Viewing affirmative mentions of gene expression of Hand2 (M. musculus) in T cells

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Iwamura et al. (2010)Th2T cellsRESULTS: Eosinophilic airway inflammation, airway hyperreactivity and Th2 cytokine production from CD4 T cells were significantly suppressed in mice that were treated with naringenin chalcone.
Prado et al. (2010)Th2T cellsMoreover, T cells from mice pretreated with Exo(Tol) showed a reduction in IL-5 and IL-13 (Th2 cytokines) production.
Serre et al. (2009)Th2T cellsEarly simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells.
Hennino et al. (2007)Th2T cellsIn sensitized mice, CD8+ T cells are rapidly and transiently recruited to the allergen-exposed site and initiate the inflammatory process leading to skin infiltration with eosinophils and Th1/Th2-producing cells.
De Silva et al. (2005)Th2T cellOverexpression of Nur77 in the T cell compartment did not affect Th1/Th2 cytokine production or balance.
Choi et al. (2005)Th2T cellCONCLUSION: TSA attenuated the development of allergic airway inflammation by decreasing expression of the Th2 cytokines, IL-4 and IL-5, and IgE, which resulted from reduced T cell infiltration.
Ko et al. (2004)Th2T cellTraditional Korean medicine (SCRT) modulate Th1/Th2 specific cytokine production in mice CD4+ T cell.
Rao et al. (2003)Th2T cellsThis switch from chronic to acute GVHD was associated with increased target organ infiltration of activated CD4(+) T cells as well as enhanced expression of Th1/Th2 cytokines, chemokines, and the antiapoptotic factor bfl1.
Bozza et al. (2001)Th2T cellsInterleukin-11 modulates Th1/Th2 cytokine production from activated CD4+ T cells.
Zhang et al. (1999)Th2T cellExpression of a dominant-negative mutant of GATA-3 in mice in a T cell-specific fashion led to a reduction in the levels of all the Th2 cytokines IL-4, IL-5, and IL-13.
Hertl and Riechers (1999)TH2T cellsAutoreactive T cells from PV patients produced both TH1 and TH2 cytokines; autoreactive T cells from normals produced TH0 cytokines.
Sveti? et al. (1993)Th2T cellsOur results demonstrated a highly consistent and novel pattern of Th1/Th2 cytokine gene expression characterized by elevated IL-10 and IFN-gamma in CD4+ T cells which rapidly manifests itself and is sustained for at least 10 days after immunization.
Quirion et al. (2009)Th2T cellsIn this study we demonstrate that Ikaros is a positive regulator of Th2 cytokine gene expression in peripheral T cells.
Quirion et al. (2009)Th2T cellThese data support a model whereby Ikaros directly activates Th2 gene expression by promoting local chromatin accessibility during CD4+ T cell differentiation and also acts indirectly to regulate expression of Th2- and Th1-specific transcription factors.
Khoruts et al. (1995)Th2T cellIn contrast, incompletely skewed T cell populations that produced high levels of both Th1 and Th2 cytokines were consistently only weakly encephalitogenic.
Cedeno-Laurent et al. (2010)Th2T cellsNot only did Gal-1hFc-binding trigger IL-10 and Th2 cytokine expression in activated T cells, but members of the CD28 family and several other immunomodulatory molecules were upregulated.
Ju et al. (2007)Th2T-cellsWhen the CD11c+CD8+ T-cells were purified and re-stimulated in vitro, they produced high levels of the Th1 cytokines, IFN- and IL-2, but low levels of the Th2 cytokines, IL-4 and IL-10.
MacDonald et al. (2003)Th2T cellsThe underlying mechanism of recruitment was further defined by use of mice deficient in the key Th2 cytokines IL-4 or IL5 and mice that lack T cells (nude mice).
Leishman et al. (1998)TH2T cellWe show that feeding 2-200 mg ovalbumin (OVA) to mice 7 days after immunisation with OVA in adjuvant produces dose-dependent suppression of delayed-type hypersensitivity (DTH), T cell proliferation, and both TH1 and TH2 cytokines, although serum IgG levels were unaffected.
Sehra et al. (1998)TH2T-cellOBJECTIVE AND METHODS: To elucidate the effect of LEA on polarization of T-cell responses, its effect on the relative production of TH1/TH2 type cytokines (namely IL-2, IL-4 and IFN-gamma by commercially available ELISA kits and immunoglobulin profile as measured by ELISA) were studied.
Oka et al. (2001)Th2T cellsIn DNP-KLH mice, IFN-gamma (Th1 cytokine) production from CD4+ T cells was suppressed and IL-4 (Th2 cytokine) production from CD4+ T cells was increased as compared to normal mice.
