gammaT cellsHowever, LC injection affected neither expression of interferon-gamma (IFN-gamma) and IL-4 mRNAs nor proliferative capacities of splenic T cells.
Lohoff et al. (1989)IFN-gammaT cellsIf anti-IFN-gamma antibodies are omitted, T cells which produce both, IFN-gamma and IL5, may mistakenly be grouped into the TH1 subtype producing only IFN-gamma, but no IL5.
Grewal et al. (1996)IFN-gammaT cellsThese mice failed to develop EAE after priming with antigen, and CD4(+) T cells remained quiescent and produced no interferon-gamma (IFN-gamma).
Hossain et al. (2000)IFN-gammaT cellsStimulation of peritoneal DN TCRalphabeta+ T cells with plate-bound anti-TCRbeta monoclonal antibodies showed proliferation and also produced IFN-gamma but not IL-4.
Meding et al. (1990)IFN-gammaT cellsMice depleted of CD4+ T cells were unable to produce IFN-gamma, but factors in addition to IFN-gamma may be important in parasite clearance.
Stuller et al. (2010)IFN-gammaT cellThese two CD4 T cell effector populations degranulate and produce IFN-gamma during steady state without need for exogenous antigenic restimulation, which is fundamentally different from that observed with gammaHV68-specific CD8 T cells.
Hassan et al. (1999)IFN-gammaT-cellAlloantigen-induced T-cell proliferation in vivo was significantly greater in IFN-gamma-/- mice than in IFN-gamma+/+ mice, and T-cell costimulation blockade abrogated alloantigen-induced T-cell proliferation in wild-type mice but failed to do so in mice that lack IFN-gamma.
Tolomeo et al. (2009)IFN-gammaT cellsThese T cells produced IL-2 and IFN-gamma, but not IL-4 or IL-10, indicating a Th1 bias of the beta2GPI-specific response.
Barnard et al. (1996)interferon-gammaT cellsHowever, a proportion of T cells from convalescent mice, especially when cultured in the presence of IL-4, secreted IL-4 and IL-5 with or without detectable IL-2 and interferon-gamma (IFN-gamma), suggesting that Th0 or Th2 cells were also primed during natural infection in vivo.
Yang et al. (1991)IFN-gammaT cellsT cells induced by p146-171 and p467-171 or a mixture of these two peptides were mainly CD4+ and produced interleukin (IL-2) and interferon-gamma (IFN-gamma) but not IL-4 upon antigen stimulation in vitro.
Erard et al. (1993)IFN-gammaT cellsMature mouse CD8+ T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8-CD4- population that was not cytolytic and did not produce IFN-gamma.
Huber et al. (2001)IFN-gammaT cellsVgamma4 and Vgamma1(+) T cells from Stat4ko mice expressed IL-4 but no or minimal IFN-gamma, whereas these cell populations derived from Stat6ko mice expressed IFN-gamma but no IL-4.
Cousens et al. (1999)IFN-gammaT cellAlthough interleukin (IL)-12 has the potential to contribute, IL-12-dependent T cell IFN-gamma has not been detected during viral infections.
Krahenbuhl and Adams (2000)IFN gammaT cellsCGD (chronic granulomatous disease) mice and iNOS-KO mice lack the ability to produce reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI), respectively, whereas the T cells of GKO mice are unable to produce interferon-gamma (IFN gamma). iNOS-KO mice exhibit an enhanced capacity to form granulomas, and the histopathology of the infected footpad tissues of this strain share many elements of borderline tuberculoid disease.
Hoyle et al. (1998)IFN-gammaT-cellIntracellular cytokine production was assayed by fluorescence-activated cell sorter (FACS), and the expanded T-cell cultures produced IL-2, IFN-gamma, and tumor necrosis factor-alpha (TNF-alpha), but not IL-4.
Hiromatsu et al. (1996)IFN-gammaT cellsInterferon-gamma (IFN-gamma) and interleukin-10 (IL-10) were produced by CD4+ T cells from Listeria-infected MAIDS mice in response to the in vitro stimulation with HKL, whereas IFN-gamma but not IL-10 were produced by those from Listeria-infected control mice.
