Viewing negative mentions of gene expression of Cd8a (M. musculus) in T cells

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Fung-Leung et al. (1993)CD8T cellsA small population of CD4- T cells expressing CD8 beta, the "tailless CD8 alpha" and the 2C TcR transgenes was present in the periphery of these mice in a selecting background, but was absent in a deleting background.
Zhang et al. (1994)CD8T cellsOur results indicate that injection of male CD4 knockout (express CD8) lymphoid cells but not CD8 knockout (do not express CD8) lymphoid cells induced a significant reduction of male H-Y Ag reactive cells in the periphery, suggesting that CD8 plays an important role in the induction of peripheral tolerance of class I-restricted T cells.
Cook et al. (2008)CD8T cellsWe now show that CD8 is essential for the development of both the AHR suppressor and enhancer gammadelta T cells, although neither type needs to express CD8 itself.
Kyburz et al. (1993)CD8T cellWhen mice were CD8 T cell-depleted with anti-CD8 monoclonal antibody or in LCMV-carrier mice, no NP was detected in the serum.
Robey et al. (1992)CD8T cellsIn male mice expressing a transgenic alpha beta TCR which recognizes a male antigen (HY), T cells which do not express normal levels of CD8 escape thymic deletion and appear in the periphery.
Pewe et al. (1996)CD8T cellMutations are not present in sequences flanking this epitope or in other CD8+ or CD4+ T cell epitopes.
Morrissey et al. (1995)CD8 alphaT cellsThe IEL compartment from SCID mice injected with highly purified CD4+/CD45RBhigh T cells or CD4+ T cells contained significant numbers of T cells that expressed both CD4 and CD8 alpha, but not CD8 beta.
Glas et al. (1994)CD8T cellBeta 2-Microglobulin-deficient (beta 2m -/-) mice are reported to lack cell surface expression of major histocompatibility complex (MHC) class I molecules, CD8+ T cells, and the ability to mount MHC class I-specific T cell responses.
Fehr et al. (2010)CD8T cellsBy generating mice lacking NFAT1 in CD4 but not CD8 cells, we demonstrate that NFAT1 is neither required for CD4 tolerance induction nor for their regulatory function on CD8 T cells.
Moskophidis et al. (1987)Lyt-2T lymphocytesDetermination of cell surface antigens of responder cells by negative and positive selection procedures disclosed that they were predominantly T lymphocytes and expressed Lyt-2 but not L3T4 surface markers.
Leifert et al. (2001)CD8T cellSynthetic PTD-peptides did not induce detectable CD8(+) T cell responses.
Riddle et al. (2008)CD8CTLThe lack of cytotoxicity may result from impaired lineage commitment of CTL in the absence of CD8, or diminished competitiveness during selection against (unimpaired) development of CD4(+) T cells on MHC class II (MHC II).
Kitagawa et al. (1991)CD8T cellsThese results demonstrate that 1) the suppression of graft rejection responses is not necessarily reflected on the reduction of MLR; 2) CD8+ CTL precursors responsible for graft rejection can be activated by either allo-class I-reactive CD8+ or CD4+ Th cells; 3) i.v. presensitization induces functional elimination of CD8+ and CD4+ proliferative/IL-2-producing T cells but not of CD8+ CTL precursors and CD4+ Th whose capacity is expressed by assistance of CTL induction but not by their own proliferation.
Engel et al. (2010)CD8T cells14i NKT cells reported that they were absent from mice in which CD8 expression was enforced in T cells and, furthermore, that their V?
Nixon-Fulton et al. (1988)Lyt-2T-cellWhile dendritic Thy-1+ EC, in vivo, do not express the T-cell markers, L3T4 and Lyt-2, short-term cultured cells displayed phenotypic heterogeneity with small but significant percentages of Lyt-2+ and L3T4+ cells appearing transiently.
Cockburn et al. (2010)CD8T cellMoreover, immunization with the related parasite P. berghei which express a different CD8+ epitope not recognized by our transgenic cells also failed to induce specific T cell proliferation further excluding the possibility of bystander activation (Figure S1A).
