Viewing negative mentions of gene expression of Cd4 (M. musculus) in T cells

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Morrissey et al. (1995)CD4T cellsThe IEL compartment from SCID mice injected with highly purified CD4+/CD45RBhigh T cells or CD4+ T cells contained significant numbers of T cells that expressed both CD4 and CD8 alpha, but not CD8 beta.
Boyer et al. (1997)CD4T cellsHere we show that a CD4 minigene comprising a combination of these elements is specifically expressed in mature CD4+ T cells of transgenic mice, but not in CD4+CD8+ double positive thymocytes.
Bix et al. (1993)CD4T cellA small subset of T cells of mature phenotype express the alpha/beta T cell receptor, but not CD4 and CD8 coreceptors (alpha/beta double-negative [DN] cells).
Jani et al. (2008)CD4T cellsThe earliest T cells express neither CD4 nor CD8 and are known as double-negative (DN) cells.
Thakar et al. (2006)CD4T cellsThe gating on CD3+ T cells removes the monocytes (expressing CD4 but not CD3 on their cell surface) from the gate.
Evans et al. (1987)L3T4T lymphocyteDetailed analysis showed that the c-myb protein is primarily expressed by an abnormal T lymphocyte population that does not express the mature T cell markers, L3T4 and Lyt-2.
Tiberghien et al. (1994)CD4T-cellAlthough being CD44+ T cells expressing neither CD4 nor CD8, they are CD3 T-cell receptor (TCR) alpha beta positive and express both Thy-1 and B220, the B-cell form of the CD45 marker.
Xue et al. (1995)CD4T cellA significant CD4+ T cell response against the transmembrane (M) protein can be detected in the spleens of C57Bl/6 mice infected intraperitoneally with a sublethal injection of the neurotropic JHM strain of mouse hepatitis virus (MHV-JHM), but not in those of mice with the chronic demyelinating encephalomyelitis caused by this virus.
Murray and Martens (1989)CD4T cellThe autoimmune mouse strain MRL/MPJ/lpr/lpr is characterized by accumulation of an abnormal T cell population which does not express CD4 or CD8 surface antigens.
Crispe (1994)CD4T cellsA minor population of alpha beta T cells expresses neither CD4 nor CD8.
Kubo et al. (1994)CD4T cellsH-2k TG mice had a large number of thymic and splenic CD4 T cells expressing the autoreactive TCR without manifestation of autoimmunity.
Chen et al. (1997)CD4T cellTen out of 11 autoreactive T cell lines expressed neither CD4 nor CD8 cell surface markers on their surface.
Christianson et al. (1996)CD4T cellsMost of the accumulating T cells express an alpha beta-TCR but are peculiar in that they express neither CD4 nor CD8 co-ligands.
Jones et al. (1988)CD4T cellsIn MLR examined in detail, the expression is highly enriched for in CD3+ "double-negative" T cells (lacking both CD4 and CD8 expression).
Penninger et al. (1993)CD4T cellsTo evaluate the requirement for p56lck in the development of T cells that have gamma delta TCRs, which generally do not express CD4 or CD8, p56lck mutant mice were bred with TCR gamma delta transgenic mice.
Cao and DeLeo (2008)CD4T lymphocytesThese infiltrating leukocytes contained predominantly CD4(+) but not CD8(+) T lymphocytes.
Killeen and Littman (1993)CD4T-lymphocyteHere we investigate the role of the CD4-p56lck interaction during T-lymphocyte development by expressing wild-type and truncated products of CD4 transgenes in mice that lack endogenous CD4 and hence have defective helper-cell development.
Dawicki et al. (2004)CD4T cellThe 4-1BBL(-/-) and double knockout mice were similarly impaired in the CD8 T cell response, whereas OX40L(-/-) and double knockout mice were similarly impaired in the CD4 T cell response to both protein Ag and influenza virus.
Deshpande et al. (2001)CD4T cellAn additional study system revealed that HSK could be induced in mouse strains, such as the OT2 x RAG1(-/-) mice (T cell receptor transgenic recognizing OVA(323-339)) that were unable to produce CD4(+) T-cell responses to any detectable HSV antigens.
Wong et al. (1998)CD4T cellsTo elucidate the relative importance of each of the subsets of cells, the NOD-rat insulin promoter (RIP)-B7-1 animals were crossed with NOD.beta2microglobulin -/- mice which lack major histocompatibility complex class I molecules and are deficient in peripheral CD8 T cells, NOD.CD4 -/- mice which lack T cells expressing CD4, and NOD.muMT -/- mice which lack B220-positive B cells.
