Viewing affirmative mentions of gene expression of Cd3e (M. musculus) in T cells

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Wang et al. (1997)CD3T lymphocyteBecause some signal transducing molecules recruited by CD3-epsilon, i.e., p56lck and p59fyn, are oncogenic and since we previously found that overexpression of CD3-epsilon transgenes causes a block in T lymphocyte and NK cell development, we tested the hypothesis that aberrant CD3-epsilon signaling leads both to abnormal T lymphocyte death and lymphomagenesis.
Renard et al. (1995)CD3 epsilonT cellsIntriguingly, the distribution of CD3 epsilon is not restricted to T cells, since activated mouse, human, and avian natural killer (NK) cells do express intracytoplasmic CD3 epsilon polypeptides.
Taniguchi et al. (1996)CD3T cellsIn V beta 8.2 but not B beta 3 transgenic mice, two NK T cells with different CD3 epsilon expressions, CD3 epsilon(dim) and CD3 epsilon(high), can be identified.
Zhang et al. (1998)CD3T cellsRecent studies demonstrate that the surface expression of CD3 components can occur independently of the clonotypic TCR complexes in both thymocytes and splenic T cells.
Ley et al. (1989)CD3T cellSurface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post-endoplasmic reticulum compartment.
Clayton et al. (1991)CD3T-cellThus, posttranscriptional and/or transcriptional regulatory mechanisms control CD3 zeta and CD3 eta expression during T-cell development.
Massaia et al. (1994)CD3T-cellIn this study we report a B-cell lymphoma in which T-cell CD3 zeta expression correlated with disease activity.
Davignon et al. (1991)CD3T-cellCD3 expression, modulation and signalling in T-cell subpopulations from MRL/Mp-lpr/lpr mice.
Davignon et al. (1991)CD3T cellsTo investigate these abnormalities further, we examined CD3 expression and modulation in subpopulations of +/+ and lpr T cells and measured mitogen-induced Ca++ mobilization in DN lpr T cells.
Davignon et al. (1991)CD3T cellsTheir expression and modulation of CD3 are intermediate, between that of SP and DN lpr T cells.
Bello et al. (2007)CD3T lymphocytesThe antigen T cell receptor (TCR)-CD3 complexes present on the cell surface of CD4(+) T lymphocytes and T cell lines express CD3 epsilon chain isoforms with different isoelectric points (pI), with important structural and functional consequences.
Wiest et al. (1994)CD3T cellDevelopmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.
Wiest et al. (1994)CD3T cellCD3 signal transducing proteins are thought to be expressed on the surface of T cells only as part of clonotypic T cell receptor (TCR) complexes.
Thompson et al. (2009)CD3T-cellsThis report describes the preclinical in vivo testing of these conjugates in transgenic mice whose T-cells express human CD3 molecules.
Pfistershammer et al. (2006)CD3T cellsIn this study, we evaluated the contribution of PD-L2 to the activation of human T cells using a novel system of engineered T cell stimulators that expresses membrane-bound anti-CD3 antibodies.
Bijl et al. (2005)CD3epsilonT-cellsWe now report the generation of a pre-B leukemia model using E2a-PBX1 transgenic mice, which lack mature and precursor T-cells as a result of engineered loss of CD3epsilon expression (CD3epsilon(-/-)).
Fang et al. (2004)CD3T cellRESULTS: The scBsAb showed nearly identical ligand binding properties at each site relative to the individual monovalent single-chain antibody prototype molecules and could bridge SKOV3 and human T cell line Jurkat, which expresses CD3 antigens on the surface of cells together.
Ciavarra et al. (2003)CD3T cellsFirst, tumor-associated T cells, but not splenic T cells from tumor-bearing animals, were profoundly deficient in expression of CD3-epsilon (CD3epsilon) and T cell receptor-beta chain (TCRbeta).