Jones et al. (1988)CD8T cellsIn MLR examined in detail, the expression is highly enriched for in CD3+ "double-negative" T cells (lacking both CD4 and CD8 expression).
Makhlouf et al. (2003)CD8T cellIn vivo CD4(+) and CD8(+) T cell-depleting strategies and genetically altered mice that did not express MHC class I or class II antigens were used to study the allorecognition and effector pathways of islet allograft rejection in different strains of mice, including autoimmunity-prone nonobese diabetic (NOD) mice.
Wu et al. (2002)CD8T cellsMice that lack IL-15 or the IL-15R alpha-chain (IL-15Ralpha) are deficient in peripheral CD8(+), but not in CD4(+), T cells.
Evans et al. (1987)Lyt-2T lymphocyteDetailed analysis showed that the c-myb protein is primarily expressed by an abnormal T lymphocyte population that does not express the mature T cell markers, L3T4 and Lyt-2.
Ewing et al. (1994)CD8T cellsAnalyzing the prevalence of V beta 8.1+ CD8+ T cells in lymph node cultures from nontransgenic (non-TG) H-2k controls primed with either virus and then stimulated in vitro with the homologous virus or with anti-CD3 epsilon showed that this TCR is not normally selected from the CD8+ T-cell repertoire during these infections.
Murray and Martens (1989)CD8T cellThe autoimmune mouse strain MRL/MPJ/lpr/lpr is characterized by accumulation of an abnormal T cell population which does not express CD4 or CD8 surface antigens.
Puliaev et al. (2008)CD8T cellCD40 stimulation bypassed the requirement for CD4 T cell help for CD8 CTL possibly by licensing dendritic cells (DC) as shown by the following: 1) greater initial activation of donor CD8 T cells, but not CD4 T cells; 2) earlier activation of host DC; 3) host DC expansion that was CD8 dependent and CD4 independent; and 4) induction of acute GVHD using CD4-depleted purified DBA CD8+ T cells.
Crooks and Littman (1994)CD8T lymphocyteDisruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.
Christianson et al. (1996)CD8T cellsMost of the accumulating T cells express an alpha beta-TCR but are peculiar in that they express neither CD4 nor CD8 co-ligands.
Harriman et al. (1990)CD8T cellThy-1- and Thy-1+ CD4 T cell lines generated from PP also coexpress CD3 and alpha beta-TCR, but are heterogeneous in expression of CD5 and again do not coexpress CD8.
Mahnke et al. (2005)CD8T cellsIn contrast, such Ag-specific memory CD8(+) T cells were not detectable by peptide-major histocompatibility complex (MHC) multimer staining in animals that had not previously received an antigenic challenge.
Gao et al. (2000)CD8T-cellIn contrast, treatment with CTLA4 fusion protein (CTLA4Ig), prolonged hepatocyte survival in CD8 KO but not CD4 KO mice, showing that CD28/B7 interactions were important in CD4(+) but not CD8(+) T-cell initiated hepatocyte rejection.
del Rio et al. (2007)CD8alphaT cellsThus, under tolerogenic conditions, CD103(-) DC are specialized in presenting innocuous Ag to CD4(+) T cells, whereas CD103(+) DC, which do not express CD8alpha, are specialized in presenting Ag exclusively to CD8(+) T cells.
Chen et al. (1997)CD8T cellTen out of 11 autoreactive T cell lines expressed neither CD4 nor CD8 cell surface markers on their surface.
Schulz et al. (2005)CD8T cellCross-presentation of cell-associated antigens plays an important role in regulating CD8+ T cell responses to proteins that are not expressed by antigen-presenting cells (APCs).
Egerton and Scollay (1990)CD8T cellsLike peripheral T cells, but unlike most other thymocytes, these TCR alpha beta+CD4-CD8- thymocytes do not express heat stable antigen.
Johnson et al. (2003)CD8CTLVirus-specific, perforin-dependent CD8(+) CTL were detected in freshly isolated cells from the mouse lung parenchyma but not from the mediastinal lymph nodes (MLN), where they are primed, or from the spleen during primary influenza virus infection.