Van et al. (2009)interferon-gammaT-cellsAll-trans retinoic acid inhibits type 1 diabetes by T regulatory (Treg)-dependent suppression of interferon-gamma-producing T-cells without affecting Th17 cells.
Corbin and Harty (2005)IFN-gammaT cellsFurthermore, L. monocytogenes-specific CD8(+) T cells in the same mice and lymphocytic choriomeningitis virus-specific CD8(+) T cells in BALB/c mice also underwent ON/OFF cycling, but if the initial Ag stimulus was maximal, they could not produce IFN-gamma after Ag re-exposure.
Franco et al. (1997)gamma interferonT-cellEvidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gamma interferon.
Moriyama et al. (1995)IFN-gammaT cellsThe asialoGM1+CD4+ T cells produced IL-2 and IFN-gamma in primary culture without stimulant but did not proliferate.
Vesosky et al. (2006)IFN-gammaT cellsThe enhanced ability of CD8 T cells to produce IFN-gamma in an antigen independent manner followed this pattern as well, beginning to increase between 6 and 12 months of age.
Bradley et al. (1991)interferon gammaT cellsWhen restimulated with specific antigen in vitro, CD4+ T cells from mice primed 5 to 7 days previously by subcutaneous administration of keyhole limpet hemocyanin (KLH) in adjuvant, produced high levels of interleukin 2 (IL-2), IL-4, and IL-3, and little or no interferon gamma (IFN-gamma) or IL-5.
Lovchik et al. (1995)IFN gammaT cellThe current studies investigated whether IFN gamma-induced NO production was involved in the protective T cell-mediated immune response against Cne.
Gorham et al. (2001)IFN-gammaT cellsBALB/c background TGF-beta1(-/-) livers contained large numbers of activated CD4(+) T cells that produced large quantities of IFN-gamma, but little IL-4, identifying them as Th1 cells.
Kobayashi et al. (2001)IFN-gammaT cellsType 1 cytokines (IFN-gamma and IL-2), however, were not produced by these T cells after the same stimulation.
Xu et al. (1997)IFN-gammaT cellA long-term uveitogenic T cell line, initially derived in the presence of IL-12, produced IFN-gamma and IL-2, but not IL-4, and was CD4+ (Th1-like).
Arase et al. (1997)IFN-gammaT cellsSimilarly, NK1.1+ T cells from FcRgamma-deficient mice did not produce IFN-gamma upon NKR-P1 crosslinking.
McKisic et al. (1993)IFN-gammaT cellsWe observed that: 1) the frequency of OVA-reactive T cells from various mouse strains was approximately the same; 2) both Th1 and Th2 cells as well as cells not encompassed within these categories could be lytic if derived from DBA/2, B10.D2, B10.A, C57BL/10, or C57BL/6 mice; and 3) the vast majority of CD4+ cloned T cells derived from BALB/c, BALB/c-H-2dm2, BALB.B, or BALB.K that did not produce IFN-gamma (including Th2 cells) did not exhibit cytolytic activity, whereas most clones derived from these strains that produced IFN-gamma were cytolytic.
McKisic et al. (1993)IFN-gammaT cellIn particular, CD4+ T cell clones which did not produce IFN-gamma were not cytolytic when they were derived from BALB/c mice and mutant or MHC congenic inbred mice having a BALB background.
Madoiwa et al. (2009)IFN-gammaT cellsThe CD4(+) T cells from thymic-injected mice could not proliferate or produce interleukin (IL)-2, IL-12 and IFN-gamma in response to FVIII.
Chowdhury et al. (2002)IFN-gammaT cellsIn contrast, T cells from anti-ICAM-1/LFA-1-treated mice expressed IFN-gamma, IL-10 and TGF-beta1 but not IL-4.
Li et al. (2008)IFNgammaT cellsEx vivo primed T cells with SGC-7901 tumor cell lysate-pulsed (TP) DCs were able to induce effective CTL activity against SGC-7901 tumor cells (E:T = 100:1, 69.55% +/- 6.05% specific lysis), but not B16 tumor cells, and produced higher levels of IFNgamma when stimulated with SGC-7901 tumor cells but not when stimulated with B16 tumor cells (1575.31 +/- 60.25 pg/mL in SGC-7901 group vs 164.11 +/- 18.52 pg/mL in B16 group, P < 0.01).
