Viewing affirmative mentions of gene expression of Cd4 (M. musculus) in T cells

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Kumar (1989)CD4T lymphocytesCells expressing the CD4 and CD8 antigens were both increased in number, with the former accounting for approximately two-thirds of the T lymphocytes.
Marques et al. (2009)CD4T cellRESULTS: Here we report that, in a virus-free mouse model, conditional ablation of activated CD4(+) T cells, the targets of immunodeficiency viruses, accelerates their turnover and produces CD4(+) T cell immune deficiency.
Zhang et al. (2007)CD4T cellsFlow cytometry was used to detect the expression of CD4 and CD25 molecules of the T cells which came from the tumor-bearing mice.
Wormley et al. (2000)CD4 proteinT lymphocytesIn addition to the recognized phenotypic distinctions of resident vaginal T lymphocytes, we recently provided evidence by fluorescence-activated cell sorter (FACS) that murine vaginal CD4+ T lymphocytes, are differentially recognized by two epitope-distinct anti-CD4 antibodies, suggesting that the CD4 protein on vaginal CD4+ cells is atypically expressed.
Lejon and Fathman (1999)CD4T cellsWe have recently reported that all "conventional Ag" reactive CD4+ T cells are contained within the subpopulation expressing high levels of the CD4 molecule, termed CD4high.
Sleckman et al. (1989)CD4T lymphocytesCD4 (T4) is a 60 kD glycoprotein expressed on a subset of T lymphocytes.
Sleckman et al. (1989)L3T4T cellTo further define the requirements for CD4 modulation, we used retroviral vectors to transfer the cDNA for CD4 and various mutants of CD4 into two murine T cell hybridomas that express L3T4.
Krieger et al. (2000)CD4T cellsThis subpopulation of T cells was distinguished by up-regulation of cell surface CD4 expression.
Krieger et al. (2000)CD4highT cellsAdoptive transfer of CD4high, but not CD4normal T cells, just before skin engraftment in CD4 knockout mice, reconstituted rejection.
Logan et al. (2004)CD4T-cellAlthough the mechanism responsible for this effect remains to be elucidated, the unexpected expression of CD4, a molecule that functions as both a coreceptor with the T-cell receptor and ligand for the pro-inflammatory cytokine IL-16, has the potential to influence experimental outcomes.
Serre et al. (2009)CD4T cellsEarly simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells.
Serre et al. (2009)CD4T cellsBy 3 days IL-4-producing effector CD4 T cells developed in the draining node and a proportion of the responding cells had migrated to B-cell follicles, while yet others had left the draining node.
Rahemtulla et al. (1991)CD4T-cellAs CD4 is expressed on the early haemopoietic progenitor as well as the early thymic precursor cells, a role for CD4 in haemopoiesis and T-cell development is implicated.
Rahemtulla et al. (1991)CD4T cellsIn these mice, the development of CD8+ T cells and myeloid components is unaltered, indicating that expression of CD4 on progenitor cells and CD4+ CD8+ (double positive) thymocytes is not obligatory.
Patenaude et al. (2005)CD4T cellsAnalysis of naive (CD62Lhigh CD44low) and effector/memory (CD62Llow CD44high) T cells showed a percent decrease, independent of the expression of CD4 or CD8 molecules.
Laouar and Ezine (1994)CD4T cellsPreviously, we demonstrated that these cells do not proliferate in the peripheral lymphoid organs that they invade; furthermore, we showed that a wide range of CD4 Ag expression was observed on lymph node CD4+ T cells.
Li et al. (2007)CD4T cellsWe demonstrate that encephalitogenic T cells, following antigen recognition, up-regulate cell surface expression of CD4.
Frank and Parnes (1998)CD4T cellTo elucidate the role of CD4 in T cell selection, we have produced a mouse strain that expresses CD4 at a reduced level.