Thompson et al. (2001)CD3epsilonT-cellsThe in vivo potency of the genetically engineered immunotoxins was assayed in the transgenic heterozygote mouse, tgepsilon 600, in which the T-cells express human CD3epsilon as well as murine CD3epsilon.
Griffin et al. (2000)CD3epsilonT cellsCoexpression of anti-CTLA-4 scFv with anti-CD3epsilon and anti-CD28 scFvs on artificial APCs reduced the proliferation and IL-2 production by resting and preactivated bulk T cells as well as CD4+ and CD8+ T cell subsets.
Biro et al. (1999)CD3T cellDuring alphabeta thymocyte development, clonotype-independent CD3 complexes are expressed at the cell surface before the pre-T cell receptor (TCR).
Sato et al. (1999)CD3epsilonT cellHere, we describe a precursor population of NKT cells (pre-NKT) that expresses NK1.1, T cell antigen receptor beta, pTalpha, and RAG1/2 but not Valpha14 and surface CD3epsilon.
Haks et al. (1998)CD3epsilonT cellsFurthermore, absence of CD3gamma results in a severe reduction in the level of TCR and CD3epsilon expression at the cell surface of thymocytes and peripheral T cells.
Ghendler et al. (1998)CD3epsilonT cellsMoreover, analysis of T cells isolated from transgenic mice expressing both human and mouse CD3epsilon genes shows that the heterologous human CD3epsilon component can replace the mouse CD3epsilon at this site.
Liu et al. (1997)CD3T cellWe conclude that FcR gamma can replace the functions of zeta in T cell development in vivo but that TCR/CD3 complexes associated with FcR gamma rather than zeta are less well expressed on cells.
Liu et al. (1997)CD3T cellsAlso, these results revealed a difference in the regulation of expression of the TCR/CD3 complex on CD4+ and CD8+ T cells.
FitzGerald et al. (1997)CD3T-cellA crosslinked bivalent diabody against carcinoembryonic antigen (CEA) and a crosslinked bispecific diabody against CEA and the T-cell co-receptor CD3 were expressed from Pichia pastoris and Escherichia coli by secretion.
Shata et al. (1995)CD3T cellIn this communication, evidence is presented suggesting an association between the surface expression of CD3/Ti and that of the type 1 interferon (IFN) receptor in a CD4+ murine T cell clone.
Yamada et al. (1995)CD3T cellDifferential expression of the T cell receptor/CD3 genes and their lymphoid-specific transcription factor genes in murine T cell x fibroblast and T cell x B cell hybrids.
Schleifer et al. (1993)CD3T cellsThe cellular phenotype of VSG-responsive T cells was that of classical Th cells in that all cells were CD4-positive and expressed the CD3 alpha/beta TCR membrane complex.
O'Neill (1993)CD3T-cellThey have the unusual property of expressing CD3/T-cell receptor alpha and beta chains (TCR-alpha beta) in the absence of other T-cell markers such as Thy-1, CD4, and CD8.
de Waal Malefyt et al. (1993)CD3T cellsIL-10 did not affect the expression of the TCR/CD3 complex, CD2, LFA-1, CD28, or IL-2R alpha- or beta-chains, nor did it inhibit the induction of the latter two molecules on T cells after activation.
Shen (1993)CD3T lymphocytesA monoclonal antibody (McAb, named HIT3a) against CD3 antigen of human T lymphocytes was produced by the mouse-mouse hybridization technique and identified by immunofluorescent test, immunohistochemistry assay, comparison with standardized McAbs, and some studies of biological properties.
Spertini et al. (1991)CD3T cellT cell activation by TS 43 mAb involved a rise in intracellular calcium level (CA2+)i and was dependent on the expression of the TCR/CD3 complex because no rise in (Ca2+)i was observed in a TCR-beta-deficient Jurkat T cell mutant.
Davidson et al. (1991)CD3epsilonT cellsIn addition, CD4 dull+ Ly-5(B220)+ cells closely resembled DN T cells in size and expression of TCR-alpha/beta, CD3epsilon, CD44, and Ly-6C.