Kobayashi et al. (2002)gamma interferonT cellsAfter stimulation with anti-CD3 monoclonal antibody, splenic T cells from thermally injured mice exposed to large amounts of HSV-1 or C. albicans did not produce gamma interferon (IFN-gamma) into their culture fluids.
Gorbachev et al. (2001)IFN-gamma-producingT cellsDevelopment of IFN-gamma-producing CD4(+) T cells during hapten sensitization was absent in wild-type mice treated with anti-CD154 mAb or in CD154(-/-) mice.
Abromson-Leeman et al. (2004)interferon-gammaT cellsFurthermore, studies using CXCR2 knockout recipients, unable to recruit neutrophils to inflammatory sites, show that although neutrophils are critical for some of these T cells to effect disease, there are also interferon-gamma-deficient T cells that induce disease in the absence of both interferon-gamma and neutrophils.
Naiki et al. (2000)IFN-gammaT cellsThe gammadelta T cells produced IFN-gamma but neither IL-4 nor IL-13 in response to heat-killed Salmonella, whereas both IFN-gamma and IL-13 but no IL-4 was produced by the gammadelta T cells stimulated with immobilized anti-TCRgammadelta mAb.
Lodge et al. (2006)IFNgammaT cellsMice depleted of CD4(+) T cells lacked tumor-specific IFNgamma producing CTL in the peritoneal cavity.
Li et al. (2001)IFN-gammaT cellsThe findings show that the lymph node T cells were deviated and produced IL-4 instead of IFN-gamma and the splenic T cells, although unable to proliferate or produce IFN-gamma, secreted a significant level of IL-2.
McDevitt (2003)IFN-gammaT cellsThus, GAD65 specific TCR transgenic T cells (1) must express a second a chain to survive negative selection, (2) produce IL-2 and IFN-gamma, and (3) have a mildly protective effect on transfer of diabetes with diabetogenic spleen cells.
Ortmann et al. (2001)IFN-gammaT cellsB10.Q/J mice have a global defect in the generation of Th1 responses, and Ag-specific T cells derived from this strain failed to produce IFN-gamma.
Brimnes et al. (2003)IFN-gammaT cellsIn the absence of influenza, these OVA-specific T cells produced little IL-2, IL-4, IL-10, and IFN-gamma, but with infection, both CD4+ and CD8+ T cells made high levels of IL-2 and IFN-gamma.
Leite-De-Moraes et al. (1999)IFN-gammaT cellsSimilar effects were observed in vivo, because splenic CD4+ NK T cells from MHC class II-deficient mice secreted IFN-gamma without further stimulation when removed 2 h after a single injection of IL-12 plus IL-18.
Bell et al. (2003)IFN-gammaT cellsIntriguingly, the anergic splenic T cells, although nonproliferative and unable to produce IFN-gamma or IL-4, secrete significant amounts of IL-2.
Hattori et al. (2006)IFN-gammaT cellsSera from TG nude mice with keratitis reacted with alpha-internexin on Western blot analysis, and the T cells of these mice on stimulation with alpha-internexin exhibited proliferation responses and produced IL-2, IFN-gamma, and TNF-alpha, but not IL-4 or IL-5.
Hovav et al. (2006)IFN-gammaT cellsFurthermore, during infection, splenocytes and purified T cells lost their ability to proliferate in response to concanavalin A stimulation more rapidly in the Mtb+27kDa-infected mice, which was accompanied by high IFN-gamma and NO production, but low TNF-alpha secretion levels.
Takeuchi et al. (1998)IFN-gammaT cellsP518-529-specific T cells produced IL-2 and IFN-gamma, but not IL-4 or IL-10, whereas P1182-1194-specific T cells produced IL-4 and IL-10, but not IL-2 or IFN-gamma Adoptive transfer of these peptide-specific T cells into naive BALB/c nude mice resulted in development of uveoretinitis only in the P518-529 case.
Sonoda et al. (2007)IFN-gammaT lymphocytesIn contrast to T lymphocytes from WT mice, WSX-1(-/-) T lymphocytes on day 9 after immunization failed to produce IFN-gamma.