Williams et al. (1994)CD4T lymphocyteThese studies demonstrate that (1) multiple T lymphocyte subpopulations can be identified based on radiosensitivity and CD4/CD8 antigen expression; (2) both CD4+ and CD8+ cells contain radioresistant subpopulations, with the CD4+ subpopulation being more resistant than the CD8+ subpopulation; and (3) although the number of radioresistant CD4+ cells is quite small, they persist in increased proportions during the periods preceding and corresponding to postirradiation hematopoietic recovery.
Tourvieille et al. (1986)L3T4T cellsIsolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain.
Tourvieille et al. (1986)L3T4T-cellL3T4 is one such T-cell surface protein that is expressed on most mouse thymocytes and on mature mouse T cells that recognize class II (Ia) major histocompatibility complex proteins.
Görgün et al. (2005)CD4T cellsChronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.
Yagi et al. (1992)CD4T cellIn contrast, transfer of the CD4+ T cell subset alone produced insulitis, but not hyperglycemia, in all the recipients.
Kerkvliet and Brauner (1990)CD4T cellT cell subsets were defined by dual parameter analysis of CD4 and CD8 expression.
Yamada et al. (1999)CD4T cellsPURPOSE: To determine, with the use of mice genetically deficient in expression of CD4 or CD8 molecules, which T cells are responsible for rejection of orthotopic corneal allografts in mice.
Tutt Landolfi et al. (1997)CD4T cellThe expression of CD4 during T cell development is a highly regulated process.
Taniuchi et al. (2002)CD4T cellAn intronic silencer within the CD4 gene is the critical cis regulatory element for T cell subset-specific expression of CD4.
McKisic et al. (1991)CD4T cellsHowever, it has been shown that a proportion of T cells recognizing class I alloantigens express CD4 surface molecules.
Locksley et al. (1993)CD4T lymphocytesExpression of either the CD4 or CD8 glycoproteins discriminates two functionally distinct lineages of T lymphocytes.
Boyer et al. (2002)CD4T cellHuman CD4 expression at the late single-positive stage of thymic development supports T cell maturation and peripheral export in CD4-deficient mice.
Boyer et al. (2002)CD4T cellAccordingly, expression of a human CD4 (hCD4) transgene beginning at the DP stage has been shown to restore normal T cell development and function in CD4-deficient mice.
Killeen and Littman (1993)CD4T lymphocytesThe CD4 and CD8 glycoproteins are expressed on helper and cytoxic T lymphocytes, respectively, and have important functions in the differentiation and activation of these cells.
Schnierle et al. (1997)CD4T cellsCD4-expressing T cells in lymphoid organs are infected by the primary strains of HIV and represent one of the main sources of virus replication.
Wadsworth et al. (1990)CD4T cellThese observations, combined with demethylation of the CD8 gene in the CD4-CD8- population, support prior expression of CD4 and/or CD8 in gld CD4-CD8- T cell ontogeny, perhaps at a CD4+CD8+ stage.
Janeway et al. (1987)L3T4T cellsMHC restricted T cells can be divided into two subsets based on the mutually exclusive expression of the cell surface differentiation antigens L3T4 and Lyt-2 in the mouse.
Kaldjian et al. (1988)CD4T lymphocytesThe membrane glycoproteins CD4 (L3T4) and CD8 (Lyt2) are expressed on distinct populations of mature murine T lymphocytes, and are thought to be receptors for monomorphic determinants expressed on MHC class II and class I molecules, respectively.
Kaldjian et al. (1988)CD4T cellSince activation of protein kinase C (PKC) is known to cause rapid down-regulation of various receptors, including the T cell receptor complex (TcR complex), we treated cells with phorbol 12-myristate 13-acetate (PMA), a PKC activator, to determine whether cell-surface expression of CD4 and CD8 would be similarly affected by this intracellular mediator.
Kaldjian et al. (1988)CD4T cellsBrief or relatively prolonged treatment with PMA induced mature murine T cells to reduce their surface expression of the TcR complex and of CD4, but not of CD8.
Mizoguchi et al. (2003)CD4T cellsAlthough CD4(+) T cells form a major subset of TCRalphabeta T cells, only a small number of TCRgammadelta T cells express CD4.