Hirahara et al. (1998)TH2T-cellRESULTS: Oral administration of the peptide to mice before, or even after, the sensitization induced oral tolerance in T-cell responses against the allergen; the tolerance was associated with decreased production of TH1 (IFN-gamma and IL-2) and TH2 (IL-4) cytokines.
Marinaro et al. (1995)Th2T cellQuantitative reverse transcriptase-PCR was performed to assess levels of mRNA for Th1 (IFN-gamma) and Th2 (IL-4) cytokine expression in TT-stimulated CD4+ T cell cultures.
Hiroi et al. (1998)Th2T cellsNALT CD3+ CD4+ T cells of Th0 type have the capacity to become Th1- and/or Th2-type cells since their activation via the TCR-CD3 complex resulted in the expression of an array of Th1 and Th2 cytokines.
Kim et al. (2006)Th2T cellsHowever, the results were contradictory to the report that CIITA functioned to suppress the production of Th2 cytokine by CD4+ T cells in CIITA deficient mice.
Fan et al. (1990)Th2T cellFour subsets were identified among these T cell clones according to their cytokine secreting profiles: Th0 producing IL-2 and IL-4, Th1 producing IL-2, Th2 producing IL-4, and Tnull, a subset producing neither cytokine.
Bel'skaya et al. (2006)Th2T cellsEffects of natural suppressor cells on production of Th1 and Th2 cytokines and proliferation of polarized T cells.
Williams et al. (1990)Th2T cellsCulture of murine T cells with immobilized (platebound) anti-CD3 antibody results in autocrine growth factor secretion in both Th1 (IL-2 producing) and Th2 (IL-4 producing) cells.
Löhning et al. (2003)Th2T cellsICOS(medium) cells, the large majority of ICOS(+) T cells in vivo, were very tightly associated with the synthesis of the T helper type 2 (Th2) cytokines IL-4, IL-5, and IL-13, and these cells exhibited potent inflammatory effects in vivo.
Tanaka et al. (2005)Th2T-cellWe report that Vav1-/- CD4+ T cells display deficient T-cell receptor (TCR)/CD28-induced IL-4 and c-Maf expression and, conversely, enhanced interferon gamma (IFN-gamma) production and T-bet expression (even when cultured under Th2-polarizing conditions), but intact expression of other Th2 cytokines and GATA-3.
Ghosh et al. (1995)Th2T cellsRecent reports have demonstrated the presence of T cells producing Th2 lymphokines (IL-4, IL-6, and IL-10) in tumor-infiltrating lymphocytes of renal cell carcinoma.
Jiang et al. (2008)Th2T cellsIn vivo Th polarization was evaluated by detecting expression of Th1/Th2 cytokine, antibody isotype and Th related transcription factor, as well as the proliferation of CD8(+) T cells.
Wang et al. (2008)Th2T cellDisease incidence and severity were monitored, mRNA expression of proinflammatory mediators was determined by real-time PCR, purified T cell proliferation was assessed using [(3)H]-thymidine incorporated assay, and T helper (Th) 17/Th1/Th2 type cytokine production was examined by ELISA.
Müller-Doblies et al. (2007)Th2T cellWhen recipient mice were infested with pathogen-free Ixodes scapularis nymphs several days prior to T cell transfer and intradermal injection of soluble cognate antigen at the feeding site, the clonotypic CD4 cells gained the ability to express the Th2 effector cytokine IL-4.
Odobasic et al. (2006)Th2T cellsThese results correlated with attenuated splenocyte production of protective Th2 cytokines IL-4 and IL-10 and decreased apoptosis of splenic CD4+ T cells.
Gregory et al. (2006)Th2T cellWhen exposed to a pathogen, a naive CD4(+) T cell is forced to make a cell fate decision that leads to a polarized population of Th1 IFN-gamma- or Th2 IL-4- producing cells.
Kiani et al. (2001)Th2T cellsReduced IFN-gamma production by NFAT1(-/-)x IL-4(-/-) T cells is observed after primary in vitro stimulation of naive CD4+ T cells, is conserved through at least 2 rounds of T-helper cell differentiation, and occurs by a cell-intrinsic mechanism that does not depend on overexpression of the Th2-specific factors GATA-3 and c-Maf.
Serreze et al. (2000)Th2T-cellsThese NOD.IFNgammaRBnull mice were characterized by normal patterns of leukocyte development and T-cells that produced greatly enhanced levels of the putatively type 1 diabetes-protective Th2 cytokine interleukin (IL)-4.
