Viewing affirmative mentions of gene expression of Cd8a (M. musculus) in T cells

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Rettig et al. (2009)CD8betaT cellsAlthough the stalk-swapped CD8beta was expressed on the cell surface as a disulfide-bonded heterodimer at equivalent levels of expression to an endogenous CD8beta molecule, it failed to restore selection of CD8(+) class I MHC-restricted T cells and it altered the response of peripheral T cells.
Maile et al. (2006)CD8T cellReduced expression of CD8 acts to limit a T cell response to HY peptide by limiting the avidity window of effective signal transduction.
MacDonald et al. (1990)CD8T cellAlthough most cells of the T cell receptor (TcR) gamma/delta lineage are CD4-CD8-, some gamma/delta cells express CD8.
Zhang et al. (1998)CD8 alphaT cellsThese results indicate that stage-specific expression of CD8 alpha in developing T cells is mediated by the differential activity of multiple functionally distinct cis-active transcriptional control mechanisms.
Fung-Leung et al. (1994)CD8T cellsThymocytes and most peripheral T cells express CD8 as heterodimers of CD8 alpha and CD8 beta.
Fung-Leung et al. (1994)CD8 alphaT cellsCD8 alpha expression on thymocytes and peripheral T cells also decreased to 44 and 53% of the normal levels, respectively.
Fung-Leung et al. (1994)CD8 alphaT cellsOur result also reveals the role of CD8 beta in regulating CD8 alpha expression on thymic derived T cells.
Winkel et al. (1997)CD8alphaT cellsThe CD8alpha(-)-expressing dendritic cells (DC) of mouse spleen have been shown to be poor inducers of interleukin (IL)-2 production by CD8 T cells when compared to the CD8- DC.
Fung-Leung et al. (1993)CD8 alphaT cells"Tailless CD8 alpha" was expressed on the cell surface of thymocytes and peripheral T cells.
Sawada et al. (1993)CD8T lymphocytesInterestingly, CD8 expression was hardly suppressed in CD4-CD8+ peripheral T lymphocytes, suggesting that the mechanisms of suppression of CD8 is developmentally regulated.
Sawada et al. (1993)CD8T cellsWe propose that the suppression of CD8 expression at CD4-CD8+ stage involves an additional mechanism of negative selection of thymic T cells.
Nesi? et al. (2000)CD8T cellsWe here show that very few CD8+ cells in beta 2m-/- mice coexpress CD8 beta, a marker of the thymus-derived CD8+ T cells.
Irie et al. (1995)CD8 alpha alphaT cellTo better understand these differences, we introduced the CD8 beta gene into a T cell hybridoma which only expressed the CD8 alpha alpha homodimer.
Gillanders et al. (1997)CD8T cellsIn addition, CD8+ 1B2+ 2C T cells that survive deletion have decreased CD8 expression levels and a significantly reduced in vitro proliferative response to specific alloantigen (clonal anergy).
Sato et al. (1993)CD8T cellsIn the present study, gamma delta T cells in mice were further characterized in terms of their expression of the interleukin-2 receptor beta-chain (IL-2R beta), CD4 and CD8, and CD8 alpha and beta.
Fung-Leung et al. (1995)CD8T cellsUnlike the T cells in other peripheral lymphoid organs, the majority of IEL express the CD8 cell surface protein.
Khan et al. (1999)CD8T cellsThe cellular immune response, especially by gamma interferon (IFN-gamma)-producing CD8(+) T cells, is an essential component of protective immunity against the parasite.
Zhang et al. (2001)CD8alphaT cellsTo examine this issue, phenotypic and functional studies were performed for thymocytes and T cells of CD8alpha(-/-) KO mice that expressed a CD8alpha Tg under control of cis-mechanism I only.
Zhang et al. (2001)CD8alphaT cellsDespite loss of CD8alpha expression at the DP CD3(low/intermediate) stage, increased populations of mature CD3(hi)CD4(-)CD8(-) thymocytes and CD3(+)CD4(-)CD8(-) peripheral T cells were detected.
