Viewing affirmative mentions of gene expression of Fas (M. musculus) in T cells

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Suda and Nagata (1997)FasT cellsIn contrast, among the lymphocyte subsets, only activated T cells and natural killer cells express readily detectable levels of Fas ligand.
Brunner et al. (1996)CD95T cellWe have previously reported that activation of murine T cell hybridomas leads to expression of Fas (CD95) and its ligand (FasL) which subsequently interact, even on the same cell, leading to apoptotic cell death.
Brunner et al. (1996)FasT cellSince the immunosuppressive drugs cyclosporin A (CsA) and FK506 block activation-induced apoptosis in T cell hybridomas, we examined whether such compounds affect cell death by interfering with expression of Fas, FasL or both, or whether they block Fas signal transduction.
Brunner et al. (1996)FasT cellsWe therefore conclude that CsA and FK506 block activation-induced apoptosis in T cell hybridomas predominantly by interfering with activation signals leading to FasL expression and, further, that the regulation of the expression of Fas and FasL on activated T cells is differentially controlled.
Judge et al. (1998)FasT cellsExpression of Fas ligand is tightly regulated, being expressed primarily by T cells after activation, where it serves as a self-regulatory mechanism for immune responses.
Zhang et al. (1999)FasT cellInduction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells.
Zhang et al. (1999)FasT cellHere, we show that profound, specific T cell unresponsiveness to alloantigen was induced by treatment of H-2k mice with H-2b APCs that expressed Fas ligand and that profound T cell unresponsiveness specific for the H-Y Ag was induced by treatment of H-2Db/H-Y TCR transgenic female mice with H-2Db/H-Y APCs that expressed Fas ligand.
Zhang et al. (1999)FasT cellThe induction of this systemic T cell tolerance required the expression of Fas ligand on the APCs as well as the expression of Fas on the T cells.
Zhang et al. (1999)FasT cellsThe rapid and profound clonal deletion of the Ag-specific, peripheral T cells mediated by the Fas ligand-expressing APCs contributed to the induction of tolerance.
Zhang et al. (1999)FasT cellThese findings demonstrate that Ag-specific T cell tolerance can be induced by APCs that express Fas ligand and suggest a novel function for APCs in the induction of T cell apoptosis.
Ludgate and Jasani (1997)FAST-cellThe overall results suggest that the degree of FAS expression on target cells may determine their sensitivity to T-cell mediated cytotoxicity in the absence of perforin or granzyme directed apoptosis mechanisms.
Tu-Rapp et al. (2004)FasT cellsMysler and co-workers and other groups showed that T cells in systemic lupus erythematosus have an abnormal increase in surface Fas expression [18,19].
Tucek-Szabo et al. (1996)FasRT lymphocytesIn this study, we document substantial expression of FasR on the vast majority of recent thymic emigrants and resting peripheral T lymphocytes.
Tucek-Szabo et al. (1996)FasRT cellsLymph node T cells from young, healthy, FasR expression-deficient MRL-Ipr/Ipr and animals could be activated in vivo through the TCR-CD3 complex.
Bellgrau et al. (1995)CD95T cellsCD95 ligand expression in the testis probably acts by inducing apoptotic cell death of CD95-expressing, recipient T cells activated in response to graft antigens.
Rhile et al. (1996)FasT cellsTogether, our studies demonstrate that although Ah locus plays the primary role, determining the toxicity of TCDD on the T cells, there are secondary factors such as expression of Fas or the MHC-phenotype which may play an important role in TCDD-mediated immunotoxicity.
Kaminski and Waterfield (1991)lpr geneT cellsThis antibody recognizes a surface antigen found on the EL 4 tumor lines and all "double negative" nonresponsive T cells from lpr gene expressing mice.
Andjeli? et al. (1994)FasT cellsRecent analysis of Fas mRNA and protein expression in normal mice showed high expression in the thymus, on activated T cells, and on 5-10% of peripheral T cells.
Fukuyama et al. (1998)FasT cellsTransgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice.
Fukuyama et al. (1998)FasT cellIn this report, we describe the establishment of a line of Fas transgenic MRL-lpr mice in which mouse Fas cDNA was expressed using the T cell-specific murine lck promoter.
Hashimoto et al. (2004)FasT cellsExpression of Fas and Fas ligand on spleen T cells of experimental animals after unmodified or leukoreduced allogeneic blood transfusions.
Bonzheim et al. (2008)FAST-cellTo investigate a possible association between the respective SNPs and the FAS or CTLA-4 expression on the protein level, we performed FAS (Santa Cruz Biotechnology, Santa Cruz, CA, USA) and CTLA-4 (BD Biosciences, San Diego, CA, USA) double fluorescence stains in combination with an antibody directed against the respective T-cell receptor (TCR) V?