Pierce et al. (1984)Lyt-2T cellsOne cell line expressed Thy-1 antigen, but none expressed Lyt-1 and Lyt-2, markers of more differentiated T cells.
Barnden et al. (1997)CD8T cellsHowever, there remained a population of CD8 single-positive T cells that exhibited impaired responsiveness to the antigenic peptide and lacked expression of the CD8 beta-chain.
Serreze et al. (1994)CD8T-cellsThese NOD-B2mnull mice do not express cell surface MHC class I molecules or produce detectable levels of CD8+ T-cells and are diabetes and insulitis resistant.
Harriman et al. (1990)CD8T cellsPhenotypic studies of fresh-isolated PP T cells demonstrate that all PP CD4 T cells (both Thy-1- and Thy-1+) express CD3, alpha beta-TCR, and CD5 (Lyt-1), whereas none coexpress CD8 (Lyt-2).
Adleman and Wofsy (1993)CD8T-cellSpecifically, we hypothesize that in all cases of T-cell loss, whether selective or not, both CD4+ T cells and CD8+ T cells will be produced until the absolute T-cell count returns to normal, even if this produces or exacerbates abnormalities in the absolute CD4+ T-cell count and absolute CD8+ T-cell count.
Zhai et al. (2007)CD8T cellDefective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help.
Mixter et al. (1991)CD8T cellsSignificant numbers of T cells reappear in the periphery about age 65 days, but these cells tend to lack expression of CD4 or CD8.
Garssen et al. (1994)CD8T cellsThe early-acting CS-initiating cells are not conventional T cells inasmuch as they are surface negative for CD4, CD8, and CD3.
Chesnutt et al. (1998)CD8T cellsThey also develop a lymphoproliferative disorder characterized by a massive accumulation of double-negative (DN) T cells that lack both CD4 and CD8.
Tripp et al. (1997)CD8T cellsIn addition, although CD4 depletion from day 11 had no effect on the Vbeta4 bias of the T cells, the Vbeta4+CD8+ expansion was absent in H-2IA(b)-deficient congenic mice.
Penninger et al. (1993)CD8T cellsTo evaluate the requirement for p56lck in the development of T cells that have gamma delta TCRs, which generally do not express CD4 or CD8, p56lck mutant mice were bred with TCR gamma delta transgenic mice.
Cohen et al. (1986)Ly-2T-cellThe T-cell lines bore Thy-1, Ly-1, L3T4, and 7D4 (interleukin 2 (IL-2) receptor), but lacked Ly-2 and surface Ig.
Kowalczyk et al. (2007)CD8T cellWe also demonstrated that coimmunization of NXS2-challenged mice with the IL-15 and IL-21 gene combination resulted in enhanced CD8(+) T cell function that was partially independent of CD4(+) T cell help in inhibiting tumor growth.
Kim et al. (2008)CD8T cellMoreover, the differential CD8(+) T cell response by IL-12p40 was still observed in IL-12Rbeta2 knockout (IL-12Rbeta2KO), but not in IL-12Rbeta1 knockout (IL-12Rbeta1KO) mice, indicating that IL-12p40 is a cytokine which can modulate Ag-specific T cell responses depending on IL-12Rbeta1.
Bajénoff et al. (2010)CD8T cellsInterestingly, CD8+ T cells genetically modified to constitutively express CCR7 cannot leave the WP and are impaired in their capacity to efficiently clear a viral infection [36].
Bajénoff et al. (2010)CD8T cellsWhile we haven't investigated the member(s) of the S1P receptors family known to be affected by FTY720, we can only speculate that S1P1, the master player controlling naive lymphocyte egress from the LNs is not expressed on memory CD8+T cells that do not home to LNs.
Kim et al. (2008)CD8T cellsAmong the CD3+ RNL, 20-30% were GL3+ gammadelta T cells, which were double-negative for CD4 and CD8 and predominantly expressed a Vgamma4/Vdelta1 TCR.