Hostert et al. (1998)CD8alphaT cellsDeletion of two of the intergenic cluster CIII DNaseI-HSS in homozygous mutant mice affects expression of CD8alphaalpha homodimers on intraepithelial T cells (IEL), particularly on the gammadeltaTCR+ subset.
Taguchi et al. (1992)Lyt-2T-cellThe lymphocytes in the thymomas expressed T-cell antigens (rat Lyt-1 and Lyt-2.3), as in the normal case, and ACI rat specific antigen.
Guilloteau et al. (1991)Lyt-2T cellsT cells expressing Lyt-2 antigen were rarely detected.
Richie et al. (1988)Lyt-2T-cellTo address this issue, we have studied alpha/beta T-cell antigen receptor gene and protein expression on normal thymocyte subsets of AKR/J mice, as well as on a panel of AKR/J primary thymic lymphomas characterized for CD4 (L3T4) and CD8 (Lyt-2) differentiation antigen expression.
Shu and Rosenberg (1985)Lyt-2T cellPhenotypic analysis of fresh, noncultured immune cells revealed that the therapeutically effective cells expressed both the Lyt-1 and the Lyt-2 T cell differentiation antigens.
Hoeveler and Malissen (1993)CD8 alpha alphaT cellWhen challenged with Kb-transfected L cells, T cell transfectants expressing CD8 alpha beta or CD8 alpha alpha dimers with substituted cytoplasmic serine residues responded nearly as well as wild-type CD8 transfectants.
Taruishi et al. (2007)CD8T cellsLevels of CD8(+) T cells producing interferon-gamma were weak in both the acute and convalescent phases in the persistently infected model.
Taruishi et al. (2007)CD8T cellsThese results indicate that hantavirus strongly suppresses the production of N-specific CD8(+) T cells throughout the course of infection in persistently infected mice.
Nikoli?-Zugi? and Bevan (1988)CD8T cellsThe results suggest that CD8 expression is an intermediate step on the differentiation pathway of mature CD4+ T cells.
Williams et al. (1991)CD8T cellsCD8 T cell differentiation antigens, expressed on class I-restricted T cells, have a key role in the control of recognition and response of these cells to antigen.
Vremec et al. (1992)CD8T cellsA substantial proportion of DC from both thymus and spleen expressed CD8 at high levels, comparable with that on T cells.
Salmon et al. (1999)CD8T cellConstitutive expression of a CD8 minigene transgene that encodes both CD8 alpha and CD8 alpha' restores CD8 T cell development in CD8 alpha mutant mice, but fails to permit the development of mismatched CD4 T cells bearing class I-specific TCRs.
Maekawa and Ovary (1986)Ly-2T cellsThe cells responsible for this immunity were shown to be T cells that express Ly-2 on their surface.
Matsumoto et al. (1993)CD8T cellIn contrast, transfer of only the CD8+ T cell-depleted fraction induced insulitis in all the recipients.
Gol'dberg et al. (1990)Lyt-2T-cellsThe existence of a subpopulation of T-cells expressing the Lyt-1+,Lyt-2+,L3T4-antigens on their surface is demonstrated.
Gao et al. (2010)CD8T lymphocytesA large amount of CD4(+) and CD8(+) T lymphocyte infiltration was present in allografts only in the allogeneic group, and few CD4(+) and CD8(+) T lymphocytes were observed in grafts in other groups.
Fernandez et al. (1999)CD8T-cellThe adoptive transfer of these CD8(+) T cell clones also protected CD4(+) T-cell-depleted mice.
Robey et al. (1992)CD8T cellsWe now describe the consequences of expression of both the anti-HY TCR transgene and a constitutive CD8.1 transgene on T cells of male mice.
Robey et al. (1992)CD8T cellsPeripheral T cells in these male 'double transgenic' mice express both the anti-HY TCR and normal levels of CD8, and can proliferate to male antigen in vitro.
Battegay et al. (1996)CD8T cellsThe transgenic IgG2a specifically binds CD8 alpha chains of the CD8.2 allotype expressed on the surface of CD8+ T cells, but not CD8 molecules expressed by the CD8.1 allele.