Kiriya et al. (2007)IFN-gammaT cellsAlthough PP deficiency did not impair the differentiation of Helicobacter-specific CD4(+) T cells into IFN-gamma--producing T(h)1 cells, Helicobacter-specific IFN-gamma--producing CD4(+) T cells in PP-null mice lacked the ability to migrate into Helicobacter-colonized gastric mucosa.
Xu et al. (1996)IFN-gammaT cellsSensitization with DNFB or Ox induced lymph node cell populations of CD8+ T cells producing interferon (IFN)-gamma and no interleukin (Il) 4 or Il-10, and CD4+ T cells producing Il-4 and Il-10 and no or little detectable IFN-gamma.
Ofosu-Appiah et al. (1996)IFN-gammaT cellWhen cultured with either heparan sulfate or Concanavalin A, the T cell clones produced high levels of IL-4 and IL-5 with no detectable IL-2 or IFN-gamma.
Mayack and Berg (2006)IFN-gammaT cellsSpecifically, activated Jak3(-/-) CD4(+) T cells produce IL-10, TGF-beta, and IFN-gamma, but not IL-2 or IL-4, and are unable to proliferate in vitro.
Chen et al. (2005)IFN-gammaT cellsThese results suggest that NOD CD8(+) T cells possess an increased propensity to produce IFN-gamma and impaired c-Maf-dependent DNA binding activities in vivo that lead to reduced IL-4 production following TCR activation.
Tsang et al. (2006)IFN-gammaT cellThe CD4(+)CD25(+) T cell lines were anergic after TCR stimulation and produced little cytokine such as IL-2 and IFN-gamma.
Doughty et al. (2001)IFN-gammaT cellsThe effect on TNF-alpha production was present in the absence of IFN-gamma, its major producers NK and T cells, and the major pathways for its induction through IL-12 and the signal transducer and activator of transcription 4 (STAT4), and therefore was IFN-gamma independent.
Cao et al. (1993)IFN-gammaT cellFive of these T cell clones produced both IL-2 and IFN-gamma but not IL-4 after stimulation with either phorbol 12-myristate 13-acetate (PMA) or concanavalin A (Con A).
Naiki et al. (1992)IFN-gammaT cellAll of the autoreactive cloned T cell lines produce significant IL-4 but no detectable IL-2 or IFN-gamma.
Takeuchi et al. (2005)IFN-gammaT cellsAlthough splenic T cells from CCR5-deficient mice produced IFN-gamma but not IL-10 on stimulation by hIRBP-p, T cells from the regional lymph nodes failed to produce both cytokines.
Une et al. (2003)IFN-gammaT cellIL-12-/- mice were extremely susceptible and failed to produce T cell-derived IFN-gamma and nitric oxide (NO), although NK cytotoxicity was induced.
Venkataraman and Kuo (2005)IFN-gammaT cellsInterestingly, primary stimulation of T cells with anti-CD3 resulted in increased IL-4 but not IL-2 or IFN-gamma production in GPR84(-/-) mice compared to wild-type mice.
Kitazawa and Streilein (2000)IFN-gammaT cellsWhen pulsed with OVA, these cells were capable of inducing proliferation among DO11.10 T cells in vitro, but the responding cells produced neither IFN-gamma nor IL-10 and IL-4.
Caprio-Young et al. (2006)IFN-gammaT cellsIntriguingly, the anergic splenic T cells, although nonproliferative and unable to produce IFN-gamma or IL-4, secrete significant amounts of IL-2.
Kuzushita et al. (2006)interferon gammaT cellsThe CD4(+) T cells obtained from mice immunized with nonstructural 5-transduced dendritic cells produced interferon gamma, but not interleukin 4, when stimulated with nonstructural 5.
Kuzushita et al. (2006)interferon gammaT cellsIn contrast, T cells derived from mice immunized with hepatitis C virus core-transduced dendritic cells produced neither interferon gamma nor interleukin 4 when stimulated with core protein.
Min et al. (2001)IFN-gammaT cellsIn prior studies, we found that exposure of newborn mice to Ig-PLP1, a chimera expressing the encephalitogenic proteolipid protein (PLP) sequence 139-151, induced deviated Th2 lymph node cells producing IL-4 instead of IL-2 and anergic splenic T cells that failed to proliferate or produce IFN-gamma yet secreted significant amounts of IL-2.