Bonzheim et al. (2008)FAST-cells691T>C located in the promoter region could potentially lead to a modified transcription factor binding site and therefore be of relevance for the expression level of the FAS gene, we analyzed the FAS expression of the neoplastic T-cells in AILT and PTCL-NOS by immunohistochemistry.
Bonzheim et al. (2008)FAST-cellsFuture studies will, therefore, have to address the exact quantification of the FAS expression across various physiological differentiation states of T-cells.
Inaba et al. (1999)FasT cellsWe further showed that the resistance to AICD in primed T cells was due to the decreased sensitivity to apoptosis induced by Fas-mediated signals, but TCR-mediated signaling equally activated both naive and primed T cells to induce Fas and Fas ligand expressions.
Chervonsky et al. (1997)FasT cellsImmunologically privileged sites express Fas ligand (FasL), which protects them from attack by activated T cells that express Fas and die upon contact with FasL.
Puliaeva et al. (2008)FasT cellOur results demonstrate a novel dichotomy of Ag-specific T cell Fas function in that: 1) Fas expression on Ag-activated T cells has costimulatory, helper, and down-regulatory roles in vivo and 2) these roles were observed only in a CTL response (acute GVHD) and not in a T-dependent B cell response (chronic GVHD).
Puliaeva et al. (2008)FasT cellSpecifically, CD4 T cell Fas expression is important for optimal CD4 initial expansion and absolutely required for help for CD8 effector CTL.
Puliaeva et al. (2008)FasT cellDonor CD8 T cell Fas expression played an important but not exclusive role in apoptosis and down-regulation.
Puliaeva et al. (2008)FasT cellThese results demonstrate a novel role for Ag-specific T cell Fas expression in in vivo CTL responses and support a review of the paradigm by which Fas deficiency accelerates lupus in MRL/lpr lupus-prone mice.
Schwarz et al. (1998)FasT cellsCoincubation of hapten-pulsed DC with T cells that were obtained from UV-tolerized mice resulted in an enhanced death rate of DC, and this cell death was dependent upon Fas expression.
Sava?an et al. (2007)FasT lymphocyteSome children with ES have increased lymphocyte Fas expression and Fas-mediated T lymphocyte apoptosis and these may be early signs of common variable immunodeficiency disorder in ES.
Matsuzawa et al. (2002)FasT cellsTaken together with the fact that DN T cells massively express Fas ligand (FasL), this study implied that FasL overexpressed on DN cells may be involved in the accumulation of DN T cells in LN, LN atrophy and wasting syndrome, and that lprcg Fas, which can bind to Fas ligand but not transduce apoptosis signal into cells, may modulate these pathological conditions by interfering with the binding of FasL to Fas.
Villa-Morales et al. (2007)FasT-cellThese results lead us to propose that germ-line functional polymorphisms affecting either the levels of expression or the biological activity of both Fas and FasL genes could be contributing to the genetic risk to develop T-cell lymphoblastic lymphomas and support the use of radiotherapy as an adequate procedure to choose in the treatment of T-cell malignancies.
Satchell et al. (2004)FasT cellsIncreased Fas ligand expression by T cells and tumour cells in the progression of actinic keratosis to squamous cell carcinoma.
Satchell et al. (2004)FasT cellsBACKGROUND: In the counterattack model of tumorigenesis, it has been proposed that tumours develop resistance to attack from Fas ligand (FasL)-expressing cytotoxic T cells by downregulating Fas (immune escape), while at the same time upregulating FasL expression to induce apoptosis in Fas-expressing T cells (counterattack).
Satchell et al. (2004)FasT cellsOBJECTIVES: The aim of this study was to examine Fas and FasL expression on tumour cells and infiltrating T cells during the progression of actinic keratoses (AK), the benign precursor lesion, to squamous cell carcinoma (SCC).
Xu et al. (2006)FasT lymphocytesChanges in the expression of Fas on T lymphocytes after allogeneic fetal thymus transplantation in systemic lupus erytematosus mice.
Zhou et al. (1995)FasT cellsFas expression and function on T cells from old (22-26-mo-old) mice was compared with young (2-mo-old) mice and old CD2-fas-transgenic mice.
Zhou et al. (1995)FasT cellsFas expression and ligand-induced apoptosis were decreased on T cells from old mice compared with young mice.
Zhou et al. (1995)FasT cellIn 26-mo-old CD2-fas-transgenic mice, Fas and CD44 expression, Fas-induced apoptosis, T cell proliferation, and cytokine production were comparable to that of the young mice.