Voss et al. (1991)CD3T-cellDifferent T-cell lines from this patient and from normal individuals were then stimulated through their T-cell antigen receptor complex and were then tested for three aspects of cellular activation: (1) transmembrane signaling (i.e., phosphoinositide turnover), (2) lymphokine secretion (i.e., release of lymphotoxin), and (3) their capacity to mediate cellular cytotoxicity (using murine anti-CD3-producing hybridoma cells as targets).
Le Deist et al. (1991)CD3T cellIn this paper we describe the main findings about the leukocyte adhesion deficiencies (LAD), the ID with low expression of the T cell receptor/CD3 complex, and the Omenn's syndrome.
Scholz et al. (1988)CD3T cellsIn addition, they expressed on their surface the antigen-specific T cell receptor-CD3 complex, which is required for T cell activation, albeit at a lower density than that found on congenic +/+ T cells.
Clevers et al. (1988)CD3T-cellThe CD3 genes are expressed early in thymocyte development, preceding the rearrangement and expression of the T-cell receptor genes.
Houghton et al. (1989)CD3T-cellThis surface expression of CD3 was accompanied by production of mRNA for the T-cell receptor alpha chain and surface expression of the T-cell receptor.
Flamand et al. (1990)CD3T cellsSince most "NK-like activity" in freshly isolated populations appears to be associated with CD3- cells, whereas antigen-specific, MHC-restricted T cells mostly express CD3 determinants, CD3 was a good marker for evaluating the role of T cells and "NK" cells in tumor resistance in vivo.
Berkhout et al. (1988)CD3T cellTransfection of genes encoding the T cell receptor-associated CD3 complex into COS cells results in assembly of the macromolecular structure.
June et al. (1987)CD3T cellIn addition, several Cd5+/CD3- T cell leukemia lines also failed to respond to CD5 stimulation, providing further evidence which indicates that the CD5 response depends on the cell surface expression of CD3 or a CD3-associated structure.
Clayton et al. (1992)CD3T cellsDespite earlier reports of the detection of human CD3 eta protein, we find no CD3 eta message in human thymus or T cells.
Gray et al. (1989)CD3T lymphocytesFinally, direct stimulation of increased intracellular Ca2+ concentration by PT and the B oligomer only occurred in T lymphocytes expressing CD3.
Chen et al. (1992)CD3T-cellIn contrast to earlier reports, combined marker and labelled-cell studies suggest that T-cell surface marker CD3 with reported specificity for human lymphocytes are indeed found, also in man-mouse chimeras, only on human cells.
de la Hera et al. (1991)CD3T cellTransgenic mice carrying and expressing the human CD3 epsilon gene incorporate the corresponding protein product into T cell receptor (TCR)/CD3 complexes on thymocyte and T cell surfaces.
Chervenak et al. (1991)CD3T cellsCharacterization of the progeny of pre-T cells maintained in vitro by IL-3: expression of the IL-2 receptor and CD3 during thymic development.
Chervenak et al. (1991)CD3T cellsThe results of these studies showed that the progeny of cultured pre-T cells were able to develop expression of the IL-2 receptor and CD3 surface antigen during their residency within the thymus.
Ohtsuka et al. (1997)CD3T cellsThe expression of CD3 and TCR alphabeta of these T cells was found to be of intermediate intensity (TCR(int) cells).
Lanier et al. (1985)CD3T lymphocytesA subset of peripheral blood T lymphocytes coexpressing CD3 and IgG Fc receptors (FcR) (CD16/Leu-11 antigen) have been identified, isolated, and functionally characterized.
Aoe et al. (1995)CD3T cellsSplenic T cells from tumor-bearing hosts lost the expression of the CD3 zeta chain without being replaced by FcR gamma, despite the normal expression of other components of the TCR complex.
Cron et al. (1989)CD3T cellsPhenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.
Lawetzky and Hünig (1988)CD3T cellAnalysis of CD3 and antigen receptor expression on T cell subpopulations of aged athymic mice.