Katamura et al. (1995)IFN-gammaT cellsProstaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.
Jump and Levine (2002)IFN-gammaT cellsUpon stimulation, only CD45RB(low)CD4(+) PP T cells produce IL-10, whereas secretion of IL-2, IL-4, and IFN-gamma was not detected.
Rosendahl et al. (1996)IFN-gammaT cellsT cells responded well to 3 daily injections of C215Fab-SEA and then gradually entered a hyporesponsive state, characterized by a reduced ability to produce IL-2, TNF-alpha and IFN-gamma and failure to mediate cytotoxicity in vitro.
Quanquin et al. (1999)IFN-gammaT cellsThis population of T cells also produces both IFN-gamma and interleukin 2 (IL-2) but not IL-4 or IL-5 when incubated with spleen cells stimulated with TolT antigen, indicating that they are of the T-helper 1 type.
Segal et al. (2002)IFN-gammaT cellsSurprisingly, glioma-specific CD4+ T cells produce IL-10 but neither IL-4 nor IFN-gamma, and glioma rejection is compromised in IL-10(-/-) hosts.
Collazo et al. (2000)IFN-gammaT cellsIntracellular cytokine staining by flow cytometry revealed that, in contrast to infected nontransgenic controls, infected PCC-Tg animals failed to develop IFN-gamma-producing CD4(+) T cells.
Franco and Greenberg (1999)interferon-gammaT cellsRotavirus-specific CD8+ T cells can mediate their antiviral effect in the absence of perforin, fas, or interferon-gamma and are preferentially represented in the subset that expresses high levels of the enteric mucosal homing receptor alpha4beta7.
Gollob and Coffman (1994)IFN-gammaT cellsIn contrast, CD4+ T cells stimulated with immobilized anti-V beta 6 under otherwise identical culture conditions generated cells that produced IFN-gamma but not IL-4 on restimulation.
Choquet-Kastylevsky et al. (2000)IFN-gammaT-cellIn CD8(+) T-cell deficient mice, there was no production of IFN-gamma or IL-6 mRNAs.
Oliveira et al. (1996)IFN-gammaT-cellThe cytokine profile of the proliferating cells was characteristic of a Th1 type, as we detected IL-2 and IFN-gamma but not IL-4 in the T-cell culture supernatants.
Bantug et al. (2008)IFN-gammaT cellsIE1(168)-specific CD8(+) T cells accumulated in the CNS and produced IFN-gamma and TNF-alpha but not IL-2 following peptide stimulation.
Chen and Jenkins (1998)IFN-gammaT cellsThe DO11.10 T cells that survived in animals injected with MalE-OVA alone were hyporesponsive to in vitro Ag restimulation and did not produce IL-2 and IFN-gamma, whereas DO11.10 T cells from mice infected with MalE-OVA-expressing bacteria produced both lymphokines.
Schountz et al. (2007)IFN-gammaT cellsThe T cells from acutely infected deer mice synthesized a broad spectrum of cytokines, including IFN-gamma, IL-4, IL-5, and TGF-beta(1), but not TNF, lymphotoxin, or IL-17.
Dace et al. (2007)IFN-gammaT cellsCD8+ T cells from rejector mice did not produce IFN-gamma in response to Ad5E1 tumor Ags or use FasL to mediate intraocular tumor rejection.
Kommajosyula et al. (2001)interferon-gammaT cellsCD4 and CD8 T cells and macrophages were excluded from islets and remained entrapped in a peri-islet location as inactive exiles, no longer expressing normal levels of interferon-gamma, interleukin-4, and iNOS.
Takahashi et al. (1996)IFN-gammaT cellsDelayed-type hypersensitivity (DTH) reactions against heat shock protein (HSP) 60 were prominently observed in A. actinomycetemcomitans-infected TCR-delta mutant and C57BL/6 mice, but were absent in TCR-alpha mutant mice, suggesting that the DTH response is exclusively dependent on HSP60-specific alpha beta T cells producing IFN-gamma and IL-2 mRNA.