Matsumoto et al. (1993)CD4T cellAlso, transfer of only the CD4+ T cell-depleted fraction did not cause insulitis.
Foucras et al. (2000)CD4T cellsInterleukin 4-producing CD4 T cells arise from different precursors depending on the conditions of antigen exposure in vivo.
Nickoloff and Wrone-Smith (1999)CD4T cellsWe conclude that injection of CD4+ T cells into PN skin triggers a series of local immunologically mediated stimulatory events that produce further T cell activation and appearance of both CD4 and CD8+ T cells that express NKRs.
Van Oers et al. (1992)CD4T cellsAugmented CD4 expression was found to markedly alter CD8-dependent negative and positive selection of T cells specific for the male (H-Y) antigen presented by H-2Db major histocompatibility complex class I molecules.
Oliveira et al. (2008)CD4T cellFurthermore, reduced or blocking levels of CD4 expression, can convert T cell responses from stimulatory to inhibitory 48.
Gassmann et al. (1993)CD4T-cellMurine T-cell hybridoma lines expressing mutant forms of CD4 were used to demonstrate that the 31 carboxyterminal aminoacids of its cytoplasmic domain, in particular cysteine-420 and cysteine-422, are crucial for the formation of CD4:p56lck complexes in vivo.
Anderson and Coleclough (1993)CD4T cellsRegulation of CD4 and CD8 expression on mouse T cells.
Denecke et al. (2010)CD4+T-cellsHowever, following the transfer of 2×106 ABM CD4+T-cells, recipients of old T-cells showed a significantly delayed graft rejection compared to recipients of young T-cells (MST: 14.0 days vs. 10.5 days, p<0.02, Fig. 7).
Richie et al. (1988)CD4T-cellTo address this issue, we have studied alpha/beta T-cell antigen receptor gene and protein expression on normal thymocyte subsets of AKR/J mice, as well as on a panel of AKR/J primary thymic lymphomas characterized for CD4 (L3T4) and CD8 (Lyt-2) differentiation antigen expression.
Aliahmad and Kaye (2008)CD4T cellsCD8(+) cytotoxic and CD4(+) helper/inducer T cells develop from common thymocyte precursors that express both CD4 and CD8 molecules.
Aliahmad and Kaye (2008)CD4T cellUpon T cell receptor signaling, these cells initiate a differentiation program that includes complex changes in CD4 and CD8 expression, allowing identification of transitional intermediates in this developmental pathway.
Christensen et al. (2001)CD4T cellsThe absence of IFN-gamma does not impair the generation of IL-2-producing CD4(+) cells, and depletion of these cells precipitates severe CD8(+) T cell-mediated immunopathology in IFN-gamma(-/-) mice, indicating an important role of CD4(+) T cells in preventing this syndrome.
Wang et al. (2001)CD4T cellsA diverse population of MHC class II-restricted CD4 lineage T cells develops in mice that lack expression of the CD4 molecule.
Fitzpatrick et al. (1996)CD4T cellsIn this report we have demonstrated that the inability of MAIDS CD4+ T cells to respond to CD3 stimulation was not associated with reduced surface expression of CD3, CD4, or CD28 and could not be overcome by costimulation with anti-CD28 antibody.
Luchetti et al. (2004)CD4T cellTherefore, while ovarian controls showed equivalent expression of CD4+ and CD8+ T cell subsets, injection of DHEA yielded a selective ovarian T cell infiltration as demonstrated by enhanced CD8+ and diminished CD4+ T lymphocyte expression.
Goldmann et al. (2006)CD4T lymphocytesWe monitored how GFP-expressing CD4 T lymphocytes injected into the entorhinal cortex after lesion or the lateral ventricle of unlesioned C57/bl6 mice reach cervical lymph nodes.
Sakaguchi and Sakaguchi (1992)CD4T cellsCsA abrogates the production of CD4+T cells and CD8+T cells in the thymus.
Sawada et al. (1998)CD4T lymphocytesWe have generated transgenic mice predominantly expressing human CD4 and CXCR4 on their CD4-positive T lymphocytes (CD4+ T cells).