Sampedro et al. (2004)CD3T lymphocyteMannan affects the expression of CD3(+) SpMC indicating that mannan inhibits mainly T lymphocyte proliferative response.
Clevers et al. (1988)CD3T-cellThe isolation, characterization, and in vitro expression of the murine CD3-epsilon gene, as reported here, represent obligatory steps toward our understanding of the complex rules that govern T-cell-specific gene expression.
Tan et al. (1991)CD3T cellTo understand the nature of the interaction between Ti and CD3, chimeric molecules which included the COOH-terminal segments of Ti alpha or beta linked to the extracellular segment of CD8, were transfected into a mutant T cell deficient in Ti beta chain expression and cell surface CD3.
Wang et al. (1995)CD3 epsilonT lymphocyteOver-expression of CD3 epsilon transgenes blocks T lymphocyte development.
Wang et al. (1995)CD3 epsilonT lymphocyteSince the number of transgene copies generally correlated with the levels of expression of the transgenic CD3 epsilon proteins, we concluded that over-expression of the CD3 epsilon protein was the likely cause of the block in T lymphocyte development.
Wang et al. (1995)CD3 epsilonT lymphocyteOver-expression of the CD3 epsilon transgene in thymocyte precursors may therefore affect T lymphocyte development in the absence of TCR and possibly in the absence of the other CD3 proteins.
Kennedy et al. (1992)CD3T cellAlthough the proportion of CD4+ and CD8+ T cells associated with bright CD3 expression increases with age, at no age are significant numbers of CD4+8+ cells observed, in contrast to intrathymic T cell maturation.
Kennedy et al. (1992)CD3T cellsIn addition to the frequently observed inversion in the ratio of CD4 to CD8, the CD8 T cell subpopulation in older nude mice contains mainly mature cells (CD8+, CD3+, HSA-) whereas only 50% of CD4+ T cells express the mature (CD4+, CD3+, HSA-) phenotype.
Stafford-Brady et al. (1989)CD3T cellsTriggering of the T-cell receptor in these lpr T cells does not lead to translocation of protein kinase C or phosphorylation of CD3, interleukin-2 production, or proliferation, whereas a combination of phorbol ester and calcium ionophore does.
Wang et al. (1997)CD3T lymphocyteCONCLUSION: The nonenzymatic CD3-epsilon protein acted as a potent oncogene when overexpressed early in T lymphocyte development.
Wang et al. (1998)CD3 epsilonT cellExpression of a CD3 epsilon transgene in CD3 epsilon(null) mice does not restore CD3 gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes.
Ono et al. (1996)CD3T cellIL-7 upregulates T cell receptor/CD3 expression by cultured dendritic epidermal T cells.
Ono et al. (1996)CD3T cellDendritic epidermal T Cells (DETC) in adult mice express uniformly the phenotype of Thy-1+, T cell receptor (TCR)-V gamma 3/V delta 1+, CD3+, CD4- and CD8-.
Doskow and Wilkinson (1992)CD3T-cellThe potential implications of this regulation on the composition and expression of the TcR/CD3 complex during T-cell ontogeny and activation is discussed.
Zhang et al. (1998)CD3T cellIn this study, we report that free noncovalently associated TCR alpha beta heterodimers that exist independently of CD3 and TCR zeta chains are expressed on the cell surface of immature thymocytes and peripheral T cells, but not of T cell lines and T cell hybridomas.
Franek et al. (1994)cCD3 epsilonT-cellIn order to study the expression of the T-cell receptor TCR/CD3 complex during pre-thymic T-cell differentiation, we have developed a flow cytometric technique for the simultaneous detection of surface (sCD3 epsilon) and cytoplasmic CD3 epsilon (cCD3 epsilon).
Szymczak et al. (2004)CD3T-cellUsing the T-cell receptor:CD3 complex as a test system, we show that a single 2A peptide-linked retroviral vector can be used to generate all four CD3 proteins (CD3epsilon, gamma, delta, zeta), and restore T-cell development and function in CD3-deficient mice.