Tone et al. (2000)CD8T cellPhenotypic analysis of the induced NK1.1(+) alpha beta T cell population suggested that these cells expressed CD8 but not CD4 molecules, which is a different characteristic from ordinary thymic NK1.1(+) alpha beta T cells.
Dubois et al. (2006)CD8T cellHere we show data suggesting that these two cell populations represent independent CD8(+) T cell subsets.
Archambaud et al. (2009)CD8T cellIn contrast to Lat(Y136F) mice that showed no CD8 T cell expansion, the CD8 T cells present in Lat(Y136F) mice deprived of STAT6 massively expanded and acquired effector potential.
Kubota et al. (1994)CD8T cellsThese results indicate that the massively accumulating lymphocytes of MRL/l mice have a property characteristic of activated T cells, although they express little surface CD4 or CD8 and do not produce IL-2.
Tiberghien et al. (1994)CD8T-cellAlthough being CD44+ T cells expressing neither CD4 nor CD8, they are CD3 T-cell receptor (TCR) alpha beta positive and express both Thy-1 and B220, the B-cell form of the CD45 marker.
Egawa et al. (2008)CD8T cellsThe results do in fact show that the vast majority of lymph node T cells and IEL with the HY transgenic TCR and low level or no expression of CD8 co-receptors are lineage diverted most likely at the DN stage of thymocyte development before expression of ROR?
Zou et al. (2010)CD8T cells-producing CD8+ T cells (Tc1), but not the IL-17-producing CD8+ T cells (Tc17).
Andjeli? et al. (1994)CD8T cellFas was not expressed on fetal nor adult CD8-CD4- (double-negative, DN) T cell precursors.
Van Houten and Budd (1992)CD8T lymphocytesMRL-lpr/lpr (lpr) mice develop a polyclonal accumulation of abnormal peripheral T lymphocytes, which bear surface alpha beta TCR, CD3, and the B220 isoform of CD45, but lack CD4, CD8, and CD2.
Browne et al. (2009)CD8T cellsOur results demonstrate that depletion of DCs leads to a loss of immune control of F-MLV, and this was found to coincide with a complete loss of F-MLV–specific IgG but no significant reduction in CD8+ T cells responses.
Boyer et al. (1997)CD8T cellsHere we show that a CD4 minigene comprising a combination of these elements is specifically expressed in mature CD4+ T cells of transgenic mice, but not in CD4+CD8+ double positive thymocytes.
Stone and Stern (2006)CD8T cellsDimeric engagement is necessary and sufficient to stimulate downstream activation processes including TCR down-regulation, Zap70 phosphorylation, and CD25 and CD69 up-regulation, even in T cells that do not express the MHC coreceptor CD8.
Beaumont et al. (1982)Lyt-2CTLThe best phenotype distinctions between NK cells and CTL were therefore based on the presence or absence of Lyt-2, Qa-4, and FcR for IgG2b on most effector cells.
Wada et al. (2001)CD8T cellsMETHODS: To determine whether select T-cell populations regulate intrarenal nephritogenic cytokines (CSF-1, GM-CSF, and TNF-alpha) and renal disease, we compared MRL-Fas(lpr) mice that are genetically deficient in T-cell receptor (TCR) alpha beta T cells, CD4 T cells, and major histocompatibility complex class I (MHC class I), lacking CD8 and double negative (DN) T cells, with wild-type mice.
Lanier et al. (1985)CD8T cellsFurthermore, a majority of these T cells lacked either CD4 or CD8 expression.
Jani et al. (2008)CD8T cellsThe earliest T cells express neither CD4 nor CD8 and are known as double-negative (DN) cells.
Romano et al. (2004)CD8T cellThe CD4(+) and CD8(+) T cell epitopes defined for PstS-3 were completely specific and not recognized in mice vaccinated with either PstS-1 or PstS-2 DNA.
Marodon and Klatzmann (2004)CD8T-cellThe early thymocyte progenitors entering the thymus do not express T-cell-specific molecules, such as CD3, the alpha or beta-chain of the TCR, or the CD4 and CD8 molecules.