Higham et al. (2010)CD8T cellsFollowing dendritic cell maturation, a significantly higher fraction of adoptively transferred, tumor-reactive (reporter) CD8(+) T cells was stimulated to express IFN-gamma and infiltrate the prostate tissue.
Luchetti et al. (2004)CD8T cellTherefore, while ovarian controls showed equivalent expression of CD4+ and CD8+ T cell subsets, injection of DHEA yielded a selective ovarian T cell infiltration as demonstrated by enhanced CD8+ and diminished CD4+ T lymphocyte expression.
Dummer et al. (2002)CD8T cellThis response was effective even for established tumors, was characterized by CD8(+) T cell-mediated tumor-specific cytotoxicity and IFN-gamma production, and was associated with long-term memory.
Appasamy et al. (1997)CD8T cellBestatin did not downregulate expression of CD8 by a mature CD8+ T cell clone.
Romero et al. (2005)CD8 alpha alphaT cellOn the significance of CD8 alpha alpha expression for T cell memory.
Bannard et al. (2009)CD8T cellsWe created a transgenic mouse line that permits mapping of the fate of granzyme B (gzmB)-expressing CD8+ T cells and their progeny by indelibly marking them with enhanced yellow fluorescent protein (EYFP).
Leclercq et al. (1992)CD8T cellSeveral groups have described that a low percentage of in vitro cultured T cell receptor (TcR) gamma/delta cells express CD8.
Zhang et al. (1994)CD8T cellsOur results indicate that injection of male CD4 knockout (express CD8) lymphoid cells but not CD8 knockout (do not express CD8) lymphoid cells induced a significant reduction of male H-Y Ag reactive cells in the periphery, suggesting that CD8 plays an important role in the induction of peripheral tolerance of class I-restricted T cells.
Mizuochi et al. (1988)CD8T cellTaken together, the present data indicate an intimate relationship between CD4/CD8 expression with MHC class specificity during T cell differentiation and selection.
Gallagher et al. (1986)Lyt-2T cellStable expression of Lyt-2 homodimers on L3T4+ T cell clones.
Gallagher et al. (1986)Lyt-2T cellsLyt-2 is normally expressed on thymocytes and peripheral T cells as a heterodimer disulfide bonded to the Lyt-3 glycopeptide, yet Lyt-3 could not be detected on the cell membranes of our clones; Lyt-2 existed as stable homodimers without Lyt-3.
Sakaguchi and Sakaguchi (1992)CD8T cellsCsA abrogates the production of CD4+T cells and CD8+T cells in the thymus.
Morrot and Zavala (2004)CD8T-cellTransgenic (Tg) mice carrying a T-cell receptor (TCR) specific for a CD8(+) T-cell epitope expressed in pre-erythrocytic stages of Plasmodium yoelii has proven to be a valuable tool to advance our understanding of this anti-parasite T-cell response, as it occurs in vivo.
Kaldjian et al. (1988)CD8T lymphocytesThe membrane glycoproteins CD4 (L3T4) and CD8 (Lyt2) are expressed on distinct populations of mature murine T lymphocytes, and are thought to be receptors for monomorphic determinants expressed on MHC class II and class I molecules, respectively.
Kaldjian et al. (1988)CD8T cellSince activation of protein kinase C (PKC) is known to cause rapid down-regulation of various receptors, including the T cell receptor complex (TcR complex), we treated cells with phorbol 12-myristate 13-acetate (PMA), a PKC activator, to determine whether cell-surface expression of CD4 and CD8 would be similarly affected by this intracellular mediator.
Zhong and Reinherz (2005)CD8T cellCD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice.
Mixter et al. (1995)CD8T cellsThe CD4-CD8- T cells that accumulate in lpr/lpr mice have previously expressed CD8, on the basis of studies of CD8 alpha gene demethylation.
Nakayama et al. (1994)CD8T cellsThe number of peripheral CD8+ T cells was restored by transfer of an exogenous CD8 beta gene into CD8 beta-deficient T cells.