Sasaki et al. (2000)CD4T cellsChanging the concentration of dietary DHA did not alter the proportion of T cells expressing CD4 or CD8.
Moutschen et al. (1996)CD4T cellIn addition to a complete refractoriness of most subsets of lymphocytes to mitogen stimulation, the development of phenotypic abnormalities occurs such as the appearance of an abnormal CD4+ T cell subset lacking membranes Thy-1.
Dianda et al. (1996)CD4T cellsBoth strains of mice have gamma delta T cells, but it is a subset of T cells expressing TCR beta and CD4 that is dominant in the germinal centers of TCR alpha-/- mice.
Dianda et al. (1996)CD4T cellsThe expression of CD4 seems to be important, for few extrafollicular T cells have CD4 and CD4 is largely absent from TCR beta-/- T cells.
Pelchen-Matthews et al. (1991)CD4T cellThe endocytosis of the T cell differentiation antigen CD4 has been investigated in CD4-transfected HeLa cells, the promyelocytic HL-60 cell line, and in a number of leukemia- or lymphoma-derived T cell lines.
Sands and Nikoli?-Zugi? (1992)CD4T cellsA total of 22 DH sites were found, seven of which are present only in T cells expressing CD4 or CD8.
Sands and Nikoli?-Zugi? (1992)CD4T cellSome of these sites inversely correlate to the CD4 expression at defined stages of T cell development, suggesting a role for these sites in repression of this gene.
Borgulya et al. (1991)CD4T cellsIn a selective model, the initial commitment, i.e. switching off the expression of either the CD4 or the CD8 gene would be a stochastic event which is then followed by a selective step rescuing only CD4+ class II and CD8+ class I specific T cells while CD4+ class I and CD8+ class II specific cells would have a very short lifespan.
O'Connor and Devaney (2002)CD4T cellsUsing carboxyfluorescein diacetate succinimydl ester and cell surface labeling, it was possible to identify a population of antigen-specific T cells from Mf-infected BALB/c mice that expressed particularly high levels of CD4 (CD4(hi)).
Zhang et al. (2007)CD4T cellsIn this study, by monitoring CD4 expression during T-cell proliferation and differentiation, we identified a new differentiation pathway for the conversion of CD4(+) T cells to DN regulatory T cells.
Asano et al. (1988)CD4T cellA new T cell subset expressing B220 and CD4 in lpr mice: defects in the response to mitogens and in the production of IL-2.
Asano et al. (1988)CD4T cellThese results indicate that an unusual T cell subset expressing both B220 and CD4 in lpr mice is functionally defective, but the intrinsic ability of B220-CD4+ cells is almost intact as compared with the counterpart in normal mice.
Derrick et al. (2007)CD4T cellsThese results confirmed previous findings on the potential for a subset of MHC class II-restricted T cells to develop and function without expression of CD4 and suggest novel vaccination strategies to assist in the control of tuberculosis in human immunodeficiency virus-infected humans who have chronic depletion of their CD4(+) T cells.
Shortman (1992)CD4T-cellThese lymphoid-restricted, prothymocyte-like cells express CD4, but neither CD4 nor CD8 seem to be involved in the early steps of T-cell development.
Malek et al. (2002)CD4T cellsHere, we show that CD4(+)CD25(+) regulatory T cells were not readily detected in IL-2Rbeta(-/-) mice, but the production of functional CD4(+)CD25(+) T cells was reconstituted in Tg -/- mice.
Rivas et al. (1988)CD4T cellsSimilar treatment of PHA-activated CD4+ T cells with anti-CD3/Ti antibodies also induced CD4 modulation; however, the same antibodies failed to affect CD4 expression on fresh resting T cells.
Xu et al. (2002)CD4T cellsWhen mice were conditioned with 300 cGy TBI plus a single dose of CyP on day +2, all engrafted, except wild-type controls and those defective in production of CD4(+) T cells.
Metz et al. (1997)CD4T cellFurthermore, MHC class II-restricted memory-T cells from CD4-deficient mice form stable conjugates, indicating that the CD4 molecule expressed on naive and memory CD4 T cells differs in function and regulates memory but not naive CD4 T cell adhesion to syngeneic APCs in the absence of Ag.