Wang et al. (2007)CD4T cellsAlloreactive PD-1(-/-) CD4 and CD8 T cells had enhanced proliferation and cytokine production compared to wild-type controls, and anergy could not be induced in PD-1-deficient CD4 T cells.
Nixon-Fulton et al. (1986)L3T4T cellThy-1+ dEC lack other typical T cell markers such as L3T4, Lyt-1, and Lyt-2; however they do express Ly-5 and asialo GM1 in common with NK cells and certain other leukocytes.
Zhai et al. (2007)CD4T cellDefective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help.
Chesnutt et al. (1998)CD4T cellsThey also develop a lymphoproliferative disorder characterized by a massive accumulation of double-negative (DN) T cells that lack both CD4 and CD8.
Kubota et al. (1994)CD4T cellsThese results indicate that the massively accumulating lymphocytes of MRL/l mice have a property characteristic of activated T cells, although they express little surface CD4 or CD8 and do not produce IL-2.
Gao et al. (2000)CD4T-cellIn contrast, treatment with CTLA4 fusion protein (CTLA4Ig), prolonged hepatocyte survival in CD8 KO but not CD4 KO mice, showing that CD28/B7 interactions were important in CD4(+) but not CD8(+) T-cell initiated hepatocyte rejection.
Mixter et al. (1991)CD4T cellsSignificant numbers of T cells reappear in the periphery about age 65 days, but these cells tend to lack expression of CD4 or CD8.
Bakir et al. (2006)CD4T cellsThe majority of B220(+) T cells were gammadelta T cells and these T cells were double-negative CD4(-) CD8(-).
Garssen et al. (1994)CD4T cellsThe early-acting CS-initiating cells are not conventional T cells inasmuch as they are surface negative for CD4, CD8, and CD3.
Kao and Allen (2005)CD4T cellsAn antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4.
Pewe et al. (1996)CD4T cellMutations are not present in sequences flanking this epitope or in other CD8+ or CD4+ T cell epitopes.
Mohamood et al. (2008)CD4T cellsNormal peripheral CD4 and CD8 T cells do not normally expressed B220 but it is expressed on activated T cells undergoing apoptosis following injection of mice with staphylococcal enterotoxin B superantigen [20]–[22].
Ardavin and Shortman (1992)CD4T cellHowever, although they do not express the T cell markers Thy-1, CD2, CD3, CD4 and CD5, 20%-30% of dendritic cells are positive for the interleukin 2 receptor alpha chain (CD25), and about 30% express intermediate levels of CD8.
Tone et al. (2000)CD4T cellPhenotypic analysis of the induced NK1.1(+) alpha beta T cell population suggested that these cells expressed CD8 but not CD4 molecules, which is a different characteristic from ordinary thymic NK1.1(+) alpha beta T cells.
Lifson et al. (1986)CD4T cellThe mechanism of giant cell formation was studied in the CD4 (T4/Leu 3) positive T cell lines JM (Jurkat) and VB and in variants of these lines that are negative for cell surface CD4 antigen.
Qian et al. (2001)CD4T cellsFurther studies on purified subpopulations of T lymphocytes indicated the existence of VIPR2 in CD8(+) T cells, but not CD4(+) and CD4CD8 double negative T cells, although all these three subpopulations displayed VIPR1.
Kishi et al. (1995)CD4T lymphocytesIMT-1 was found to be expressed on 40 to 50% of CD4-8- double negative (DN), 5 to 10% of CD4-8+, and 5 to 20% of CD4+8+ double positive (DP) thymocytes in adult mice, but not expressed on CD4+8- thymocytes or peripheral T lymphocytes.
Kitagawa et al. (1991)CD4T cellsThese results demonstrate that 1) the suppression of graft rejection responses is not necessarily reflected on the reduction of MLR; 2) CD8+ CTL precursors responsible for graft rejection can be activated by either allo-class I-reactive CD8+ or CD4+ Th cells; 3) i.v. presensitization induces functional elimination of CD8+ and CD4+ proliferative/IL-2-producing T cells but not of CD8+ CTL precursors and CD4+ Th whose capacity is expressed by assistance of CTL induction but not by their own proliferation.