Hegde and Niederkorn (2000)CD8T-cellMETHODS: BALB/c donor corneas were grafted orthotopically onto C57BL/6, perforin knockout, or CD8(+) T-cell knockout mice.
Pinto et al. (2000)CD8T-cellHowever, if the expression of the genes is confined to skeletal muscle cells, the CD8(+) T-cell response is much weaker and expression is maintained for more than 6 weeks.
Nicholson et al. (1996)CD8T lymphocytesAdoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice.
Giorgi et al. (1982)Lyt-2T cellThe relationship between cell surface antigen expression and function in cytotoxic T cells directed against a non-H-2-restricted plasmacytoma antigen was examined using Lyt-2- variants of a continuous T cell line.
Zhang et al. (1998)CD8 alphaT cellDistinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development.
Deb et al. (2010)CD8T cellWe have previously observed that genetic deletion of the CD8+ T cell effector molecule perforin leads to preservation of motor function and preservation of spinal axons in chronically demyelinated mice.
Mora et al. (1999)CD8alphaT cellsWhereas most CD8+ T cells in lymph nodes and spleen express the CD8alpha beta heterodimer and depend absolutely on thymic competence for their development, a substantial population of T cells expressing CD8alpha alpha matures extrathymically.
Baptista et al. (2010)CD8T-cellHere, we show that mice protected from cerebral malaria by CD8+ T-cell depletion have significantly fewer parasites in the brain.
Guy-Grand et al. (1991)Lyt-2T cellOne bears heterodimeric alpha/beta CD8 chains (Lyt-2+, Lyt-3+), a T cell receptor (TCR) made of alpha/beta chains, and is Thy-1+; it represents the progeny of T blasts elicited in Peyer's patches by antigenic stimulation.
Han Lee et al. (2006)CD8T-cellAcute polyoma virus infection of mouse allograft recipients augmented the alloreactive CD8+ T-cell response, while maintaining the anti-viral CD8+ T-cell response.
Hafalla et al. (2003)CD8T cellFollowing immunization with Plasmodium yoelii sporozoites, the CD8(+) T cell population specific for the SYVPSAEQI epitope expressed in sporozoite and liver stages of this malaria parasite revealed the existence of a short term Ag presentation process that translated into a single clonal burst.
Yoshioka et al. (1988)Lyt-2T cellsThis contrasted with the failure of treatment with anti-Lyt-1 antibody plus C to isolate all T cells expressing Lyt-2 marker.
Fung-Leung et al. (1994)CD8T cellsReduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.
Peng et al. (2000)CD8T cellSoluble CD8 selectively inhibited CD8 T cell proliferation and IFN-gamma production and could also attenuate peptide-specific CD8 T cell responses in vivo.
Itoh et al. (2002)CD8T-cellThe ability of i-IEL to produce gamma interferon in response to immobilized T-cell receptor (TCR) alpha beta or TCR gamma delta monoclonal antibodies was significantly lower in CD8 alpha(-/-) mice than in CD8 alpha(+/-) mice.
Eichmann et al. (1987)CD8T cellWe consider the possibility that similar cross-linking requirements may also exist during T cell repertoire selection in ontogeny, thus accounting for the strict coexpression of MHC class I and class II-restricted T cell receptors with CD8 and CD4 molecules, respectively.
Sumida et al. (1994)CD8T cellsThese findings support the notion that the expression of MHC class I molecules and/or CD8+ T cells plays an essential role in the infiltration of CD4+ T cells in islets as well as the development of diabetes in NOD mice.
Kienzle et al. (2002)CD8T cellsA clonal culture system demonstrates that IL-4 induces a subpopulation of noncytolytic T cells with low CD8, perforin, and granzyme expression.
Huang et al. (2010)CD8T cellsSignificant correlations were observed between KI67 counts and %CD8 in CD3+ blood T cells (r?