Clayton et al. (1991)CD3T-cellCD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development.
Wilde and Goa (1996)CD3T cellThe murine monoclonal antibody muromonab CD3 (OKT3) is directed against the CD3 antigen on peripheral human T cells and effectively blocks all T cell function.
Sussman et al. (1988)CD3T cellTo explore the roles of the individual CD3 components, an antigen-specific murine T cell hybridoma was chemically mutagenized and antigen-induced growth inhibition was used to select CD3/Ti expression variants.
Davignon et al. (1991)CD3T cellsWe found that expression and modulation of CD3 in CD4hi and CD8hi lpr single positive (SP) T cells are similar to that in +/+ T cells.
Sato et al. (1990)CD3T cellSince Thy-1-mediated activation is suggested to require co-expression of the CD3-TCR complex, we compared the T cell proliferative response in mature T cells stimulated with anti-Thy-1 (G7) and anti-CD3-epsilon (2C11).
Levelt et al. (1993)CD3T-cellThymic repertoire selection requires the expression of the alpha beta CD3 T-cell receptor (TCR) together with the coreceptors CD4 and CD8.
Kenai et al. (1995)CD3T cellReverse transcription-polymerase chain reaction analysis showed both CD3- populations express the recombination-activating gene -1, which is indispensable in gene rearrangement of TCR and expressed by thymic T cell precursors.
Kenai et al. (1995)CD3intT cellsCD3int LMNC express NK1.1 and show a skewed T cell receptor (TCR) V region repertoire with relatively high levels of V beta 8 and V alpha 14 expression, further suggesting that they belong to a different lineage from conventional T cells, which lack NK1.1 expression and V region skewing.
Kokaji et al. (2008)CD3epsilonT cellImportantly, IL-15 transpresentation and TCR ligation by anti-CD3epsilon or peptide MHC complexes exhibited synergism in stimulating CD8(+) T cell responses.
Chervin et al. (2008)CD3T cellThe method relies on the display of the TCR, in its normal, signaling competent state, as a CD3 complex on the T cell surface.
Chiodetti et al. (2006)CD3epsilonT cellsTo examine the biochemical changes in TCR signaling present in this state, we used a mouse model in which Rag2(-/-) TCR-transgenic CD4(+) T cells were transferred into CD3epsilon(-/-) recipients expressing their cognate Ag.
Bernard et al. (2006)CD3epsilonT cellsRainbow trout IELs contain mainly T cells, because they expressed transcripts of T cell marker homologs of CD8, CD4, CD28, CD3epsilon, TCRzeta, TCRgamma, and TCRbeta and lacked IgM.
Nam et al. (2006)CD3T cellsIn contrast, the compound did not block CD3/TCR-induced cADPR production and the increase of [Ca2+]i in Jurkat T cells, which express CD38 exclusively.
Saul et al. (2005)CD3epsilonT cellUV-induced tumors were measured weekly from week 11 through week 34, blood was collected at week 34, and tissues were collected at week 35. mRNA expression of interleukin (IL)-12p40, interferon (IFN)-gamma, IL-4, IL-10, CD3epsilon, and CCL27/CTACK, the skin T cell-homing chemokine, in dorsal skin was quantified using real-time polymerase chain reaction.
Ciavarra et al. (2004)CD3epsilonT cellsIn contrast to alphabeta-T cells, tumor-infiltrating gammadelta-T cells maintained expression of their antigen receptors but not CD3epsilon.
Claveau et al. (2004)CD3T cellsWe have also shown that the PDE4 inhibitors rolipram and L-826,141 are potent inhibitors of CD3-plus CD28-stimulated IL-2 production in naive human T cells.
Ardouin et al. (1999)CD3T cellTherefore, the ITAMs present in the CD3-gammadeltaepsilon module are sufficient for qualitatively normal TCR signaling and those present in CD3-zeta have no exclusive role during T cell activation.