Viana da Costa et al. (1998)Th-2T-cellThe T-cell response, assessed after in vitro stimulation of splenocytes, showed a predominant production of Th-2 cytokines (IL-4, IL-5 and IL-10) occurring after egg laying.
Mueller et al. (1997)Th2T cellsWe have recently shown that transgenic expression of the Th2 cytokine IL-4 by pancreatic beta cells completely protects nonobese diabetic (NOD) mice from autoimmune diabetes by inducing functional tolerance among autoreactive T cells.
Azouaou et al. (1997)Th2T-lymphocyteMycobacterium avium infection in mice is associated with time-related expression of Th1 and Th2 CD4+ T-lymphocyte response.
Ruzek and Mathur (1995)Th2T cellHowever, no alterations in the production of the Th2 cytokines IL-4 and IL-10 were observed in these stimulated splenocyte or T cell cultures from the tumor-bearing mice.
Tang et al. (2000)Th2T cellsIn contrast, when cultured with mouse CII, T cells from mice immunized with the nonarthritogenic CB10 produced predominantly Th2 (IL-4 and IL-10) cytokines whereas the arthritogenic mutant rCB10 induced predominantly Th1 (IFN-gamma) cytokines.
Tuohy et al. (1995)Th2T cellsThe repertoire deletions are accompanied by low level production of pathogenic Th1 cytokines (IFN gamma; IL-2) and increased production of regulatory Th2 (IL-4) cytokine in activated p104-117 primed T cells.
Shimohata et al. (2009)Th2T lymphocytesMETHODS: To examine how Th1/Th2 imbalance affects the development of autoimmune disease, we overexpressed T-bet in the T lymphocytes of C57BL/6xBXSB/MpJ-Yaa F1 (Yaa) mice.
Yamamoto et al. (2009)Th2T-cellsOn the other hand, splenic expression of transcription factor T-bet (Th1-specific), GATA-3 (Th2-specific) and Foxp3 (gene marker for regulatory CD4+CD25+ T-cells) mRNAs was suppressed in these mice, but not in the combination of 5 or 50 ppm toluene with PGN.
Hirahara et al. (1998)TH2T-cellOBJECTIVE: To evaluate immune suppressive efficacy of oral administration of an immunodominant peptide, we investigated changes in T-cell proliferation, TH1 - and TH2 -cytokine production, and TH1 - and TH2 -mediated antibody production in mice after oral administration of a peptide.
Tang et al. (1998)Th2T cellsTogether, these data indicate that both Th1 and Th2 cytokines produced by CD4(+) T cells are involved in induction and development of granulomatous EAT, and CD8-dependent resolution of granulomatous EAT is apparently not mediated by these cytokines.
Chen et al. (2009)Th2T-lymphocyteEffects of SML on T-lymphocyte subsets and the production of Th1 cytokines IL-2 and IFN-gamma, and Th2 cytokines IL-4 and IL-10 from ConA-stimulated mice splenocytes were detected by flow-cytometric analysis and ELISA method, respectively.
Chen et al. (2009)Th2T cellsSML not only significantly decreased the percentage of CD4(+) T cells and the CD4(+)/CD8(+) ratio, but reduced the production of Th1/Th2 cytokines in a concentration-dependent manner.
Mäkelä et al. (2003)TH2T lymphocytesHowever, in mice previously exposed to ovalbumin through the airways and subsequently infected with RSV, the degree of AHR was significantly increased and was associated with an increased proportion of TH2 (IL-4, IL-5) cytokine-producing T lymphocytes.
Creusot et al. (2001)Th2T cellsNumerous antigen-specific T cells synthesising IFN-gamma (Th1) and IL-4 (Th2) were detectable using both intracellular staining and ELISPOT assays.
Zheng and Flavell (1997)Th2T cellsThe transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.
Butler et al. (2002)Th2-specificT cellsFurthermore, expression of Th1- and Th2-specific transcription factors T-bet and GATA-3, as well as the nuclear factor of activated T cells transcription factor, NFATc, was not significantly different between the two mice.
Koya et al. (2009)Th2T cellsLung T cells from both protocols produced Th2 cytokines in response to OVA in vitro.
Hasegawa et al. (2006)Th2T cellThere have been substantial numbers of reports on T cell function in aged mice and humans, such as on the production of Th1 and Th2 cytokines, but the results show considerable variation and contradictions.
Malfitano et al. (2008)Th2T cellFurthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Quirion et al. (2009)Th2T cellsThe decreased ability to express Th2 cytokines in Ikaros(null)T cells corresponds with histone 3 hypoacetylation across the Th2 cytokine locus as well as decreased GATA3 and cMaf and increased T-bet and STAT1 expression.