Huang et al. (2010)CD8T cellsAll QTLs that control the proportions of CD4+ and CD8+ T cells also have an impact on neurogenesis, with the glaring exception of the strongest of them, the H2-Ea locus [17], whose homolog has also been identified in human GWAS studies of CD4+/CD8+ ratio determinism [18].
Zúñiga-Pflücker et al. (1990)CD8T cellsFurthermore, selective blocking of one CD8 allele with F(ab')2 mAbs in F1 mice expressing both CD8 alleles did not interfere with the development of CD4-/CD8+ cells, demonstrating that the absence of CD8+ T cells in homozygous mice is not due to depletion, but rather is caused by a lack of positive selection.
Williams et al. (1994)CD8T lymphocyteThese studies demonstrate that (1) multiple T lymphocyte subpopulations can be identified based on radiosensitivity and CD4/CD8 antigen expression; (2) both CD4+ and CD8+ cells contain radioresistant subpopulations, with the CD4+ subpopulation being more resistant than the CD8+ subpopulation; and (3) although the number of radioresistant CD4+ cells is quite small, they persist in increased proportions during the periods preceding and corresponding to postirradiation hematopoietic recovery.
Leo et al. (1988)Lyt-2T cellsSelective expression of the Ly-6C.2 epitope on Lyt-2+ T cells that can develop in the absence of thymic influence.
Angelov et al. (2009)CD8T cellsConsistent with this, we report here that CD8+ T cells from CD8beta knockout (KO) P14 TCR transgenic mice proliferate inefficiently in vitro.
Devine et al. (2000)CD8T cellThe T cell coreceptor CD8 exists on mature T cells as disulfide-linked homodimers of CD8 alpha polypeptide chains and heterodimers of CD8 alpha- and CD8 beta-chains.
Zamoyska and Parnes (1988)Ly-2T cellThe murine CD8 T cell differentiation antigen is a glycoprotein expressed on the cell surface as a heterodimer comprising the products of two closely linked genes, Ly-2 and Ly-3.
Legrand and Freitas (2001)CD8T cellsWhen developing in the presence of self-Ag, the dual-receptor-expressing CD8 T cells escape central deletion, but are not fully competent to respond to cognate stimuli.
Christensen et al. (2000)CD8T-cellThe great majority of the CD8(+) D(b)NP(366)(+) set that localized to the infected respiratory tract had, however, cycled at least once, though recent cell division was shown not to be a prerequisite for T-cell extravasation.
Witte et al. (1999)CD8alphaT cellIn order to now examine the role of CD8beta in TCR recognition, the CD8alpha cDNA alone or in combination with CD8beta cDNA was transfected into the mouse T cell hybridoma, N15wt, specific for VSV8/Kb.
Das and Janeway (1999)CD8alphaT cellsPeripheral CD8(+) T cells mainly use CD8alpha/beta, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins K(b) and D(b) in H-2(b) mice.
Leo et al. (1987)Lyt-2T cellActivation of murine T lymphocytes with monoclonal antibodies: detection on Lyt-2+ cells of an antigen not associated with the T cell receptor complex but involved in T cell activation.
Asano et al. (1986)Lyt-2T-cellThe immunity was passively transferable to recipients by T cells, especially by T-cell subset of phenotype Lyt-1 but not those of phenotype Lyt-2.3 and Lyt-1.2.3.
Evans (1984)Lyt-2T lymphocytesThese infiltrating cells were shown to be T lymphocytes, most of them having the Lyt-1 and Lyt-2 antigens on their cell membrane.
Dumont and Habbersett (1982)Lyt-2T cellsIn agreement with recent observations by Lewis, Giorgi & Warner (1981) lpr/lpr T cells exhibited lower levels of Thy-1 and Lyt-1 antigens than +/+ T cells and were mostly devoid of Lyt-2 antigen.
Myers et al. (1981)Lyt-2T-cellUsing Lyt-1.2 and Lyt-2.2 alloantisera and complement to prepare either Lyt-1.2 or Lyt-2.2 depleted T-cell populations, it was found that the Lyt-1.2 subpopulation was responsible for the release of LAIF in this test system.