Tanaka et al. (1993)CD4T cellsWe found that, contrary to the previous report, the CD4-8-B220+ alpha beta T cells in lymph node (LN) of MRL/lpr mice were negative for both IL-2R alpha and IL-2R beta expression.
Udhayakumar et al. (1989)L3T4T cellAll of the tumors did not express the T cell specific markers Thy 1.2, L3T4, and Lyt2.1.
Shores et al. (1988)L3T4T cellsIn the present investigation, these T cells were found to express the L3T4+/Lyt-2- phenotype, unlike the aberrant L3T4-/Lyt-2-"double negative" 1pr T cells, and to utilize the L3T4 determinant in generating help for the anti-Sm response.
Gallegos et al. (2008)CD4T cellsThe same protocol was used to make polyclonal Th1 CD4+ T cells, except the CD4+ T cells were taken from B6 mice and stimulated in the presence of 1 ?
Xu et al. (1996)CD4T cellsT cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.
Salmon et al. (1996)CD4T cellsCharacterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes.
Andjeli? et al. (1994)CD4T cellFas was not expressed on fetal nor adult CD8-CD4- (double-negative, DN) T cell precursors.
Zaldumbide et al. (2002)CD4T cellsWe show that, in young animals, there are fewer T cells in Deltaets2 transgenic thymi and that the maturation of these T cells is affected at the CD4(-)CD8(-) double-negative to CD4(+)CD8(+) double-positive transition compared with wild-type littermate mice.
Wiest et al. (1994)CD4T cellsCIC complexes are expressed in normal mice on early thymocytes through the CD4+CD8+ stage of development, but not on mature peripheral T cells.
Lamant et al. (2004)CD4T-cellBoth large and small malignant cells were positive for CD43/MT1 T-cell associated antigen, perforin, granzyme B and TIA-1, but negative for CD2, CD3, CD5, CD7, CD4 and CD8 antigens.
Lee et al. (1998)CD4T cellsThe majority of the thymocytes are immature T cells that express neither CD4 nor CD8 molecules, indicating that T cells are affected at an early stage of thymic differentiation.
Harriman et al. (1990)CD4T cellThy-1- and Thy-1+ CD4 T cell lines generated from PP also coexpress CD3 and alpha beta-TCR, but are heterogeneous in expression of CD5 and again do not coexpress CD8.
Cowley et al. (2007)CD4T cellAlthough the magnitude of CD4(+) T cell-induced macrophage NO production clearly depended on TNF, control of LVS growth by both CD4(+) and CD8(+) T cells did not correlate with levels of nitrite.
Marodon and Klatzmann (2004)CD4T-cellThe early thymocyte progenitors entering the thymus do not express T-cell-specific molecules, such as CD3, the alpha or beta-chain of the TCR, or the CD4 and CD8 molecules.
Collazo et al. (2000)CD4T cellsIntracellular cytokine staining by flow cytometry revealed that, in contrast to infected nontransgenic controls, infected PCC-Tg animals failed to develop IFN-gamma-producing CD4(+) T cells.
Fehr et al. (2010)CD4T cellsBy generating mice lacking NFAT1 in CD4 but not CD8 cells, we demonstrate that NFAT1 is neither required for CD4 tolerance induction nor for their regulatory function on CD8 T cells.
Villeneuve et al. (2008)CD4T cellsMore precisely, T cells with helper or cytotoxic function were sensitive to dexamethasone, but not those that were negative for the CD4 and CD8 molecules, including gammadelta and natural killer (NK) T cells.
Kowalczyk et al. (2007)CD4T cellWe also demonstrated that coimmunization of NXS2-challenged mice with the IL-15 and IL-21 gene combination resulted in enhanced CD8(+) T cell function that was partially independent of CD4(+) T cell help in inhibiting tumor growth.
Renno et al. (1998)CD4T lymphocytesWhile activated microglia/macrophages persisted in demyelinating lesions for over 100 days, CD4(+) T lymphocytes were no longer present in CNS.
Kim et al. (2008)CD4T cellsAmong the CD3+ RNL, 20-30% were GL3+ gammadelta T cells, which were double-negative for CD4 and CD8 and predominantly expressed a Vgamma4/Vdelta1 TCR.
Weigmann et al. (2004)CD4T cellsIn contrast, transfer of CD4(+)CD62L(-) T cells from c-Maf transgenic, but not wild-type mice induced colitis and augmented colitis induced by CD4(+)CD62L(+) T cells from wild-type mice in an IL-4-independent pathway, as determined by macroscopic, histologic, and endoscopic criteria.