Brunner et al. (1995)FasT-cellHere we show that the Fas/CD95 receptor, which can transduce a potent apoptotic signal when ligand, is rapidly expressed following activation of T-cell hybridomas, as is its functional, membrane-bound ligand.
Ashany et al. (1995)FasT cellsRecent evidence indicates that this regulatory function operates through deletion of activated T and B lymphocytes by CD4+ T cells expressing the Fas ligand.
Maksimow et al. (2003)FasT-cellCompared with cells becoming apoptotic, the surviving cells expressed lower levels of Fas and higher levels of T-cell receptor (TCR), CD4, and interleukin-2 receptor (IL-2R).
van Parijs et al. (1998)CD95T cellsUnder these conditions, the T cells co-express Fas (CD95) and Fas ligand (FasL), and engagement of Fas triggers apoptotic death of the T cells.
Kawamura et al. (2000)FasT cellsThese results suggest that LC may acquire the susceptibility to Fas-mediated apoptosis through up-regulation of the Fas expression by IFN-gamma derived from activated T cells and that the elimination of LC may be important for preventing excess cutaneous inflammatory diseases.
Roberts and Orme (1998)CD95T cellsIn view of recent evidence that this pathway might be defective in aged mice, this study investigated CD95 expression on T cells in old mice activated by infection with Mycobacterium tuberculosis.
Roberts and Orme (1998)CD95T cellsThe results of the study do not support the hypothesis that CD95 is poorly expressed on CD4 T cells from old mice; instead, it was found that similar numbers of T cells from young and old mice expressed CD95, with the intensity of expression if anything higher on the cells from the old mice.
Roberts and Orme (1998)CD95T cellsIn addition, the study demonstrated that changes in CD44 and CD45RB expression previously observed in young infected mice proceeded in a similar fashion in old animals and, as would be predicted, that CD95(hi) expression was primarily associated with CD4 T cells expressing the activated CD44(hi) CD45RBhi phenotype.
Stuart et al. (2005)FasT cellExamination of the T cell compartment in gld mice revealed that these cells express higher levels of Fas and are more susceptible to Fas-mediated death than wild-type cells.
Saint Fleur et al. (2009)FasT cellsFinally, we demonstrated that activated but not resting CD4(+) T cells with targeted deletion of a Cyclon allele show reduced AICD and expression of Fas, indicating a critical role of Cyclon in Fas expression in activated T cells.
Saint Fleur et al. (2009)FasT cellsDespite its prime importance in cell death, regulation of Fas expression in T cells is poorly understood.
Liu et al. (2006)FasT cellsIn order to investigate the inhibition role of anti-Fas hammerhead ribozyme on Fas expression and Fas-mediated apoptosis in CTLL-2 cells (mouse CTL cell line), and to explore a new way for enhancing the ability of T cells against Leukemia in donor lymphocytes infusion, CTLL-2 cells were transfected with pEGFP-RZ596 and pEGFPC1 (mock-transfected) via electroporation.
Beltinger et al. (1998)CD95T cellsIn leukemic blasts and normal T cells of a second patient, a homozygous mutation in the promoter of CD95 causing disruption of a consensus sequence for AP-2 binding without decreasing constitutive CD95 expression was detected.
Wu et al. (1993)FasT cellsThe interdependence of ETn expression and abnormal Fas expression was then analyzed in a CD2-Fas transgenic mouse model in which a full-length murine Fas cDNA under the regulation of the CD2 promoter and enhancer was used to correct defective Fas expression in T cells of MRL-lpr/lpr mice.
Takeda et al. (1998)FasT cellsFas ligand (FasL) is highly expressed in testicular tissues and thought to be responsible for protection from allograft rejection by inducing apoptosis of anti-graft activated T cells.
Georgantas et al. (2000)CD95T cellsFas ligand (FasL, CD95L) induces apoptosis in activated T cells with upregulated Fas (CD95) expression through the process termed activation-induced cell death (AICD).
Wada et al. (1999)FasT cellsThe engagement of T cells bearing FasL with Fas expressing tubular epithelial cells (TECs) induced TEC apoptosis in vitro.
Jacobson et al. (1997)FasT lymphocytesThe inability of B and T lymphocytes from mice expressing the lpr mutation to express functional Fas on their cell surface leads to an immunoregulatory defect associated with excessive autoantibody production.
Lamy et al. (1998)CD95T cellsWe found that leukemic LGL from each patient expressed constitutively high levels of CD95/CD95L, similar to those seen in normal activated T cells.
Teh et al. (1996)FasT cellsThis form of apoptotic cell death has been shown to be dependent on the expression of the Fas (CD95) antigen and can occur via an autocrine mechanism involving the concomitant up-regulation of Fas and its ligand on activated T cells.