Mountz et al. (1990)CD4T cellsThis supports the hypothesis that in lpr/lpr mice, self-reactive CD4+ T cells are eliminated in the thymus, and that these cells lose expression of CD4 and acquire expression of 6B2 in the periphery.
Annacker et al. (2000)CD4T cellsWe followed the expansion of CD45RBhigh (naive) and CD45RBlow (activated/memory) CD4 T cells transferred from normal mice into syngeneic Rag-20/0 recipients and the dynamics of peripheral reconstitution when both populations were coinjected.
Linkes et al. (2010)CD4loT cellTo determine if enhanced proliferation would lead to alterations in the unique expression of CD4lo/CD4hi phenotype in NOD T cell blasts, we analyzed CD4 expression on Con A blasts incited in the presence of exogenous cytokine, 24 and 72?
Brabletz et al. (1999)CD4T cellsNegative regulation of CD4 expression in T cells by the transcriptional repressor ZEB.
Brabletz et al. (1999)CD4T cellCD4 expression during the various stages of T cell differentiation is controlled at the transcriptional level by a complex array of regulatory elements in the CD4 gene locus, consisting of at least three enhancers, one promoter and one silencer.
Brabletz et al. (1999)CD4T cellsWe show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells.
Killeen et al. (1993)CD4T cellIn vivo experiments show that, whereas helper T cell development is impaired in CD4-deficient mice, high level expression of a transgenic CD4 that cannot bind lck rescues development of this T cell subset.
Doyon et al. (1994)CD4T-cellCD4 is a cell surface molecule expressed mostly on cells of the T-cell lineage.
Doyon et al. (1994)CD4T-cellIt is not surprising therefore, that in T-cell ontogeny, CD4 starts to be expressed on thymocyte subpopulations about to undergo these selection processes.
Fujiwara et al. (2007)CD4T cellsWe also examined the role of T-bet expression of CD4(+) T cells in airway inflammation by adoptive transfer experiments.
Muto et al. (1990)CD4T cellT cell lymphomas developed from CD4- CD8+ prelymphoma cells mainly expressed CD4- CD8+ or CD4+ CD8+ phenotype.
Sawada et al. (1994)CD4T lymphocyteA lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development.
Sawada et al. (1994)CD4T lymphocytesDuring development of T lymphocytes, differential regulation of expression of the CD4 and CD8 glycoproteins is coupled to the choice of one of two pathways of differentiation.
Adleman and Wofsy (1993)CD4T cellsThis hypothesis implies that the selective loss of CD4+ T cells will induce the production of both CD4+ T cells and CD8+ T cells with the result that T-cell count will return to normal, but a persistent CD8+ T-cell lymphocytosis and CD4+ T-cell lymphopenia will be produced.
Wallace et al. (1992)CD4T cellsCD4 expression is differentially required for deletion of MLS-1a-reactive T cells.
Wallace et al. (1992)CD4T cellsMice deficient for CD4 expression provide a unique model system to study the contribution of the CD4 molecule in negative selection of T cells reactive against the major histocompatibility complex class II-associated retroviral self-superantigen, Mls-1a.
Wallace et al. (1992)CD4T cellsHowever, in instances where the TCR affinity for Mls-1a is low, as in the case of V beta 7+ T cells, CD4 expression was required for clonal deletion.
Liu et al. (2000)CD4T cellsAntigen-specific T cells detected by the tetramers can up-regulate their CD4 expression on the cell surface after being restimulated with the GAD peptides in vitro.
Peters et al. (2009)CD4T cellWe conclude that the generation of CD4 T cells producing IL-2, IFN-gamma and IL-4 requires CD4 T cell cooperation and that this cooperation is not mediated simply by CD40-CD40L interactions.
Robey et al. (1991)CD4T cellsImmature thymocytes, which coexpress CD4 and CD8, give rise to mature CD4+CD8- and CD4-CD8+ T cells.