Derecki et al. (2010)CD4T cellsA recent study showed that acute depletion of T cells by administration of anti-CD3 antibodies results in cognitive impairment within 5 d, and that the effect is mediated by CD4+ but not CD8+ T cells (Wolf et al., 2009).
Dwyer et al. (2007)CD4T cellThe majority of human CD19+ B cells express CD39; however, within the T cell compartment CD39+ cells are present in the CD4+ subset (not shown).
Suto et al. (2008)CD4T cellsAs shown in Fig. 7 C, a neutralizing antibody against IL-6 decreased the number of IL-21–producing CD4+ T cells by 50% without any significant change in the number of IL-4 single-positive cells.
Van Houten and Budd (1992)CD4T lymphocytesMRL-lpr/lpr (lpr) mice develop a polyclonal accumulation of abnormal peripheral T lymphocytes, which bear surface alpha beta TCR, CD3, and the B220 isoform of CD45, but lack CD4, CD8, and CD2.
Matesic et al. (1998)CD4T cellsAdoptive transfer of the IL-4/IL-5-producing CD4+ T cells, but not the CD8+ T cells, induced a distinct histopathology characterized by marked eosinophilic infiltration of the skin.
Gorbachev et al. (2001)CD4T cellsDevelopment of IFN-gamma-producing CD4(+) T cells during hapten sensitization was absent in wild-type mice treated with anti-CD154 mAb or in CD154(-/-) mice.
Suarez-Pinzon et al. (1999)CD4T-cellsIn contrast, Fas was expressed on CD4+ T-cells, CD8+ T-cells, and beta-cells in islet grafts from diabetic mice, but it was nearly or totally absent on these cells in islet grafts from normoglycemic mice.
Lech et al. (2008)CD4T cellThe functional effect of this observation on autoreactive T cells remains uncertain because the CD4/CD8–double negative T cell population was not significantly affected by the Tir8 genotype.
Lanier et al. (1985)CD4T cellsFurthermore, a majority of these T cells lacked either CD4 or CD8 expression.
Nagarkatti et al. (1988)CD4T cellsIt was observed that L3T4+ (CD4+) or Lyt-2+ (CD8+) T cells from BCNU-cured mice could provide significant protection (80 and 40% survival, respectively) in irradiated or nude mice but not in normal mice.
Zhang et al. (2009)CD4T cellsIn partial support of this hypothesis, earlier studies reported that the severity of CHS was significantly lessened in mice lacking either CD4+ or CD8+ T cells, and these data suggested that the involvement of T cells in the development of CHS [7].
Nixon-Fulton et al. (1988)L3T4T-cellWhile dendritic Thy-1+ EC, in vivo, do not express the T-cell markers, L3T4 and Lyt-2, short-term cultured cells displayed phenotypic heterogeneity with small but significant percentages of Lyt-2+ and L3T4+ cells appearing transiently.
Wu et al. (2002)CD4T cellsMice that lack IL-15 or the IL-15R alpha-chain (IL-15Ralpha) are deficient in peripheral CD8(+), but not in CD4(+), T cells.
Hill and Dunn (1993)CD4T cellCytofluorometric studies revealed that the Thy+ CD4- CD8- cells responsible were negative for the CD3 T cell marker.
Kelly et al. (2007)CD4T cellThis occurs in T cell precursors, which do not express the major histocompatibility complex (MHC) receptors CD4 and CD8 (double-negative (DN) thymocytes).
Maryanski et al. (1987)L3T4CTLThe CTL were Lyt-2+/L3T4- and lysed L cell transfectant clones that expressed the hTR gene but not control untransfected L cells or transfectants selected for the expression of an unrelated human cell surface antigen, 4F2.
Bank et al. (2001)CD4T-cellsThree of four had elevated IgE, thrombotic manifestations and lung involvement (asthma and/or infiltrates), and one had deforming sero-negative arthritis of the hands. 66-95% of their peripheral T-cells expressed CD4 but not CD3 or TCR molecules on the cell surface membrane.
Crosbie et al. (1998)CD4T-cellCirculating CD3+ T lymphocytes that express neither the CD4 nor CD8 surface molecules (double-negative T lymphocytes) are phenotypically and functionally distinct from single-positive CD3+CD4+ and CD3+CD8+ lymphocytes and are thought to represent a distinct T-cell lineage.
Dias et al. (2009)CD4T cellsThe protective effect by IL-12 required CD8+, but not CD4+ T cells.