Wada et al. (2005)FasT cellsExpression of Fas ligand (FasL) in tumors produced antitumor effects by generating both inflammation and T cell-mediated immunity, although the Fas/FasL interaction induces an apoptotic process of Fas-positive activated T cells.
Tong et al. (2010)FasT cellsFas ligand expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma.
Tóth et al. (2004)CD95T cellsRetinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cells.
Xiao et al. (2004)FasT cellsThe exquisite sensitivity of these abnormal DN T cells is attributed to their increased membrane Fas expression with a concomitant reduction of cytosolic FLIP(L).
Tamma and Coico (2003)FasT cellBased on our previous findings that immunoglobulin D (IgD) receptor (IgD-R) cross-linking with oligomeric IgD (IgD-R-xL) led to T cell activation, we examined the effect of IgD-R-xL on the expression of Fas antigen and apoptosis induction.
Hiromatsu et al. (2003)FasT cellsFas ligand (Fas L) expression was induced on intrahepatic NK1.1(+) T cells in vivo after an intraperitoneal inoculation of Escherichia coli.
Miyazawa et al. (2002)FasT cellsIn the clamped kidney, the accumulated intermediate T cells had less cytotoxic activity against tumor cells; however, the expression of the Fas ligand (FasL) increased, indicating a cell-mediated tissue injury via the Fas/FasL system.
Whartenby et al. (2002)FasT cellsFasL-modified lin(-) BMs killed Fas-expressing T cells in vitro.
Tóth et al. (2001)CD95T cellsActivation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells.
Hsu et al. (2001)FasT-cellThe decreased AICD of T cells from 16-month-old mice is associated with a decreased expression of Fas and Fas ligand (FasL), decreased susceptibility to anti-Fas-induced apoptosis, and an increased expansion of a CD8(+) T-cell population.
Caamaño et al. (2000)FasT cellsThis loss of T cells correlated with increased levels of apoptosis and with elevated expression of the pro-apoptotic molecule Fas by T cells from infected NF-kappaB(2)(-/-) mice.
Tóth et al. (1999)CD95T cellRegulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)-mediated apoptosis in activation-induced T cell death involves calcineurin and protein kinase C, respectively.
Majlessi and Bordenave (1999)FasT cellsIn this study, using T cells from Igha/a Pfp+/+ or Pfpo/o mice, the latter obtained by crossbreeding, and B cells from Ighb/b Fas+/+ or Faslpr/lpr (lymphoproliferation) mice in appropriate adoptive transfer models, we demonstrated that: 1) under blockage of the Pfp-mediated pathway, Igha/a T cells were still able to induce suppression against wild-type IgG2ab+ B cells, 2) IgG2ab+ B cells with impaired Fas expression were also subjected to suppression by WT Igha/a T splenocytes, and 3) the suppression establishment was totally inhibited when both Pfp- and Fas-dependent mechanisms were simultaneously blocked, i.e., when Igha/a Pfpo/o T cells were used to induce suppression against Ighb/b Faslpr/lpr B cells.
Matsue et al. (1999)FasT cellsRT-PCR and FACS analyses revealed the expression of CD95 (Fas) by XS52 DC and of CD95 ligand (CD95L) (Fas ligand) by activated HDK-1 T cells, suggesting a functional role for these molecules.
Zhang et al. (1999)FasT lymphocytesRestimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation-based signaling cascades that evoke Fas ligand expression and induction of Fas-mediated programmed cell death.
Gärdby et al. (1998)CD95T cellsRather, CD4+ T cells stimulated by oral immunization in Tg mice appeared to be inappropriately primed, as evidenced by a significantly reduced level of CD40 ligand and CD44 expression and an increased expression of CD95 compared to those in wild-type mice.
Fogler et al. (1998)FasT cellsRecruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas.
Suzuki et al. (1997)FasT cellsActivated T cells in IL-2R beta-deficient mice expressed normal levels of Fas antigen and underwent normal apoptosis in response to induction with anti-Fas mAb.
Sumita et al. (1996)FasT cellsMV1 T cells also killed a CD95 (Fas)-transfected T lymphoma line, but not its parental Fas-negative cell line.
Desbarats et al. (1996)CD95T cellsFas (CD95) expression and death-mediating function are induced by CD4 cross-linking on CD4+ T cells.
Suda et al. (1995)FasT cellExpression of the Fas ligand in cells of T cell lineage.
Nishimura et al. (1995)FasT cellsSpleen T cells were resistant to anti-Fas, whereas they expressed Fas Ag.