Butcher et al. (1982)Lyt-2T cellThey do not express the T cell-lineage antigens Thy-1, Lyt-1, or Lyt-2 (only 1 to 3% positive).
Hill and Dunn (1993)CD8T cellCytofluorometric studies revealed that the Thy+ CD4- CD8- cells responsible were negative for the CD3 T cell marker.
Lech et al. (2008)CD8T cellThe functional effect of this observation on autoreactive T cells remains uncertain because the CD4/CD8–double negative T cell population was not significantly affected by the Tir8 genotype.
Ismail et al. (2004)CD8T cellsCross-protection was associated with substantial expansion of IFN-gamma-producing CD4(+) and CD8(+) cells, but not TNF-alpha-producing CD8(+) T cells, a high titer of IgG2a, and a low serum level of TNF-alpha.
Markel et al. (2010)CD8T cellsCD8+ T cells failed to produce IL-17A even at the high infection dose (Figure 5, B1).
Rausch et al. (2006)CD8T cellsIn the absence of IL-15, CD8+ T cells failed to efficiently accumulate in draining lymph nodes and at the site of infection.
Dias et al. (2009)CD8T cellsThe protective effect by IL-12 required CD8+, but not CD4+ T cells.
Takano et al. (2007)CD8T cellOrally administered capsicum extract and capsaicin did not change the T cell subset (CD4(+) and CD8(+)), Th1 (IFN-gamma(+)) and T2 (IL-4(+)) ratio.
Mohamood et al. (2008)CD8T cellsNormal peripheral CD4 and CD8 T cells do not normally expressed B220 but it is expressed on activated T cells undergoing apoptosis following injection of mice with staphylococcal enterotoxin B superantigen [20]–[22].
Roose et al. (2003)CD8T cellThe Jurkat T cell leukemic line E6–1 expresses high levels of mature TCR and low levels of CD4, but no CD8 or MHC class II.
Kelly et al. (2007)CD8T cellThis occurs in T cell precursors, which do not express the major histocompatibility complex (MHC) receptors CD4 and CD8 (double-negative (DN) thymocytes).
De Klerck et al. (2004)CD8T cellsR KO mice showed an increased proportion of CD11b+ haematopoietic cells but unchanged proportions of CD4+ and CD8+ T cells and B cells.
Bhadra et al. (2010)CD8T cellWe demonstrate that while lack of IL-7 or IL-15 alone has minimal impact on splenic CD8(+) T cell maturation or effector function development during acute Toxoplasmosis, absence of both IL-7 and IL-15 only in the context of infection severely down-regulates the development of a potent CD8(+) T cell response.
Nakamoto et al. (2009)CD8T cellsOf note, CTLA-4 was preferentially expressed in PD-1-high, but not PD-1-intermediate or PD-1-negative CD8 (Figure 1D) and CD4 T cells (data not shown) with a strong association between PD-1 MFI and CTLA-4 expression in percentage (R?
Feunou Feunou et al. (2010)CD8T cellsT cells from BPZE1-immunized mice, whereas the CD8+ T cells did not contribute to the PTX-specific IFN-?
Harty and Bevan (1996)CD8T cellsInterestingly, significant immunity was observed in parent-->F1 chimeras when the L. monocytogenes-immune CD8 T cells were not syngeneic with the bone marrow donor, suggesting that recognition of Listeria-infected non-bone-marrow-derived cells such as hepatocytes may also occur in vivo.
Kaufmann et al. (1995)CD8T cellGene disruption mutant mice include: A beta-/-, which lack conventional CD4+ T cell receptor alpha/beta (TCR alpha/beta) T lymphocytes; beta 2 microglobulin -/-, which lack conventional CD8+ TCR alpha/beta lymphocytes; TCR beta-/-, which lack all TCR alpha/beta lymphocytes; TCR delta-/-, which lack all TCR gamma/delta lymphocytes; and RAG-1-/- mutants, which lack mature T and B lymphocytes.