Kim (2008)CD4T cellOne of the earliest colonizing cells in lymphoid tissues is the lymphoid tissue inducer (LTi) cell, expressing CD4 and CD45 but not lineage markers including CD3 (T cell marker), CD11c (dendritic cell marker), B220 (B and plasmacytoid dendritic cell marker) or macrophage cell marker.1 LTi cells are a unique subset of the liver derived haematopoietic cells found to colonize fetal secondary lymphoid organs early in embryonic day 13 (E13) in mice.1,2 Since they are found in recombinase activating gene (RAG)-deficient or T cell deficient mice, they do not require receptor rearrangement.3,4
Romano et al. (2004)CD4T cellThe CD4(+) and CD8(+) T cell epitopes defined for PstS-3 were completely specific and not recognized in mice vaccinated with either PstS-1 or PstS-2 DNA.
Zhang et al. (2007)CD4T cellsdim T cells at 14 weeks (Figure 5C); this relationship held true for CD4+ but not CD8+ T cells, whereas no such association was found between clinical response to anti-TNF and other cellular parameters, such as total lymphocyte counts, or the percent CD3+ or CD45RO+ T cells (data not shown).
Church et al. (2010)CD4T cellsConsidering the importance of IL-23 to the development and maintenance of Th17 cells, it is striking that over 90% and 85% of IL-17-producing CD4 T cells in the SF and blood respectively did not express IL-23R.
McClanahan et al. (1999)CD4T-cellsThe majority of normal gammadelta-T-cells are negative for surface CD4 and CD8 and a subpopulation does not express CD5, two immunophenotypic findings strongly suggestive of neoplasia in alpha beta T-cells.
Capocasale et al. (1995)CD4T cellsOur results indicate that unlike normal CD4+ T cells, CD4+ T cells from 9 of 12 SzS patients expressed little, if any, surface TGF beta RII in response to mitogen stimulation.
Roose et al. (2003)CD4T cellThe Jurkat T cell leukemic line E6–1 expresses high levels of mature TCR and low levels of CD4, but no CD8 or MHC class II.
Pietropaolo et al. (2008)CD4T-cellsFor instance, the mouse MHC is distinct in many aspects from that of humans in that the MHC class II is expressed on activated human but not murine CD4+ T-cells.
Xu et al. (1996)CD4T cellsSensitization with DNFB or Ox induced lymph node cell populations of CD8+ T cells producing interferon (IFN)-gamma and no interleukin (Il) 4 or Il-10, and CD4+ T cells producing Il-4 and Il-10 and no or little detectable IFN-gamma.
Spolski et al. (1988)CD4T cellResults indicate that the Abelson T cell lines do not express the cell surface markers CD4 and CD8, but express relatively high levels of gamma chain transcripts.
Fink et al. (2010)CD4T cellsSCART1 was present in 86% of the gammadelta T cells and was not found in CD4(+) or CD8(+) T cells.
Obar et al. (2010)CD4T cellsHere we have studied effector and memory CD8(+) T cell differentiation following infection with three pathogens (Listeria monocytogenes, vesicular stomatitis virus, and vaccinia virus) in the absence of both CD4(+) T cells and IL-2 signaling.
Takano et al. (2007)CD4T cellOrally administered capsicum extract and capsaicin did not change the T cell subset (CD4(+) and CD8(+)), Th1 (IFN-gamma(+)) and T2 (IL-4(+)) ratio.
Eshima et al. (2003)CD4T cellsWithout CD154, CD4 T cells were not capable of mediating help in disease development in NOD mice.
Glinka and Prud'homme (2008)CD4T cellsIt should be noted that this population overlaps with but is not identical to the CD4+CD25+ population analyzed in Figure 3, C and D, as approximately two-thirds of CD4+Nrp1+ T cells does not express CD25 (Fig. 3E).
Davis and Littman (1995)CD4T cellsThe double-transgenic mice continued to generate thymocytes and T cells that expressed the transgenic TCR, but these cells did not express endogenous CD4.
Elrefaei et al. (2010)CD4T cellsHIV-specific TGF-beta-positive CD4+ T cells do not express regulatory surface markers and are regulated by CTLA-4.
Jankovic et al. (2002)CD4T cellIn the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.
Lech et al. (2008)CD4T cellIn the absence of Sigirr, CD4 T cell numbers were increased and CD4(+)CD25(+) T cell numbers were reduced.