Yokota et al. (2003)Th2T cellsCD4 T cells can functionally differentiate to either a Th1 (IFN-gamma producing) or the counterbalancing Th2 (IL-4) phenotype.
Malissen et al. (2005)Th2T cellsMore recently, LAT "knock-ins" harboring point mutations in the four COOH-terminal tyrosine residues, were found to develop lymphoproliferative disorders involving polyclonal T cells that produced high amounts of T helper-type 2 (Th2) cytokines.
Inoue et al. (1993)Th2T cellThe results are analogous to the situation within CD4+ T cell clones in which Th1 and Th2 subtypes can be distinguished by CD45 isoforms and cytokines they produce.
Miyahara et al. (2006)Th2T cellsRecent studies in allergen-induced airway hyperresponsiveness and inflammation using mice lacking BLT1 have shown crucial new roles for leukotriene B4 and BLT1 in Th2 cytokine IL-13 production from lung T cells and recruitment of antigen-specific effector CD8+ T cells, suggesting novel mechanisms for their actions.
Chen et al. (1998)Th2T cellThe consequences of cross-linking of CTLA-4, together with CD3 and CD28, include inhibition of T cell proliferation and interleukin (IL)-2 secretion, as well as suppression of both interferon gamma (Th1) and IL-4 (Th2).
Watanabe et al. (1997)Th2T cellIn the present study, by utilizing completely differentiated Th1 and Th2 cell populations obtained from ovalbumin-specific T cell receptor (TCR)-transgenic mice, the FasL expression on Th1 and Th2 was determined.
Sahu et al. (2008)Th2T cellsWe demonstrate here that Txk-null CD4(+) T cells are capable of producing both Th1 and Th2 cytokines similar to those produced by wild-type CD4(+) T cells.
Boogaard et al. (2007)Th2T cellsThe mDCs stimulated with RSV and ovalbumin (OVA) enhanced proliferation of OVA-specific T cells, which produced both Th1 and Th2 cytokines.
Shao et al. (2009)Th2T-cellAnalysis of the cellular responses revealed that animals immunized with rAd-F0DeltaTM and rAd-F0 elicited CD4(+) T-cell responses of the Th1 and Th2 phenotypes, as well as F protein-specific CTLs.
Field et al. (2008)TH2T cellsThe demonstration that several different FTIs can block the production of TH1 and TH2 cytokines from T cells in culture [43] may provide a partial explanation for the effects of these drugs in our experiments.
Huang et al. (2009)TH2T-cellSTC1 had minimal effects, however, on both T-cell number in the glomeruli and interstitium and on cytokine expression characteristic of either TH1 or TH2 activation.
Rennert et al. (2006)Th2T cellThe recently described T cell and airway phenotype regulator locus, containing the T cell, Ig domain, mucin domain (TIM) genes, is genetically associated with Th2 cytokine production and Th2-dependent immune responses.
Clay et al. (2009)Th2T cellsmice had decreased cellular infiltrates in the airways, decreased airway eosinophilia, decreased serum IgE, and defective Th2 cytokine production upon in vitro restimulation of T cells from the lungs and draining lymph nodes.
Cua et al. (1995)Th2-typeT cellsIn contrast to the transfer of myelin basic protein (MBP)-specific Th1-type T cells derived from female mice, which induced acute and relapse EAE, transfer of MBP-specific Th2-type T cells derived from male mice resulted in no clinical or histologic evidence of EAE.
Sahu et al. (2008)Th2T cellThe inducible T cell tyrosine kinase Itk regulates the production of Th2 cytokines as well as migration in response to chemokine gradients.
Shankar and Titus (1995)Th2T cellsIn contrast, both sham chimeric, BALB/c ATXBM hosts given naive BALB/c T cells, and control irradiated euthymic mice succumbed to infection, producing Th2 profiles (IFN-gamma loIL-4hiIL-10hi).
Chitnis et al. (2001)Th2T cellsExperimental autoimmune encephalomyelitis (EAE) is mediated by myelin-specific CD4(+) T cells secreting Th1 cytokines, while recovery from disease is associated with expression of Th2 cytokines.
Yokozeki et al. (2000)Th2T cellsThe expression of Th2 cytokines (IL-4, IL-5) in TNCB-challenged skin tissues and the supernatants from T cells stimulated by 2,4,6-trinitrobenzene sulfonate-modified spleen cells, as well as the immunoglobulin (Ig)E and IgG1 response after challenge, were also profoundly reduced in STAT6(-/)- mice, whereas the expression of interferon gamma was the same in STAT6(-/)- and wt mice after challenge.
Kikuchi et al. (2010)Th2T cellsWe also assessed Th1 and Th2 cytokine production in lung T cells.
Gilchrist et al. (2008)Th2T cellSimilar levels of OVA-specific IgE and IgG1 were induced in ATF3-null mice, indicating that they are competent in their ability to generate OVA-specific T cell responses and undergo Ig isotype switching, although this is not enhanced despite increased Th2 cytokine production.
Karussis et al. (1999)TH2T-cellOur observations indicate that downregulation of TH1 cytokines (especially IL-12) and enhancement of TH2 cytokine production may play an important role in the control of T-cell-mediated autoimmunity.
Matheson et al. (2005)Th2T cellsTaken together, these results indicate that TDI asthma, like immune-mediated asthma produced by large-molecular-weight materials, is driven primarily by CD4+ T cells and is dependent upon the expression of Th2 cytokines.
Marais et al. (1999)Th2T cellInoculation of BALB/c and C57 BL/6 mice with HPV-16 VLP resulted in HPV VLP-specific T cell proliferative responses characterized by the production of both Th1 and Th2 cytokines, and afforded protection against virus challenge from recombinant VV expressing HPV-16 L1 (VVL1R-16).
Camelo et al. (2001)Th2T cellsComparison of CVS infection in these two strains of mice indicated that decreased immune responsiveness is associated with: (1) an in vivo reduction of the percentages of Th1 (IL-2, IFN-gamma and TNF-alpha) but not of Th2 (IL-4) cytokine-secreting T cells; and (2) an in vivo increase of the percentages of CD25 and CD69-expressing splenocytes.
Kazi and Qian (2009)TH2T cellsThese results suggest that crocetin-mediated inhibition of IL-12 production led to the inhibition of TH1 and a possible enhancement of TH2 cytokine synthesis in CD4+ T cells.
Xu et al. (2004)Th2T cellsCD4 T cells were polarized in vitro to IFN-gamma-producing Th1-like cells and non-IFN-gamma-producing Th2-like cells, labeled, and adoptively transferred.
Kosaka et al. (2006)Th2T cellsWhile demonstrating a bias against Th2 differentiation, overall these experiments have indicated that the most significant failing is an inability of Itk-/- CD4+ T cells to produce Th2 cytokines in a recall response, rather than an absolute defect in Th2 differentiation by T cells lacking Itk.
Tamura et al. (2001)Th2T cellsThe fyn(-/-) naive CD4+ T cells efficiently produced Th2 cytokines and polarized toward the Th2 subset even in the absence of IL-4 and IL-13.
Elias et al. (1997)Th2T-cellsWe now report that the effectiveness of p277 treatment is associated with the transient activation of anti-p277 splenic T-cells that produce the Th2 cytokines interleukin-4 (IL-4) and IL-10.
Seo et al. (1998)Th2-typeT cellsDown-regulation of tumoricidal NK and NK T cell activities by MHC Kb molecules expressed on Th2-type gammadelta T and alphabeta T cells coinfiltrating in early B16 melanoma lesions.
Spender et al. (1998)Th2T cellsTh2 cytokine protein production by T cells showed no apparent change.
DeKruyff et al. (1998)Th2T cellsThese results help to resolve previous conflicting observations regarding the effects of corticosteroids on cytokine production by T cells, and indicate that while corticosteroids may directly inhibit Th1 and Th2 cytokine production in T cells, corticosteroids, by reducing IL-12 production in APCs, have the potential to indirectly enhance Th2 cytokine synthesis.
Beyers et al. (1998)Th2T cellsThe factors regulating the polarization of mouse or human T cells to produce Th1 or Th2 cytokines are briefly reviewed.
Chan et al. (1995)Th2T cellsIn vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection.
Makar and Wilson (2004)Th2T cellsTh2 cytokine expression also increased in Dnmt1(-/-) CD4 T cells, but the increase ( approximately 20-40-fold for IL-4 and IL-10,
Makar and Wilson (2004)Th2T cellsAs a result, both Dnmt1(-/-) CD4 and CD8 T cells expressed high and comparable amounts of Th2 cytokines.
Diehl et al. (2004)Th2T cellsWe have observed that inhibition of NFAT in T cells results in a reduction of Ag-specific Th2 Ab levels and IL-4 production by CD4+ T cells.
van Hamburg et al. (2008)Th2T cellsWe activated naïve primary T cells in vitro in the presence of transforming growth factor-beta and IL-6, and found that enforced GATA3 expression induced co-expression of Th2 cytokines in IL-17-producing T cells.